Annotation Detail for ALPL

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Basic Information Top

Gene Symbol:	ALPL ( AP-TNAP,APTNAP,FLJ40094,FLJ93059,HOPS,MGC161443,MGC167935,TNAP,TNSALP )
Gene Full Name:	alkaline phosphatase, liver/bone/kidney
Band:	1p36.12
Quick Links	Entrez ID:249; OMIM: 171760; Uniprot ID:PPBT_HUMAN; ENSEMBL ID: ENSG00000162551; HGNC ID: 438
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

Related Pathway Information

BioCyc:0 results
KEGG PATHWAY:2 results
Reactome:0 results
PID:0 results
PANTHER:0 results
PID Reactome:0 results

Pathway ID	Pathway Name
hsa01100	Metabolic pathways
hsa00790	Folate biosynthesis

Related Diseases/Disorders

KEGG DISEASE:3 results
FunDO:8 results
GAD:4 results
NHGRI GWAS Catalog:2 results
OMIM:4 results

Desease ID	Desease Name
	Inherited disorders of cofactor/vitamin metabolism
H00213	Hypophosphatasia
	Genetic disorders

Comparative Toxicogenomics Database

Chemicals:167 results
Diseases:537 results
Pathways:2 results

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
C097949	1,25-dihydroxyvitamin D	[Dexamethasone co-treated with 1,25-dihydroxyvitamin D] inhibits the reaction [WNT3A protein results in increased expression of ALPL protein]	affects cotreatment\|decreases reaction\|increases expression	15270777
C009505	4,4'-diaminodiphenylmethane	4,4'-diaminodiphenylmethane results in decreased expression of ALPL protein	decreases expression	11289319
C462031	6-(1,1-dimethylallyl)naringenin	[6-(1,1-dimethylallyl)naringenin binds to ESR1 protein] which results in increased activity of ALPL protein	affects binding\|increases activity	12650720
C462031	6-(1,1-dimethylallyl)naringenin	fulvestrant inhibits the reaction [[6-(1,1-dimethylallyl)naringenin binds to ESR1 protein] which results in increased activity of ALPL protein]	affects binding\|decreases reaction\|increases activity	12650720
C119737	8-prenylnaringenin	[8-prenylnaringenin binds to ESR1 protein] which results in increased activity of ALPL protein	affects binding\|increases activity	12650720
C119737	8-prenylnaringenin	8-prenylnaringenin results in increased activity of ALPL protein	increases activity	16019205
C119737	8-prenylnaringenin	8-prenylnaringenin results in increased expression of ALPL mRNA	increases expression	16019205
C119737	8-prenylnaringenin	fulvestrant inhibits the reaction [[8-prenylnaringenin binds to ESR1 protein] which results in increased activity of ALPL protein]	affects binding\|decreases reaction\|increases activity	12650720
D000082	Acetaminophen	Acetaminophen affects the expression of ALPL mRNA	affects expression	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of ALPL mRNA	increases expression	19784758
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of ALPL protein	affects expression	20106945
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of ALPL mRNA	increases expression	17898587
D000537	Aluminum Oxide	Aluminum Oxide results in increased expression of ALPL mRNA	increases expression	19464052
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of ALPL mRNA	affects expression	16483693
C040896	AST 120	AST 120 results in increased expression of ALPL mRNA	increases expression	16820376
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ALPL mRNA	affects cotreatment\|increases expression	18164116
C031463	beta-glycerophosphoric acid	ALPL protein results in increased hydrolysis of beta-glycerophosphoric acid	increases hydrolysis	18500657
C031463	beta-glycerophosphoric acid	[ALPL protein results in increased hydrolysis of beta-glycerophosphoric acid] which results in increased abundance of Phosphates	increases abundance\|increases hydrolysis	18500657
C031463	beta-glycerophosphoric acid	beta-glycerophosphoric acid results in increased activity of ALPL protein	increases activity	18500657
C031463	beta-glycerophosphoric acid	beta-glycerophosphoric acid results in increased expression of ALPL mRNA	increases expression	18500657
C031463	beta-glycerophosphoric acid	Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased activity of ALPL protein]	decreases reaction\|increases activity	18500657
C031463	beta-glycerophosphoric acid	Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased expression of ALPL mRNA]	decreases reaction\|increases expression	18500657
C031463	beta-glycerophosphoric acid	ALPL protein results in increased degradation of beta-glycerophosphoric acid	increases degradation	17383965
C031463	beta-glycerophosphoric acid	[ALPL protein results in increased degradation of beta-glycerophosphoric acid] which results in increased abundance of Phosphates	increases abundance\|increases degradation	17383965
C031463	beta-glycerophosphoric acid	Diphosphates inhibits the reaction [ALPL protein results in increased degradation of beta-glycerophosphoric acid]	decreases reaction\|increases degradation	17383965
C031463	beta-glycerophosphoric acid	Diphosphates inhibits the reaction [[ALPL protein results in increased degradation of beta-glycerophosphoric acid] which results in increased abundance of Phosphates]	decreases reaction\|increases abundance\|increases degradation	17383965
C095105	bexarotene	bexarotene results in increased expression of ALPL mRNA	increases expression	16648578
C070515	bisindolylmaleimide I	bisindolylmaleimide I results in decreased activity of ALPL protein	decreases activity	11171635
C006780	bisphenol A	[bisphenol A binds to ESR1 protein] which results in increased activity of ALPL protein	affects binding\|increases activity	12650720
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of ALPL mRNA	decreases expression	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased activity of ALPL protein	increases activity	18436364
D002251	Carbon Tetrachloride	phenyl caffeate inhibits the reaction [Carbon Tetrachloride results in increased activity of ALPL protein]	decreases reaction\|increases activity	18436364
D004390	Chlorpyrifos	[cypermethrin co-treated with Chlorpyrifos] results in increased expression of ALPL protein	affects cotreatment\|increases expression	15991261
D004390	Chlorpyrifos	Plant Extracts inhibits the reaction [[cypermethrin co-treated with Chlorpyrifos] results in increased expression of ALPL protein]	affects cotreatment\|decreases reaction\|increases expression	15991261
D002857	Chromium	Chromium results in decreased activity of ALPL protein	decreases activity	16866188
D002995	Clofibric Acid	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ALPL mRNA	affects cotreatment\|affects expression	17602206
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of ALPL mRNA	decreases expression	16772336
D003375	Coumestrol	[Coumestrol binds to ESR1 protein] which results in increased activity of ALPL protein	affects binding\|increases activity	12650720
D003375	Coumestrol	fulvestrant inhibits the reaction [[Coumestrol binds to ESR1 protein] which results in increased activity of ALPL protein]	affects binding\|decreases reaction\|increases activity	12650720
D016572	Cyclosporine	Cyclosporine results in decreased expression of ALPL mRNA	decreases expression	20106945
C017160	cypermethrin	[cypermethrin co-treated with Chlorpyrifos] results in increased expression of ALPL protein	affects cotreatment\|increases expression	15991261
C017160	cypermethrin	Plant Extracts inhibits the reaction [[cypermethrin co-treated with Chlorpyrifos] results in increased expression of ALPL protein]	affects cotreatment\|decreases reaction\|increases expression	15991261
C017160	cypermethrin	cypermethrin results in increased activity of ALPL protein	increases activity	15365239
C004742	daidzein	[daidzein binds to ESR1 protein] which results in increased activity of ALPL protein	affects binding\|increases activity	12650720
C004742	daidzein	fulvestrant inhibits the reaction [[daidzein binds to ESR1 protein] which results in increased activity of ALPL protein]	affects binding\|decreases reaction\|increases activity	12650720
D003676	Deferoxamine	Deferoxamine results in decreased expression of ALPL mRNA	decreases expression	16772336
D003907	Dexamethasone	[Dexamethasone co-treated with 1,25-dihydroxyvitamin D] inhibits the reaction [WNT3A protein results in increased expression of ALPL protein]	affects cotreatment\|decreases reaction\|increases expression	15270777
D004052	Diethylnitrosamine	[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased activity of ALPL protein	affects cotreatment\|increases activity	15548946
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ALPL mRNA	affects cotreatment\|increases expression	18164116
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ALPL mRNA	affects cotreatment\|affects expression	17602206
D004052	Diethylnitrosamine	Tocotrienols affects the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased activity of ALPL protein]	affects cotreatment\|affects reaction\|increases activity	15548946
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of ALPL mRNA	increases expression	15289156 15591538
D011756	Diphosphates	ALPL protein inhibits the reaction [Diphosphates results in increased expression of ANK mRNA]	decreases reaction\|increases expression	17383965
D011756	Diphosphates	Diphosphates inhibits the reaction [ALPL protein results in increased degradation of beta-glycerophosphoric acid]	decreases reaction\|increases degradation	17383965
D011756	Diphosphates	Diphosphates inhibits the reaction [[ALPL protein results in increased degradation of beta-glycerophosphoric acid] which results in increased abundance of Phosphates]	decreases reaction\|increases abundance\|increases degradation	17383965
D011756	Diphosphates	Diphosphates results in increased activity of ALPL protein	increases activity	17383965
D011756	Diphosphates	Diphosphates results in increased expression of ALPL mRNA	increases expression	17383965
D011756	Diphosphates	ALPL protein results in increased degradation of Diphosphates	increases degradation	17383965 18500657
D004958	Estradiol	[Estradiol binds to ESR1 protein] which results in increased activity of ALPL protein	affects binding\|increases activity	12650720
D004958	Estradiol	fulvestrant inhibits the reaction [[Estradiol binds to ESR1 protein] which results in increased activity of ALPL protein]	affects binding\|decreases reaction\|increases activity	12650720
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in increased expression of ALPL mRNA	affects cotreatment\|increases expression	17404688
D004958	Estradiol	Estradiol results in increased expression of ALPL mRNA	increases expression	15289156
D004997	Ethinyl Estradiol	VDR gene polymorphism affects the reaction [[Ethinyl Estradiol co-treated with Levonorgestrel] affects the expression of ALPL protein]	affects cotreatment\|affects expression\|affects reaction	12521655
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of ALPL protein	decreases expression	17240242
D015025	Zearalenone	fulvestrant inhibits the reaction [[Zearalenone binds to ESR1 protein] which results in increased activity of ALPL protein]	affects binding\|decreases reaction\|increases activity	12650720
D015025	Zearalenone	[Zearalenone binds to ESR1 protein] which results in increased activity of ALPL protein	affects binding\|increases activity	12650720
C017690	fenvalerate	fenvalerate inhibits the reaction [Progesterone results in increased activity of ALPL protein]	decreases reaction\|increases activity	16326432
C017690	fenvalerate	fenvalerate results in increased activity of ALPL protein	increases activity	15696646
D015073	2-Acetylaminofluorene	[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased activity of ALPL protein	affects cotreatment\|increases activity	15548946
D015073	2-Acetylaminofluorene	Tocotrienols affects the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased activity of ALPL protein]	affects cotreatment\|affects reaction\|increases activity	15548946
C070081	fulvestrant	fulvestrant inhibits the reaction [[6-(1,1-dimethylallyl)naringenin binds to ESR1 protein] which results in increased activity of ALPL protein]	affects binding\|decreases reaction\|increases activity	12650720
C070081	fulvestrant	fulvestrant inhibits the reaction [[8-prenylnaringenin binds to ESR1 protein] which results in increased activity of ALPL protein]	affects binding\|decreases reaction\|increases activity	12650720
C070081	fulvestrant	fulvestrant inhibits the reaction [[Coumestrol binds to ESR1 protein] which results in increased activity of ALPL protein]	affects binding\|decreases reaction\|increases activity	12650720
C070081	fulvestrant	fulvestrant inhibits the reaction [[daidzein binds to ESR1 protein] which results in increased activity of ALPL protein]	affects binding\|decreases reaction\|increases activity	12650720
C070081	fulvestrant	fulvestrant inhibits the reaction [[Estradiol binds to ESR1 protein] which results in increased activity of ALPL protein]	affects binding\|decreases reaction\|increases activity	12650720
C070081	fulvestrant	fulvestrant inhibits the reaction [[Genistein binds to ESR1 protein] which results in increased activity of ALPL protein]	affects binding\|decreases reaction\|increases activity	12650720
C070081	fulvestrant	fulvestrant inhibits the reaction [[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein]	affects binding\|decreases reaction\|increases activity	12650720
C070081	fulvestrant	fulvestrant inhibits the reaction [[Zearalenone binds to ESR1 protein] which results in increased activity of ALPL protein]	affects binding\|decreases reaction\|increases activity	12650720
D019833	Genistein	fulvestrant inhibits the reaction [[Genistein binds to ESR1 protein] which results in increased activity of ALPL protein]	affects binding\|decreases reaction\|increases activity	12650720
D019833	Genistein	[Genistein binds to ESR1 protein] which results in increased activity of ALPL protein	affects binding\|increases activity	12650720
D019833	Genistein	Genistein results in increased expression of ALPL mRNA	increases expression	15289156
D019307	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in decreased activity of ALPL protein	decreases activity	11171635
C513449	icarisid II	icarisid II results in increased expression of ALPL mRNA	increases expression	17764702
C499403	icaritin	icaritin results in increased expression of ALPL mRNA	increases expression	17764702
C028904	isoproturon	[Lindane co-treated with isoproturon] results in decreased activity of ALPL protein	affects cotreatment\|decreases activity	11180283
C028904	isoproturon	[Lindane co-treated with isoproturon] results in increased expression of ALPL protein	affects cotreatment\|increases expression	11180283
D001556	Lindane	[Lindane co-treated with isoproturon] results in decreased activity of ALPL protein	affects cotreatment\|decreases activity	11180283
D001556	Lindane	[Lindane co-treated with isoproturon] results in increased expression of ALPL protein	affects cotreatment\|increases expression	11180283
D001556	Lindane	Lindane results in increased activity of ALPL protein	increases activity	11180283
D001556	Lindane	Lindane results in increased expression of ALPL protein	increases expression	11180283
C030814	menatetrenone	menatetrenone results in increased activity of ALPL protein	increases activity	11113387
D008769	Methylnitronitrosoguanidine	Methylnitronitrosoguanidine results in increased expression of ALPL mRNA	increases expression	12634122
C005273	naringenin	fulvestrant inhibits the reaction [[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein]	affects binding\|decreases reaction\|increases activity	12650720
C005273	naringenin	[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein	affects binding\|increases activity	12650720
C025256	nonylphenol	[nonylphenol binds to ESR1 protein] which results in increased activity of ALPL protein	affects binding\|increases activity	12650720
D016912	Levonorgestrel	VDR gene polymorphism affects the reaction [[Ethinyl Estradiol co-treated with Levonorgestrel] affects the expression of ALPL protein]	affects cotreatment\|affects expression\|affects reaction	12521655
C474055	octylphenol	[octylphenol binds to ESR1 protein] which results in increased activity of ALPL protein	affects binding\|increases activity	12650720
C084656	paricalcitol	[Phosphorus co-treated with paricalcitol] results in increased expression of ALPL mRNA	affects cotreatment\|increases expression	17715259
D026023	Permethrin	Permethrin inhibits the reaction [Progesterone results in increased activity of ALPL protein]	decreases reaction\|increases activity	16326432
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of ALPL mRNA]	affects reaction\|increases expression	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of ALPL mRNA	increases expression	19482888
C500434	phenyl caffeate	phenyl caffeate inhibits the reaction [Carbon Tetrachloride results in increased activity of ALPL protein]	decreases reaction\|increases activity	18436364
D010710	Phosphates	[ALPL protein results in increased hydrolysis of beta-glycerophosphoric acid] which results in increased abundance of Phosphates	increases abundance\|increases hydrolysis	18500657
D010710	Phosphates	[ALPL protein results in increased degradation of beta-glycerophosphoric acid] which results in increased abundance of Phosphates	increases abundance\|increases degradation	17383965
D010710	Phosphates	Diphosphates inhibits the reaction [[ALPL protein results in increased degradation of beta-glycerophosphoric acid] which results in increased abundance of Phosphates]	decreases reaction\|increases abundance\|increases degradation	17383965
D010710	Phosphates	ALPL protein results in increased chemical synthesis of Phosphates	increases chemical synthesis	18500657
D010758	Phosphorus	[Phosphorus co-treated with paricalcitol] results in increased expression of ALPL mRNA	affects cotreatment\|increases expression	17715259
D048789	Phytoestrogens	Phytoestrogens results in increased activity of ALPL protein	increases activity	16019205
D048789	Phytoestrogens	Phytoestrogens results in increased expression of ALPL mRNA	increases expression	16019205
C006253	pirinixic acid	pirinixic acid results in increased expression of ALPL mRNA	increases expression	20059764
C006253	pirinixic acid	pirinixic acid results in increased expression of ALPL protein	increases expression	19176532
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in increased expression of ALPL mRNA]	increases expression\|increases reaction	20059764
C006253	pirinixic acid	RXRA protein promotes the reaction [pirinixic acid results in increased expression of ALPL protein]	increases expression\|increases reaction	19176532
D010936	Plant Extracts	[Plant Extracts binds to ESR1 protein] which results in increased activity of ALPL protein	affects binding\|increases activity	12650720
D010936	Plant Extracts	Plant Extracts inhibits the reaction [[cypermethrin co-treated with Chlorpyrifos] results in increased expression of ALPL protein]	affects cotreatment\|decreases reaction\|increases expression	15991261
D011192	Potassium Dichromate	Potassium Dichromate results in decreased activity of ALPL protein	decreases activity	16866188
D011374	Progesterone	fenvalerate inhibits the reaction [Progesterone results in increased activity of ALPL protein]	decreases reaction\|increases activity	16326432
D011374	Progesterone	Permethrin inhibits the reaction [Progesterone results in increased activity of ALPL protein]	decreases reaction\|increases activity	16326432
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in increased expression of ALPL mRNA	affects cotreatment\|increases expression	17404688
D011374	Progesterone	Progesterone results in increased activity of ALPL protein	increases activity	16326432
D011374	Progesterone	Progesterone results in increased expression of ALPL mRNA	increases expression	17404688
D020845	Selective Estrogen Receptor Modulators	Selective Estrogen Receptor Modulators results in decreased expression of ALPL protein	decreases expression	17240242
D012906	Smoke	Smoke results in decreased expression of ALPL protein	decreases expression	18035141
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ALPL mRNA	affects expression	20106945
D007978	Levamisole	Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased activity of ALPL protein]	decreases reaction\|increases activity	18500657
D007978	Levamisole	Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased expression of ALPL mRNA]	decreases reaction\|increases expression	18500657
D007978	Levamisole	Levamisole results in decreased activity of ALPL protein	decreases activity	18500657
D013853	Thioacetamide	Thioacetamide results in decreased expression of ALPL mRNA	decreases expression	19784758
C009495	titanium dioxide	titanium dioxide results in increased expression of ALPL mRNA	increases expression	19464052
D024508	Tocotrienols	Tocotrienols affects the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased activity of ALPL protein]	affects cotreatment\|affects reaction\|increases activity	15548946
D014108	Tosylphenylalanyl Chloromethyl Ketone	Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]]	decreases reaction\|increases activity	10567916
D014108	Tosylphenylalanyl Chloromethyl Ketone	Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]]	decreases reaction\|increases activity	10567916
D014108	Tosylphenylalanyl Chloromethyl Ketone	Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]]	decreases reaction\|increases activity	10567916
D014212	Tretinoin	Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]]	decreases reaction\|increases activity	10567916
D014212	Tretinoin	Tretinoin inhibits the reaction [Tunicamycin results in increased degradation of ALPL protein]	decreases reaction\|increases degradation	10567916
D014212	Tretinoin	Tretinoin results in increased activity of ALPL protein	increases activity	10567916
D014212	Tretinoin	Tretinoin results in increased expression of and results in increased N-linked glycosylation of ALPL protein	increases expression\|increases N-linked glycosylation	10567916
D014212	Tretinoin	Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]	decreases reaction\|increases activity	10567916
D014212	Tretinoin	Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]]	decreases reaction\|increases activity	10567916
D014212	Tretinoin	Tretinoin results in increased activity of ALPL protein	increases activity	10567916
D014212	Tretinoin	Tretinoin results in increased expression of ALPL mRNA	increases expression	16604517
D014212	Tretinoin	Tretinoin results in increased expression of and results in increased N-linked glycosylation of ALPL protein	increases expression\|increases N-linked glycosylation	10567916
D014212	Tretinoin	Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]	decreases reaction\|increases activity	10567916
D014212	Tretinoin	EGF protein inhibits the reaction [Tretinoin results in increased activity of ALPL protein]	decreases reaction\|increases activity	11171635
D014212	Tretinoin	IL1B protein promotes the reaction [Tretinoin results in increased expression of ALPL mRNA]	increases expression\|increases reaction	11171635
D014212	Tretinoin	IL1B protein promotes the reaction [Tretinoin results in increased expression of and results in increased activity of ALPL protein]	increases activity\|increases expression\|increases reaction	11171635
D014212	Tretinoin	IL2 protein inhibits the reaction [Tretinoin results in increased activity of ALPL protein]	decreases reaction\|increases activity	11171635
D014212	Tretinoin	IL4 protein inhibits the reaction [Tretinoin results in increased activity of ALPL protein]	decreases reaction\|increases activity	11171635
D014212	Tretinoin	IL5RA protein inhibits the reaction [Tretinoin results in increased activity of ALPL protein]	decreases reaction\|increases activity	11171635
D014212	Tretinoin	Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]]	decreases reaction\|increases activity	10567916
D014212	Tretinoin	Tretinoin results in increased activity of ALPL protein	increases activity	11171635 10567916
D014212	Tretinoin	Tretinoin results in increased expression of ALPL mRNA	increases expression	10567916
D014212	Tretinoin	Tretinoin results in increased expression of and results in increased N-linked glycosylation of ALPL protein	increases expression\|increases N-linked glycosylation	10567916
D014212	Tretinoin	Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]	decreases reaction\|increases activity	10567916
D014415	Tunicamycin	Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]]	decreases reaction\|increases activity	10567916
D014415	Tunicamycin	Tretinoin inhibits the reaction [Tunicamycin results in increased degradation of ALPL protein]	decreases reaction\|increases degradation	10567916
D014415	Tunicamycin	Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]	decreases reaction\|increases activity	10567916
D014415	Tunicamycin	Tunicamycin results in increased degradation of ALPL protein	increases degradation	10567916
D014415	Tunicamycin	Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]]	decreases reaction\|increases activity	10567916
D014415	Tunicamycin	Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]	decreases reaction\|increases activity	10567916
D014415	Tunicamycin	Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]]	decreases reaction\|increases activity	10567916
D014415	Tunicamycin	Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]	decreases reaction\|increases activity	10567916
C104536	xanthohumol	xanthohumol results in increased activity of ALPL protein	increases activity	16019205
C104536	xanthohumol	xanthohumol results in increased expression of ALPL mRNA	increases expression	16019205
C028541	zirconium oxide	zirconium oxide results in increased expression of ALPL mRNA	increases expression	19464052
C088658	zoledronic acid	TNFRSF11B protein affects the reaction [zoledronic acid results in decreased activity of ALPL protein]	affects reaction\|decreases activity	18496637
C088658	zoledronic acid	zoledronic acid results in decreased activity of ALPL protein	decreases activity	18496637

