AutismKB 2.0

Annotation Detail for FUS


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:FUS ( ALS6,FUS1,HNRNPP2,POMP75,TLS )
Gene Full Name: fused in sarcoma
Band: 16p11.2
Quick LinksEntrez ID:2521; OMIM: 137070; Uniprot ID:FUS_HUMAN; ENSEMBL ID: ENSG00000089280; HGNC ID: 4010
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
mRNA Processing
Gene Expression
No data
No data
Pathway IDPathway Name
500866mRNA Splicing - Major Pathway
Related Diseases/Disorders Top
Desease IDDesease Name
H00049Myxoid liposarcoma
Cancers
Nervous system diseases
Neurodegenerative diseases
Cancers of soft tissues and bone
H00058Amyotrophic lateral sclerosis
No data
No data
No data
Desease Name
Amyotrophic lateral sclerosis 6, autosomal recessive
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of FUS mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of FUS mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of FUS mRNAaffects expression 17562736
D001151 Arsenic Arsenic results in decreased expression of FUS mRNAdecreases expression 19654921
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of FUS mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of FUS mRNAaffects expression 20018196
C006780 bisphenol A bisphenol A affects the expression of FUS mRNAaffects expression 20170705
D003474 Curcumin Curcumin results in decreased expression of FUS mRNAdecreases expression 17999991
D003474 Curcumin Curcumin results in increased expression of FUS mRNAincreases expression 17198877
D004391 Dust Dust results in decreased expression of FUS mRNAdecreases expression 17805423
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of FUS mRNAaffects expression 20170705
C031721 naphthalene naphthalene results in decreased expression of FUS mRNAdecreases expression 14595851
C008776 pelargonic acid pelargonic acid results in increased expression of FUS mRNAincreases expression 11379042
C006253 pirinixic acid pirinixic acid results in increased expression of FUS mRNAincreases expression 18445702
16985257
D012643 Selenium Selenium results in increased expression of FUS mRNAincreases expression 19244175
D013629 Tamoxifen Tamoxifen results in decreased expression of FUS mRNAdecreases expression 16202921
D014051 Toluene 2,4-Diisocyanate Toluene 2,4-Diisocyanate results in decreased expression of FUS mRNAdecreases expression 11379042
D014212 Tretinoin Tretinoin results in decreased expression of FUS mRNAdecreases expression 16249480
D014810 Vitamin E Vitamin E results in increased expression of FUS mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5214745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9117505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.0818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.1420464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.1414692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.513712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.516695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.4416434500
MESH:D018246 Adrenocortical Adenoma Arsenic 5.1817306315
MESH:D019973 Alcohol-Related Disorders Curcumin 5.0517887948
MESH:D000505 Alopecia Tretinoin 3.5815955085
MESH:D000544 Alzheimer Disease Curcumin 2.6115590663
MESH:D000690 Amyotrophic Lateral Sclerosis marker/mechanism
MESH:D000799 Angioedema Acetaminophen 3.8110982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0319183758
MESH:D020261 Arsenic Poisoning Arsenic 2.8518414634 16835338 16251483 12569548
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.1115885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.1116412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.7016807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.7016292516
MESH:D001249 Asthma Toluene 2,4-Diisocyanate 5.2315590890 12585506 18394133 11742282 10934080 12684321 170078 12762349 19187332 11467998 7684630 16210060 20032816 11077013 3040596 8156442 6091945 16792590 15590891 10797510 17015710 15855793 6091946
MESH:D001249 Asthma Tretinoin 5.2316456186
MESH:D050197 Atherosclerosis Arsenic 6.8212928151 19371607
MESH:D050197 Atherosclerosis Curcumin 6.8218704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001327 Autoimmune Diseases Curcumin 4.4519761891
MESH:D001471 Barrett Esophagus Tretinoin 4.3616935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.991440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.8419483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.8416197459 16206674
MESH:D001862 Bone Resorption bisphenol A 3.8211985600
MESH:D002545 Brain Ischemia Curcumin 4.2916770732
MESH:D001932 Brain Neoplasms Curcumin 3.9017596214
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9520146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 2.9517123778
MESH:D001943 Breast Neoplasms Curcumin 2.9518593918 16243823 19250217 18462866
