AutismKB 2.0

Annotation Detail for NR5A1


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Basic Information Top
Gene Symbol:NR5A1 ( AD4BP,ELP,FTZ1,FTZF1,POF7,SF-1,SF1 )
Gene Full Name: nuclear receptor subfamily 5, group A, member 1
Band: 9q33.3
Quick LinksEntrez ID:2516; OMIM: 184757; Uniprot ID:STF1_HUMAN; ENSEMBL ID: ENSG00000136931; HGNC ID: 7983
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Gene Expression
No data
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Related Diseases/Disorders Top
No data
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Desease Name
micropenis
diabetes, type 2 insulin
METABOLIC
cryptorchidism
DEVELOPMENTAL
No data
Desease Name
46XY gonadal dysgenesis, complete or partial, with or without adrenal failure
Adrenocortical insufficiency
Premature ovarian failure 7
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of NR5A1 mRNA]affects expression|affects reaction 19414516
C003585 22-hydroxycholesterol 22-hydroxycholesterol promotes the reaction [NR5A1 protein results in increased expression of STAR protein]increases expression|increases reaction 9804848
C007997 25-hydroxycholesterol 25-hydroxycholesterol promotes the reaction [NR5A1 protein results in increased expression of STAR protein]increases expression|increases reaction 9804848
C007997 25-hydroxycholesterol 25-hydroxycholesterol results in increased activity of NR5A1 proteinincreases activity 9144161
C076996 27-hydroxycholesterol 27-hydroxycholesterol promotes the reaction [NR5A1 protein results in increased expression of STAR protein]increases expression|increases reaction 9804848
C076996 27-hydroxycholesterol 27-hydroxycholesterol results in increased activity of NR5A1 proteinincreases activity 9144161
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of NR5A1 mRNAdecreases expression 16788091
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NR5A1 mRNAaffects expression 16483693
D001280 Atrazine Atrazine binds to NR5A1 proteinaffects binding 17520059
D001280 Atrazine Atrazine promotes the reaction [[NR5A1 protein binds to CYP19A1 gene] which results in increased expression of CYP19A1 mRNA]affects binding|increases expression|increases reaction 17520059
D001280 Atrazine Atrazine results in increased expression of NR5A1 mRNAincreases expression 17520059
D001280 Atrazine Atrazine results in increased expression of NR5A1 proteinincreases expression 17520059
D001280 Atrazine Atrazine results in increased phosphorylation of NR5A1 proteinincreases phosphorylation 18461179
D001280 Atrazine NR5A1 protein affects the reaction [Atrazine results in increased expression of CYP19A1 mRNA]affects reaction|increases expression 18461179
D001280 Atrazine NR5A1 protein affects the reaction [Atrazine results in increased expression of LHB mRNA]affects reaction|increases expression 18461179
D001280 Atrazine NR5A1 protein promotes the reaction [Atrazine results in increased expression of CYP11A1 mRNA]increases expression|increases reaction 18461179
D001280 Atrazine NR5A1 protein promotes the reaction [Atrazine results in increased expression of HSD11B2 mRNA]increases expression|increases reaction 18461179
D001280 Atrazine NR5A1 protein promotes the reaction [Atrazine results in increased expression of INHA mRNA]increases expression|increases reaction 18461179
D001280 Atrazine NR5A1 protein promotes the reaction [Atrazine results in increased expression of STAR mRNA]increases expression|increases reaction 18461179
D001280 Atrazine Atrazine results in increased activity of NR5A1 proteinincreases activity 18461179
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of NR5A1 mRNAincreases expression 17520059
C014347 decitabine decitabine affects the methylation of NR5A1 promoteraffects methylation 17519303
D003994 Bucladesine Bucladesine inhibits the reaction [CTBP1 protein binds to NR5A1 protein]affects binding|decreases reaction 18184656
D003633 Dichlorodiphenyl Dichloroethylene Dichlorodiphenyl Dichloroethylene affects the expression of NR5A1 mRNAaffects expression 16707152
D004026 Dieldrin Dieldrin affects the expression of NR5A1 mRNAaffects expression 16707152
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in decreased expression of NR5A1 mRNAdecreases expression 16690193
D004958 Estradiol Estradiol results in increased activity of NR5A1 proteinincreases activity 19549922
D004958 Estradiol U 0126 inhibits the reaction [Estradiol results in increased activity of NR5A1 protein]decreases reaction|increases activity 19549922
D004958 Estradiol wortmannin inhibits the reaction [Estradiol results in increased activity of NR5A1 protein]decreases reaction|increases activity 19549922
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NR5A1 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of NR5A1 mRNAdecreases expression 17222921
D005485 Flutamide Flutamide results in decreased expression of NR5A1 mRNAdecreases expression 17222921
C516216 GSK 8470 GSK 8470 binds to and results in increased activity of NR5A1 proteinaffects binding|increases activity 17154495
D019289 Pyruvic Acid Pyruvic Acid inhibits the reaction [CTBP1 protein binds to NR5A1 protein]affects binding|decreases reaction 18184656
D019289 Pyruvic Acid Pyruvic Acid promotes the reaction [NR5A1 protein binds to CYP17A1 promoter]affects binding|increases reaction 18184656
D012839 Simazine Simazine results in increased expression of NR5A1 mRNAincreases expression 17520059
D014284 Triiodothyronine Triiodothyronine affects the expression of NR5A1 mRNAaffects expression 17403546
D013629 Tamoxifen Tamoxifen analog results in increased activity of NR5A1 proteinincreases activity 19549922
