AutismKB 2.0

Annotation Detail for FUT4


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Basic Information Top
Gene Symbol:FUT4 ( CD15,ELFT,FCT3A,FUC-TIV,FUTIV,LeX,SSEA-1 )
Gene Full Name: fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
Band: 11q21
Quick LinksEntrez ID:2526; OMIM: 104230; Uniprot ID:FUT4_HUMAN; ENSEMBL ID: ENSG00000196371; HGNC ID: 4015
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00601Glycosphingolipid biosynthesis - lacto and neolacto series
hsa01100Metabolic pathways
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone results in decreased expression of FUT4 mRNAdecreases expression 17991464
D000643 Ammonium Chloride Ammonium Chloride affects the expression of FUT4 mRNAaffects expression 16483693
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of FUT4 mRNAincreases expression 16715494
D003513 Cycloheximide Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FUT4 mRNA]decreases reaction|increases expression 11007951
D002117 Calcitriol Calcitriol results in decreased expression of FUT4 mRNAdecreases expression 16002434
D004317 Doxorubicin Doxorubicin results in decreased expression of FUT4 proteindecreases expression 17852453
D013749 Tetrachlorodibenzodioxin Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FUT4 mRNA]decreases reaction|increases expression 11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of FUT4 mRNAincreases expression 11007951
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2411752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D000230 Adenocarcinoma Doxorubicin 2.6217418594
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D000419 Albuminuria Doxorubicin 4.8721441931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.0718218290 20041841 18057881
MESH:D001281 Atrial Fibrillation Amiodarone 4.1118651412 19698954
MESH:D001778 Blood Coagulation Disorders Amiodarone 10.0019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 10.0012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.1414601052
MESH:D001932 Brain Neoplasms Doxorubicin 4.0717150277
MESH:D001943 Breast Neoplasms Calcitriol 1.9311237771
MESH:D001943 Breast Neoplasms Doxorubicin 1.9315136595 16595493 18695136 16322301 19526202 15692762 15939500 16115903 16264153 11325840 18628466 16826403 16096432 17426702 15994142 15567936 16935488 18234424 15993339 17369602 17983394 18382427 15634643 15668708
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9320435547
MESH:D002276 Carcinoid Tumor Doxorubicin 5.2516051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 2.2517876044 16234567 16023760 18059187
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.271485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 5.1311237771
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 5.136189445
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.7015792986 16109756 16455267 16364871 17382496 17131338 17007740 16731534 16612575 16651473 16278810 15476868 16952015 18627295 15811867 17308081 16242529 15505089 17924179 17519947 17928571 17329180 17351982 17974986 16269455
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 6.2415710769 19225199
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 6.2416243910 17334414
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.4818974383
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2012621046 15340226 16354765 8697196 15668235
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418802399 18259882
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Amiodarone 6.6915265979 18218290
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 6.6917416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.6920420201
MESH:D004362 Drug Toxicity Doxorubicin 8.7918602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.7911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3516714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.2615138306
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.6217359293
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2910568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.6018037988
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Amiodarone 3.8014986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.9819069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D005909 Glioblastoma Doxorubicin 3.5217150277
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.7015692506
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4610048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 3.6712587719 16330681 16707910 16879835 16144979 16244372 17888722 17875725 18674790 14766674 16244371 16495754 18006777
MESH:D006333 Heart Failure Doxorubicin 3.5017481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.1815692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Amiodarone 9.7615265979
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.7616120746 15340226 12621046
MESH:D006689 Hodgkin Disease Doxorubicin 3.6517606976 18501091 15147373
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4916959395 15340226 18606429 16354765 8697196
MESH:D006937 Hypercholesterolemia Amiodarone 4.158137927 9751232
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918850075 18670907
MESH:D007037 Hypothyroidism Amiodarone 4.8718020914 17991464
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9812200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007674 Kidney Diseases Doxorubicin 3.2016775033 15369732 15699352
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.4416707910
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.6016085563
MESH:D008064 Lipidoses Amiodarone 3.7017567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.5016595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.5012878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8016984957
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 6.4517085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.4512151625
MESH:D008133 Long QT Syndrome Amiodarone 3.7917391786 11989578 15350150
MESH:D008171 Lung Diseases Amiodarone 3.5512587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.9218516814
MESH:D008175 Lung Neoplasms Doxorubicin 2.4617418594 6189445
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4611884234 19555203
MESH:D008223 Lymphoma Doxorubicin 3.6516098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 4.0217654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.9315621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.1915458769
MESH:D008545 Melanoma Doxorubicin 2.3216827129
MESH:D008654 Mesothelioma Doxorubicin 3.1517638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.7815792986
MESH:D009041 Motion Sickness Dextroamphetamine 5.961613127
MESH:D052016 Mucositis Doxorubicin 5.1917415656
MESH:D009181 Mycoses Amiodarone 5.3412754197 17974566
MESH:D009203 Myocardial Infarction Doxorubicin 3.0415857846 19429709
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0418259882
MESH:D009401 Nephrosis Doxorubicin 5.1316899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.2516889571 15640375
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D009447 Neuroblastoma Doxorubicin 3.3915555623
MESH:D012516 Osteosarcoma Doxorubicin 4.3415930896
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.6017983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.6017638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911896295 11222880 11118676 11399792
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.1815572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.4316644109 16289102 12479363 18247401 15754350
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.4316888761 18437689 15749863 15897917 16729912 16868541
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9412490602 11597910 12832656
MESH:D051437 Renal Insufficiency Doxorubicin 4.5817922066
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012509 Sarcoma Doxorubicin 4.2517203757 15625365 18313854 16767912 15675481 17710206
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.5714601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.1917846226
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.4818724381
MESH:D012878 Skin Neoplasms Doxorubicin 6.0715692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0716192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.9315625365 17203757 16767912
MESH:D013276 Stomach Ulcer Amiodarone 3.5918087811
MESH:D013610 Tachycardia Amiodarone 4.6211238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.5219225199
MESH:D013959 Thyroid Diseases Amiodarone 13.5819731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 13.5812697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.5817909728 16010429
MESH:D013971 Thyrotoxicosis Amiodarone 5.2219584973 18020914
MESH:D016171 Torsades de Pointes Amiodarone 4.5917467628 11989578
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 2.8517653716
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.5817678736 17334414 17638931 16364871
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
Pathway ID Pathway Name
KEGG:00601 Glycosphingolipid biosynthesis - lacto and neolacto series
KEGG:01100 Metabolic pathways
KEGG:00514 Other types of O-glycan biosynthesis
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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