MESH:D001943 Breast Neoplasms Tamoxifen 2.9515668708 20005174 11161223 16873071 20135344 19487384 19084267 17049068 18855134 18425577 20859285 19244106 18815881 17440819 19011961 16818667 19155303 21152245 18629630 19289846 17893378 19288272 19115204 18821012 19221464 18997820 19189212 20065188 18351453 20390343 19189210 19410462 15565566 17242785 20544844 21138602 16202921 18984771 19142967 17261762 19103187 19066611 19059307 19200415 16273361
MESH:D001943 Breast Neoplasms Toluene 2,4-Diisocyanate 2.9511921183
MESH:D001943 Breast Neoplasms Tretinoin 2.9516873071 16443354 16166294
MESH:D016535 Bronchial Hyperreactivity Toluene 2,4-Diisocyanate 4.5012507178 15590891 8156442
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5516813970
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.8916050911
MESH:D002277 Carcinoma Curcumin 3.8018593918
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5717687452 15504454
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4719066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1316168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.3116705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 11.317296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.313084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 11.3117306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 11.3116924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.311917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.9517123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.9618414057
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.657296757
MESH:D002294 Carcinoma, Squamous Cell Arsenic 10.7218922899 15504454 17687452
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.7220419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 10.7218462866
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.7216096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Arsenic 9.3718640142
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.3717572228
MESH:D002318 Cardiovascular Diseases Arsenic 3.4217938729 15738583 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.2718022660 16973168
MESH:D002386 Cataract Acetaminophen 7.1410977129
MESH:D002386 Cataract Tretinoin 7.1417460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.547505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.5420889678
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5516129372
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.1819486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 13.1811677210 16919318 17110522 16105132 15861022 17681005 17333356
MESH:D002779 Cholestasis pirinixic acid 13.1819176532
MESH:D002822 Choriocarcinoma Tretinoin 5.1316461808
MESH:D002972 Cleft Palate Tretinoin 2.659407595
MESH:D003092 Colitis Curcumin 15.8316782535 18200517 16804969
MESH:D003092 Colitis Selenium 15.8317936198
MESH:D003092 Colitis Tretinoin 15.8317035595
MESH:D003103 Coloboma Curcumin 4.5118809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5016340194 19359593
MESH:D016510 Corneal Neovascularization Curcumin 4.8618497527
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.688800419 16925845 14991402 10589399 9224671 17551590 9125849 9664655 9142499 9211117
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.6819769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.9718551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3219031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 7.1718759878 2524372 8156756 14531868 11906362 8970840 12868966 11298694
MESH:D017449 Dermatitis, Allergic Contact Toluene 2,4-Diisocyanate 7.1715491423 18759878 12956900
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4018249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 9.462952479 3621924
MESH:D003877 Dermatitis, Contact Toluene 2,4-Diisocyanate 9.4617010967
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.6918403477
MESH:D003928 Diabetic Nephropathies Curcumin 8.9318204486
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.9319279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.8621346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 8.8618692083 16192314 18289764 6679447 6482804 1440618 18648102 7440962 11289319 8291058 9653073 9328219 9022650
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.8616485898 12958197 17562736 14725611 16109766 19739265 2444490 16227642 19923254 11461765 19370779 16177239 16393943 10915739 19420014 16081117 18713872 11421492 11739529 18071297 11743745 14550746 12594235 12153990 10774834 12705907 11529661 19085960 19164858 16781746 15619225 14986274 12392966 12540782 10663392 11287661 15968718 11834606 17906064 19416960 17522070
MESH:D056486 Drug-Induced Liver Injury Selenium 8.8615131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0719426721
MESH:D004381 Duodenal Ulcer Curcumin 4.0117351913
MESH:C538011 Eales disease Vitamin E 4.689068938
MESH:D004487 Edema pirinixic acid 2.4412083418