D013629 Tamoxifen Tamoxifen analog results in increased phosphorylation of NR5A1 proteinincreases phosphorylation 19549922
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NR5A1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of NR5A1 mRNAdecreases expression 16254025
D014212 Tretinoin Tretinoin results in decreased expression of NR5A1 mRNAdecreases expression 16604517
16788091
C113580 U 0126 U 0126 inhibits the reaction [Estradiol results in increased activity of NR5A1 protein]decreases reaction|increases activity 19549922
C025643 vinclozolin vinclozolin results in decreased expression of NR5A1 mRNAdecreases expression 18042343
C009687 wortmannin wortmannin inhibits the reaction [Estradiol results in increased activity of NR5A1 protein]decreases reaction|increases activity 19549922
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
OMIM:612965 46,XY SEX REVERSAL 3 marker/mechanism
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3414745880
MESH:D000014 Abnormalities, Drug-Induced Diethylhexyl Phthalate 8.016734493
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.0111752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.3518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7317505938
MESH:D000168 Acrocephalosyndactylia U 0126 5.2617694057
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.6820127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 6.6811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.6814692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.536695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.1716835633
MESH:D000309 Adrenal Insufficiency marker/mechanism
MESH:D000382 Agricultural Workers' Diseases Atrazine 13.6011874814
MESH:D000382 Agricultural Workers' Diseases Dichlorodiphenyl Dichloroethylene 13.6016487989
MESH:D000382 Agricultural Workers' Diseases Simazine 13.6012661182
MESH:D000505 Alopecia Tretinoin 3.4515955085
MESH:D000544 Alzheimer Disease 27-hydroxycholesterol 3.6814523054 20157255
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7611748828
MESH:D001008 Anxiety Disorders vinclozolin 3.4819015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8719183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7815885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.7816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2216292516
MESH:D001249 Asthma Tretinoin 2.2816456186
MESH:D050197 Atherosclerosis 27-hydroxycholesterol 4.3111166758 9059518
MESH:D001471 Barrett Esophagus Tretinoin 4.2016935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.3116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6315746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.5617474063 20146248
MESH:D001943 Breast Neoplasms decitabine 4.5618320071 19208741
MESH:D001943 Breast Neoplasms Dichlorodiphenyl Dichloroethylene 4.5615061365
MESH:D001943 Breast Neoplasms Dieldrin 4.5611859874 15770527
MESH:D001943 Breast Neoplasms Estradiol 4.5619861407 17289903 17018787 12948864 14630087 16675129 18497071 17261762
MESH:D001943 Breast Neoplasms Tamoxifen 4.5620390343 19142967 16273361 18351453 18984771 19011961 20005174 18815881 19059307 16202921 19244106 19084267 20065188 19189212 21152245 19155303 17242785 17440819 19103187 15668708 17261762 16873071 21138602 20859285 19288272 20544844 18997820 19189210 19200415 17893378 20135344 15565566 19289846 19221464 11161223 18855134 18821012 18629630 19410462 19115204 19487384 16818667 19066611 18425577 17049068
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.5620435547
MESH:D001943 Breast Neoplasms Tretinoin 4.5616873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3816813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3019066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9516168501
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.3916924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.3916924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.391917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.1720419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.1719215824
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.1716051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4317572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2516120746 18670907 18850075
MESH:D002386 Cataract Tretinoin 2.9717460283
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.6318566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3816129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.7217333356 17681005 15861022 16105132 11677210 16919318 17110522
MESH:D002822 Choriocarcinoma Tretinoin 4.9516461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4715668235 16354765 12621046 8697196 15340226
MESH:D002972 Cleft Palate Tretinoin 5.479407595
MESH:D003092 Colitis Tretinoin 3.5017035595
MESH:D003110 Colonic Neoplasms decitabine 2.3017616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.3815322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.389224671 17551590 8800419 10589399 9664655 16925845 9211117 14991402 9125849 9142499
MESH:D003456 Cryptorchidism vinclozolin 4.1414966744
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1519031437
MESH:D003715 Dengue 27-hydroxycholesterol 5.4719427377
MESH:D003876 Dermatitis, Atopic Diethylhexyl Phthalate 3.9516882537
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6217107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.2519279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.2519279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.4820420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6111462148
MESH:D004417 Dyspnea Dichlorodiphenyl Dichloroethylene 5.0516487989
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.2011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.2318230668 16714409 15322242
