AutismKB 2.0

Annotation Detail for FUT8


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Basic Information Top
Gene Symbol:FUT8 ( MGC26465 )
Gene Full Name: fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
Band: 14q23.3
Quick LinksEntrez ID:2530; OMIM: 602589; Uniprot ID:FUT8_HUMAN; ENSEMBL ID: ENSG00000033170; HGNC ID: 4019
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00533Glycosaminoglycan biosynthesis - keratan sulfate
hsa00510N-Glycan biosynthesis
hsa01100Metabolic pathways
No data
No data
Pathway IDPathway Name
P00045Notch signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of FUT8 mRNAincreases expression 20713471
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of FUT8 mRNAaffects expression 21346803
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of FUT8 mRNAdecreases expression 20064835
20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FUT8 mRNAdecreases expression 20382639
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of FUT8 mRNAdecreases expression 20524982
D005047 Etoposide FUT8 protein affects the susceptibility to Etoposideaffects response to substance 16217747
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of FUT8 mRNAincreases expression 20713471
D009151 Mustard Gas Mustard Gas affects the expression of FUT8 mRNAaffects expression 15651846
D010634 Phenobarbital Phenobarbital results in increased expression of FUT8 mRNAincreases expression 19270015
C006253 pirinixic acid pirinixic acid results in increased expression of FUT8 mRNAincreases expression 17426115
18301758
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of FUT8 mRNAincreases expression 17555868
D014501 Uranium Uranium affects the expression of FUT8 mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of FUT8 mRNAaffects expression 15672453
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.696195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.6915322242 14514962 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0020464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 11.506695378
MESH:D000236 Adenoma Diethylnitrosamine 11.506695378 10737359
MESH:D000236 Adenoma Methylcholanthrene 11.506695378 10545420
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 25.9117162532 17620307 19061943 19052882 16434500 18056438
MESH:D018248 Adenoma, Liver Cell Phenobarbital 25.9117620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 25.9116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 25.9116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1819183758
MESH:D001249 Asthma Mustard Gas 2.7310378619
MESH:D050197 Atherosclerosis Methylcholanthrene 3.5011922910
MESH:D001768 Blister Mustard Gas 5.2819167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D019046 Bone Marrow Neoplasms Etoposide 5.3014601052
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 3.0011921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.0017474063 20146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.0017474063
MESH:D001943 Breast Neoplasms Etoposide 3.0016322251
MESH:D001943 Breast Neoplasms Methylcholanthrene 3.0017474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.0020435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.2815286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.1117687719 10378619
MESH:D002277 Carcinoma Methylcholanthrene 8.5510545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.5516835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6616705839
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.6616935385 16878318 16698587 16502159 20512989 17173139 18665156 16288022 19519916 3084413 18691550 10672840 20432363 16328049 20007298 20514400 18978308 17055752 11831363 17138121 21159647 19171122 20727157 18210153 19383236 17978847 16830150 19539802 16779866 19701751 17162532 19208518 10737359 18393292 18971187 19052882 19418558 18788625 19822196 19919837 16569478 16807293 19107877 19394651 20524982 18506893 17428255 19335982 20214788 3581430 20935162 20084675 16540662 18785209 16681979 17761372 18056438 20101231 18494052
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.6617173139 6705139 20935162 1701930 20007298
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0720419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4116120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.6120889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.6117174075 2727394 21159647 7505956
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 11.6116192471
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.364080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.5719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.5716835633
MESH:D002779 Cholestasis pirinixic acid 2.8819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1312621046 15340226 15668235 8697196 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1218551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2820387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2817107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.3118551238 21346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.3119107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004421 Dystonia Phenobarbital 4.091851702
MESH:D004487 Edema Mustard Gas 11.9111402378 9260866 11428631 11428647
MESH:D004487 Edema pirinixic acid 11.9112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.9111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0416714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1010568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.213659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.0011558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.9320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.616401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.367750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.143659116
MESH:D004890 Erythema Mustard Gas 5.289357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2516302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4120426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4116530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Diethylnitrosamine 7.9521071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 7.9519236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.0610962813 14633661
