AutismKB 2.0

Annotation Detail for IL27


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:IL27 ( IL-27,IL-27A,IL27p28,IL30,MGC71873,p28 )
Gene Full Name: interleukin 27
Band: 16p12.1-p11.2
Quick LinksEntrez ID:246778; OMIM: 608273; Uniprot ID:IL27A_HUMAN; ENSEMBL ID: ENSG00000197272; HGNC ID: 19157
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
Pathway IDPathway Name
200023IL27-mediated signaling events
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1770Melanoma
1804Chronic obstructive airway disease
2052Infection
2074Asthma
Desease Name
type 1 diabetes
IMMUNE
inflammatory bowel disease (early onset)
respiratory syncytial virus bronchiolitis
INFECTION
Desease Name
Type 1 diabetes
Inflammatory bowel disease (early onset)
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of IL27 mRNAdecreases expression 17557909
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of IL27 mRNAincreases expression 19426678
D008070 Lipopolysaccharides Luteolin inhibits the reaction [Lipopolysaccharides results in increased expression of IL27 mRNA]decreases reaction|increases expression 19426678
D047311 Luteolin Luteolin inhibits the reaction [Lipopolysaccharides results in increased expression of IL27 mRNA]decreases reaction|increases expression 19426678
D047311 Luteolin Luteolin inhibits the reaction [Poly I-C results in increased expression of IL27 mRNA]decreases reaction|increases expression 19426678
D011070 Poly I-C Luteolin inhibits the reaction [Poly I-C results in increased expression of IL27 mRNA]decreases reaction|increases expression 19426678
D011070 Poly I-C Poly I-C results in increased expression of IL27 mRNAincreases expression 19426678
D018038 Sodium Selenite Sodium Selenite results in increased expression of IL27 mRNAincreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.5517505938
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.4311850527 18653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8814692618
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8615885639
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1311677210 16919318 15861022 16105132 17333356 17681005 17110522
MESH:D019457 Chromosome Breakage Sodium Selenite 5.2415894690
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.1016285004
MESH:D003922 Diabetes Mellitus, Type 1 marker/mechanism 19430480
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 2.3615131321
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.6312538720
MESH:D019446 Endotoxemia Lipopolysaccharides 4.9315821434 17637181 15328337
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.1815345470
MESH:D005334 Fever Lipopolysaccharides 4.369205823 11852909
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.7316366002
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2916569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7117937319
MESH:D007249 Inflammation Lipopolysaccharides 3.0312878042 17255318 17237260 9205823 17963957
MESH:D007333 Insulin Resistance Sodium Selenite 3.4914714311
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 5.0317255318
MESH:D007970 Leukopenia Lipopolysaccharides 5.2415821434
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 3.3812878042
MESH:D008106 Liver Cirrhosis, Experimental Poly I-C 3.3818166357
MESH:D055370 Lung Injury Lipopolysaccharides 4.4921114838
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.4614737004
MESH:D010051 Ovarian Neoplasms Luteolin 3.8319005980
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0911578682
MESH:D011014 Pneumonia Lipopolysaccharides 5.0911605937 12224865
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3418760546
MESH:D011537 Pruritus Ethinyl Estradiol 3.8515861022 16919318
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.9510835634
MESH:D013088 Spermatocele Ethinyl Estradiol 4.5516709447
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.5115821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4815669648
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.7414692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9114671159 15869587
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved