AutismKB 2.0

Annotation Detail for FYN


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Basic Information Top
Gene Symbol:FYN ( MGC45350,SLK,SYN )
Gene Full Name: FYN oncogene related to SRC, FGR, YES
Band: 6q21
Quick LinksEntrez ID:2534; OMIM: 137025; Uniprot ID:FYN_HUMAN; ENSEMBL ID: ENSG00000010810; HGNC ID: 4037
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04360Axon guidance
hsa04650Natural killer cell mediated cytotoxicity
hsa05416Viral myocarditis
hsa05130Pathogenic Escherichia coli infection
hsa04520Adherens junction
hsa04510Focal adhesion
hsa05020Prion diseases
hsa04660T cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
Pathway IDPathway Name
Axon guidance
Interactions of the immunoglobulin superfamily (IgSF) member proteins
Hemostasis
Signaling in Immune system
HIV Infection
Pathway IDPathway Name
200033Signaling events mediated by PTP1B
200187Alpha-synuclein signaling
200003Fc-epsilon receptor I signaling in mast cells
200009ErbB4 signaling events
200132Nephrin/Neph1 signaling in the kidney podocyte
200121EPHA forward signaling
200127PDGFR-beta signaling pathway
200125E-cadherin signaling in keratinocytes
200082IL2-mediated signaling events
200083CXCR4-mediated signaling events
200069Thromboxane A2 receptor signaling
200062TCR signaling in naive CD8+ T cells
200066Angiopoietin receptor Tie2-mediated signaling
200098Class I PI3K signaling events
200170Syndecan-3-mediated signaling events
200173Ephrin B reverse signaling
200074Netrin-mediated signaling
200161Signaling events mediated by VEGFR1 and VEGFR2
200048Ephrin A reverse signaling
200108amb2 Integrin signaling
200022TCR signaling in naive CD4+ T cells
200021Glypican 1 network
200192Signaling events mediated by focal adhesion kinase
200051Reelin signaling pathway
200054Regulation of p38-alpha and p38-beta
Pathway IDPathway Name
P00012Cadherin signaling pathway
P00049Parkinson disease
P00007Axon guidance mediated by semaphorins
P00034Integrin signalling pathway
Pathway IDPathway Name
500305Cell surface interactions at the vascular wall
500075SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
500079NCAM signaling for neurite out-growth
500486CD28 dependent Vav1 pathway
500288Collagen adhesion via GPVI
500755Nef and signal transduction
Related Diseases/Disorders Top
No data
No data
Desease Name
CARDIOVASCULAR
CHEMDEPENDENCY
blood pressure, arterial hypertension
Alzheimer's disease
alcoholism
NEUROLOGICAL
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C027309 3,4,5,3',4',5'-hexachlorobiphenyl 3,4,5,3',4',5'-hexachlorobiphenyl results in increased expression of FYN mRNAincreases expression 16050139
D000082 Acetaminophen Acetaminophen affects the expression of FYN mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of FYN proteinaffects expression 20106945
C000188 alachlor alachlor results in increased expression of FYN mRNAincreases expression 12419858
D000643 Ammonium Chloride Ammonium Chloride affects the expression of FYN mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of FYN mRNAdecreases expression 20106945
20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of FYN mRNAincreases expression 16050139
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FYN mRNAdecreases expression 20018196
19150397
D002330 Carmustine Carmustine results in decreased expression of FYN mRNAdecreases expression 15980968
D003520 Cyclophosphamide Cyclophosphamide results in increased expression of FYN mRNAincreases expression 17403535
D016572 Cyclosporine Cyclosporine results in decreased expression of FYN mRNAdecreases expression 20106945
C014347 decitabine decitabine affects the expression of FYN mRNAaffects expression 18337055
C014347 decitabine decitabine affects the expression of FYN proteinaffects expression 18337055
C014347 decitabine decitabine results in increased expression of FYN mRNAincreases expression 16367923
19151715
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of FYN mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of FYN mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of FYN mRNAincreases expression 19619570
D000431 Ethanol Ethanol results in increased phosphorylation of FYN proteinincreases phosphorylation 18182400
D000431 Ethanol sodium arsenite promotes the reaction [Ethanol results in increased phosphorylation of FYN protein]increases phosphorylation|increases reaction 18182400
D005047 Etoposide FYN protein affects the susceptibility to Etoposideaffects response to substance 16217747
D005472 Fluorouracil FYN protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
C030691 gluconic acid gluconic acid results in decreased expression of FYN mRNAdecreases expression 16556975
D007854 Lead FYN protein affects the reaction [Lead results in decreased expression of PDGFRA protein]affects reaction|decreases expression 17298174
D007854 Lead Lead results in increased activity of FYN proteinincreases activity 17298174