Disease ID	Disease Name	Direct Evidence	Inference Chemical Name	Inference Score	Publication
MESH:D000014	Abnormalities, Drug-Induced		Phenobarbital	6.00	6195326
MESH:D000014	Abnormalities, Drug-Induced		Tetrachlorodibenzodioxin	6.00	15322242 14514962 11752688
MESH:D000138	Acidosis		Ammonium Chloride	2.86	18287403
MESH:D000152	Acne Vulgaris		Ethinyl Estradiol	3.23	17505938
MESH:D058186	Acute Kidney Injury		zoledronic acid	3.84	19715164
MESH:D055371	Acute Lung Injury		pirinixic acid	2.48	18653653
MESH:D000210	Acute-Phase Reaction		zoledronic acid	4.78	20200999
MESH:D000230	Adenocarcinoma		daidzein	8.22	11473722
MESH:D000230	Adenocarcinoma		Estradiol	8.22	11473722
MESH:D000230	Adenocarcinoma		Ethinyl Estradiol	8.22	14692618
MESH:D000230	Adenocarcinoma		Genistein	8.22	11473722
MESH:D000236	Adenoma		2-Acetylaminofluorene	12.32	10737359
MESH:D000236	Adenoma		4,4'-diaminodiphenylmethane	12.32	3712494
MESH:D000236	Adenoma		beta-Naphthoflavone	12.32	19389873
MESH:D000236	Adenoma		Diethylnitrosamine	12.32	10737359 6695378
MESH:D002759	Adenoma, Bile Duct		2-Acetylaminofluorene	5.29	6705139
MESH:D018248	Adenoma, Liver Cell		Diethylnitrosamine	19.16	19052882 17162532 19061943 18056438 16434500 17620307
MESH:D018248	Adenoma, Liver Cell		Phenobarbital	19.16	17620307
MESH:D018248	Adenoma, Liver Cell		pirinixic acid	19.16	16434500
MESH:D018248	Adenoma, Liver Cell		Tetrachlorodibenzodioxin	19.16	16835633
MESH:D000382	Agricultural Workers' Diseases		Chlorpyrifos	10.72	16611668 11874814 17119214
MESH:D000382	Agricultural Workers' Diseases		cypermethrin	10.72	16487989
MESH:D000382	Agricultural Workers' Diseases		Lindane	10.72	12661182
MESH:D000505	Alopecia		Tretinoin	3.04	15955085
MESH:D000544	Alzheimer Disease		Plant Extracts	2.83	16962711
MESH:D000686	Amyloidosis		Diethylstilbestrol	3.81	15469931
MESH:D000740	Anemia		Tetrachlorodibenzodioxin	2.34	11748828
MESH:D000799	Angioedema		Acetaminophen	3.13	10982225
MESH:D001161	Arteriosclerosis		Ethinyl Estradiol	2.78	11256880
MESH:D001169	Arthritis, Experimental		Dexamethasone	18.06	17659584
MESH:D001169	Arthritis, Experimental		Ethinyl Estradiol	18.06	15885639
MESH:D001169	Arthritis, Experimental		Plant Extracts	18.06	14686799
MESH:D001169	Arthritis, Experimental		Tosylphenylalanyl Chloromethyl Ketone	18.06	18706406
MESH:D001169	Arthritis, Experimental		Tretinoin	18.06	16412693
MESH:D001172	Arthritis, Rheumatoid		Tretinoin	2.06	16292516
MESH:D001249	Asthma		Tretinoin	2.09	16456186
MESH:D001284	Atrophy		fulvestrant	4.18	11514358
MESH:D001321	Autistic Disorder		Acetaminophen	1.53	18445737
MESH:D001471	Barrett Esophagus		Tretinoin	3.73	16935849
MESH:D001660	Biliary Tract Diseases		4,4'-diaminodiphenylmethane	4.30	1440618 11289319
MESH:D001778	Blood Coagulation Disorders		pirinixic acid	16.81	19483382
MESH:D001778	Blood Coagulation Disorders		Tetrachlorodibenzodioxin	16.81	12125929
MESH:D001778	Blood Coagulation Disorders		Thioacetamide	16.81	19483382
MESH:D001778	Blood Coagulation Disorders		Tretinoin	16.81	16206674 16197459
MESH:D001836	Body Weight Changes		Tetrachlorodibenzodioxin	3.08	15340226
MESH:D001848	Bone Diseases, Developmental		Tetrachlorodibenzodioxin	2.28	15746008
MESH:D001859	Bone Neoplasms		zoledronic acid	4.31	19442620 17312309 11697798 15867366 16121404 16778634
MESH:D001862	Bone Resorption		bisphenol A	7.70	11985600
MESH:D001862	Bone Resorption		zoledronic acid	7.70	18404659 15845617 16769263 11869084 18496637 8053405
MESH:D020201	Brain Hemorrhage, Traumatic		Progesterone	4.62	17868700
MESH:D001930	Brain Injuries		Progesterone	3.58	15845082 15665606 15380490
MESH:D002545	Brain Ischemia		Plant Extracts	4.03	16041641
MESH:D001943	Breast Neoplasms		bexarotene	12.26	16818667 16344269
MESH:D001943	Breast Neoplasms		bisphenol A	12.26	17123778
MESH:D001943	Breast Neoplasms		Chromium	12.26	15986119
MESH:D001943	Breast Neoplasms		Deferoxamine	12.26	15993339
MESH:D001943	Breast Neoplasms		Diethylnitrosamine	12.26	17474063
MESH:D001943	Breast Neoplasms		Diethylstilbestrol	12.26	15324884 17129689
MESH:D001943	Breast Neoplasms		Estradiol	12.26	17261762 12948864 14630087 17289903 16675129 17018787 19861407 18497071
MESH:D001943	Breast Neoplasms		fulvestrant	12.26	18984771
MESH:D001943	Breast Neoplasms		Genistein	12.26	16541309 17200150 16873071
MESH:D001943	Breast Neoplasms		Lindane	12.26	14688026
MESH:D001943	Breast Neoplasms		Phytoestrogens	12.26	17158751 17176212
MESH:D001943	Breast Neoplasms		Progesterone	12.26	15562024 16175315 17614352
MESH:D001943	Breast Neoplasms		Tetrachlorodibenzodioxin	12.26	20435547
MESH:D001943	Breast Neoplasms		Tretinoin	12.26	16873071 16443354 16166294
MESH:D001943	Breast Neoplasms		zoledronic acid	12.26	18695136 16096432
MESH:D001997	Bronchopulmonary Dysplasia		Tretinoin	3.89	16813970
MESH:D002057	Burns, Chemical		Plant Extracts	4.62	9625245
MESH:D002181	Candidiasis, Vulvovaginal		Estradiol	3.76	16111702
MESH:D002252	Carbon Tetrachloride Poisoning		Carbon Tetrachloride	3.10	10355542 16192424 15721981 18705752 16227642 16050911 15700767 16124888 15673190 16097048 3786805 16011737
MESH:D002277	Carcinoma		Tetrachlorodibenzodioxin	2.24	16835633
MESH:D018236	Carcinoma, Embryonal		Tretinoin	4.44	16168501
MESH:D006528	Carcinoma, Hepatocellular		2-Acetylaminofluorene	27.89	10737359 3084413 3581430 17761372 6705139
MESH:D006528	Carcinoma, Hepatocellular		4,4'-diaminodiphenylmethane	27.89	3581430 7296757
MESH:D006528	Carcinoma, Hepatocellular		Acetaminophen	27.89	3084413
MESH:D006528	Carcinoma, Hepatocellular		Aflatoxin B1	27.89	12907637 12619106 21507988
MESH:D006528	Carcinoma, Hepatocellular		Carbon Tetrachloride	27.89	18788625
MESH:D006528	Carcinoma, Hepatocellular		Diethylnitrosamine	27.89	19822196 19701751 20101231 18393292 20524982 17428255 17162532 20935162 20007298 19335982 16540662 20084675 18691550 19539802 16681979 17173139 18056438 3581430 18494052 19394651 20432363 19919837 11831363 19052882 16779866 19171122 20512989 17761372 18978308 3084413 16830150 16288022 21159647 18785209 19107877 19519916 16698587 17978847 19383236 18506893 20727157 17138121 20214788 18788625 10672840 16878318 10737359 18210153 16502159 16807293 16935385 16328049 19208518 17055752 20514400 18665156 18971187 19418558 16569478
MESH:D006528	Carcinoma, Hepatocellular		Diethylstilbestrol	27.89	16924424 15948411
MESH:D006528	Carcinoma, Hepatocellular		Estradiol	27.89	16924424
MESH:D006528	Carcinoma, Hepatocellular		Genistein	27.89	16924424
MESH:D006528	Carcinoma, Hepatocellular		Phenobarbital	27.89	20935162 1701930 6705139 20007298 17173139
MESH:D006528	Carcinoma, Hepatocellular		Plant Extracts	27.89	18834353
MESH:D006528	Carcinoma, Hepatocellular		Thioacetamide	27.89	17997003
MESH:D006528	Carcinoma, Hepatocellular		Tretinoin	27.89	1917145
MESH:D002278	Carcinoma in Situ		bisphenol A	4.29	17123778
