AutismKB 2.0

Annotation Detail for MTOR


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Basic Information Top
Gene Symbol:MTOR ( FLJ44809,FRAP,FRAP1,FRAP2,RAFT1,RAPT1 )
Gene Full Name: mechanistic target of rapamycin (serine/threonine kinase)
Band: 1p36.22
Quick LinksEntrez ID:2475; OMIM: 601231; Uniprot ID:MTOR_HUMAN; ENSEMBL ID: ENSG00000198793; HGNC ID: 3942
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04920Adipocytokine signaling pathway
hsa04910Insulin signaling pathway
hsa04012ErbB signaling pathway
hsa04150mTOR signaling pathway
hsa05221Acute myeloid leukemia
hsa05214Glioma
hsa05215Prostate cancer
hsa05200Pathways in cancer
hsa04930Type II diabetes mellitus
Pathway IDPathway Name
Signalling by NGF
Signaling by Insulin receptor
Signaling in Immune system
Pathway IDPathway Name
200034IL12-mediated signaling events
200032Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
200080mTOR signaling pathway
200083CXCR4-mediated signaling events
200061LKB1 signaling events
200095EGFR-dependent Endothelin signaling events
200099IL2 signaling events mediated by PI3K
200072Regulation of Telomerase
200150CXCR3-mediated signaling events
200018IL4-mediated signaling events
200169Class I PI3K signaling events mediated by Akt
200119ErbB2/ErbB3 signaling events
200113ErbB1 downstream signaling
200110IFN-gamma pathway
200057CDC42 signaling events
Pathway IDPathway Name
P00030Hypoxia response via HIF activation
P00036Interleukin signaling pathway
Pathway IDPathway Name
500865mTOR signalling
500921S6K1-mediated signalling
500965Release of eIF4E
500980mTORC1-mediated signalling
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C097240 15-deoxy-delta(12,14)-prostaglandin J2 [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of MTOR proteinaffects cotreatment|decreases phosphorylation 16611854
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of MTOR mRNAdecreases expression 12419474
C065250 4-hydroxy-equilenin 4-hydroxy-equilenin results in decreased expression of MTOR mRNAdecreases expression 15135645
C103303 alitretinoin [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of MTOR proteinaffects cotreatment|decreases phosphorylation 16611854
D000638 Amiodarone Amiodarone inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]decreases reaction|increases phosphorylation 19771169
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MTOR mRNAaffects expression 16483693
D000735 Androstenedione Androstenedione affects the activity of MTOR proteinaffects activity 16033851
D000735 Androstenedione everolimus inhibits the reaction [Androstenedione affects the activity of MTOR protein]affects activity|decreases reaction 16033851
D000735 Androstenedione [letrozole co-treated with everolimus] inhibits the reaction [Androstenedione affects the activity of MTOR protein]affects activity|affects cotreatment|decreases reaction 16033851
D000735 Androstenedione letrozole inhibits the reaction [Androstenedione affects the activity of MTOR protein]affects activity|decreases reaction 16033851
D020001 1-Butanol 1-Butanol affects the activity of MTOR proteinaffects activity 16537399
D002118 Calcium Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]affects reaction|increases activity|increases phosphorylation 12935885
C107676 deguelin deguelin metabolite results in decreased expression of MTOR proteindecreases expression 19139008
C107676 deguelin deguelin results in decreased expression of MTOR proteindecreases expression 19139008
D004958 Estradiol Estradiol affects the activity of MTOR proteinaffects activity 16033851
D004958 Estradiol Estradiol results in increased activity of MTOR proteinincreases activity 16024245
D004958 Estradiol everolimus inhibits the reaction [Estradiol affects the activity of MTOR protein]affects activity|decreases reaction 16033851
D004958 Estradiol letrozole inhibits the reaction [Estradiol affects the activity of MTOR protein]affects activity|decreases reaction 16033851
D000431 Ethanol Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]decreases reaction|increases activity|increases phosphorylation 12935885
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of MTOR mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MTOR mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MTOR mRNAaffects cotreatment|increases expression 17942748
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of MTOR geneincreases mutagenesis 15485918
