AutismKB 2.0

Annotation Detail for NR5A2


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Basic Information Top
Gene Symbol:NR5A2 ( B1F,B1F2,CPF,FTF,FTZ-F1,FTZ-F1beta,LRH-1,LRH1,hB1F,hB1F-2 )
Gene Full Name: nuclear receptor subfamily 5, group A, member 2
Band: 1q32.1
Quick LinksEntrez ID:2494; OMIM: 604453; Uniprot ID:NR5A2_HUMAN; ENSEMBL ID: ENSG00000116833; HGNC ID: 7984
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04950Maturity onset diabetes of the young
Pathway IDPathway Name
Regulation of beta-cell development
Gene Expression
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
pancreatic cancer
CANCER
Desease Name
Pancreatic cancer
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of NR5A2 mRNA]affects expression|affects reaction 19414516
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of NR5A2 mRNAdecreases expression 18648102
C508470 7-(2-(2,2-difluoroethoxy)-3,5-di-tert-butylbenzene)-3-methylocta-2,4,6-trienoic acid 7-(2-(2,2-difluoroethoxy)-3,5-di-tert-butylbenzene)-3-methylocta-2,4,6-trienoic acid results in decreased expression of NR5A2 mRNAdecreases expression 16357189
D000082 Acetaminophen Acetaminophen affects the expression of NR5A2 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of NR5A2 proteinaffects expression 20106945
C103303 alitretinoin alitretinoin inhibits the reaction [NR5A2 protein promotes the reaction [[Forskolin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA]]affects cotreatment|decreases reaction|increases expression|increases reaction 16357189
C103303 alitretinoin alitretinoin inhibits the reaction [NR5A2 protein results in increased expression of CYP19A1 mRNA]decreases reaction|increases expression 16357189
C103303 alitretinoin alitretinoin results in decreased expression of NR5A2 mRNAdecreases expression 16357189
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NR5A2 mRNAaffects expression 16483693
D001280 Atrazine Atrazine results in increased activity of NR5A2 proteinincreases activity 18461179
C477843 bicyclol bicyclol inhibits the reaction [Diethylnitrosamine results in increased expression of NR5A2 mRNA]decreases reaction|increases expression 17106253
D002635 Chenodeoxycholic Acid Chenodeoxycholic Acid results in decreased expression of NR5A2 mRNAdecreases expression 15629111
D016572 Cyclosporine Cyclosporine results in decreased expression of NR5A2 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine bicyclol inhibits the reaction [Diethylnitrosamine results in increased expression of NR5A2 mRNA]decreases reaction|increases expression 17106253
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of NR5A2 mRNAincreases expression 17106253
D004958 Estradiol Estradiol results in decreased expression of NR5A2 mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of NR5A2 mRNAincreases expression 20607599
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NR5A2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NR5A2 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of NR5A2 mRNAdecreases expression 15834898
D005576 Forskolin alitretinoin inhibits the reaction [NR5A2 protein promotes the reaction [[Forskolin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA]]affects cotreatment|decreases reaction|increases expression|increases reaction 16357189
D005576 Forskolin Forskolin results in increased expression of NR5A2 mRNAincreases expression 16357189
D005576 Forskolin NR5A2 protein promotes the reaction [[Forskolin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA]affects cotreatment|increases expression|increases reaction 16357189
C516216 GSK 8470 GSK 8470 binds to and results in increased activity of NR5A2 proteinaffects binding|increases activity 17154495
C516216 GSK 8470 GSK 8470 promotes the reaction [NR5A2 protein results in increased expression of NR0B2 mRNA]increases expression|increases reaction 17154495
C017461 lead nitrate lead nitrate results in increased expression of NR5A2 mRNAincreases expression 16049268
C095104 LG 100268 LG 100268 results in decreased expression of NR5A2 mRNAdecreases expression 16357189
D010126 Ozone Ozone results in decreased expression of NR5A2 mRNAdecreases expression 16183385
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of NR5A2 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of NR5A2 mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in decreased expression of NR5A2 mRNAdecreases expression 18445702
D011374 Progesterone NR5A2 gene mutant form results in decreased abundance of Progesteronedecreases abundance 17409375
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of NR5A2 mRNAdecreases expression 20055451
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of NR5A2 mRNAdecreases expression 17517823
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NR5A2 mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NR5A2 mRNAaffects cotreatment|increases expression 17942748
D013755 Tetradecanoylphorbol Acetate alitretinoin inhibits the reaction [NR5A2 protein promotes the reaction [[Forskolin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA]]affects cotreatment|decreases reaction|increases expression|increases reaction 16357189
D013755 Tetradecanoylphorbol Acetate NR5A2 protein promotes the reaction [[Forskolin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA]affects cotreatment|increases expression|increases reaction 16357189
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.726195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.7215322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.3918287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7717505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9618653653
MESH:D000230 Adenocarcinoma Estradiol 4.0711473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.0714692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.343712494
MESH:D000236 Adenoma Diethylnitrosamine 6.346695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 23.4417620307 19052882 17162532 16434500 18056438 19061943
MESH:D018248 Adenoma, Liver Cell Phenobarbital 23.4417620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 23.4416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 23.4416835633
MESH:D000382 Agricultural Workers' Diseases Atrazine 4.0511874814
MESH:D000544 Alzheimer Disease Ozone 2.4015513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8011748828
MESH:D000799 Angioedema Acetaminophen 3.6710982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5615885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5215570426
MESH:D001249 Asthma Ozone 2.5917854713 16373670
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.8511289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.2519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6515746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1717868700
MESH:D001930 Brain Injuries Progesterone 4.0915665606 15845082 15380490
MESH:D001943 Breast Neoplasms alitretinoin 2.8916344269
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.8917474063
MESH:D001943 Breast Neoplasms Estradiol 2.8918497071 16675129 12948864 17261762 17289903 19861407 17018787 14630087
MESH:D001943 Breast Neoplasms LG 100268 2.8916818667
MESH:D001943 Breast Neoplasms Progesterone 2.8916175315 17614352 15562024
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.8920435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5415516495 17626835 16777450 19059883 18417511 14754758 18315731
MESH:D002100 Cachexia Ozone 4.5716183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2916111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6616835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 11.027296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.023084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 11.0221507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 11.023084413 16502159 19822196 16935385 19701751 16569478 18056438 19539802 20935162 20514400 18494052 17055752 17428255 20214788 11831363 17978847 19519916 16698587 20007298 20727157 20084675 16288022 18691550 17173139 19052882 16328049 20432363 17761372 18785209 19919837 17162532 18788625 18665156 16830150 18210153 19208518 20524982 16878318 10737359 18506893 19394651 16540662 20512989 10672840 16807293 19171122 18393292 17138121 19107877 16779866 20101231 18978308 19335982 19383236 18971187 19418558 21159647 3581430 16681979
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.0216924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 11.0220007298 17173139 1701930 6705139 20935162
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.607296757
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 2.9118922899
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2716120746 18850075 18670907
MESH:D002386 Cataract Acetaminophen 2.4810977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 15.047505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.0412371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 15.042727394 7505956 17174075 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.0418566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.084080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.8419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.8416835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 18.179022650 19486331
MESH:D002779 Cholestasis Cyclosporine 18.1719486331
MESH:D002779 Cholestasis Ethinyl Estradiol 18.1716919318 16105132 17333356 11677210 17681005 15861022 17110522
MESH:D002779 Cholestasis pirinixic acid 18.1719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0315668235 8697196 12621046 15340226 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2515322242 10048152 20055451
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.6411906362 14531868 12868966 11298694 8156756 8970840 18759878 2524372
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3518249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.333621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.0820387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2719279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.3217187935
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 11.4918648102 18692083 18289764 6679447 6482804 9022650 8291058 11289319 9328219 16192314 1440618 9653073 7440962
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.4914550746 14986274 19164858 11421492 10774834 16109766 11529661 11461765 12392966 11287661 19420014 12958197 18713872 19370779 11743745 19416960 12153990 19923254 11739529 11834606 12540782 12705907 10663392 16177239 17906064 17562736 15619225 12594235 19739265 16781746 19085960 16485898 10915739 16393943 2444490 17522070 18071297 16081117 16227642 15968718 14725611
MESH:D056486 Drug-Induced Liver Injury bicyclol 11.4915998439
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.4919107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.4920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6311462148
MESH:D004421 Dystonia Phenobarbital 3.841851702
MESH:D004487 Edema pirinixic acid 10.5712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.5711000095 12711302