MESH:D002289	Carcinoma, Non-Small-Cell Lung		bexarotene	5.04	16247446
MESH:D002289	Carcinoma, Non-Small-Cell Lung		zoledronic acid	5.04	19233551
MESH:D002292	Carcinoma, Renal Cell		4,4'-diaminodiphenylmethane	5.52	7296757
MESH:D002292	Carcinoma, Renal Cell		zoledronic acid	5.52	18507039
MESH:D002294	Carcinoma, Squamous Cell		Tretinoin	2.06	16096774 16051514
MESH:D006332	Cardiomegaly		Plant Extracts	5.53	17645561
MESH:D006332	Cardiomegaly		Tetrachlorodibenzodioxin	5.53	18850075 16120746 18670907
MESH:D002318	Cardiovascular Diseases		daidzein	9.58	16332659
MESH:D002318	Cardiovascular Diseases		Genistein	9.58	16332659
MESH:D002318	Cardiovascular Diseases		Phytoestrogens	9.58	16862667
MESH:D002386	Cataract		Acetaminophen	5.71	10977129
MESH:D002386	Cataract		Tretinoin	5.71	17460283
MESH:D002418	Cattle Diseases		Levamisole	5.72	14651886
MESH:D002471	Cell Transformation, Neoplastic		4,4'-diaminodiphenylmethane	15.70	7505956
MESH:D002471	Cell Transformation, Neoplastic		Cyclosporine	15.70	12371664
MESH:D002471	Cell Transformation, Neoplastic		Diethylnitrosamine	15.70	17174075 2727394 7505956 21159647
MESH:D002471	Cell Transformation, Neoplastic		Estradiol	15.70	18566989
MESH:D002471	Cell Transformation, Neoplastic		Methylnitronitrosoguanidine	15.70	2727394
MESH:D002493	Central Nervous System Diseases		Phenobarbital	3.57	4080065
MESH:D018290	Cervical Intraepithelial Neoplasia		Tretinoin	3.89	16129372
MESH:D018281	Cholangiocarcinoma		Diethylnitrosamine	12.65	19052882
MESH:D018281	Cholangiocarcinoma		Tetrachlorodibenzodioxin	12.65	16835633
MESH:D018281	Cholangiocarcinoma		Thioacetamide	12.65	18291259
MESH:D002779	Cholestasis		4,4'-diaminodiphenylmethane	19.58	9022650 19486331
MESH:D002779	Cholestasis		Cyclosporine	19.58	19486331
MESH:D002779	Cholestasis		Ethinyl Estradiol	19.58	16919318 11677210 17110522 16105132 15861022 17681005 17333356
MESH:D002779	Cholestasis		Levonorgestrel	19.58	15861022
MESH:D002779	Cholestasis		pirinixic acid	19.58	19176532
MESH:D002822	Choriocarcinoma		Tretinoin	4.44	16461808
MESH:D002972	Cleft Palate		Tetrachlorodibenzodioxin	4.59	16354765 8697196 12621046 15668235 15340226
MESH:D002972	Cleft Palate		Tretinoin	4.59	9407595
MESH:D003092	Colitis		Tretinoin	3.03	17035595
MESH:D003110	Colonic Neoplasms		Dexamethasone	3.35	15824018
MESH:D003110	Colonic Neoplasms		Genistein	3.35	17182828
MESH:D015179	Colorectal Neoplasms		Levamisole	4.11	15148649
MESH:D000013	Congenital Abnormalities		Tetrachlorodibenzodioxin	2.46	14669216 17141729
MESH:D003327	Coronary Disease		Phytoestrogens	4.71	17367797
MESH:D019465	Craniofacial Abnormalities		Dexamethasone	4.53	17728286
MESH:D019465	Craniofacial Abnormalities		Permethrin	4.53	19861644
MESH:D019465	Craniofacial Abnormalities		Tetrachlorodibenzodioxin	4.53	20055451 10048152 15322242
MESH:D019465	Craniofacial Abnormalities		Tretinoin	4.53	14991402 10589399 9664655 9125849 9142499 8800419 9211117 17551590 16925845 9224671
MESH:D003456	Cryptorchidism		Diethylstilbestrol	3.89	16002989 12952375
MESH:D017449	Dermatitis, Allergic Contact		4,4'-diaminodiphenylmethane	11.15	18759878 11906362 11298694 8156756 12868966 14531868 8970840 2524372
MESH:D017449	Dermatitis, Allergic Contact		cobaltous chloride	11.15	11298694 15059100 16823706
MESH:D017449	Dermatitis, Allergic Contact		Dexamethasone	11.15	12438553
MESH:D017449	Dermatitis, Allergic Contact		Potassium Dichromate	11.15	16823706
MESH:D003876	Dermatitis, Atopic		pirinixic acid	2.05	18249437
MESH:D003877	Dermatitis, Contact		4,4'-diaminodiphenylmethane	7.52	3621924 2952479
MESH:D003877	Dermatitis, Contact		Permethrin	7.52	14617103
MESH:D003924	Diabetes Mellitus, Type 2		daidzein	8.31	16647724
MESH:D003924	Diabetes Mellitus, Type 2		Diethylnitrosamine	8.31	20387270
MESH:D003924	Diabetes Mellitus, Type 2		Genistein	8.31	16647724
MESH:D003924	Diabetes Mellitus, Type 2		Tetrachlorodibenzodioxin	8.31	17107852
MESH:D003928	Diabetic Nephropathies		Estradiol	7.19	19279558
MESH:D003928	Diabetic Nephropathies		Plant Extracts	7.19	19706694
MESH:D003929	Diabetic Neuropathies		Progesterone	3.81	17187935
MESH:D003967	Diarrhea		Dexamethasone	3.06	7237001
MESH:D056486	Drug-Induced Liver Injury		4,4'-diaminodiphenylmethane	11.68	7440962 18648102 6679447 6482804 16192314 11289319 9328219 18289764 1440618 9653073 8291058 18692083 9022650
MESH:D056486	Drug-Induced Liver Injury		Acetaminophen	11.68	16485898 17522070 16177239 11421492 19164858 14725611 16109766 16781746 10774834 12958197 16393943 10915739 17562736 12705907 12392966 14986274 19923254 18071297 16081117 11287661 2444490 11834606 19085960 16227642 15619225 17906064 15968718 14550746 12594235 18713872 19420014 10663392 19370779 19416960 12540782 11743745 12153990 19739265 11739529 11461765 11529661
MESH:D056486	Drug-Induced Liver Injury		Carbon Tetrachloride	11.68	15027814 15998439 7179309 9327722 6884620 11566570 2869522 7120509 10092053 19336974 19085960 3786805 15968718 4309450 16177239 6623471 16227642 3732212 7440962 17522070 21278145 10915739
MESH:D056486	Drug-Induced Liver Injury		Diethylnitrosamine	11.68	19107877
MESH:D056486	Drug-Induced Liver Injury		Tetrachlorodibenzodioxin	11.68	20420201
MESH:D056486	Drug-Induced Liver Injury		Thioacetamide	11.68	12963478
MESH:D056487	Drug-Induced Liver Injury, Chronic		Acetaminophen	3.38	19426721
MESH:D004362	Drug Toxicity		Tetrachlorodibenzodioxin	2.22	11462148
MESH:D004417	Dyspnea		cypermethrin	4.68	16487989
MESH:D004421	Dystonia		Phenobarbital	3.35	1851702
MESH:D004485	Eczema		Dexamethasone	3.79	12438553
MESH:D004487	Edema		bisindolylmaleimide I	15.11	8273558
MESH:D004487	Edema		Dexamethasone	15.11	19703484
MESH:D004487	Edema		pirinixic acid	15.11	12083418
MESH:D004487	Edema		Plant Extracts	15.11	12787963
MESH:D004487	Edema		Tetrachlorodibenzodioxin	15.11	11000095 12711302
MESH:D004489	Edema, Cardiac		Tetrachlorodibenzodioxin	9.58	18230668 15322242 16714409
MESH:D004489	Edema, Cardiac		Tretinoin	9.58	18230668
MESH:D004681	Encephalomyelitis, Autoimmune, Experimental		Ethinyl Estradiol	6.83	12538720
MESH:D004681	Encephalomyelitis, Autoimmune, Experimental		Progesterone	6.83	17692515
MESH:D004714	Endometrial Hyperplasia		Diethylstilbestrol	16.33	16402032
MESH:D004714	Endometrial Hyperplasia		Genistein	16.33	16402032
MESH:D004714	Endometrial Hyperplasia		Phytoestrogens	16.33	16402032
MESH:D016889	Endometrial Neoplasms		daidzein	22.76	11473722
MESH:D016889	Endometrial Neoplasms		Diethylstilbestrol	22.76	16804899 15700306
MESH:D016889	Endometrial Neoplasms		Estradiol	22.76	18566989 19148513 11473722
MESH:D016889	Endometrial Neoplasms		Genistein	22.76	11473722
MESH:D016889	Endometrial Neoplasms		Phytoestrogens	22.76	16543667
MESH:D016889	Endometrial Neoplasms		Tretinoin	22.76	16569247
MESH:D004715	Endometriosis		Progesterone	6.89	16134523