16724327
C107135 everolimus everolimus inhibits the reaction [Androstenedione affects the activity of MTOR protein]affects activity|decreases reaction 16033851
C107135 everolimus everolimus inhibits the reaction [Estradiol affects the activity of MTOR protein]affects activity|decreases reaction 16033851
C107135 everolimus everolimus results in decreased activity of MTOR proteindecreases activity 16033851
C107135 everolimus [letrozole co-treated with everolimus] inhibits the reaction [Androstenedione affects the activity of MTOR protein]affects activity|affects cotreatment|decreases reaction 16033851
D006581 Hexachlorobenzene Hexachlorobenzene results in decreased expression of MTOR mRNAdecreases expression 15159207
D004441 Ecdysterone Ecdysterone results in decreased expression of MTOR mRNAdecreases expression 15776001
C097613 imatinib imatinib promotes the reaction [NVP ADW742 inhibits the reaction [IGF1 protein results in increased phosphorylation of MTOR protein]]decreases reaction|increases phosphorylation|increases reaction 16740780
C097613 imatinib imatinib results in decreased expression of MTOR proteindecreases expression 19208803
C097613 imatinib tetraarsenic tetrasulfide promotes the reaction [imatinib results in decreased expression of MTOR protein]decreases expression|increases reaction 19208803
C067431 letrozole [letrozole co-treated with everolimus] inhibits the reaction [Androstenedione affects the activity of MTOR protein]affects activity|affects cotreatment|decreases reaction 16033851
C067431 letrozole letrozole inhibits the reaction [Androstenedione affects the activity of MTOR protein]affects activity|decreases reaction 16033851
C067431 letrozole letrozole inhibits the reaction [Estradiol affects the activity of MTOR protein]affects activity|decreases reaction 16033851
C032881 lysophosphatidic acid lysophosphatidic acid results in increased phosphorylation of MTOR proteinincreases phosphorylation 14769825
D008345 Manganese Manganese results in decreased phosphorylation of MTOR proteindecreases phosphorylation 17043766
D008345 Manganese Manganese results in increased phosphorylation of MTOR proteinincreases phosphorylation 17043766
D009534 Niclosamide Niclosamide inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]decreases reaction|increases phosphorylation 19771169
C502355 NVP ADW742 imatinib promotes the reaction [NVP ADW742 inhibits the reaction [IGF1 protein results in increased phosphorylation of MTOR protein]]decreases reaction|increases phosphorylation|increases reaction 16740780
C502355 NVP ADW742 NVP ADW742 inhibits the reaction [IGF1 protein results in increased phosphorylation of MTOR protein]decreases reaction|increases phosphorylation 16740780
C030110 oxaliplatin oxaliplatin results in increased phosphorylation of MTOR proteinincreases phosphorylation 19147571
D010269 Paraquat Paraquat results in decreased phosphorylation of MTOR proteindecreases phosphorylation 17341480
D010480 Perhexiline Perhexiline inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]decreases reaction|increases phosphorylation 19771169
D010656 Phenylephrine Phenylephrine results in increased phosphorylation of MTOR proteinincreases phosphorylation 17976640
D010656 Phenylephrine wortmannin inhibits the reaction [Phenylephrine results in increased phosphorylation of MTOR protein]decreases reaction|increases phosphorylation 17976640
D010656 Phenylephrine Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]affects reaction|increases activity|increases phosphorylation 12935885
D010656 Phenylephrine Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]decreases reaction|increases activity|increases phosphorylation 12935885
D010656 Phenylephrine [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR proteinincreases activity|increases phosphorylation 12935885
D010712 Phosphatidic Acids Phosphatidic Acids results in increased phosphorylation of MTOR proteinincreases phosphorylation 18621911
D010712 Phosphatidic Acids [Phosphatidic Acids results in increased phosphorylation of MTOR protein] which results in increased phosphorylation of RPS6KB1 proteinincreases phosphorylation 18621911
D010712 Phosphatidic Acids [Phosphatidic Acids results in increased phosphorylation of MTOR protein] which results in increased phosphorylation of RPS6 proteinincreases phosphorylation 18621911
D010712 Phosphatidic Acids MTOR protein affects the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein]affects reaction|increases activity 12087098