MESH:D004487 Edema Tetradecanoylphorbol Acetate 10.578113982 7812673 8273558 11698051 9599246 16716910 15177302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7315322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.4812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.4817692515
MESH:D016889 Endometrial Neoplasms Estradiol 2.8719148513 18566989 11473722
MESH:D004715 Endometriosis Progesterone 8.4316134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.439294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.943659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.703922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.406401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.087750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.853659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9416302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.073581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8911564622
MESH:D005234 Fatty Liver bicyclol 23.0116409862
MESH:D005234 Fatty Liver Cyclosporine 23.0119224547
MESH:D005234 Fatty Liver Diethylnitrosamine 23.0120387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 23.0115345470
MESH:D005234 Fatty Liver pirinixic acid 23.0119236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2911858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.856705139
MESH:D005355 Fibrosis Cyclosporine 7.9212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.9220067830
MESH:D005756 Gastritis Acetaminophen 3.5016983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.058708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.887505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2410048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2515720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1811000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.356705139
MESH:D006529 Hepatomegaly Phenobarbital 13.3916109766
MESH:D006529 Hepatomegaly pirinixic acid 13.3919772884 19176532 16221962 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.3915340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.8615709030
MESH:D019584 Hot Flashes Estradiol 3.5817088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.878697196 16354765 16959395 15340226 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.5716870215
MESH:D006943 Hyperglycemia pirinixic acid 3.0320558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7715034207
MESH:D006973 Hypertension Cyclosporine 4.7310903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7318850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6416569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.2315869954
MESH:D007247 Infertility, Female marker/mechanism 17409375
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3012013081
MESH:D007248 Infertility, Male Atrazine 6.5312948887
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.5317937319
MESH:D007249 Inflammation Diethylnitrosamine 11.2618785209
MESH:D007249 Inflammation Progesterone 11.2615869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.2612200463 12878042
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 11.267562506 8273558 15177302 7812673 11698051
MESH:D007333 Insulin Resistance Estradiol 6.8316393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 6.8316306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.858074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2715604871
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.4616144296
MESH:D007674 Kidney Diseases Acetaminophen 9.4115629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 9.4118776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 9.4115618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 11.556582329
MESH:D007680 Kidney Neoplasms Cyclosporine 11.5512371664
MESH:D007680 Kidney Neoplasms Estradiol 11.5515610895
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.3318665156 19638242 18522880 18407596 20032147
MESH:D008103 Liver Cirrhosis Phenobarbital 6.3321047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.0915034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental bicyclol 4.8516603200 15730626
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.8514716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.8515474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.8512878042
MESH:D008107 Liver Diseases Acetaminophen 6.2212969438 16610002 16611625 12587719 19460945 19784758 19014921 11587558
MESH:D008107 Liver Diseases Diethylnitrosamine 6.2217034775
MESH:D008107 Liver Diseases Phenobarbital 6.2219363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0817185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 13.5418177683 9163691 2125692 15890375
MESH:D008113 Liver Neoplasms Diethylnitrosamine 13.5410737359 18977376 2422723 19499222 21047994 19812893 15885732 20137499 19073162 18648771 18754104 19255062 20492335 19294768 19427195 12112319 18644402 20452335 20405173 12771043 19256749 20101389 20501860 19638242 21167192 19996281 19551842 19642983 16942905 20583210 9163691 21278145 21071580 19690152 2862719 15175105 18978307 19254457 20434301 20118626 19090486 19833225 19850985 19426721
MESH:D008113 Liver Neoplasms Phenobarbital 13.5419812893 19482888 15975961 8742319 19073162 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 13.5420007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.5416984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 17.513712494 1399818 598648 6587162
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 17.518603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 17.5119009564 18093689 18544905 18164116 18282651 19126423 19519916 21159647 18308698 19004024 18079962 3124819 16267830 17174075 19539802 18253720 18775883 17942915 9362446 17854601 16842330 2563599
