AutismKB 2.0

Annotation Detail for ALPPL2


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Basic Information Top
Gene Symbol:ALPPL2 ( ALPG,ALPPL,GCAP )
Gene Full Name: alkaline phosphatase, placental-like 2
Band: 2q37.1
Quick LinksEntrez ID:251; OMIM: 171810; Uniprot ID:PPBN_HUMAN; ENSEMBL ID: ENSG00000163286; HGNC ID: 441
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa01100Metabolic pathways
hsa00790Folate biosynthesis
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of ALPPL2 mRNAaffects expression 18648102
C014036 4-hydroxyestradiol-17 beta 4-hydroxyestradiol-17 beta results in increased activity of ALPPL2 proteinincreases activity 15993745
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ALPPL2 mRNAdecreases expression 20018196
C006780 bisphenol A bisphenol A results in increased expression of ALPPL2 mRNAincreases expression 19371625
C004742 daidzein daidzein metabolite results in increased expression of ALPPL2 mRNAincreases expression 15993745
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of ALPPL2 mRNAincreases expression 19371625
C007610 equol equol results in increased expression of ALPPL2 mRNAincreases expression 15993745
D004958 Estradiol Estradiol results in increased activity of ALPPL2 proteinincreases activity 15993745
D004958 Estradiol Estradiol results in increased expression of ALPPL2 mRNAincreases expression 15993745
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ALPPL2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALPPL2 mRNAaffects cotreatment|increases expression 17942748
D005047 Etoposide ALPPL2 protein affects the susceptibility to Etoposideaffects response to substance 16217747
D015025 Zearalenone Zearalenone results in increased expression of ALPPL2 mRNAincreases expression 19371625
D019833 Genistein Genistein results in increased expression of ALPPL2 mRNAincreases expression 19371625
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALPPL2 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9615322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D000230 Adenocarcinoma daidzein 10.4011473722
MESH:D000230 Adenocarcinoma Estradiol 10.4011473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 10.4014692618
MESH:D000230 Adenocarcinoma Genistein 10.4011473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.803712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4916835633
MESH:D000686 Amyloidosis Diethylstilbestrol 4.5715469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.1511289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D019046 Bone Marrow Neoplasms Etoposide 5.3014601052
MESH:D001862 Bone Resorption bisphenol A 3.9411985600
MESH:D001943 Breast Neoplasms 4-hydroxyestradiol-17 beta 4.8016675129
MESH:D001943 Breast Neoplasms bisphenol A 4.8017123778
MESH:D001943 Breast Neoplasms Diethylstilbestrol 4.8017129689 15324884
MESH:D001943 Breast Neoplasms equol 4.8016898868
MESH:D001943 Breast Neoplasms Estradiol 4.8012948864 18497071 14630087 19861407 17289903 17018787 16675129 17261762
MESH:D001943 Breast Neoplasms Etoposide 4.8016322251
MESH:D001943 Breast Neoplasms Genistein 4.8016541309 16873071 17200150
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.8020435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5816111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.703581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 6.7015948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.7016924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.7016924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.1117123778
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.717296757
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases daidzein 7.9816332659
MESH:D002318 Cardiovascular Diseases Genistein 7.9816332659
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 16.597505956
MESH:D002471 Cell Transformation, Neoplastic 4-hydroxyestradiol-17 beta 16.5918226522 18566989
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.5920889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 16.5918566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.0619486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0615861022 17681005 17110522 16105132 17333356 16919318 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1315340226 8697196 12621046 16354765 15668235
MESH:D003110 Colonic Neoplasms Genistein 2.3017182828
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.6512952375 16002989
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9018759878 11906362 12868966 14531868 8970840 8156756 11298694 2524372
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.582952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 daidzein 7.3816647724
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 7.3816647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.3817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4819279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.761440618 9328219 16192314 11289319 6679447 18648102 9653073 18692083 7440962 6482804 9022650 18289764 8291058
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0415322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2812538720
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 12.2916402032
MESH:D004714 Endometrial Hyperplasia Genistein 12.2916402032
MESH:D016889 Endometrial Neoplasms daidzein 18.2911473722
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 18.2915700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 18.2918566989 19148513 11473722
MESH:D016889 Endometrial Neoplasms Genistein 18.2911473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1010568697 9294722
MESH:D007172 Erectile Dysfunction daidzein 5.1114972507
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.453581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4520426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 2.8915345470
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7015751030 16611131 16002989 16534752 16513791
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.156705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0520067830
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.0616452187
MESH:D005909 Glioblastoma Genistein 3.3116598420