D010712 Phosphatidic Acids Phosphatidic Acids results in increased activity of MTOR proteinincreases activity 16537399
C006253 pirinixic acid pirinixic acid results in increased expression of MTOR mRNAincreases expression 18301758
D017035 Pravastatin Pravastatin results in increased phosphorylation of MTOR proteinincreases phosphorylation 15625077
C059514 resveratrol resveratrol results in increased expression of MTOR mRNAincreases expression 12002526
C085746 rottlerin rottlerin inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]decreases reaction|increases phosphorylation 19771169
D020123 Sirolimus MTOR protein inhibits the reaction [Sirolimus results in decreased activity of RPS6KB2 protein]decreases activity|decreases reaction 12087098
D020123 Sirolimus Sirolimus results in decreased activity of MTOR mRNAdecreases activity 17996122
D020123 Sirolimus Sirolimus results in decreased activity of MTOR proteindecreases activity 15782132
15050414
D020123 Sirolimus [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]decreases activity|decreases reaction|increases activity|increases phosphorylation 15919668
D020123 Sirolimus Sirolimus results in decreased activity of MTOR proteindecreases activity 17510244
D013629 Tamoxifen Tamoxifen results in decreased activity of MTOR proteindecreases activity 19931998
D013629 Tamoxifen [Tamoxifen results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6KB1 proteindecreases activity|decreases phosphorylation 19931998
D013629 Tamoxifen Tamoxifen affects the expression of MTOR mRNAaffects expression 17555576
C401859 temsirolimus temsirolimus results in decreased activity of MTOR proteindecreases activity 16033649
C401859 temsirolimus temsirolimus results in decreased activity of MTOR proteindecreases activity 16954435
C534735 tetraarsenic tetrasulfide tetraarsenic tetrasulfide promotes the reaction [imatinib results in decreased expression of MTOR protein]decreases expression|increases reaction 19208803
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MTOR mRNAaffects cotreatment|increases expression 17942748
D013755 Tetradecanoylphorbol Acetate RAF1 protein affects the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MTOR protein]affects reaction|increases phosphorylation 17976640
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased phosphorylation of MTOR proteinincreases phosphorylation 17976640
C009687 wortmannin wortmannin inhibits the reaction [Phenylephrine results in increased phosphorylation of MTOR protein]decreases reaction|increases phosphorylation 17976640
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.1314745880
MESH:D000014 Abnormalities, Drug-Induced Ethanol 7.1318926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.1311752688 15322242 14514962
MESH:D000015 Abnormalities, Multiple imatinib 4.8918322153
MESH:D000022 Abortion, Spontaneous imatinib 5.8018322153
MESH:D000138 Acidosis Ammonium Chloride 9.1218287403
MESH:D000138 Acidosis Ethanol 9.1211192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5317505938
MESH:D058186 Acute Kidney Injury resveratrol 3.4916538975
MESH:D055371 Acute Lung Injury pirinixic acid 2.7518653653
MESH:D000230 Adenocarcinoma Estradiol 3.8311473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.8314692618
MESH:D000236 Adenoma Ethylnitrosourea 6.396695378
MESH:D000236 Adenoma resveratrol 6.3915688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.5516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.5516835633
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.3711874814
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.9015451039 15451040
MESH:D000544 Alzheimer Disease resveratrol 2.4816162502 16183991
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.8410965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6011748828
MESH:D000756 Anemia, Sideroblastic Manganese 4.5016910769
MESH:D000853 Anophthalmos Ethanol 4.4215513904
MESH:D001008 Anxiety Disorders Ethanol 3.6811141031
MESH:D001145 Arrhythmias, Cardiac Amiodarone 7.9818218290 18057881 20041841
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 7.9817460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.5115885639
MESH:D001169 Arthritis, Experimental resveratrol 6.5117115116
MESH:D001259 Ataxia 1-Butanol 5.217820390
MESH:D050197 Atherosclerosis resveratrol 3.0317967414 16873680
MESH:D001281 Atrial Fibrillation Amiodarone 3.6018651412 19698954
MESH:D001321 Autistic Disorder Sirolimus 3.2521115397
MESH:D001778 Blood Coagulation Disorders Amiodarone 13.2119483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.2119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5015746008
MESH:D001859 Bone Neoplasms imatinib 4.9515867366
MESH:D001919 Bradycardia Phenylephrine 4.1415306635
MESH:D001927 Brain Diseases Ethylnitrosourea 4.5314991843
MESH:D002545 Brain Ischemia resveratrol 3.8817600658
MESH:D001932 Brain Neoplasms Ethylnitrosourea 3.9418412241 16651633 16357521 15144691 16436596
MESH:D001943 Breast Neoplasms alitretinoin 6.4816344269
MESH:D001943 Breast Neoplasms deguelin 6.4817035597 18593368
MESH:D001943 Breast Neoplasms Estradiol 6.4817289903 17018787 12948864 17261762 19861407 14630087 16675129 18497071
MESH:D001943 Breast Neoplasms Hexachlorobenzene 6.4812709520 15061365
MESH:D001943 Breast Neoplasms imatinib 6.4817614352
MESH:D001943 Breast Neoplasms letrozole 6.4816002280 17892469
MESH:D001943 Breast Neoplasms resveratrol 6.4817651959 16393696 17534123
MESH:D001943 Breast Neoplasms Tamoxifen 6.4819142967 17440819 21138602 18629630 16202921 20544844 19410462 21152245 18984771 19155303 16273361 20135344 19059307 20859285 16873071 11161223 19289846 19200415 17242785 19189212 18425577 15668708 20005174 18815881 17049068 15565566 19288272 18351453 19487384 19189210 16818667 18855134 20390343 19221464 19244106 19115204 19103187 19011961 19066611 17893378 20065188 19084267 17261762 18997820 18821012
MESH:D001943 Breast Neoplasms temsirolimus 6.4816954435
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.4820435547
MESH:D002056 Burns Ethanol 4.2616374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0616111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.4816835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1119066611
MESH:D006528 Carcinoma, Hepatocellular deguelin 10.3918575727
MESH:D006528 Carcinoma, Hepatocellular Estradiol 10.3916924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 10.3918788625 15763234 15289165
MESH:D006528 Carcinoma, Hepatocellular resveratrol 10.3916227395 19321006
MESH:D006528 Carcinoma, Hepatocellular Sirolimus 10.3919335982
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 10.3916924424
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.1916675471
MESH:D002294 Carcinoma, Squamous Cell resveratrol 7.0716227395
MESH:D002294 Carcinoma, Squamous Cell Sirolimus 7.0719435901
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 7.0718922899
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.2617572228
MESH:D006332 Cardiomegaly Ethanol 10.1419332462
MESH:D006332 Cardiomegaly Phenylephrine 10.1415728586 11754973 17124262 17287366 16170337 11179087
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 10.1418850075 16120746 18670907
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.7419225199 15710769
MESH:D002318 Cardiovascular Diseases resveratrol 3.1915458977
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.6818974383
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.0818566989
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 6.0816003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.5717160924
MESH:D002659 Child Development Disorders, Pervasive Androstenedione 4.4421398041
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D002779 Cholestasis Ethinyl Estradiol 6.7415861022 16919318 17110522 17681005 11677210 16105132 17333356
MESH:D002779 Cholestasis pirinixic acid 6.7419176532
MESH:D016770 Ciliophora Infections Niclosamide 5.3212113305
MESH:D002971 Cleft Lip Ethanol 3.3715513904
MESH:D002972 Cleft Palate Ethanol 5.3515513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.3516354765 8697196 15340226 12621046 15668235
MESH:D003092 Colitis resveratrol 3.7316474422
MESH:D003110 Colonic Neoplasms oxaliplatin 3.9716004971 16510598 16024531
MESH:D003110 Colonic Neoplasms resveratrol 3.9716338953
MESH:D015179 Colorectal Neoplasms oxaliplatin 2.9118509181 17255274 17695437 17594712 17401013 18448328
MESH:D015179 Colorectal Neoplasms resveratrol 2.9116550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7217141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.4916507316
MESH:D019465 Craniofacial Abnormalities Ethanol 3.7215451039 15513904 19302082 15451040 10194807 11198716 11873399
MESH:D019465 Craniofacial Abnormalities imatinib 3.7218322153
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7220055451 10048152 15322242
MESH:D003711 Demyelinating Diseases Tamoxifen 3.9619031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2318249437
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.4416873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.5617107852
MESH:D003928 Diabetic Nephropathies Estradiol 13.0519279558
MESH:D003928 Diabetic Nephropathies resveratrol 13.0516286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.0519279558
MESH:D056486 Drug-Induced Liver Injury Amiodarone 5.5318218290 15265979
MESH:D056486 Drug-Induced Liver Injury Ethanol 5.5311566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.5320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4611462148
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.5718357618
MESH:D004487 Edema imatinib 17.8619703484
MESH:D004487 Edema pirinixic acid 17.8612083418
MESH:D004487 Edema resveratrol 17.868985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 17.8611000095 12711302
MESH:D004487 Edema Tetradecanoylphorbol Acetate 17.867812673 15177302 8273558 16716910 8113982 9599246 11698051
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.4916714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental 15-deoxy-delta(12,14)-prostaglandin J2 18.8216844232
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 18.8212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 18.8217872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 18.8219031437
MESH:D016889 Endometrial Neoplasms Estradiol 6.4911473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.4916202921 19155303 20544844 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.6710568697 9294722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.4517923197
MESH:D004938 Esophageal Neoplasms Ethanol 2.6516704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7111564622
MESH:D005234 Fatty Liver Amiodarone 20.8114986274
MESH:D005234 Fatty Liver Ethanol 20.8119236843 16409862 18620774
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.8115345470
MESH:D005234 Fatty Liver pirinixic acid 20.8120131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 20.8114986274 19224547
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.2517920746
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.9816709447
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.8916946407 15451040 10194807 15513904
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0611858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.1214745880
MESH:D018222 Fibromatosis, Aggressive imatinib 10.4817453242
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 10.4819069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.5620067830
MESH:D005393 Fish Diseases Niclosamide 5.2812113305
MESH:D005756 Gastritis Ethanol 4.2815046732
MESH:D005909 Glioblastoma Ethylnitrosourea 6.8616436596
MESH:D005909 Glioblastoma Manganese 6.8617043766
MESH:D005910 Glioma Ethylnitrosourea 3.3216357521 18412241 16651633
MESH:D005911 Gliosis Paraquat 4.7511124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1810696789
MESH:D006258 Head and Neck Neoplasms Sirolimus 4.1919435901
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1110048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.2820558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9711000095
MESH:D006529 Hepatomegaly Amiodarone 12.1215265979
MESH:D006529 Hepatomegaly pirinixic acid 12.1219772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.1216120746 12621046 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.6215709030
MESH:D006561 Herpes Simplex resveratrol 3.7816876885
MESH:D019584 Hot Flashes Estradiol 3.3417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6316959395 15340226 16354765 8697196 18606429
MESH:D006930 Hyperalgesia Ethanol 7.3618783367
MESH:D006930 Hyperalgesia oxaliplatin 7.3617418472
MESH:D006937 Hypercholesterolemia Amiodarone 13.498137927 9751232
MESH:D006937 Hypercholesterolemia Pravastatin 13.4917188708
MESH:D006937 Hypercholesterolemia resveratrol 13.4917188708
MESH:D006943 Hyperglycemia pirinixic acid 2.8320558911
MESH:D006949 Hyperlipidemias resveratrol 3.6616873680
MESH:D006973 Hypertension Phenylephrine 4.758949925 12717712
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7518670907 18850075
MESH:D006984 Hypertrophy Phenylephrine 9.8012791704 18502941
MESH:D006984 Hypertrophy Sirolimus 9.8019211884