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 17.5118308698 17172636 6150874 1399818 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.5112151625
MESH:D008171 Lung Diseases Ozone 3.2619066396 8266340
MESH:D055370 Lung Injury Ozone 3.6820417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 8.2814755239
MESH:D008175 Lung Neoplasms alitretinoin 8.2816413115
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.2821163286 20970405 20512841 6695378
MESH:D008175 Lung Neoplasms Ozone 8.288597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.2819555203 11884234
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 8.2811807781
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 13.5011807958 11408345 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental LG 100268 13.5012374698
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 13.5011408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 13.508985016
MESH:D020149 Manganese Poisoning Estradiol 4.3119453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4019513568
MESH:D008654 Mesothelioma Atrazine 3.461916698
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6216801185
MESH:D008679 Metaplasia Ozone 4.9310496685
MESH:D009135 Muscular Diseases pirinixic acid 3.3416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.8116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.8116411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.3017484760
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.473581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.473581430 9029167
MESH:D009369 Neoplasms alitretinoin 4.9416946489
MESH:D009369 Neoplasms pirinixic acid 4.9417405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5617289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1418481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 8.9111399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.9114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.806679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.7118514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.7120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9420387270
MESH:D009765 Obesity pirinixic acid 1.7720558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.276482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.853988306
MESH:D010018 Osteomalacia Phenobarbital 4.1917016548
MESH:D010051 Ovarian Neoplasms Estradiol 4.6919401270
MESH:D010051 Ovarian Neoplasms Progesterone 4.6916525653 17393432
MESH:D010146 Pain Acetaminophen 2.2516870215
MESH:D010190 Pancreatic Neoplasms marker/mechanism 20101243
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.3416540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.3416965848
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 8.3415976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5311578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 8.837296757
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 8.838330346 12065085 18922899 18404319
MESH:D010300 Parkinson Disease Atrazine 3.2117218051
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0812520081
MESH:D010538 Peritonitis Ozone 3.9616369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.306228378
MESH:D011014 Pneumonia Ozone 4.2218007984 18381685 18929643
MESH:D017499 Porokeratosis alitretinoin 5.8316144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3918163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.4312371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.432563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.432563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0211222880 11118676 11399792 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7320887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.1316740699
MESH:D011537 Pruritus Ethinyl Estradiol 3.1415861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.3212752131
MESH:D011565 Psoriasis Cyclosporine 2.1716882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.3019058328
MESH:D012135 Respiratory Sounds Atrazine 4.3511874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.253692021
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8018045962
MESH:D012640 Seizures Phenobarbital 2.584039156 3137016 11442880 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.656407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5416192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 5.548985016 8330346 11807781 12065085 18404319
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7716709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.1116503802 15862959
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7312697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 11.206582329 7505956 6587162 3712494 1399818
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.207505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 11.201399818
MESH:D013978 Tibial Fractures Estradiol 4.5119048282
MESH:D014376 Tuberculosis Chenodeoxycholic Acid 4.9316040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.218074119
MESH:D014581 Urticaria Acetaminophen 2.8210982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1314692618
MESH:D014605 Uveitis Cyclosporine 3.811336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.2717120751
Pathway ID Pathway Name
REACT:71 Gene Expression
KEGG:04950 Maturity onset diabetes of the young
REACT:13698 Regulation of beta-cell development
REACT:13641 Regulation of Beta-Cell Development
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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