C008261 lead acetate FYN protein affects the reaction [lead acetate results in decreased expression of PDGFRA protein]affects reaction|decreases expression 17298174
C008261 lead acetate lead acetate results in increased activity of FYN proteinincreases activity 17298174
D008767 Methylmercury Compounds FYN protein affects the reaction [Methylmercury Compounds results in increased ubiquitination of and results in increased degradation of PDGFRA protein]affects reaction|increases degradation|increases ubiquitination 17298174
D008767 Methylmercury Compounds Methylmercury Compounds results in increased activity of FYN proteinincreases activity 17298174
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of FYN mRNAincreases expression 12634122
C008493 methylselenic acid methylselenic acid results in increased expression of FYN mRNAincreases expression 18548127
D016685 Mitomycin FYN protein affects the susceptibility to Mitomycinaffects response to substance 16217747
D008942 Mitoxantrone FYN protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
D009151 Mustard Gas Mustard Gas results in decreased expression of FYN mRNAdecreases expression 15674843
C029938 nickel sulfate nickel sulfate results in increased expression of FYN mRNAincreases expression 16780908
D010269 Paraquat FYN protein affects the reaction [Paraquat results in decreased expression of PDGFRA protein]affects reaction|decreases expression 17298174
D010269 Paraquat Paraquat affects the expression of FYN mRNAaffects expression 15206577
D010269 Paraquat Paraquat results in increased activity of FYN proteinincreases activity 17298174
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of FYN mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of FYN mRNAdecreases expression 19482888
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FYN mRNAaffects binding|decreases expression|increases activity 19710929
C010327 salinomycin salinomycin results in decreased expression of FYN mRNAdecreases expression 19682730
C017947 sodium arsenite sodium arsenite promotes the reaction [Ethanol results in increased phosphorylation of FYN protein]increases phosphorylation|increases reaction 18182400
C017947 sodium arsenite sodium arsenite results in increased expression of FYN mRNAincreases expression 12016162
C017947 sodium arsenite sodium arsenite results in increased expression of FYN mRNAincreases expression 16014739
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of FYN mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of FYN mRNAdecreases expression 19619570
C024746 tobacco tar tobacco tar results in decreased expression of FYN mRNAdecreases expression 19559774
C025643 vinclozolin vinclozolin affects the expression of FYN mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 12.3717676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 12.376195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.3715322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 9.3818287403
MESH:D000138 Acidosis Ethanol 9.3811192467
MESH:D055371 Acute Lung Injury nickel sulfate 8.1519131640 12718980 11954676 16100012
MESH:D055371 Acute Lung Injury pirinixic acid 8.1518653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.5620127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 6.5611473722
MESH:D000230 Adenocarcinoma Fluorouracil 6.5617638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.476695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 15.4017620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.4016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.4016835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5716712894 17306315
MESH:D000382 Agricultural Workers' Diseases alachlor 8.0011874814 14769641
MESH:D000382 Agricultural Workers' Diseases Paraquat 8.0011874814
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.9915451040 15451039
MESH:D000740 Anemia Fluorouracil 7.7515504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.7511748828
MESH:D000799 Angioedema Acetaminophen 3.5110982225
MESH:D000853 Anophthalmos Ethanol 4.5015513904
MESH:D001008 Anxiety Disorders Ethanol 8.1711141031
MESH:D001008 Anxiety Disorders vinclozolin 8.1719015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7619183758
MESH:D001161 Arteriosclerosis Cyclophosphamide 4.2815014928
MESH:D001249 Asthma Mustard Gas 2.6110378619
MESH:D001321 Autistic Disorder Acetaminophen 1.4518445737
MESH:D001768 Blister Mustard Gas 4.8319167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.8019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.8012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5615746008
MESH:D019046 Bone Marrow Neoplasms Etoposide 4.8314601052
MESH:D001932 Brain Neoplasms Carmustine 4.1116187019
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.4420146248 17474063
