AutismKB 2.0

Annotation Detail for RICTOR


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Basic Information Top
Gene Symbol:RICTOR ( DKFZp686B11164,KIAA1999,MGC39830,PIA,mAVO3 )
Gene Full Name: RPTOR independent companion of MTOR, complex 2
Band: 5p13.1
Quick LinksEntrez ID:253260; OMIM: 609022; Uniprot ID:RICTR_HUMAN; ENSEMBL ID: ENSG00000164327; HGNC ID: 28611
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04150mTOR signaling pathway
Pathway IDPathway Name
Signalling by NGF
Signaling in Immune system
Pathway IDPathway Name
200080mTOR signaling pathway
200083CXCR4-mediated signaling events
200150CXCR3-mediated signaling events
200169Class I PI3K signaling events mediated by Akt
200113ErbB1 downstream signaling
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1860Brain tumor
2052Infection
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RICTOR mRNAdecreases expression 19150397
D003010 Clorgyline Clorgyline results in increased expression of RICTOR mRNAincreases expression 19691856
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of RICTOR mRNAaffects binding|decreases expression|increases activity 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.6418653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.2216434500
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.6319483382
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 3.0120889678
MESH:D002779 Cholestasis pirinixic acid 3.1519176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5918249437
MESH:D004487 Edema pirinixic acid 2.9612083418
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1520426865
MESH:D005234 Fatty Liver pirinixic acid 3.2520131406 19236843
MESH:D006333 Heart Failure pirinixic acid 2.7820558911
MESH:D006529 Hepatomegaly pirinixic acid 3.6419772884 18467677 19176532 16221962
MESH:D006943 Hyperglycemia pirinixic acid 3.6320558911
MESH:D007333 Insulin Resistance pirinixic acid 2.9016306350
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms pirinixic acid 1.9420007298 16377806 15890375
MESH:D009135 Muscular Diseases pirinixic acid 4.1616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2916411023
MESH:D009369 Neoplasms pirinixic acid 2.1217405874
MESH:D009765 Obesity pirinixic acid 1.8920558911
MESH:D011471 Prostatic Neoplasms Clorgyline 4.2219691856
MESH:D015427 Reperfusion Injury pirinixic acid 2.5619058328
Pathway ID Pathway Name
KEGG:04150 mTOR signaling pathway
REACT:6900 Signaling in Immune system
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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