MESH:D004715	Endometriosis		Tetrachlorodibenzodioxin	6.89	9294722 10568697
MESH:D004719	Endomyocardial Fibrosis		Plant Extracts	4.97	15268973
MESH:D004831	Epilepsies, Myoclonic		Phenobarbital	3.43	3659116
MESH:D004828	Epilepsies, Partial		Phenobarbital	3.17	3922381 11558140
MESH:D004827	Epilepsy		Phenobarbital	5.59	20417680
MESH:D004827	Epilepsy		Plant Extracts	5.59	19439326 19700373
MESH:D004832	Epilepsy, Absence		Phenobarbital	2.95	6401628
MESH:D017029	Epilepsy, Complex Partial		Phenobarbital	3.57	7750514
MESH:D004830	Epilepsy, Tonic-Clonic		Phenobarbital	3.32	3659116
MESH:D007172	Erectile Dysfunction		daidzein	4.35	14972507
MESH:D004931	Esophageal Achalasia		Diethylnitrosamine	4.40	16302075
MESH:D004938	Esophageal Neoplasms		4,4'-diaminodiphenylmethane	1.90	3581430
MESH:D005124	Eye Abnormalities		Tetrachlorodibenzodioxin	7.02	11564622
MESH:D005124	Eye Abnormalities		Tretinoin	7.02	16938888 9664655
MESH:D005218	Fat Necrosis		Thioacetamide	5.01	16456712
MESH:D005234	Fatty Liver		Carbon Tetrachloride	22.62	15959796 17595544 12795759 12631006 16239168 16045604 61145 19224547
MESH:D005234	Fatty Liver		Cyclosporine	22.62	19224547
MESH:D005234	Fatty Liver		Diethylnitrosamine	22.62	21071580 20387270
MESH:D005234	Fatty Liver		Ethinyl Estradiol	22.62	15345470
MESH:D005234	Fatty Liver		pirinixic acid	22.62	20131406 19236843
MESH:D005234	Fatty Liver		Plant Extracts	22.62	15975614
MESH:D052776	Female Urogenital Diseases		Diethylstilbestrol	3.19	16534752 15751030 16611131 16002989 16513791
MESH:D005264	Femoral Fractures		zoledronic acid	5.13	16234978
MESH:D005313	Fetal Death		Tetrachlorodibenzodioxin	2.77	11858732
MESH:D005350	Fibroma		4,4'-diaminodiphenylmethane	4.30	6705139
MESH:D005355	Fibrosis		Carbon Tetrachloride	15.57	18705752
MESH:D005355	Fibrosis		Cyclosporine	15.57	12639820 12168785
MESH:D005355	Fibrosis		Tetrachlorodibenzodioxin	15.57	20067830
MESH:D005355	Fibrosis		Tretinoin	15.57	17994277
MESH:D005756	Gastritis		Acetaminophen	2.96	16983495
MESH:D005833	Genital Neoplasms, Female		Diethylstilbestrol	4.25	16452187
MESH:D005885	Gingival Hyperplasia		Cyclosporine	3.52	8708960
MESH:D005909	Glioblastoma		Genistein	5.58	16598420
MESH:D005909	Glioblastoma		Tretinoin	5.58	17312396
MESH:D006042	Goiter		4,4'-diaminodiphenylmethane	3.39	7505956
MESH:D006058	Gonadal Disorders		Tetrachlorodibenzodioxin	3.88	10696789
MESH:D006258	Head and Neck Neoplasms		Tretinoin	2.69	16096774
MESH:D006317	Hearing Loss, Noise-Induced		Tretinoin	4.44	16084493
MESH:D006330	Heart Defects, Congenital		Tetrachlorodibenzodioxin	5.14	11294989 10048152
MESH:D006330	Heart Defects, Congenital		Tretinoin	5.14	14991402 9664655
MESH:D006333	Heart Failure		pirinixic acid	5.68	20558911
MESH:D006333	Heart Failure		Plant Extracts	5.68	18097624
MESH:D006390	Hemangioendothelioma		2-Acetylaminofluorene	4.60	6705139
MESH:D006394	Hemangiosarcoma		2-Acetylaminofluorene	3.78	6705139
MESH:D006457	Hemoglobinuria, Paroxysmal		Cyclosporine	3.72	15720958
MESH:D006470	Hemorrhage		Tetrachlorodibenzodioxin	2.70	11000095
MESH:D006501	Hepatic Encephalopathy		Thioacetamide	3.94	15929193 18665440 17276928
MESH:D006505	Hepatitis		4,4'-diaminodiphenylmethane	17.03	6705139
MESH:D006505	Hepatitis		Carbon Tetrachloride	17.03	19900420 19110552
MESH:D006505	Hepatitis		cypermethrin	17.03	16487989
MESH:D006505	Hepatitis		Thioacetamide	17.03	16456712
MESH:D006529	Hepatomegaly		fenvalerate	15.19	15602828
MESH:D006529	Hepatomegaly		Phenobarbital	15.19	16109766
MESH:D006529	Hepatomegaly		pirinixic acid	15.19	18467677 19772884 16221962 19176532
MESH:D006529	Hepatomegaly		Tetrachlorodibenzodioxin	15.19	12621046 15340226 16120746
MESH:D006548	Hernia, Diaphragmatic		Dexamethasone	2.78	7520565
MESH:D006558	Herpes Genitalis		Estradiol	4.32	15709030
MESH:D006561	Herpes Simplex		Plant Extracts	3.93	10715843
MESH:D015658	HIV Infections		Plant Extracts	3.28	12878215
MESH:D019584	Hot Flashes		8-prenylnaringenin	13.31	17088409
MESH:D019584	Hot Flashes		Estradiol	13.31	17088409
MESH:D019584	Hot Flashes		Plant Extracts	13.31	16566672 17454163 14716179
MESH:D006869	Hydronephrosis		Tetrachlorodibenzodioxin	3.33	16354765 18606429 8697196 15340226 16959395
MESH:D006930	Hyperalgesia		Acetaminophen	9.86	16870215
MESH:D006930	Hyperalgesia		Tretinoin	9.86	16870215
MESH:D006930	Hyperalgesia		zoledronic acid	9.86	16769263
MESH:D006932	Hyperbilirubinemia		Carbon Tetrachloride	3.83	16899240
MESH:D006934	Hypercalcemia		zoledronic acid	4.41	18089816 19622757
MESH:D017681	Hypereosinophilic Syndrome		Tretinoin	3.88	16778211
MESH:D006943	Hyperglycemia		pirinixic acid	2.57	20558911
MESH:D020138	Hyperhomocysteinemia		Plant Extracts	3.87	16484555
MESH:D006949	Hyperlipidemias		Plant Extracts	3.83	15268973 15975614
MESH:D006965	Hyperplasia		4,4'-diaminodiphenylmethane	8.57	15034207
MESH:D006965	Hyperplasia		Diethylstilbestrol	8.57	12960047 14722030
MESH:D006973	Hypertension		Cyclosporine	9.70	10903974
MESH:D006973	Hypertension		daidzein	9.70	17169123
MESH:D006973	Hypertension		Dexamethasone	9.70	17042910
MESH:D006973	Hypertension		Tetrachlorodibenzodioxin	9.70	18670907 18850075
MESH:D006975	Hypertension, Portal		Carbon Tetrachloride	3.40	15338365
MESH:D006996	Hypocalcemia		zoledronic acid	5.48	12669777
OMIM:146300	HYPOPHOSPHATASIA, ADULT	marker/mechanism
OMIM:241510	HYPOPHOSPHATASIA, CHILDHOOD	marker/mechanism
OMIM:241500	HYPOPHOSPHATASIA, INFANTILE	marker/mechanism
MESH:D007021	Hypospadias		Diethylstilbestrol	8.97	16002989
MESH:D007021	Hypospadias		Ethinyl Estradiol	8.97	16945680 16569931
MESH:D020244	Infarction, Middle Cerebral Artery		Progesterone	3.72	15869954
MESH:D007246	Infertility		Diethylstilbestrol	3.69	15036965
MESH:D007247	Infertility, Female		Ethinyl Estradiol	2.81	12013081
MESH:D007248	Infertility, Male		Coumestrol	12.15	16892005
MESH:D007248	Infertility, Male		Ethinyl Estradiol	12.15	17937319
MESH:D007248	Infertility, Male		fulvestrant	12.15	11514358
MESH:D007248	Infertility, Male		Phytoestrogens	12.15	16731787
MESH:D007249	Inflammation		bisindolylmaleimide I	14.59	8273558
MESH:D007249	Inflammation		Dexamethasone	14.59	8960868 11099482
MESH:D007249	Inflammation		Diethylnitrosamine	14.59	18785209
MESH:D007249	Inflammation		Plant Extracts	14.59	15997105 16366677 12787963 19332304
MESH:D007249	Inflammation		Progesterone	14.59	15869954
MESH:D007249	Inflammation		Tetrachlorodibenzodioxin	14.59	12878042 12200463
MESH:D007299	Insect Bites and Stings		cypermethrin	10.84	15189238
MESH:D007299	Insect Bites and Stings		Permethrin	10.84	12749493 15189238 12971516
MESH:D007333	Insulin Resistance		bisphenol A	9.46	16393666
MESH:D007333	Insulin Resistance		Estradiol	9.46	16627594 16393666
MESH:D007333	Insulin Resistance		pirinixic acid	9.46	16306350
MESH:D007410	Intestinal Diseases		Tretinoin	3.09	17994277
