AutismKB 2.0

Annotation Detail for FNDC5


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:FNDC5 ( FRCP2 )
Gene Full Name: fibronectin type III domain containing 5
Band: 1p35.1
Quick LinksEntrez ID:252995; OMIM: 611906; Uniprot ID:FNDC5_HUMAN; ENSEMBL ID: ENSG00000160097; HGNC ID: 20240
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of FNDC5 mRNAaffects expression 16483693
D004041 Dietary Fats Dietary Fats results in increased expression of FNDC5 mRNAincreases expression 18042831
D004317 Doxorubicin Doxorubicin results in decreased expression of FNDC5 mRNAdecreases expression 17888722
D015025 Zearalenone Zearalenone results in decreased expression of FNDC5 mRNAdecreases expression 19371625
D019833 Genistein Genistein results in decreased expression of FNDC5 mRNAdecreases expression 19371625
C041786 palm oil palm oil results in increased expression of FNDC5 mRNAincreases expression 18042831
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D000230 Adenocarcinoma Doxorubicin 4.8517418594
MESH:D000230 Adenocarcinoma Genistein 4.8511473722
MESH:D000419 Albuminuria Doxorubicin 4.9321441931
MESH:D001161 Arteriosclerosis Dietary Fats 4.3115238619
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.2214601052
MESH:D001932 Brain Neoplasms Doxorubicin 4.1117150277
MESH:D001943 Breast Neoplasms Dietary Fats 1.9920435547
MESH:D001943 Breast Neoplasms Doxorubicin 1.9915567936 15939500 15692762 18695136 16115903 18628466 15136595 16264153 17369602 19526202 17983394 16096432 16935488 18234424 16595493 16322301 11325840 15994142 17426702 16826403 18382427 15634643 15668708 15993339
MESH:D001943 Breast Neoplasms Genistein 1.9916541309 17200150 16873071
MESH:D002276 Carcinoid Tumor Doxorubicin 5.3316051944
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 3.3917876044 18059187 16234567 16023760
MESH:D006528 Carcinoma, Hepatocellular Genistein 3.3916924424
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.2816201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.706189445
MESH:D009202 Cardiomyopathies Doxorubicin 3.7216952015 16242529 17924179 16455267 17974986 15792986 16278810 17928571 16109756 17382496 17329180 17007740 16731534 15811867 17308081 16612575 17519947 18627295 15476868 16651473 17351982 16269455 17131338 15505089 16364871
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0317334414 16243910
MESH:D002318 Cardiovascular Diseases Genistein 3.5116332659
MESH:D003110 Colonic Neoplasms Genistein 2.3317182828
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1518802399 18259882
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5416647724
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 2.5117416283
MESH:D004362 Drug Toxicity Doxorubicin 3.9018602426
MESH:D050171 Dyslipidemias Dietary Fats 3.6718367378
MESH:D004714 Endometrial Hyperplasia Genistein 5.0516402032
MESH:D016889 Endometrial Neoplasms Doxorubicin 8.3317359293
MESH:D016889 Endometrial Neoplasms Genistein 8.3311473722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.6818037988
MESH:D005234 Fatty Liver Dietary Fats 3.5618296743 17967931 19551842 19004024
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 5.0519069698
MESH:D005355 Fibrosis Dietary Fats 3.9418296743
MESH:D005909 Glioblastoma Doxorubicin 7.9817150277
MESH:D005909 Glioblastoma Genistein 7.9816598420
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.7315692506
MESH:D006331 Heart Diseases Doxorubicin 3.6918674790 16144979 16244372 16244371 16879835 17888722 16707910 12587719 14766674 16330681 17875725 18006777 16495754
MESH:D006333 Heart Failure Doxorubicin 3.5217481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.2315692506
MESH:D006689 Hodgkin Disease Doxorubicin 3.6915147373 17606976 18501091
MESH:D006937 Hypercholesterolemia Dietary Fats 3.9221332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.9721332399
MESH:D007249 Inflammation Dietary Fats 2.5720412841
MESH:D007333 Insulin Resistance Dietary Fats 3.3018457598 11836018
MESH:D007674 Kidney Diseases Doxorubicin 3.2116775033 15699352 15369732
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.4816707910
MESH:D007938 Leukemia Genistein 3.1618980019 17468513
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.6816085563
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0318296743
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.8116595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.8117823541
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 3.1916842330 17085340
MESH:D008175 Lung Neoplasms Doxorubicin 2.1517418594 6189445
MESH:D008223 Lymphoma Doxorubicin 3.6816098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 4.0617654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.9815621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.9015458769
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.9014578162 12929590
MESH:D008545 Melanoma Doxorubicin 2.3216827129
MESH:D008654 Mesothelioma Doxorubicin 3.1617638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.8315792986
MESH:D052016 Mucositis Doxorubicin 5.2517415656
MESH:D009203 Myocardial Infarction Doxorubicin 6.3415857846 19429709
MESH:D009203 Myocardial Infarction Genistein 6.3417141266
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.9017141266
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0518259882
MESH:D009401 Nephrosis Doxorubicin 5.1916636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.2915640375 16889571
MESH:D009421 Nervous System Malformations Genistein 4.4116427766
MESH:D009447 Neuroblastoma Doxorubicin 3.4015555623
MESH:D009765 Obesity Dietary Fats 2.3418674790 21332399 20132043 17217161 20518802 16723640 11836018 18457598 19632207
MESH:D010024 Osteoporosis Genistein 3.4319401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.4416169203
MESH:D012516 Osteosarcoma Doxorubicin 4.3715930896
MESH:D010051 Ovarian Neoplasms Genistein 2.6719005980
MESH:D003557 Phyllodes Tumor Doxorubicin 5.6817983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.6817638057
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.3916729912 16888761 15897917 16868541 18437689 15749863
MESH:D011471 Prostatic Neoplasms Genistein 3.3916925846 15378649 15256057
MESH:D051437 Renal Insufficiency Doxorubicin 4.6417922066
MESH:D012509 Sarcoma Doxorubicin 4.2918313854 15625365 15675481 16767912 17203757 17710206
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.6214601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.2517846226
MESH:D012878 Skin Neoplasms Doxorubicin 3.0815692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.9815625365 16767912 17203757
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.6116010429 17909728
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 2.8617653716
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.6417334414 17638931 17678736 16364871
MESH:D015430 Weight Gain Dietary Fats 4.0216723640
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved