AutismKB 2.0

Annotation Detail for PELI3


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Basic Information Top
Gene Symbol:PELI3 ( MGC35521 )
Gene Full Name: pellino homolog 3 (Drosophila)
Band: 11q13.2
Quick LinksEntrez ID:246330; OMIM: 609827; Uniprot ID:PELI3_HUMAN; ENSEMBL ID: ENSG00000174516; HGNC ID: 30010
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Signaling in Immune system
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016572 Cyclosporine Cyclosporine results in increased expression of PELI3 mRNAincreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of PELI3 mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Estradiol 2.1811473722
MESH:D001943 Breast Neoplasms Estradiol 2.1019861407 17289903 17018787 12948864 17261762 18497071 14630087 16675129
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.3516111702
MESH:D006528 Carcinoma, Hepatocellular Estradiol 1.8016924424
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.6712371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.6718566989
MESH:D002779 Cholestasis Cyclosporine 3.2819486331
MESH:D003928 Diabetic Nephropathies Estradiol 3.8819279558
MESH:D016889 Endometrial Neoplasms Estradiol 3.2819148513 18566989 11473722
MESH:D005234 Fatty Liver Cyclosporine 3.4019224547
MESH:D005355 Fibrosis Cyclosporine 3.9012639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 5.118708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.3115720958
MESH:D006558 Herpes Genitalis Estradiol 6.1015709030
MESH:D019584 Hot Flashes Estradiol 4.8217088409
MESH:D006973 Hypertension Cyclosporine 2.2410903974
MESH:D007333 Insulin Resistance Estradiol 3.2616627594 16393666
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.5115604871
MESH:D007674 Kidney Diseases Cyclosporine 6.7710903974 18776723 8314463
MESH:D007674 Kidney Diseases Estradiol 6.7715618244
MESH:D007680 Kidney Neoplasms Cyclosporine 8.7512371664
MESH:D007680 Kidney Neoplasms Estradiol 8.7515610895
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6914659978 14716833
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.8516891317 11807958 17203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 5.5519453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.8616801185
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.6616810080
MESH:D009389 Neovascularization, Pathologic Estradiol 4.6217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.5117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.7519348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 4.3211399458 16427766
MESH:D010051 Ovarian Neoplasms Estradiol 2.3319401270
MESH:D011230 Precancerous Conditions Cyclosporine 3.6912371664
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.4420887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0116740699
MESH:D011565 Psoriasis Cyclosporine 2.3516882103
MESH:D013978 Tibial Fractures Estradiol 5.7619048282
MESH:D014605 Uveitis Cyclosporine 5.051336536
MESH:D014985 Xerophthalmia Cyclosporine 5.5117120751
Pathway ID Pathway Name
REACT:6900 Signaling in Immune system
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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