MESH:D007414	Intestinal Neoplasms		Plant Extracts	4.00	12628509 12584176 12351151
MESH:D007565	Jaundice		4,4'-diaminodiphenylmethane	4.30	9022650 8074119
MESH:D007569	Jaw Abnormalities		Tetrachlorodibenzodioxin	7.83	16580747
MESH:D007569	Jaw Abnormalities		Tretinoin	7.83	17551590 15992940
MESH:D007638	Keratoconjunctivitis Sicca		Cyclosporine	3.73	15604871
MESH:D007674	Kidney Diseases		Acetaminophen	14.34	15629191 12587719
MESH:D007674	Kidney Diseases		Chromium	14.34	17934191
MESH:D007674	Kidney Diseases		Cyclosporine	14.34	10903974 8314463 18776723
MESH:D007674	Kidney Diseases		Estradiol	14.34	15618244
MESH:D007674	Kidney Diseases		Potassium Dichromate	14.34	19665454
MESH:D007680	Kidney Neoplasms		4,4'-diaminodiphenylmethane	13.02	6582329
MESH:D007680	Kidney Neoplasms		Cyclosporine	13.02	12371664
MESH:D007680	Kidney Neoplasms		Diethylstilbestrol	13.02	14681315 15003126 16762066
MESH:D007680	Kidney Neoplasms		Estradiol	13.02	15610895
MESH:D007859	Learning Disorders		Diethylstilbestrol	3.39	17184923
MESH:D007938	Leukemia		Genistein	8.33	18980019 17468513
MESH:D007938	Leukemia		Permethrin	8.33	12937054
MESH:D007938	Leukemia		Tretinoin	8.33	17143497
MESH:D015459	Leukemia-Lymphoma, Adult T-Cell		zoledronic acid	4.14	18089816
MESH:D007951	Leukemia, Myeloid		Tretinoin	3.07	16932348 16482212 19285840
MESH:D015470	Leukemia, Myeloid, Acute		Deferoxamine	3.79	20368581
MESH:D015470	Leukemia, Myeloid, Acute		Tretinoin	3.79	19850784 16294345 17596541
MESH:D015473	Leukemia, Promyelocytic, Acute		Tretinoin	2.66	19029980 17712046 19225113 16891316 17361223 9834237 16935935 16788101 12679006 17294898 19075265 17649720 17506722 16823087 17301526 16331271 17217047 17368321 19642359 17339181 16140955 16766008 19035177 15748426 17107899
MESH:D017880	Limb Deformities, Congenital		Tretinoin	2.78	9224671
MESH:D008103	Liver Cirrhosis		Carbon Tetrachloride	12.22	16239168 17157831 21278145 17334410 16221502 17174718 16943688 11903743 11408273
MESH:D008103	Liver Cirrhosis		Diethylnitrosamine	12.22	18522880 18665156 18407596 20032147 19638242
MESH:D008103	Liver Cirrhosis		Phenobarbital	12.22	21047994
MESH:D008103	Liver Cirrhosis		Plant Extracts	12.22	17157831
MESH:D008105	Liver Cirrhosis, Biliary		4,4'-diaminodiphenylmethane	2.72	9327722 15034207
MESH:D008106	Liver Cirrhosis, Experimental		Carbon Tetrachloride	15.23	18472332 16011737 16015684 15996030 11481614 15362042 18054572 18339082 18412020 16033810 17805973 18205269 18210741 16097048 18395914 12741479 17481882 15123356 17922224 17900296 12649538 13678700 15931870 18279442 16116963 10355542 18705752 15052691 15893842 17721639 14620537 18429990 15057751 16027843 18472094 14716833 12666154 18263696 12445418 15959796 14512876 18420326 18481824 12586293 14716496 18395095 20821823 12609069 12389079 17976157 14724832 17714472 16248980 15818738 14748882 17557913 17944888 12667390 17565644 15876570 18277467 18376398 17698563 12632512 15338365 17766677 17869086 18418968 18317297 18156304 18006644 17761835 16638106 17708605 18166357 12445421 15370692 17631135 17823541 15730626 15650968 12546737 15925388 12958196 16136751 12898905 15673190 17640975 12632514 16192424 18251166 18187930 17525996
MESH:D008106	Liver Cirrhosis, Experimental		Dexamethasone	15.23	16718785
MESH:D008106	Liver Cirrhosis, Experimental		Estradiol	15.23	14716833 14659978
MESH:D008106	Liver Cirrhosis, Experimental		Genistein	15.23	17823541
MESH:D008106	Liver Cirrhosis, Experimental		naringenin	15.23	14709902
MESH:D008106	Liver Cirrhosis, Experimental		pirinixic acid	15.23	15474484
MESH:D008106	Liver Cirrhosis, Experimental		Plant Extracts	15.23	15479170
MESH:D008106	Liver Cirrhosis, Experimental		Tetrachlorodibenzodioxin	15.23	12878042
MESH:D008106	Liver Cirrhosis, Experimental		Thioacetamide	15.23	16343077 15078482 17355460 11682029 18031379 15075984 12891558 18032466 15716488 17629604 15158331 18458672 12085344 15095483 18606216 15316131 18380797 16126171 17292413 12531686 15288472 12679928 16097051 16098781 18395095 14739098 17050028 11481614 15362042 15474484 16511523 11172339 15465738 18295389 12557150 18416461 18615449 15288473 10677585 15334695 17127702 16248980 12175628 18263696 16489207
MESH:D008106	Liver Cirrhosis, Experimental		Tretinoin	15.23	18397230 16248980
MESH:D008107	Liver Diseases	marker/mechanism			19784758
MESH:D008107	Liver Diseases		Acetaminophen	25.23	16611625 19784758 12587719 19460945 11587558 12969438 16610002 19014921
MESH:D008107	Liver Diseases		Carbon Tetrachloride	25.23	16964402 16246199 17285989 15830285 15720792
MESH:D008107	Liver Diseases		Chlorpyrifos	25.23	15991261
MESH:D008107	Liver Diseases		cypermethrin	25.23	15991261
MESH:D008107	Liver Diseases		Diethylnitrosamine	25.23	17034775
MESH:D008107	Liver Diseases		Lindane	25.23	1715830
MESH:D008107	Liver Diseases		naringenin	25.23	16945181
MESH:D008107	Liver Diseases		Phenobarbital	25.23	19363144
MESH:D008107	Liver Diseases		Plant Extracts	25.23	17034775
MESH:D008107	Liver Diseases		Thioacetamide	25.23	15158337 18374380 16337175
MESH:D017093	Liver Failure		Carbon Tetrachloride	3.48	15123358
MESH:D017114	Liver Failure, Acute		Acetaminophen	12.69	17185352 16871587
MESH:D017114	Liver Failure, Acute		Carbon Tetrachloride	12.69	14706259 16899240
MESH:D017114	Liver Failure, Acute		Thioacetamide	12.69	17276928 15313186 12479984 15633222
MESH:D008113	Liver Neoplasms		2-Acetylaminofluorene	30.79	14678523 18001218 10737359 10672840 11376686 16273603
MESH:D008113	Liver Neoplasms		Aflatoxin B1	30.79	15890375 18177683 2125692 9163691
MESH:D008113	Liver Neoplasms		beta-Naphthoflavone	30.79	21295105 19389873
MESH:D008113	Liver Neoplasms		Carbon Tetrachloride	30.79	19294768
MESH:D008113	Liver Neoplasms		Clofibric Acid	30.79	17602206
MESH:D008113	Liver Neoplasms		Diethylnitrosamine	30.79	19642983 19996281 20101389 20118626 19090486 18978307 2862719 20583210 2422723 16942905 19294768 20501860 19551842 19255062 18648771 21167192 18977376 19427195 21071580 15885732 15175105 19073162 19254457 19850985 20137499 20434301 12771043 19833225 21278145 20405173 20492335 18754104 9163691 18644402 21047994 19499222 19812893 19690152 12112319 10737359 19638242 20452335 19426721 19256749
MESH:D008113	Liver Neoplasms		Diethylstilbestrol	30.79	15890375 16712894
MESH:D008113	Liver Neoplasms		Phenobarbital	30.79	8742319 15975961 21047994 19073162 19482888 19812893
MESH:D008113	Liver Neoplasms		pirinixic acid	30.79	15890375 16377806 20007298
MESH:D008113	Liver Neoplasms		Plant Extracts	30.79	19168119
MESH:D008113	Liver Neoplasms		Tetrachlorodibenzodioxin	30.79	16984957
MESH:D008114	Liver Neoplasms, Experimental		2-Acetylaminofluorene	24.94	1399818 6150874 534488
MESH:D008114	Liver Neoplasms, Experimental		4,4'-diaminodiphenylmethane	24.94	1399818 3712494 598648 6587162
MESH:D008114	Liver Neoplasms, Experimental		Aflatoxin B1	24.94	8603461