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.127505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3711294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.616705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0012621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.1715709030
MESH:D006561 Herpes Simplex Etoposide 4.6810809021
MESH:D006689 Hodgkin Disease Etoposide 3.9417606976 18180244 15147373 16200630 16135485
MESH:D019584 Hot Flashes Estradiol 3.8917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1816959395 18606429 8697196 15340226 16354765
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 11.1915034207
MESH:D006965 Hyperplasia Diethylstilbestrol 11.1912960047 14722030
MESH:D006973 Hypertension daidzein 5.6217169123
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.6218670907 18850075
MESH:D007021 Hypospadias Diethylstilbestrol 11.6016002989
MESH:D007021 Hypospadias Ethinyl Estradiol 11.6016945680 16569931
MESH:D007246 Infertility Diethylstilbestrol 4.4515036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5417937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8912200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 7.6116393666
MESH:D007333 Insulin Resistance Estradiol 7.6116393666 16627594
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.158074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007674 Kidney Diseases Estradiol 2.6315618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.876582329
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 12.8716762066 15003126 14681315
MESH:D007680 Kidney Neoplasms Estradiol 12.8715610895
MESH:D007859 Learning Disorders Diethylstilbestrol 4.1617184923
MESH:D007938 Leukemia Genistein 3.0618980019 17468513
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2415034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.5217823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5212878042
MESH:D008113 Liver Neoplasms Diethylstilbestrol 4.6415890375 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6416984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 5.896587162 1399818 3712494 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.8912151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.2715166399
MESH:D008223 Lymphoma Diethylstilbestrol 8.1115700306
MESH:D008223 Lymphoma Etoposide 8.1112556972 12854902
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.6516002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.2517203775 16891317 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.2514578162 12929590
MESH:D020149 Manganese Poisoning Estradiol 4.6219453300
MESH:D009203 Myocardial Infarction Genistein 2.8917141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.7216810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.7217141266
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.503581430
MESH:D009369 Neoplasms Diethylstilbestrol 2.8015313581
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8517289903
MESH:D009421 Nervous System Malformations bisphenol A 31.8611399458 16427766
MESH:D009421 Nervous System Malformations Diethylstilbestrol 31.8611399458
MESH:D009421 Nervous System Malformations Estradiol 31.8616427766 11399458
MESH:D009421 Nervous System Malformations Genistein 31.8616427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 31.8614600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.966679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.506482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.153988306
MESH:D010024 Osteoporosis Genistein 3.3019401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1716169203
MESH:D010049 Ovarian Diseases bisphenol A 5.1111985600
MESH:D010051 Ovarian Neoplasms Estradiol 4.9819401270
MESH:D010051 Ovarian Neoplasms Genistein 4.9819005980
MESH:D010190 Pancreatic Neoplasms Etoposide 3.2919003803
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.597296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.606228378
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.3014722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.7715687265 16977796
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 17.0010548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 17.0017184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 17.0011399792 11896295 11222880 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.8320887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.8320887781
MESH:D011471 Prostatic Neoplasms bisphenol A 1.9116740699
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.9115046698 15846301 17136230
MESH:D011471 Prostatic Neoplasms equol 1.9116898868 16925846
MESH:D011471 Prostatic Neoplasms Estradiol 1.9116740699
MESH:D011471 Prostatic Neoplasms Etoposide 1.9117172428
MESH:D011471 Prostatic Neoplasms Genistein 1.9116925846 15256057 15378649
MESH:D011537 Pruritus Ethinyl Estradiol 3.4315861022 16919318
MESH:D011629 Puberty, Precocious bisphenol A 4.9010548101
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.433692021
MESH:D012512 Sarcoma, Ewing's Etoposide 4.8014601052
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D013088 Spermatocele Diethylstilbestrol 12.1716002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 12.1716709447
MESH:D019966 Substance-Related Disorders bisphenol A 4.1016045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.956587162 6582329 7505956 3712494 1399818
MESH:D013978 Tibial Fractures Estradiol 4.8219048282
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.288074119
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 5.2816712894 16452187 17306315
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.1116175088
MESH:D014591 Uterine Diseases bisphenol A 14.2714652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 14.2714652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 9.7915809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.7914692618
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.5416513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
Pathway ID Pathway Name
KEGG:00790 Folate biosynthesis
KEGG:01100 Metabolic pathways
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00848 antagonist Levamisole Antirheumatic Agents;Antinematodal Agents;Adjuvants, Immunologic
DB01143 agonist Amifostine Radiation-Protective Agents
No data
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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