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.9517488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4116945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 4.1217991464 18020914
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.2517600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.8317937319
MESH:D007248 Infertility, Male Paraquat 5.834850670
MESH:D007249 Inflammation resveratrol 10.1816366677
MESH:D007249 Inflammation Tamoxifen 10.1819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.1812200463 12878042
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 10.1815177302 7812673 11698051 8273558 7562506
MESH:D007251 Influenza, Human resveratrol 4.1316624496
MESH:D007333 Insulin Resistance Estradiol 6.3016627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.3016306350
MESH:D007569 Jaw Abnormalities Ethanol 8.9115513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.9116580747
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.2316144296
MESH:D007674 Kidney Diseases Estradiol 2.3515618244
MESH:D007680 Kidney Neoplasms Estradiol 10.6415610895
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 10.6417379185
MESH:D007680 Kidney Neoplasms Tamoxifen 10.6418625569
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.6316316344
MESH:D007859 Learning Disorders Ethanol 3.8215451040
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive imatinib 8.4615107311 19208803 17301526 15748426
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive tetraarsenic tetrasulfide 8.4619208803
MESH:D007951 Leukemia, Myeloid imatinib 4.7417236224
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.3116087638
MESH:D017880 Limb Deformities, Congenital Ethanol 3.5217676605
MESH:D008064 Lipidoses Amiodarone 11.7115342952 17567588
MESH:D008064 Lipidoses Perhexiline 11.7117567588 15342952
MESH:D008064 Lipidoses Tamoxifen 11.7117567588 15342952
MESH:D008103 Liver Cirrhosis Ethanol 3.1415289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.6918295389
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 9.9814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 9.9818166357
MESH:D008106 Liver Cirrhosis, Experimental imatinib 9.9816596278
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 9.9815474484
MESH:D008106 Liver Cirrhosis, Experimental Sirolimus 9.9817050028
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 9.9818564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 9.9812878042
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.2617347304 17207112
MESH:D008113 Liver Neoplasms pirinixic acid 9.3120007298 15890375 16377806
MESH:D008113 Liver Neoplasms resveratrol 9.3120405173 19812893 19321006 19073162
MESH:D008113 Liver Neoplasms Tamoxifen 9.3116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 9.3116984957
MESH:D008114 Liver Neoplasms, Experimental Hexachlorobenzene 5.331423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.3312151625
MESH:D008133 Long QT Syndrome Amiodarone 3.2711989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 3.1012587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.0718516814
MESH:D008175 Lung Neoplasms alitretinoin 7.8016413115
MESH:D008175 Lung Neoplasms deguelin 7.8016288123 19336726
MESH:D008175 Lung Neoplasms Ethylnitrosourea 7.806695378 16019985 17703301 16271038
MESH:D008175 Lung Neoplasms Tamoxifen 7.8018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 7.8019555203 11884234
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 7.8011807781
MESH:D008223 Lymphoma Ethylnitrosourea 3.6515790496
MESH:D016393 Lymphoma, B-Cell resveratrol 3.9317088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.5414749477
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 4.6515375218
MESH:D016778 Malaria, Falciparum Perhexiline 5.5716882315
MESH:D015674 Mammary Neoplasms, Animal resveratrol 8.6515688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 8.6519428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 16.0311408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 16.0310767621 18041768 10838139
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 16.0311606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 16.0316827153 14580682 19196722 11731420 19196723
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 16.038985016
MESH:D020149 Manganese Poisoning Estradiol 19.9919453300
MESH:D020149 Manganese Poisoning Manganese 19.9916568477 19453300 16551646
MESH:D020149 Manganese Poisoning Tamoxifen 19.9919453300