MESH:D008114	Liver Neoplasms, Experimental		beta-Naphthoflavone	24.94	18164116
MESH:D008114	Liver Neoplasms, Experimental		Carbon Tetrachloride	24.94	12014681 15583823
MESH:D008114	Liver Neoplasms, Experimental		Diethylnitrosamine	24.94	19126423 3124819 18308698 18079962 18282651 18544905 19004024 16267830 18164116 18093689 16842330 18775883 18253720 17942915 17854601 19539802 21159647 19009564 19519916 2563599 9362446 17174075
MESH:D008114	Liver Neoplasms, Experimental		Phenobarbital	24.94	18308698 1399818 17172636 2563599 6150874
MESH:D008114	Liver Neoplasms, Experimental		Tetrachlorodibenzodioxin	24.94	12151625
MESH:D008175	Lung Neoplasms		2-Acetylaminofluorene	10.64	11376686
MESH:D008175	Lung Neoplasms		Aflatoxin B1	10.64	14755239
MESH:D008175	Lung Neoplasms		bexarotene	10.64	17849452
MESH:D008175	Lung Neoplasms		Dexamethasone	10.64	15824018 11195469
MESH:D008175	Lung Neoplasms		Diethylnitrosamine	10.64	20512841 20970405 6695378 21163286
MESH:D008175	Lung Neoplasms		Plant Extracts	10.64	20869020
MESH:D008175	Lung Neoplasms		Smoke	10.64	11091918
MESH:D008175	Lung Neoplasms		Tetrachlorodibenzodioxin	10.64	19555203 11884234
MESH:D008181	Lupus Nephritis		Diethylstilbestrol	4.45	15166399
MESH:D008223	Lymphoma		Diethylstilbestrol	2.96	15700306
MESH:D016410	Lymphoma, T-Cell, Cutaneous		bexarotene	4.46	11161223
MESH:D052801	Male Urogenital Diseases		Diethylstilbestrol	4.80	16002989
MESH:D008325	Mammary Neoplasms, Experimental		bexarotene	13.72	19196723 19196722 15591091
MESH:D008325	Mammary Neoplasms, Experimental		Estradiol	13.72	11408345 11807958 17203775 16891317
MESH:D008325	Mammary Neoplasms, Experimental		Genistein	13.72	14578162 12929590
MESH:D008325	Mammary Neoplasms, Experimental		Progesterone	13.72	11408345 17203775
MESH:D008325	Mammary Neoplasms, Experimental		zoledronic acid	13.72	17312309
MESH:D020149	Manganese Poisoning		Estradiol	3.77	19453300
MESH:D008527	Medulloblastoma		Tretinoin	2.46	17453147
MESH:D008545	Melanoma		Tretinoin	1.84	16752155
MESH:D008546	Melanoma, Experimental		Acetaminophen	2.88	19513568
MESH:D008591	Meningomyelocele		Tretinoin	3.74	16940565
MESH:D001523	Mental Disorders		Phosphates	4.34	12686366
MESH:D008654	Mesothelioma		zoledronic acid	3.42	16675582
MESH:D008664	Metal Metabolism, Inborn Errors		Cyclosporine	4.07	16801185
MESH:D053842	Microsatellite Instability		Methylnitronitrosoguanidine	5.19	17671175
MESH:D008881	Migraine Disorders		Phytoestrogens	4.47	12224599
MESH:D009101	Multiple Myeloma		Dexamethasone	6.05	16118317 15867202 15744524
MESH:D009101	Multiple Myeloma		zoledronic acid	6.05	18089719 16996129 19621390
MESH:D009135	Muscular Diseases		pirinixic acid	2.83	16239165
MESH:D009190	Myelodysplastic Syndromes		Dexamethasone	6.05	9809623
MESH:D009190	Myelodysplastic Syndromes		Tretinoin	6.05	17596541
MESH:D009203	Myocardial Infarction		Genistein	4.51	17141266
MESH:D009203	Myocardial Infarction		pirinixic acid	4.51	19151258
MESH:D017202	Myocardial Ischemia		Tetrachlorodibenzodioxin	2.45	12213967
MESH:D015428	Myocardial Reperfusion Injury		Estradiol	10.96	16810080
MESH:D015428	Myocardial Reperfusion Injury		Genistein	10.96	17141266
MESH:D015428	Myocardial Reperfusion Injury		pirinixic acid	10.96	16411023
MESH:D020191	Myoclonic Epilepsies, Progressive		Phenobarbital	3.78	17484760
MESH:D009362	Neoplasm Metastasis		4,4'-diaminodiphenylmethane	7.62	3581430
MESH:D009362	Neoplasm Metastasis		Diethylnitrosamine	7.62	3581430 9029167
MESH:D009362	Neoplasm Metastasis		zoledronic acid	7.62	15867366 17312309 19139120
MESH:D009369	Neoplasms		Diethylstilbestrol	14.63	15313581
MESH:D009369	Neoplasms		fenvalerate	14.63	2895627
MESH:D009369	Neoplasms		Lindane	14.63	16818664 12807735
MESH:D009369	Neoplasms		naringenin	14.63	15185748
MESH:D009369	Neoplasms		pirinixic acid	14.63	17405874
MESH:D009369	Neoplasms		Tretinoin	14.63	16946489 16594593
MESH:D009376	Neoplasms, Hormone-Dependent		bexarotene	9.28	19196722
MESH:D009376	Neoplasms, Hormone-Dependent		Phytoestrogens	9.28	16912569
MESH:D009389	Neovascularization, Pathologic		Estradiol	3.04	17289903
MESH:D009402	Nephrosis, Lipoid		Cyclosporine	3.73	17954296
MESH:D009404	Nephrotic Syndrome		Cyclosporine	2.69	18481113 19348381
MESH:D009421	Nervous System Malformations		bisphenol A	29.71	16427766 11399458
MESH:D009421	Nervous System Malformations		Diethylstilbestrol	29.71	11399458
MESH:D009421	Nervous System Malformations		Estradiol	29.71	16427766 11399458
MESH:D009421	Nervous System Malformations		Genistein	29.71	16427766
MESH:D009421	Nervous System Malformations		Tetrachlorodibenzodioxin	29.71	14600291
MESH:D009421	Nervous System Malformations		Tretinoin	29.71	9125849
MESH:D009436	Neural Tube Defects		4,4'-diaminodiphenylmethane	5.59	6679447
MESH:D009436	Neural Tube Defects		Tretinoin	5.59	9142499
MESH:D019954	Neurobehavioral Manifestations		Plant Extracts	4.50	17168769
MESH:D019636	Neurodegenerative Diseases		Acetaminophen	6.25	18514411
MESH:D019636	Neurodegenerative Diseases		Diethylnitrosamine	6.25	20387270
MESH:D009461	Neurologic Manifestations		Diethylnitrosamine	4.40	20387270
MESH:D020258	Neurotoxicity Syndromes		Chlorpyrifos	3.67	15081274
MESH:D009765	Obesity		pirinixic acid	3.97	20558911
MESH:D009765	Obesity		Plant Extracts	3.97	19056576 20132043
MESH:D009784	Occupational Diseases		4,4'-diaminodiphenylmethane	2.81	6482804 4026338
MESH:D009902	Optic Neuritis		4,4'-diaminodiphenylmethane	4.30	3988306
MESH:D010014	Osteolysis		zoledronic acid	4.67	15867366
MESH:D010018	Osteomalacia		Phenobarbital	3.66	17016548
MESH:D010024	Osteoporosis		Genistein	9.47	19401787
MESH:D010024	Osteoporosis		Levonorgestrel	9.47	12665316
MESH:D010024	Osteoporosis		zoledronic acid	9.47	17882678
MESH:D015663	Osteoporosis, Postmenopausal		Genistein	3.44	16169203
MESH:D010049	Ovarian Diseases		bisphenol A	4.29	11985600
MESH:D010051	Ovarian Neoplasms		Estradiol	8.94	19401270
MESH:D010051	Ovarian Neoplasms		Genistein	8.94	19005980
MESH:D010051	Ovarian Neoplasms		Progesterone	8.94	17393432 16525653
MESH:D010051	Ovarian Neoplasms		Tretinoin	8.94	16936753
MESH:D010146	Pain		Acetaminophen	8.02	16870215
MESH:D010146	Pain		Tretinoin	8.02	16870215
MESH:D010146	Pain		zoledronic acid	8.02	16475674
MESH:D010190	Pancreatic Neoplasms		Diethylnitrosamine	6.77	16540662
MESH:D010190	Pancreatic Neoplasms		Phenobarbital	6.77	16965848
MESH:D010190	Pancreatic Neoplasms		Tretinoin	6.77	15976015
MESH:D010195	Pancreatitis		Phytoestrogens	4.60	17269527
MESH:D016584	Panic Disorder		Ethinyl Estradiol	3.04	11578682
MESH:D010212	Papilloma		4,4'-diaminodiphenylmethane	7.21	7296757
MESH:D010212	Papilloma		Plant Extracts	7.21	15173996 16517061
MESH:D010243	Paralysis		fenvalerate	5.30	8952708
MESH:D010382	Peliosis Hepatis		Tetrachlorodibenzodioxin	3.53	12520081
