AutismKB 2.0

Annotation Detail for ADAM2


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Basic Information Top
Gene Symbol:ADAM2 ( CRYN1,CRYN2,CT15,FTNB,PH-30b,PH30 )
Gene Full Name: ADAM metallopeptidase domain 2
Band: 8p11.22
Quick LinksEntrez ID:2515; OMIM: 601533; Uniprot ID:ADAM2_HUMAN; ENSEMBL ID: ENSG00000104755; HGNC ID: 198
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of ADAM2 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of ADAM2 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ADAM2 mRNAaffects expression 16483693
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ADAM2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADAM2 mRNAaffects cotreatment|increases expression 17942748
C006253 pirinixic acid pirinixic acid results in decreased expression of ADAM2 mRNAdecreases expression 17950772
C025299 polyphenols polyphenols results in decreased expression of ADAM2 mRNAdecreases expression 16293270
C017947 sodium arsenite sodium arsenite results in increased expression of ADAM2 mRNAincreases expression 16014739
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADAM2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ADAM2 mRNAincreases expression 17942748
15328365
D015032 Zinc Zinc results in decreased expression of ADAM2 mRNAdecreases expression 16870260
C016837 zinc chloride zinc chloride results in decreased expression of ADAM2 mRNAdecreases expression 16870260
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0814514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D000169 Acrodermatitis Zinc 5.6417202136 16889938 17190629
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.843712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.7116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.7116835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.9615276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.1716712894 17306315
MESH:D000544 Alzheimer Disease Zinc 2.7917119284 16580781 16325427 16410023
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000755 Anemia, Sickle Cell Zinc 5.1016916123
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001249 Asthma Zinc 3.0017085522
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.281440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.3519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.3512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001930 Brain Injuries Zinc 4.9017109824
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6920435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.673581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.673084413
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.6716507464 17306315 15276417
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.757296757
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 5.0618572023
MESH:D002294 Carcinoma, Squamous Cell Zinc 5.0616543248
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Zinc 3.7716936243
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.127505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.1220056578 19524636
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 14.129022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 14.1216919318 15861022 17681005 17110522 16105132 17333356 11677210
MESH:D002779 Cholestasis pirinixic acid 14.1219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1612621046 15340226 16354765 15668235 8697196
MESH:D003110 Colonic Neoplasms polyphenols 2.7016293270
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.7115322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Zinc 2.7119302082
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0118759878 14531868 8156756 11906362 8970840 12868966 11298694 2524372
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.673621924 2952479
MESH:D003920 Diabetes Mellitus Zinc 4.3616479319
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.366482804 18289764 9022650 9328219 8291058 16192314 18648102 1440618 11289319 7440962 18692083 9653073 6679447
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.3615619225 11461765 12958197 11287661 16109766 19416960 14986274 18713872 17522070 19085960 11834606 18071297 16227642 12705907 12392966 15968718 16081117 11743745 10774834 14725611 19420014 16781746 11421492 19739265 12594235 11739529 14550746 16177239 19164858 17906064 12540782 10915739 12153990 16393943 16485898 17562736 11529661 19370779 2444490 19923254 10663392
MESH:D056486 Drug-Induced Liver Injury polyphenols 9.3619370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.3620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004487 Edema pirinixic acid 7.1112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.1111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1718230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3812538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.803581430
MESH:D004938 Esophageal Neoplasms Zinc 4.8016543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.1215345470
MESH:D005234 Fatty Liver pirinixic acid 8.1219236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1620067830
MESH:D005756 Gastritis Acetaminophen 12.0716983495
MESH:D005756 Gastritis Zinc 12.0717241300
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.9216452187
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006130 Growth Disorders Zinc 4.0717217573
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4111294989 10048152
MESH:D006333 Heart Failure pirinixic acid 7.4820558911
MESH:D006333 Heart Failure Zinc 7.4817162251
MESH:D006335 Heart Injuries Zinc 6.0317074742
MESH:D016481 Helicobacter Infections Zinc 4.7217241300
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.716705139
MESH:D006527 Hepatolenticular Degeneration Zinc 4.9017276780
MESH:D006529 Hepatomegaly pirinixic acid 8.9919772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.9916120746 15340226 12621046
MESH:D006689 Hodgkin Disease sodium arsenite 3.3012676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3116354765 15340226 18606429 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.0117937319
MESH:D007248 Infertility, Male sodium arsenite 7.0115346721 12646999
MESH:D007249 Inflammation polyphenols 5.4216366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4212200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007511 Ischemia Zinc 4.8516584753
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.289022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007674 Kidney Diseases Acetaminophen 10.6815629191 12587719
MESH:D007674 Kidney Diseases sodium arsenite 10.6820008137
MESH:D007674 Kidney Diseases Zinc 10.6816960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.5916518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.116582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1815474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1812878042
MESH:D008107 Liver Diseases Acetaminophen 4.2816611625 12969438 16610002 12587719 19014921 19460945 19784758 11587558
MESH:D008107 Liver Diseases polyphenols 4.2816698588
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4017185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 7.6916377806 20007298 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 7.6916712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6916984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.076587162 598648 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.0712151625
MESH:D008171 Lung Diseases sodium arsenite 3.2819095001
MESH:D008175 Lung Neoplasms sodium arsenite 2.3517077188 19931552 17306315 15276417 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3511884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Zinc 3.4012773700
MESH:D008545 Melanoma sodium arsenite 2.0516487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.533581430
MESH:D009369 Neoplasms pirinixic acid 5.2017405874
MESH:D009369 Neoplasms sodium arsenite 5.2011559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8820056578
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.626679447
MESH:D009436 Neural Tube Defects sodium arsenite 7.6212854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.586482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4815276417 17306315
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011225 Pre-Eclampsia Zinc 4.3117114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311222880 11118676 11896295 11399792
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.4616039940
MESH:D011471 Prostatic Neoplasms Zinc 3.4616606632 16517595 16700911 12429649
MESH:D011537 Pruritus Ethinyl Estradiol 3.5516919318 15861022
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 9.433692021
MESH:D012162 Retinal Degeneration Zinc 9.4316584753
MESH:D012878 Skin Neoplasms sodium arsenite 5.8418572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9312854658
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.5217997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.017505956 1399818 3712494 6582329 6587162
MESH:D014062 Tongue Neoplasms Zinc 4.5616543248
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.298074119
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.2916452187 16712894 17306315 11723127
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9311813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D014652 Vascular Diseases sodium arsenite 4.6617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7115869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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