MESH:D004489 Edema, Cardiac Tretinoin 4.4418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.8112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.8119031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.3416202921 20544844 19155303 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 7.3416569247
MESH:D004802 Eosinophilia Toluene 2,4-Diisocyanate 4.618156442
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.123581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.1220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.1216530937
MESH:D005124 Eye Abnormalities Tretinoin 3.549664655 16938888
MESH:D005128 Eye Diseases Toluene 2,4-Diisocyanate 5.7118447907
MESH:D005234 Fatty Liver Curcumin 18.4419297423
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.4415345470
MESH:D005234 Fatty Liver pirinixic acid 18.4420131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 18.4419224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2116709447
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.996705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1519069698
MESH:D005355 Fibrosis Curcumin 8.8718705752
MESH:D005355 Fibrosis Tretinoin 8.8717994277
MESH:D005534 Foot Diseases Arsenic 5.536392382
MESH:D005756 Gastritis Acetaminophen 3.6516983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.6518462866
MESH:D005909 Glioblastoma Curcumin 7.1917596214
MESH:D005909 Glioblastoma Tretinoin 7.1917312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.007505956
MESH:D006258 Head and Neck Neoplasms Curcumin 7.7918829502 18462866
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.7916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1316084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.0520471113
MESH:D006330 Heart Defects, Congenital Tretinoin 11.0514991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin E 11.0516080930
MESH:D006333 Heart Failure pirinixic acid 6.8620558911
MESH:D006333 Heart Failure Selenium 6.8617162251
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.476705139
MESH:D006529 Hepatomegaly pirinixic acid 2.9619772884 16221962 18467677 19176532
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.0017701891
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6916863852 16490937
MESH:D019584 Hot Flashes Vitamin E 3.9414716179
MESH:D006930 Hyperalgesia Acetaminophen 7.5016870215
MESH:D006930 Hyperalgesia Tretinoin 7.5016870215
MESH:D006937 Hypercholesterolemia Curcumin 4.0118704882
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5316778211
MESH:D006943 Hyperglycemia pirinixic acid 3.1420558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.4217050553
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9015034207
MESH:D006967 Hypersensitivity Toluene 2,4-Diisocyanate 4.5611019492 10880147
MESH:D006973 Hypertension Arsenic 2.8516076760 11953799 9931084
MESH:D006987 Hypesthesia Arsenic 5.5316093927
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4617937319
MESH:D007249 Inflammation Curcumin 5.1916956363 17151092 18403477
MESH:D007249 Inflammation Tamoxifen 5.1919457130
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1918596194 18200517
MESH:D007251 Influenza, Human Selenium 10.8616624496
MESH:D007251 Influenza, Human Vitamin E 10.8616624496
MESH:D007333 Insulin Resistance bisphenol A 7.2216393666
MESH:D007333 Insulin Resistance pirinixic acid 7.2216306350
MESH:D007410 Intestinal Diseases Tretinoin 3.7317994277
MESH:D007414 Intestinal Neoplasms Curcumin 4.1810783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.999022650 8074119
MESH:D007569 Jaw Abnormalities Tretinoin 3.8617551590 15992940
MESH:D007642 Keratosis Arsenic 4.9512749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 5.8815629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 5.8812488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.8416518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.1916705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.196582329
MESH:D007680 Kidney Neoplasms Tamoxifen 12.1918625569
MESH:D007889 Leiomyoma Curcumin 4.5318555241
MESH:D007938 Leukemia Curcumin 6.4218462866
MESH:D007938 Leukemia Tretinoin 6.4217143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.1616106398
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6619285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0717596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 7.6617339181
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.6616891316 16935935 17294898 16766008 19642359 19029980 9834237 17301526 12679006 16140955 19075265 19225113 19035177 15748426 17712046 16331271 17649720 17339181 17506722 17107899 17361223 17217047 16823087 17368321 16788101
MESH:D015458 Leukemia, T-Cell Curcumin 4.7216106398
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.279224671
MESH:D008064 Lipidoses Tamoxifen 3.1217567588 15342952
MESH:D018208 Liposarcoma, Myxoid marker/mechanism 7503811 8510758
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.179327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 6.6918006644 18705752 17355460
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.6915474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.6918564211
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.6916248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.6916169303
MESH:D008107 Liver Diseases Acetaminophen 6.5419014921 16610002 19784758 11587558 19460945 12587719 12969438 16611625
MESH:D008107 Liver Diseases Arsenic 6.5411134558
MESH:D008107 Liver Diseases Curcumin 6.5416956363
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2016871587 17185352
MESH:D008113 Liver Neoplasms Arsenic 10.5716368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.5720195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 10.5716377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 10.5716684651
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.506587162 598648 3712494 1399818
MESH:D008171 Lung Diseases Vitamin E 3.1516863852
MESH:D055370 Lung Injury naphthalene 4.986834280
MESH:D008175 Lung Neoplasms Arsenic 6.5519168569 17976673 17306315
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.556695378 17053015 18520028 20064080 20135361 20869020 18816296 18569708 20464547
MESH:D008175 Lung Neoplasms Curcumin 6.5519359593 18462866 16243823
MESH:D008175 Lung Neoplasms Tamoxifen 6.5518625569
MESH:D008175 Lung Neoplasms Vitamin E 6.5511062179
MESH:D008223 Lymphoma Curcumin 3.5518462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.6516173963
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7219428831
MESH:D008325 Mammary Neoplasms, Experimental Selenium 5.9515318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.9514580682 19196723 11731420 19196722 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.5219453300
MESH:D008527 Medulloblastoma Tretinoin 2.7717453147
MESH:D008545 Melanoma Curcumin 5.1017885582 18462866
MESH:D008545 Melanoma Tamoxifen 5.1012393984 19393235
MESH:D008545 Melanoma Tretinoin 5.1016752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1515990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5319513568
MESH:D008569 Memory Disorders Curcumin 4.1117263510
MESH:D008591 Meningomyelocele Tretinoin 4.3916940565
MESH:D008654 Mesothelioma Selenium 2.7715107826
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1516381670
MESH:D009101 Multiple Myeloma Curcumin 3.4819372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.8817962980
MESH:D009135 Muscular Diseases pirinixic acid 3.4716239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0517596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1219151258
MESH:D017202 Myocardial Ischemia Arsenic 3.9515371236
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9116411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.8218551238
MESH:D009361 Neoplasm Invasiveness Curcumin 4.3318495463
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.643581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5019410462
MESH:D009369 Neoplasms Benzo(a)pyrene 8.0611141357
MESH:D009369 Neoplasms pirinixic acid 8.0617405874
MESH:D009369 Neoplasms Tretinoin 8.0616946489 16594593
MESH:D009374 Neoplasms, Experimental Toluene 2,4-Diisocyanate 4.691670384
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 10.7512497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 10.7519200415 19196722 19189210
MESH:D009421 Nervous System Malformations bisphenol A 9.6616427766 11399458
MESH:D009421 Nervous System Malformations Tretinoin 9.669125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.6018462866
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 12.006679447
MESH:D009436 Neural Tube Defects Arsenic 12.0016620997
MESH:D009436 Neural Tube Defects Tretinoin 12.009142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8318514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.3317056641
MESH:D009765 Obesity Curcumin 4.5719297423
MESH:D009765 Obesity pirinixic acid 4.5720558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 15.0116049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 15.016482804 4026338
MESH:D009784 Occupational Diseases Toluene 2,4-Diisocyanate 15.0118394133 8156442 3040596 11077013 6091945 12585506 6091946
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.993988306
MESH:D010024 Osteoporosis Curcumin 3.4418719352
MESH:D010049 Ovarian Diseases bisphenol A 4.9511985600
MESH:D010051 Ovarian Neoplasms Arsenic 7.9217306315
MESH:D010051 Ovarian Neoplasms Curcumin 7.9219020741 18462866
MESH:D010051 Ovarian Neoplasms Tretinoin 7.9216936753
MESH:D010146 Pain Acetaminophen 6.4616870215
MESH:D010146 Pain Tretinoin 6.4616870215
MESH:D010190 Pancreatic Neoplasms Curcumin 5.3919196508 17440100 19401701
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.3915976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6511578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.447296757