MESH:D001943 Breast Neoplasms Cyclophosphamide 4.4415136595 17388661 12006526 11325840 18323546 18234424 17020986 15093573 16978400
MESH:D001943 Breast Neoplasms decitabine 4.4418320071 19208741
MESH:D001943 Breast Neoplasms Estradiol 4.4414630087 17289903 19861407 12948864 17261762 17018787 16675129 18497071
MESH:D001943 Breast Neoplasms Etoposide 4.4416322251
MESH:D001943 Breast Neoplasms Fluorouracil 4.4418357371 16557594 15136595 16595493 19217205 16110121 18608205
MESH:D001943 Breast Neoplasms salinomycin 4.4419682730
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.4420435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.8315286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.6510378619 17687719
MESH:D002056 Burns Ethanol 4.3316374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1416111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.3416051944
MESH:D002277 Carcinoma Fluorouracil 7.3417121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.3416835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 15.893084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 15.8921507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 15.8919701751
MESH:D006528 Carcinoma, Hepatocellular Estradiol 15.8916924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 15.8915289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 15.8916332177 16799960 18930000 17088986 17045692 17971768
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 15.8920007298 17173139 6705139 1701930 20935162
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 15.8917306315 15276417 16507464
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.5616152834
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 6.2916201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.2918695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 9.9620419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 9.9619215824
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 9.9616280240 16757204 17066447 18986760
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 9.9618572023
MESH:D006332 Cardiomegaly Ethanol 6.2419332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.2416120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.3910977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 23.4720889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 23.4712371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 23.4718566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 23.472727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 23.4720056578 19524636
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 23.4719559774
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.934080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D002779 Cholestasis Cyclosporine 6.9619486331
MESH:D002779 Cholestasis pirinixic acid 6.9619176532
MESH:D002971 Cleft Lip Ethanol 3.4115513904
MESH:D002972 Cleft Palate Ethanol 5.4815513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.488697196 15340226 12621046 16354765 15668235
MESH:D003110 Colonic Neoplasms decitabine 3.6517616700
MESH:D003110 Colonic Neoplasms Fluorouracil 3.6515001691 16340194 17725105 17016597 18772588 17287894 16510598 17018589 17169374 17172411
MESH:D015179 Colorectal Neoplasms decitabine 2.5518981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.5516303861 17594712 15148649 17255274 17454858 17094418 18949393 15289873 18383874 18288408 17401013 18448328 18509181 14970324 20501625 17016601 16331619 17695437 16282729 18802399 16524972 16391804
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7917141729 14669216
MESH:D019465 Craniofacial Abnormalities Ethanol 5.2215451039 11873399 19302082 15451040 10194807 15513904 11198716
MESH:D019465 Craniofacial Abnormalities Lead 5.2219769572
MESH:D019465 Craniofacial Abnormalities lead acetate 5.2219769572
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.2215322242 20055451 10048152
MESH:D003456 Cryptorchidism vinclozolin 4.0314966744
MESH:D003556 Cystitis Cyclophosphamide 4.6518710439 18372110 16989017 18093676 16651033 12913760 10700343 18433785 17979934 15643279 11948286 16413132 18483878 16614059 18295254 12388444 12161096 10498854 17010015 15276878
MESH:D007644 Darier Disease Fluorouracil 4.4716733453
MESH:D003704 Dementia Lead 9.7216140633
MESH:D003704 Dementia Methylmercury Compounds 9.7216140633
MESH:D017449 Dermatitis, Allergic Contact alachlor 6.618428444
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 6.6111298694 16823706 16780908
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2718249437
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 3.8110990075 15331540 11751995
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.1218772604
