AutismKB 2.0

Annotation Detail for FYB


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Basic Information Top
Gene Symbol:FYB ( ADAP,PRO0823,SLAP-130 )
Gene Full Name: FYN binding protein
Band: 5p13.1
Quick LinksEntrez ID:2533; OMIM: 602731; Uniprot ID:FYB_HUMAN; ENSEMBL ID: ENSG00000082074; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Interactions of the immunoglobulin superfamily (IgSF) member proteins
Cell junction organization
Signaling in Immune system
Pathway IDPathway Name
200022TCR signaling in naive CD4+ T cells
No data
Pathway IDPathway Name
500481Generation of second messenger molecules
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of FYB mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of FYB mRNAincreases expression 15761015
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of FYB mRNAdecreases expression 20064835
C051890 irinotecan irinotecan analog results in decreased expression of FYB mRNAdecreases expression 18927307
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FYB mRNAaffects binding|decreases expression|increases activity 19710929
D014212 Tretinoin Tretinoin results in increased expression of FYB mRNAincreases expression 16249480
16129123
C034028 vanadyl sulfate vanadyl sulfate results in decreased expression of FYB mRNAdecreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.5411798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5420127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8816434500
MESH:D000505 Alopecia Tretinoin 3.8415955085
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.2316412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Tretinoin 2.4116456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001471 Barrett Esophagus Tretinoin 4.7316935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 17.0616206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 17.0619483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 17.0616197459 16206674
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0820146248 17474063
MESH:D001943 Breast Neoplasms Tretinoin 2.0816166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9916813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6311589617
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6016168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.753084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.7511135700 16217749 15553829 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.751917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.3219014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3812490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7920419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.7916051514 16096774
MESH:D002386 Cataract Acetaminophen 7.7210977129
MESH:D002386 Cataract Tretinoin 7.7217460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9916129372
MESH:D002779 Cholestasis pirinixic acid 3.0319176532
MESH:D002822 Choriocarcinoma Tretinoin 5.6016461808
MESH:D002972 Cleft Palate Tretinoin 2.769407595
MESH:D003092 Colitis Tretinoin 4.0617035595
MESH:D003110 Colonic Neoplasms irinotecan 2.6317287894 17725105
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.7320501625
MESH:D015179 Colorectal Neoplasms irinotecan 2.7318259882 17454858 16391804 16303861 17159606 18509181 15273666
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.7410525206
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.749211117 10589399 9125849 16925845 9224671 17551590 14991402 8800419 9664655 9142499
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4015213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 4.6116684804
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6517522070 16177239 12705907 16081117 11421492 19085960 16781746 16109766 14725611 12958197 15968718 11834606 11461765 16227642 18071297 14986274 19416960 10774834 17906064 19739265 10663392 16393943 19923254 10915739 12392966 16485898 11287661 12153990 19420014 19370779 19164858 12540782 15619225 12594235 18713872 17562736 14550746 11529661 11739529 2444490 11743745
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D004489 Edema, Cardiac Tretinoin 4.9118230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2816569247
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6312903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.6316530937
MESH:D005124 Eye Abnormalities Tretinoin 3.789664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 8.6715073043
MESH:D005234 Fatty Liver pirinixic acid 8.6720131406 19236843
MESH:D005355 Fibrosis Tretinoin 3.8717994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5916904648
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005909 Glioblastoma Tretinoin 3.1717312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6016084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 7.0920471113
MESH:D006330 Heart Defects, Congenital Tretinoin 7.0914991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006529 Hepatomegaly pirinixic acid 3.3519176532 16221962 18467677 19772884
MESH:D006930 Hyperalgesia Acetaminophen 8.3716870215
MESH:D006930 Hyperalgesia Tretinoin 8.3716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9316778211
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007410 Intestinal Diseases Tretinoin 4.1217994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.1817551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 2.3412587719 15629191
MESH:D007938 Leukemia arsenic trioxide 6.7515070760
MESH:D007938 Leukemia Tretinoin 6.7517143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0812560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 10.4319077051
MESH:D007951 Leukemia, Myeloid Tretinoin 10.4316482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0216467208 19850784 17050201 16968895 20471514
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.0219850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 8.2017107899 15336539 11468182 17217047 17712046 15213294 17649720 11161223 19075265 19225113 19642359 12679006 16112521 17869043 16823087 12018890 12712474 16966277 16331271 15622746 9834237 16891316 19035177 16330433 15748426
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 8.2016935935 17217047 16788101 19035177 17368321 16891316 19029980 17649720 19075265 17712046 19225113 19642359 17301526 9834237 12679006 17107899 15748426 17361223 16766008 16823087 16331271 17294898 16140955 17339181 17506722
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6816882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.509224671
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4115474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.4116248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.6819460945 16610002 19784758 12587719 19014921 16611625 12969438 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 7.9214682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.9220195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 7.9216377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.8920377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5615213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.4819825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4820464547 18816296 18520028 18569708 6695378 20064080 20135361 17053015 20869020
MESH:D008527 Medulloblastoma Tretinoin 2.8717453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008591 Meningomyelocele Tretinoin 4.7816940565
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D052016 Mucositis irinotecan 5.4017159606
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2919417148 19549372 14977855 15949261 11468182
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.8716105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.8717596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2916624393
MESH:D009362 Neoplasm Metastasis irinotecan 3.2618259882
MESH:D009369 Neoplasms Benzo(a)pyrene 8.9111141357
MESH:D009369 Neoplasms pirinixic acid 8.9117405874
MESH:D009369 Neoplasms Tretinoin 8.9116594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 4.119125849
MESH:D009436 Neural Tube Defects arsenic trioxide 7.8710525206
MESH:D009436 Neural Tube Defects Tretinoin 7.879142499
MESH:D009447 Neuroblastoma irinotecan 3.608761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D017599 Neuroectodermal Tumors irinotecan 5.128761367
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.1112452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Tretinoin 5.1116936753
MESH:D010146 Pain Acetaminophen 7.3716870215
MESH:D010146 Pain Tretinoin 7.3716870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.5715580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.5715976015
MESH:D010235 Paraganglioma arsenic trioxide 4.4719927285
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.1219131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1217292933
MESH:D011507 Proteinuria Tretinoin 3.9116636307
MESH:D011625 Pterygium Tretinoin 5.1916723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4016116481 16283617
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2916646077
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.0610029692 19755658
MESH:D012878 Skin Neoplasms Tretinoin 6.0616467112
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.9217007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.9220155912 2093021
MESH:D013274 Stomach Neoplasms irinotecan 4.9215723263
MESH:D013274 Stomach Neoplasms Tretinoin 4.9217261132
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.9219014326
MESH:D013964 Thyroid Neoplasms Tretinoin 7.9217045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.0516051514
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3615213294
MESH:D014376 Tuberculosis Tretinoin 3.3816040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.3512845720 20435036 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3517053015
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9416129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.0516752155
MESH:D014820 Vitiligo Tretinoin 4.3916761959
MESH:D009396 Wilms Tumor Tretinoin 4.2216287080
Pathway ID Pathway Name
REACT:20676 Cell junction organization
REACT:23853 Interactions of the immunoglobulin superfamily (IgSF) member proteins
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28452
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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