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0520067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.5820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5811294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly Phenobarbital 15.0116109766
MESH:D006529 Hepatomegaly pirinixic acid 15.0118467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.0112621046 16120746 15340226
MESH:D006561 Herpes Simplex Etoposide 4.6810809021
MESH:D006689 Hodgkin Disease Etoposide 3.9417606976 18180244 16135485 15147373 16200630
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1816354765 8697196 18606429 15340226 16959395
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318670907 18850075
MESH:D007249 Inflammation Diethylnitrosamine 8.5618785209
MESH:D007249 Inflammation Mustard Gas 8.5617524151 9357497 8975870 11402378 9260866 16001271 11428620 11428647 11428631
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.5612878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.6816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.0416705839
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.7819638242 20032147 18407596 18522880 18665156
MESH:D008103 Liver Cirrhosis Phenobarbital 6.7821047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1612878042
MESH:D008107 Liver Diseases Diethylnitrosamine 4.1717034775
MESH:D008107 Liver Diseases Phenobarbital 4.1719363144
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.5421137059 20195826
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.5421047994 20118626 19812893 20434301 21278145 19996281 19638242 16942905 19499222 20492335 20452335 19294768 18644402 2422723 18977376 19255062 18648771 15885732 20101389 9163691 19690152 19850985 19254457 2862719 12112319 21167192 19426721 19427195 15175105 19256749 18754104 20583210 12771043 19833225 20137499 10737359 19090486 18978307 20501860 21071580 19073162 19642983 19551842 20405173
MESH:D008113 Liver Neoplasms Phenobarbital 14.5419812893 15975961 21047994 19482888 8742319 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 14.5420007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.5416984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.5618079962 19539802 18775883 19009564 3124819 16267830 18544905 17854601 17942915 2563599 9362446 19126423 19519916 18282651 18308698 17174075 18164116 19004024 21159647 18253720 18093689 16842330
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 14.561399818 598648
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 14.562563599 17172636 6150874 1399818 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.5612151625
MESH:D008171 Lung Diseases Mustard Gas 3.5018161513 18702808
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.696695378 18816296 18520028 20464547 20135361 20064080 17053015 18569708 20869020
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.696695378 21163286 20512841 20970405
MESH:D008175 Lung Neoplasms Methylcholanthrene 6.6917909032 16337739 10545420 1399818 21163286 15390079 20512841 7750092 6695378 20970405 11893704 9230183 16271038
MESH:D008175 Lung Neoplasms Mustard Gas 6.693148597 8781369
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.6919555203 11884234
MESH:D008223 Lymphoma Etoposide 3.9812854902 12556972
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 3.6311921183
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2516381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5917484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.9718551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.593581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9511141357
MESH:D009369 Neoplasms pirinixic acid 4.9517405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2520387270
MESH:D009503 Neutropenia Mustard Gas 4.0616761898 7688884
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5016049721 12819281
MESH:D010018 Osteomalacia Phenobarbital 4.4817016548
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.8816540662
MESH:D010190 Pancreatic Neoplasms Etoposide 8.8819003803
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.8816965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D011041 Poisoning Mustard Gas 3.8815727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.332563599
MESH:D011230 Precancerous Conditions Phenobarbital 9.332563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111399792 11222880 11118676 11896295
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.4317292933
MESH:D011471 Prostatic Neoplasms Etoposide 3.4317172428
MESH:D011537 Pruritus Mustard Gas 4.2118058305
MESH:D019310 Pseudolymphoma Phenobarbital 4.6312752131
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9510334151 17894541 17720292 17266442 17620002
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012512 Sarcoma, Ewing's Etoposide 4.8014601052
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1118551238
MESH:D012640 Seizures Phenobarbital 6.113137016 11442880 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.946407741
MESH:D012871 Skin Diseases Mustard Gas 2.7315451306 12880345 16961503
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5910029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5916192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.352093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3518456281
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.397505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.391399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.0716049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.0717053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4310091137
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
Pathway ID Pathway Name
KEGG:00533 Glycosaminoglycan biosynthesis - keratan sulfate
KEGG:01100 Metabolic pathways
REACT:17015 Metabolism of proteins
KEGG:00510 N-Glycan biosynthesis
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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