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.5917107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.1419279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.6010774834 14725611 17562736 16227642 19420014 11834606 12392966 16177239 16393943 11421492 16485898 17522070 19164858 12705907 19923254 12958197 19370779 19085960 10663392 16081117 11529661 11287661 11739529 10915739 2444490 14986274 11743745 17906064 12594235 18071297 18713872 15968718 16109766 16781746 15619225 12540782 19739265 19416960 11461765 12153990 14550746
MESH:D056486 Drug-Induced Liver Injury Ethanol 5.6011566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.6020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5211462148
MESH:D004421 Dystonia Phenobarbital 3.701851702
MESH:D004487 Edema Mustard Gas 9.7611428631 9260866 11428647 11402378
MESH:D004487 Edema pirinixic acid 9.7612083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.7611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5718230668 15322242 16714409
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.7819294695
MESH:D016889 Endometrial Neoplasms Estradiol 2.7711473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.7410568697 9294722
MESH:D004802 Eosinophilia Cyclophosphamide 3.9011006010
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.793659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.543922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.7220417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.276401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.937750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.693659116
MESH:D004890 Erythema Mustard Gas 4.839357497
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.6520426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 9.6516530937
MESH:D004938 Esophageal Neoplasms Ethanol 9.6516704527
MESH:D004938 Esophageal Neoplasms Fluorouracil 9.6516481741 15173087 16785472 16337965 17638652
MESH:D020329 Essential Tremor Lead 5.6018007985 14594619
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7711564622
MESH:D005234 Fatty Liver Cyclosporine 11.4519224547
MESH:D005234 Fatty Liver Ethanol 11.4519236843 16409862 18620774
MESH:D005234 Fatty Liver pirinixic acid 11.4519236843 20131406
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.3317920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.9716946407 10194807 15451040 15513904
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1411858732
MESH:D005317 Fetal Growth Retardation Lead 10.6819769572
MESH:D005317 Fetal Growth Retardation lead acetate 10.6819769572
MESH:D005355 Fibrosis Cyclosporine 7.4312168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.4320067830
MESH:D005756 Gastritis Acetaminophen 10.0216983495
MESH:D005756 Gastritis Ethanol 10.0215046732
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6116973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.9716417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3516452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.898708960
MESH:D005909 Glioblastoma Carmustine 3.7216187019
MESH:D005910 Glioma Fluorouracil 2.7416145905
MESH:D018316 Gliosarcoma Cyclophosphamide 5.1911389073
MESH:D005911 Gliosis Paraquat 4.8311124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2610696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.7216376943 11014644 15172196
MESH:D006258 Head and Neck Neoplasms decitabine 7.1819215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.1815162350 18337622 15102660
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.8720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.8711294989 10048152
MESH:D006331 Heart Diseases Mitoxantrone 3.9316019553
MESH:D006333 Heart Failure pirinixic acid 2.3420558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0915720958
MESH:D006467 Hemophilia A Cyclophosphamide 4.9711918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0511000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.2014986274
MESH:D006529 Hepatomegaly Phenobarbital 12.5416109766
MESH:D006529 Hepatomegaly pirinixic acid 12.5419772884 19176532 18467677 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.5415340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.7015709030
MESH:D006561 Herpes Simplex Etoposide 4.2410809021
MESH:D006689 Hodgkin Disease Cyclophosphamide 10.8617606976 16135485
MESH:D006689 Hodgkin Disease Etoposide 10.8615147373 18180244 16135485 17606976 16200630
MESH:D006689 Hodgkin Disease sodium arsenite 10.8612676792
MESH:D019584 Hot Flashes Estradiol 3.4217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7115340226 16959395 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 6.9716870215
MESH:D006930 Hyperalgesia Ethanol 6.9718783367
MESH:D006943 Hyperglycemia pirinixic acid 2.9020558911
MESH:D006973 Hypertension Cyclosporine 4.5210903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.5218670907 18850075
MESH:D007154 Immune System Diseases Cyclophosphamide 5.0016076520
MESH:D007248 Infertility, Male alachlor 28.5016466525 12948887 17049205