MESH:D008545 Melanoma resveratrol 6.7817992120
MESH:D008545 Melanoma Sirolimus 6.7819282848
MESH:D008545 Melanoma Tamoxifen 6.7812393984 19393235
MESH:D008545 Melanoma temsirolimus 6.7817508024
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.7815990972
MESH:D008569 Memory Disorders Ethanol 3.8015451040 18411066
MESH:D008579 Meningioma Ethylnitrosourea 5.5717943659
MESH:D008659 Metabolic Diseases resveratrol 4.0117112576
MESH:D009062 Mouth Neoplasms Sirolimus 4.4019435901
MESH:D009069 Movement Disorders Manganese 4.6416551646
MESH:D009101 Multiple Myeloma resveratrol 3.1816267019 17049120 17164350 14749477 17935668 16490592
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.4617962980
MESH:D009135 Muscular Diseases pirinixic acid 3.1116239165
MESH:D009181 Mycoses Amiodarone 4.4912754197 17974566
MESH:D009203 Myocardial Infarction pirinixic acid 8.6519151258
MESH:D009203 Myocardial Infarction Pravastatin 8.6517188708
MESH:D009203 Myocardial Infarction resveratrol 8.6517188708 16456233 17125593 16317513 16525036 17015251
MESH:D017202 Myocardial Ischemia resveratrol 7.9417125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.9412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.2216810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.2216411023
MESH:D009205 Myocarditis resveratrol 4.3517322642
MESH:D009362 Neoplasm Metastasis imatinib 5.6815867366
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.6819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3719410462
MESH:D009369 Neoplasms alitretinoin 7.3316946489
MESH:D009369 Neoplasms deguelin 7.3317764071
MESH:D009369 Neoplasms pirinixic acid 7.3317405874
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 8.1816707424
MESH:D009374 Neoplasms, Experimental resveratrol 8.188985016
MESH:D009376 Neoplasms, Hormone-Dependent imatinib 9.8017614352
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 9.8019200415 19189210 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3317289903
MESH:D009410 Nerve Degeneration Manganese 7.7516551646
MESH:D009410 Nerve Degeneration Paraquat 7.7516893418
MESH:D009421 Nervous System Malformations Estradiol 8.1816427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.1814600291
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.0117160924 16651423 16003739
MESH:D019636 Neurodegenerative Diseases resveratrol 3.4817652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.0217929310
MESH:D009765 Obesity pirinixic acid 1.7120558911
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.5717160924
MESH:D010014 Osteolysis imatinib 5.3315867366
MESH:D010024 Osteoporosis Calcium 3.5317882678
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 3.8817513867
MESH:D010051 Ovarian Neoplasms Estradiol 2.0919401270
MESH:D010190 Pancreatic Neoplasms Ethanol 5.1712384795
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 5.1715976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3111578682
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 3.9018922899 18404319 12065085 8330346
MESH:D010300 Parkinson Disease Manganese 7.9811181820
MESH:D010300 Parkinson Disease Paraquat 7.9812911755 11124998 11445065 15451049 16510128 16140633 11181820 15824117
MESH:D010300 Parkinson Disease Sirolimus 7.9819682553
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.0316190885
MESH:D020734 Parkinsonian Disorders Manganese 4.1216140633
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8312520081
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.0911550810
MESH:D011014 Pneumonia Paraquat 4.0512504350
MESH:D017499 Porokeratosis alitretinoin 5.5916144296
MESH:D017119 Porphyria Cutanea Tarda Hexachlorobenzene 9.829918132
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 9.8218163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma imatinib 4.2512476293
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 8.2416679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.2411896295 11118676 11399792 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5220887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.7316740699
MESH:D011471 Prostatic Neoplasms resveratrol 2.7316731767 17804756 17718901 17636462 17675339 15767336
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.7315067354
MESH:D011537 Pruritus Ethinyl Estradiol 2.9116919318 15861022
MESH:D011658 Pulmonary Fibrosis Amiodarone 5.2812832656 12490602 11597910