MESH:D004489 Edema, Cardiac Tretinoin 11.2318230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental 27-hydroxycholesterol 14.3417410599
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.3412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.3419031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.9019294695
MESH:D016889 Endometrial Neoplasms Estradiol 11.6411473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.6419155303 16202921 17893378 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 11.6416569247
MESH:D004715 Endometriosis marker/mechanism 17519303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8410568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.3211564622
MESH:D005124 Eye Abnormalities Tretinoin 8.329664655 16938888
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.0715345470
MESH:D005234 Fatty Liver Tamoxifen 7.0719224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2511858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9719069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.9320067830
MESH:D005355 Fibrosis Tretinoin 7.9317994277
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.7216973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0916417039
MESH:D005909 Glioblastoma Tretinoin 2.8717312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3810696789
MESH:D006258 Head and Neck Neoplasms decitabine 7.3719215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.3716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9516084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.4620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.4610048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 10.469664655 14991402
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1511000095
MESH:D006505 Hepatitis Dichlorodiphenyl Dichloroethylene 4.8416487989
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6912621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.8215709030
MESH:D019584 Hot Flashes Estradiol 3.5417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.838697196 16354765 15340226 18606429 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.0516870215
MESH:D017588 Hyperandrogenism Flutamide 5.2515356085
MESH:D006937 Hypercholesterolemia 27-hydroxycholesterol 4.9717873880
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3616778211
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8318850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6016945680 16569931
MESH:D007247 Infertility, Female Dieldrin 9.6410630421
MESH:D007247 Infertility, Female Ethinyl Estradiol 9.6412013081
MESH:D007248 Infertility, Male Atrazine 19.6712948887
MESH:D007248 Infertility, Male decitabine 19.6717581917
MESH:D007248 Infertility, Male Dichlorodiphenyl Dichloroethylene 19.6712948891 17192596
MESH:D007248 Infertility, Male Ethinyl Estradiol 19.6717937319
MESH:D007248 Infertility, Male vinclozolin 19.6716467254
MESH:D007249 Inflammation Tamoxifen 4.5319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.5312200463 12878042
MESH:D007333 Insulin Resistance Estradiol 2.8316393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 3.5617994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.3016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.3015992940 17551590
MESH:D007674 Kidney Diseases Estradiol 2.4715618244
MESH:D007680 Kidney Neoplasms Estradiol 6.8215610895
MESH:D007680 Kidney Neoplasms Tamoxifen 6.8218625569
MESH:D007938 Leukemia decitabine 6.0818980019 19235587
MESH:D007938 Leukemia Tretinoin 6.0817143497
MESH:D007948 Leukemia, Monocytic, Acute U 0126 5.1016972261
MESH:D007951 Leukemia, Myeloid decitabine 8.9319117987 18454857 17236224
MESH:D007951 Leukemia, Myeloid Tretinoin 8.9319285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.8418460780 19010910 18704418 19387464 18206229 17679729
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.8419850784 17596541 16294345
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.2518055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0219035177 16766008 17339181 16331271 19642359 19225113 17107899 17368321 17361223 9834237 17294898 17217047 16823087 17506722 17649720 15748426 19075265 16140955 17301526 12679006 16788101 17712046 16891316 19029980 16935935
MESH:D007984 Leydig Cell Tumor vinclozolin 4.5216417039
MESH:D017880 Limb Deformities, Congenital Dichlorodiphenyl Dichloroethylene 8.1512745335
MESH:D017880 Limb Deformities, Congenital Tretinoin 8.159224671
MESH:D008064 Lipidoses Tamoxifen 3.0117567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.7214659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.7218564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.7212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.7218397230 16248980
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 13.4220195826 21137059
MESH:D008113 Liver Neoplasms Dieldrin 13.429539021 8742319
MESH:D008113 Liver Neoplasms Diethylhexyl Phthalate 13.4211940454
MESH:D008113 Liver Neoplasms Tamoxifen 13.4216684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.4216984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 1.9812151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.2017053015 20064080 18520028 20135361 20869020 20464547 18816296 18569708 6695378
MESH:D008175 Lung Neoplasms Tamoxifen 3.2018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.2011884234 19555203
MESH:D008223 Lymphoma decitabine 3.2719470736
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5519428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.5311408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.5316827153 11731420 19196722 14580682 19196723