MESH:D007248 Infertility, Male Cyclophosphamide 28.5016517039 7193160
MESH:D007248 Infertility, Male decitabine 28.5017581917
MESH:D007248 Infertility, Male Lead 28.5016780224
MESH:D007248 Infertility, Male Paraquat 28.504850670
MESH:D007248 Infertility, Male sodium arsenite 28.5012646999 15346721
MESH:D007248 Infertility, Male vinclozolin 28.5016467254
MESH:D007249 Inflammation Mustard Gas 4.4811428631 8975870 9357497 9260866 11402378 11428620 16001271 17524151 11428647
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.4812878042 12200463
MESH:D007333 Insulin Resistance Estradiol 6.4916627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.4916306350
MESH:D007569 Jaw Abnormalities Ethanol 9.1515513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.1516580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1115604871
MESH:D007674 Kidney Diseases Acetaminophen 12.8615629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 12.8618776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 12.8615618244
MESH:D007674 Kidney Diseases sodium arsenite 12.8620008137
MESH:D007680 Kidney Neoplasms Cyclosporine 10.8912371664
MESH:D007680 Kidney Neoplasms Estradiol 10.8915610895
MESH:D007680 Kidney Neoplasms Fluorouracil 10.8916985049
MESH:D007855 Lead Poisoning Lead 5.6016700817
MESH:D007859 Learning Disorders Ethanol 9.1415451040
MESH:D007859 Learning Disorders Lead 9.1416384672
MESH:D007938 Leukemia alachlor 9.8014769641
MESH:D007938 Leukemia Cyclophosphamide 9.8010602166
MESH:D007938 Leukemia decitabine 9.8019235587 18980019
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 6.5017802794 17008537 17296974 18587576 17658394 18172266
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 6.5018172266
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 3.8510373061
MESH:D007951 Leukemia, Myeloid decitabine 3.7119117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3218704418 19010910 18206229 18460780 19387464 17679729
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.1318055864
MESH:D007970 Leukopenia Cyclophosphamide 4.6411830472 10052129
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4116417039
MESH:D017880 Limb Deformities, Congenital Ethanol 3.5817676605
MESH:D008103 Liver Cirrhosis Ethanol 6.2415289165
MESH:D008103 Liver Cirrhosis Phenobarbital 6.2421047994
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.7718295389
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.5814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 4.5818166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.5815474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.5812878042
MESH:D008107 Liver Diseases Acetaminophen 3.6319460945 16611625 12969438 12587719 19784758 11587558 19014921 16610002
MESH:D008107 Liver Diseases Phenobarbital 3.6319363144
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.3317207112 17347304
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9616871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 23.6815890375 9163691 18177683 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 23.6820195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 23.6815113037 18383874 16603448 17045692
MESH:D008113 Liver Neoplasms Mitomycin 23.6815113037
MESH:D008113 Liver Neoplasms Phenobarbital 23.6819812893 21047994 8742319 19073162 15975961 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 23.6816377806 15890375 20007298
MESH:D008113 Liver Neoplasms sodium arsenite 23.6815276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 23.6816984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 8.648603461
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 8.642563599 17172636 6150874 1399818 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.6412151625
MESH:D008171 Lung Diseases Mustard Gas 6.8218702808 18161513
MESH:D008171 Lung Diseases sodium arsenite 6.8219095001
MESH:D008175 Lung Neoplasms Aflatoxin B1 7.9714755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 7.9718569708 6695378 20464547 17053015 20064080 20135361 18816296 18520028 20869020
MESH:D008175 Lung Neoplasms Fluorouracil 7.9715246190
MESH:D008175 Lung Neoplasms Mustard Gas 7.978781369 3148597
MESH:D008175 Lung Neoplasms sodium arsenite 7.9715276417 17306315 19931552 16712894 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 7.9711884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.4715086387
MESH:D008223 Lymphoma Cyclophosphamide 11.4112854902
MESH:D008223 Lymphoma decitabine 11.4119470736
MESH:D008223 Lymphoma Etoposide 11.4112854902 12556972
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.3016675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 3.9111911406
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.7011807958 16891317 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 5.7019682730
MESH:D020149 Manganese Poisoning Estradiol 4.1519453300
MESH:D008545 Melanoma Carmustine 4.9012393984