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.1416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.9515371236 6392382 16905509
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.446228378
MESH:D010954 Plasmacytoma Selenium 4.8615087411
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 3.9210548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.1720887781
MESH:D011471 Prostatic Neoplasms Arsenic 1.8916140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8917292933
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8916740699
MESH:D011471 Prostatic Neoplasms Curcumin 1.8911398177 18226269 10851300 18769126 18156803 15129424 12497104
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8915067354
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8915084515
MESH:D011507 Proteinuria Arsenic 9.1421343184
MESH:D011507 Proteinuria Tretinoin 9.1416636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.2815861022 16919318
MESH:D011625 Pterygium Tretinoin 4.7616723453
MESH:D011629 Puberty, Precocious bisphenol A 4.7510548101
MESH:D011656 Pulmonary Emphysema Curcumin 4.4919168576
MESH:D011657 Pulmonary Eosinophilia Toluene 2,4-Diisocyanate 5.5914606601
MESH:D015427 Reperfusion Injury pirinixic acid 2.3619058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.9810666014 18379247
MESH:D012130 Respiratory Hypersensitivity Toluene 2,4-Diisocyanate 4.407692837 20219652 16940033
MESH:D012140 Respiratory Tract Diseases Toluene 2,4-Diisocyanate 5.0918447907
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.343692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0616116481 16283617
MESH:D012220 Rhinitis Toluene 2,4-Diisocyanate 4.5419050374
MESH:D012221 Rhinitis, Allergic, Perennial Toluene 2,4-Diisocyanate 5.2512617775 15015336
MESH:D006255 Rhinitis, Allergic, Seasonal Toluene 2,4-Diisocyanate 5.4819075512
MESH:D012509 Sarcoma Curcumin 4.0818462866
MESH:D012640 Seizures 2,4-dinitrotoluene 2.5018551238
MESH:D018805 Sepsis Curcumin 4.0418389075
MESH:D012871 Skin Diseases Arsenic 5.0016353154 19834688 16702368 17938729 15952646 16759981 17050553 17453740 18709164 17548696 6392382
MESH:D012871 Skin Diseases Vitamin E 5.0018709164
MESH:D012878 Skin Neoplasms Arsenic 9.4017976673 15504454 17029826 19538983 16251483 17050553
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.4010029692 19755658
MESH:D012878 Skin Neoplasms Tretinoin 9.4016467112
MESH:D012912 Sneezing Toluene 2,4-Diisocyanate 5.4819075512 19050374
MESH:D013088 Spermatocele Ethinyl Estradiol 11.4716709447
MESH:D013088 Spermatocele Tamoxifen 11.4716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0019457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3420155912 2093021
MESH:D013274 Stomach Neoplasms Tretinoin 2.3417261132
MESH:D013276 Stomach Ulcer Curcumin 3.4616631530 19188055
MESH:D020521 Stroke Vitamin E 3.4816517955
MESH:D019966 Substance-Related Disorders bisphenol A 3.9516684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1115669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.026582329 6587162 3712494 7505956 1399818
MESH:D013964 Thyroid Neoplasms Tretinoin 7.0217045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.7516051514
MESH:D014376 Tuberculosis Tretinoin 3.2016040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 19.6816049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 19.688074119
MESH:D001749 Urinary Bladder Neoplasms Arsenic 19.6811144890 18640142 17976673 17306315 19322015 15987713 19429237
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 19.6817053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 19.6818593936
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 19.6817572228 8653321 16712894
MESH:D014565 Urogenital Neoplasms Curcumin 5.2318462866
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.2810091137
MESH:D014581 Urticaria Acetaminophen 2.9410982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6416129372
MESH:D014591 Uterine Diseases bisphenol A 4.9814652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2614692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.5816752155
MESH:D014652 Vascular Diseases Arsenic 4.7017056641
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5015869587 14671159
MESH:D014820 Vitiligo Tretinoin 4.0216761959
MESH:D009396 Wilms Tumor Tretinoin 3.9316287080
Pathway ID Pathway Name
REACT:71 Gene Expression
REACT:1675 mRNA Processing
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28425
    • No data
    Releated disease ID Related disease Name
    PA446661Carcinoma, Small Cell
    PA444818Lung Neoplasms
    PA443332Amyotrophic Lateral Sclerosis
    PA443622Carcinoma, Non-Small-Cell Lung
    Releated drug ID Related drug Name
    PA131301952gefitinib
    PA449014cisplatin
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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