MESH:D020149 Manganese Poisoning Estradiol 11.9419453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.9419453300
MESH:D008527 Medulloblastoma Tretinoin 2.7017453147
MESH:D008545 Melanoma decitabine 4.9016505122 17785578
MESH:D008545 Melanoma Tamoxifen 4.9019393235 12393984
MESH:D008545 Melanoma Tretinoin 4.9016752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9715990972
MESH:D008591 Meningomyelocele Tretinoin 4.2216940565
MESH:D008654 Mesothelioma Atrazine 3.451916698
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0316381670
MESH:D009101 Multiple Myeloma decitabine 3.2018172295
MESH:D009190 Myelodysplastic Syndromes decitabine 7.0819010910 16882708 19157545 18608210
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.0817596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.1216810080
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4519410462
MESH:D009369 Neoplasms Benzo(a)pyrene 11.0711141357
MESH:D009369 Neoplasms decitabine 11.0717925555 19116145 19470736
MESH:D009369 Neoplasms Dieldrin 11.078820588
MESH:D009369 Neoplasms Tretinoin 11.0716946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7919196722 19200415 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5217289903
MESH:D009421 Nervous System Malformations Estradiol 15.1611399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.1614600291
MESH:D009421 Nervous System Malformations Tretinoin 15.169125849
MESH:D009436 Neural Tube Defects Tretinoin 2.929142499
MESH:D010051 Ovarian Neoplasms decitabine 10.7919259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 10.7919401270
MESH:D010051 Ovarian Neoplasms Tretinoin 10.7916936753
MESH:D010051 Ovarian Neoplasms U 0126 10.7916211241
MESH:D010146 Pain Tretinoin 2.7416870215
MESH:D010190 Pancreatic Neoplasms decitabine 5.1219294695
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.1215976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4911578682
MESH:D010300 Parkinson Disease Atrazine 5.6917218051
MESH:D010300 Parkinson Disease Dieldrin 5.6916809432 17291500 16112328 11181820 11445065
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0412520081
MESH:D011085 Polycystic Ovary Syndrome Flutamide 4.8215356085
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3618163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.7911399792 11118676 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.7918042343 18220299 19015723
MESH:D055728 Primary Myelofibrosis decitabine 4.5217616702
MESH:D016649 Primary Ovarian Insufficiency marker/mechanism
MESH:D011469 Prostatic Diseases vinclozolin 4.7218220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.9217292933
MESH:D011471 Prostatic Neoplasms Estradiol 1.9216740699
MESH:D011471 Prostatic Neoplasms Flutamide 1.923169114
MESH:D011471 Prostatic Neoplasms Simazine 1.9212661182
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.9215067354
MESH:D011472 Prostatitis vinclozolin 4.7218629315
MESH:D011507 Proteinuria Tretinoin 3.4116636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.1015861022 16919318
MESH:D011625 Pterygium Tretinoin 4.5816723453
MESH:D011649 Pulmonary Alveolar Proteinosis 27-hydroxycholesterol 6.1815466366
MESH:D012135 Respiratory Sounds Atrazine 4.3111874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6418990726
MESH:D012208 Rhabdomyosarcoma decitabine 10.3019155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.3016283617 16116481
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.8119755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.8116192470
MESH:D012878 Skin Neoplasms Tretinoin 8.8116467112
MESH:D019082 Smith-Lemli-Opitz Syndrome 27-hydroxycholesterol 5.8111254748
OMIM:270800 SPASTIC PARAPLEGIA 5A, AUTOSOMAL RECESSIVE 27-hydroxycholesterol 6.1619812052
MESH:D013088 Spermatocele Ethinyl Estradiol 10.8516709447
MESH:D013088 Spermatocele Tamoxifen 10.8516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8319457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.2620155912 2093021
MESH:D013274 Stomach Neoplasms decitabine 3.2619037991
MESH:D013274 Stomach Neoplasms Tretinoin 3.2617261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6912697716
MESH:D013964 Thyroid Neoplasms decitabine 6.7717967635
MESH:D013964 Thyroid Neoplasms Tretinoin 6.7716026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.4719048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.6016051514
MESH:D014376 Tuberculosis Tretinoin 3.1016040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.8517053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 7.8519087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 7.8516712894 8653321 17572228
MESH:D014570 Urologic Diseases Dichlorodiphenyl Dichloroethylene 5.5316487989
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4916129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1014692618
MESH:D014604 Uveal Neoplasms decitabine 12.1217785578
MESH:D014604 Uveal Neoplasms Tretinoin 12.1216752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3514671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.8516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0415886252
MESH:D009396 Wilms Tumor Tretinoin 3.7916287080
Pathway ID Pathway Name
REACT:71 Gene Expression
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31764
    • No data
    Releated disease ID Related disease Name
    PA445203Ovarian Diseases
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB04683 - (2R)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(9E)-HEXADEC-9-ENOYLOXY]PROPYL (9E)-OCTADEC-9-ENOATE
    DB04752 - Phosphatidyl ethanol
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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