MESH:D011658 Pulmonary Fibrosis Paraquat 5.2816324872 17997886
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.1716325855
MESH:D015427 Reperfusion Injury pirinixic acid 5.8819058328
MESH:D015427 Reperfusion Injury resveratrol 5.8816317513 16314181 15827377 17520802 17058453
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.5311700416
MESH:D012135 Respiratory Sounds Paraquat 3.6611874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4518990726
MESH:D012162 Retinal Degeneration Paraquat 3.5616458197
MESH:D012512 Sarcoma, Ewing's NVP ADW742 6.0716740780
MESH:D012640 Seizures Ethanol 2.919754883
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.6818724381
MESH:D012852 Sinusitis Phenylephrine 4.307327846
MESH:D012878 Skin Neoplasms deguelin 12.0216041863
MESH:D012878 Skin Neoplasms resveratrol 12.0215837718 8985016
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.0216192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 12.0218404319 8985016 8330346 11807781 12065085
MESH:D013088 Spermatocele Ethinyl Estradiol 10.1816709447
MESH:D013088 Spermatocele Tamoxifen 10.1816709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.6319457130
MESH:D013274 Stomach Neoplasms Ethanol 3.0218456281
MESH:D013274 Stomach Neoplasms imatinib 3.0215786421
MESH:D013276 Stomach Ulcer Amiodarone 6.3018087811
MESH:D013276 Stomach Ulcer Ethanol 6.3017189318 11906479 9562338 17918041 16755016 9211565
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.1316321402
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.909754883
MESH:D013610 Tachycardia Amiodarone 3.9011238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.8019225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8115669648
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 4.7515790496
MESH:D013959 Thyroid Diseases Amiodarone 10.6719731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.6712697716
MESH:D013964 Thyroid Neoplasms imatinib 4.1316940797
MESH:D013971 Thyrotoxicosis Amiodarone 4.4619584973 18020914
MESH:D013978 Tibial Fractures Estradiol 4.2719048282
MESH:D014062 Tongue Neoplasms resveratrol 3.8616227395
MESH:D016171 Torsades de Pointes Amiodarone 3.7911989578 17467628
MESH:D014402 Tuberous Sclerosis everolimus 11.5218495876
MESH:D014402 Tuberous Sclerosis Sirolimus 11.5218495876 21115397
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.208653321 16712894 17572228
MESH:D002583 Uterine Cervical Neoplasms resveratrol 3.7517473185
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.2214692618
MESH:D014594 Uterine Neoplasms resveratrol 8.2217044934
MESH:D014605 Uveitis Sirolimus 5.221336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1814671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 3.9117488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8315886252
MESH:D014947 Wounds and Injuries lysophosphatidic acid 4.9815541073
Pathway ID Pathway Name
KEGG:05221 Acute myeloid leukemia
KEGG:04920 Adipocytokine signaling pathway
KEGG:04012 ErbB signaling pathway
KEGG:05214 Glioma
KEGG:04910 Insulin signaling pathway
KEGG:04150 mTOR signaling pathway
KEGG:05200 Pathways in cancer
KEGG:05215 Prostate cancer
KEGG:03013 RNA transport
REACT:498 Signaling by Insulin receptor
REACT:6900 Signaling in Immune system
REACT:11061 Signalling by NGF
KEGG:04930 Type II diabetes mellitus
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28360
    • Releated gene ID Related gene Name
    PA28054FBXW7
    PA33942PTEN
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    PA443622Carcinoma, Non-Small-Cell Lung
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA444283Glioblastoma
    PA445062Neoplasms
    PA444685Kidney Neoplasms
    Releated drug ID Related drug Name
    PA451365sirolimus
    PA451365sirolimus
    PA449014cisplatin
    PA448771capecitabine
    PA451283rosiglitazone
    PA164746311everolimus
    PA165291475ridaforolimus
    PA164746890temsirolimus
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00337 potentiator Pimecrolimus Enzyme Inhibitors;Dermatologic Agents;Immunosuppressive Agents
    DB00877 inhibitor Sirolimus Anti-Bacterial Agents;Antifungals;Immunosuppressive Agents;Antifungal Agents;Antibiotics, Antineoplastic;Macrolides
    DB01590 inhibitor Everolimus Immunosuppressive Agents
    DB06287 inhibitor Temsirolimus Antineoplastic Agents;Protein Kinase Inhibitors
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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