MESH:D010787	Photosensitivity Disorders		4,4'-diaminodiphenylmethane	3.76	6228378
MESH:D010900	Pituitary Diseases		Diethylstilbestrol	4.46	14722030
MESH:D010911	Pituitary Neoplasms		Diethylstilbestrol	3.99	16977796 15687265
MESH:D017119	Porphyria Cutanea Tarda		Tetrachlorodibenzodioxin	2.89	18163543
MESH:D011230	Precancerous Conditions		Cyclosporine	11.81	12371664
MESH:D011230	Precancerous Conditions		Diethylnitrosamine	11.81	2563599
MESH:D011230	Precancerous Conditions		Phenobarbital	11.81	2563599
MESH:D054198	Precursor Cell Lymphoblastic Leukemia-Lymphoma		Dexamethasone	3.11	21297632
MESH:D011297	Prenatal Exposure Delayed Effects		bisphenol A	12.26	10548101
MESH:D011297	Prenatal Exposure Delayed Effects		Diethylstilbestrol	12.26	17184923
MESH:D011297	Prenatal Exposure Delayed Effects		Tetrachlorodibenzodioxin	12.26	11118676 11896295 11399792 11222880
MESH:D019048	Prostatic Intraepithelial Neoplasia		bisphenol A	8.45	20887781
MESH:D019048	Prostatic Intraepithelial Neoplasia		Estradiol	8.45	20887781
MESH:D011471	Prostatic Neoplasms		bisphenol A	2.57	16740699
MESH:D011471	Prostatic Neoplasms		Coumestrol	2.57	16921512
MESH:D011471	Prostatic Neoplasms		Diethylstilbestrol	2.57	15846301 15046698 17136230
MESH:D011471	Prostatic Neoplasms		Estradiol	2.57	16740699
MESH:D011471	Prostatic Neoplasms		Genistein	2.57	15256057 16925846 15378649
MESH:D011471	Prostatic Neoplasms		Lindane	2.57	12661182 14688026
MESH:D011471	Prostatic Neoplasms		Phytoestrogens	2.57	16921512
MESH:D011471	Prostatic Neoplasms		Plant Extracts	2.57	17804756 14666653
MESH:D011471	Prostatic Neoplasms		zoledronic acid	2.57	19103299 12438248
MESH:D011507	Proteinuria		Tretinoin	2.96	16636307
MESH:D011537	Pruritus		Ethinyl Estradiol	7.69	15861022 16919318
MESH:D011537	Pruritus		Levonorgestrel	7.69	15861022
MESH:D019310	Pseudolymphoma		Phenobarbital	3.78	12752131
MESH:D011565	Psoriasis		Cyclosporine	1.94	16882103
MESH:D011625	Pterygium		Tretinoin	4.09	16723453
MESH:D011629	Puberty, Precocious		bisphenol A	4.09	10548101
MESH:D015427	Reperfusion Injury		pirinixic acid	2.00	19058328
MESH:D012128	Respiratory Distress Syndrome, Adult		Dexamethasone	3.38	18379247 11700416
MESH:D012135	Respiratory Sounds		Chlorpyrifos	3.96	16611668 11874814 17119214
MESH:D015619	Respiratory System Abnormalities		Tetrachlorodibenzodioxin	3.17	18990726
MESH:D012140	Respiratory Tract Diseases		Chlorpyrifos	4.18	16611668 17119214
MESH:D012162	Retinal Degeneration		4,4'-diaminodiphenylmethane	2.83	3692021
MESH:D012208	Rhabdomyosarcoma		Tretinoin	3.45	16116481 16283617
MESH:D012468	Salivary Gland Neoplasms		Progesterone	2.56	18045962
MESH:D012512	Sarcoma, Ewing's		zoledronic acid	4.27	16121404
MESH:D012640	Seizures		Lindane	4.68	15475178 7539098 12842176
MESH:D012640	Seizures		Phenobarbital	4.68	3137016 4039156 11442880 16876388
MESH:D003294	Seizures, Febrile		Phenobarbital	4.12	6407741
MESH:D012729	Sex Chromosome Aberrations		Chlorpyrifos	5.37	6418539
MESH:D012878	Skin Neoplasms		Plant Extracts	7.29	16517061 15173996
MESH:D012878	Skin Neoplasms		Tetrachlorodibenzodioxin	7.29	16192470
MESH:D012878	Skin Neoplasms		Tretinoin	7.29	16467112
MESH:D013088	Spermatocele		Diethylstilbestrol	9.35	16709447 16002989
MESH:D013088	Spermatocele		Ethinyl Estradiol	9.35	16709447
MESH:D013119	Spinal Cord Injuries		Progesterone	3.58	15862959 16503802
MESH:D013272	Stomach Diseases		Dexamethasone	3.63	15472012
MESH:D013274	Stomach Neoplasms		Diethylnitrosamine	2.19	18456281
MESH:D013274	Stomach Neoplasms		Tretinoin	2.19	17261132
MESH:D013276	Stomach Ulcer		Dexamethasone	5.63	15138204
MESH:D013276	Stomach Ulcer		Plant Extracts	5.63	18193104 12787963 15255614 17135157 18237397
MESH:D013322	Strongyloidiasis		Levamisole	6.21	14651886
MESH:D019966	Substance-Related Disorders		bisphenol A	3.29	16045194 16684133
MESH:D013705	Temporomandibular Joint Disorders		Plant Extracts	4.77	17997062
MESH:D019851	Thrombophilia		Ethinyl Estradiol	2.97	11994571
MESH:D013927	Thrombosis		Ethinyl Estradiol	2.56	15669648
MESH:D013959	Thyroid Diseases		Tetrachlorodibenzodioxin	3.19	12697716
MESH:D013964	Thyroid Neoplasms		4,4'-diaminodiphenylmethane	12.58	1399818 6582329 7505956 3712494 6587162
MESH:D013964	Thyroid Neoplasms		Diethylnitrosamine	12.58	7505956
MESH:D013964	Thyroid Neoplasms		Phenobarbital	12.58	1399818
MESH:D013964	Thyroid Neoplasms		Tretinoin	12.58	16026305 17045167
MESH:D013978	Tibial Fractures		Estradiol	3.97	19048282
MESH:D014062	Tongue Neoplasms		Tretinoin	3.17	16051514
MESH:D014202	Tremor		fenvalerate	4.86	8952708
MESH:D014376	Tuberculosis		Tretinoin	2.75	16040207
MESH:D014511	Uremia		AST 120	6.85	17057375
MESH:D001749	Urinary Bladder Neoplasms		2-Acetylaminofluorene	6.52	15867355 15289314 1399818
MESH:D001749	Urinary Bladder Neoplasms		4,4'-diaminodiphenylmethane	6.52	8074119
MESH:D001749	Urinary Bladder Neoplasms		Diethylstilbestrol	6.52	16712894 17306315 16452187
MESH:D014570	Urologic Diseases		cypermethrin	5.15	16487989
MESH:D014581	Urticaria		Acetaminophen	2.34	10982225
MESH:D002583	Uterine Cervical Neoplasms		Diethylstilbestrol	7.46	16175088
MESH:D002583	Uterine Cervical Neoplasms		Tretinoin	7.46	16129372
MESH:D014591	Uterine Diseases		bisphenol A	11.45	14652134
MESH:D014591	Uterine Diseases		Diethylstilbestrol	11.45	14652134
MESH:D014594	Uterine Neoplasms		Diethylstilbestrol	7.27	15809267 16690809
MESH:D014594	Uterine Neoplasms		Ethinyl Estradiol	7.27	14692618
MESH:D014604	Uveal Neoplasms		Tretinoin	3.90	16752155
MESH:D014605	Uveitis		Cyclosporine	9.40	1336536
MESH:D014605	Uveitis		Dexamethasone	9.40	1336536
MESH:D014625	Vaginal Neoplasms		Diethylstilbestrol	3.75	16002989 16513791
MESH:D054079	Vascular Malformations		Tetrachlorodibenzodioxin	3.88	12125929
MESH:D020246	Venous Thrombosis		Ethinyl Estradiol	8.68	14671159 15869587
MESH:D020246	Venous Thrombosis		Levonorgestrel	8.68	15869587
MESH:D018487	Ventricular Dysfunction, Left		Plant Extracts	4.07	18097624
MESH:D020257	Ventricular Remodeling		Plant Extracts	4.62	18097624
MESH:D014820	Vitiligo		Tretinoin	3.39	16761959
MESH:D019282	Wasting Syndrome		Tetrachlorodibenzodioxin	3.53	15886252
MESH:D009396	Wilms Tumor		Tretinoin	3.36	16287080
MESH:D014947	Wounds and Injuries		Plant Extracts	3.67	19894650 20213670
MESH:D014985	Xerophthalmia		Cyclosporine	3.73	17120751

Pharmacogenomics Knowledge Base

PharmGKB Accession:PA24729

Related Genes:0 results
Related Diseases:1 results
Related Drugs:2 results

Releated disease ID	Related disease Name
PA446155	Precursor Cell Lymphoblastic Leukemia-Lymphoma

Drug Bank

Targets:0 results
Enzymes:1 results
Transporters:0 results
Carriers:0 results

Drugbank ID	Action	Drug Name	Description
DB01143	-	Amifostine	Radiation-Protective Agents

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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