MESH:D008545 Melanoma decitabine 4.9016505122 17785578
MESH:D008545 Melanoma sodium arsenite 4.9019082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 9.7719513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 9.7716388313
MESH:D008569 Memory Disorders Ethanol 14.4915451040 18411066
MESH:D008569 Memory Disorders Lead 14.4917263510 16384672
MESH:D008569 Memory Disorders Methylmercury Compounds 14.4918436314
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4616801185
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.5617671175
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.7116381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.7116757204 18986760
MESH:D009069 Movement Disorders Methylmercury Compounds 5.0218436314
MESH:D009101 Multiple Myeloma alachlor 7.0514769641
MESH:D009101 Multiple Myeloma decitabine 7.0518172295
MESH:D009135 Muscular Diseases pirinixic acid 3.1916239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.2016882708 19157545 18608210 19010910
MESH:D009203 Myocardial Infarction pirinixic acid 2.0119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.4316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.4316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.1517484760
MESH:D009369 Neoplasms Benzo(a)pyrene 21.5211141357
MESH:D009369 Neoplasms Cyclophosphamide 21.5218854779
MESH:D009369 Neoplasms decitabine 21.5219116145 19470736 17925555
MESH:D009369 Neoplasms Fluorouracil 21.5218239605 18600527 16928823
MESH:D009369 Neoplasms Mitoxantrone 21.5216640825
MESH:D009369 Neoplasms pirinixic acid 21.5217405874
MESH:D009369 Neoplasms sodium arsenite 21.5211559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3520056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4117289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0118481113 19348381
MESH:D009410 Nerve Degeneration Paraquat 3.4716893418
MESH:D009421 Nervous System Malformations Estradiol 8.4416427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.4414600291
MESH:D009436 Neural Tube Defects sodium arsenite 2.9312854658
MESH:D009447 Neuroblastoma Cyclophosphamide 3.4715176712 8761367 16115947
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6118514411
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.568761367 12837982
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2216436463
MESH:D009503 Neutropenia Cyclophosphamide 8.538291058
MESH:D009503 Neutropenia Mustard Gas 8.537688884 16761898
MESH:D009669 Nose Neoplasms alachlor 4.5016178123 11127290 15580706 16698726 14563481
MESH:D009765 Obesity pirinixic acid 1.7320558911
MESH:D009845 Oligospermia Cyclophosphamide 4.3916517039
MESH:D010018 Osteomalacia Phenobarbital 4.0417016548
MESH:D010051 Ovarian Neoplasms decitabine 7.2819259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 7.2819401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.2817306315 15276417
MESH:D010146 Pain Acetaminophen 5.9916870215
MESH:D010146 Pain Cyclophosphamide 5.9912161096 18093676
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 22.9911332152
MESH:D010190 Pancreatic Neoplasms decitabine 22.9919294695
MESH:D010190 Pancreatic Neoplasms Ethanol 22.9912384795
MESH:D010190 Pancreatic Neoplasms Etoposide 22.9919003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 22.9919003803 16500647 16929163 15113037
MESH:D010190 Pancreatic Neoplasms Mitomycin 22.9915113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 22.9916965848
MESH:D010300 Parkinson Disease Paraquat 2.6912911755 11181820 11445065 16510128 15451049 11124998 15824117 16140633
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.1116190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9212520081
MESH:D011014 Pneumonia Paraquat 4.1312504350
MESH:D011041 Poisoning Mustard Gas 3.5015727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2518163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.0712371664
MESH:D011230 Precancerous Conditions Phenobarbital 8.072563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.6221297632
MESH:D011297 Prenatal Exposure Delayed Effects Lead 20.6816384672
MESH:D011297 Prenatal Exposure Delayed Effects Methylmercury Compounds 20.6818436314
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 20.6811399792 11118676 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 20.6818042343 18220299 19015723
MESH:D055728 Primary Myelofibrosis decitabine 4.4117616702
MESH:D011469 Prostatic Diseases vinclozolin 4.6118220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0517292933
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.0517136230
MESH:D011471 Prostatic Neoplasms Estradiol 2.0516740699
MESH:D011471 Prostatic Neoplasms Etoposide 2.0517172428
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0518626508 19082440
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.0516205645
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0516039940
MESH:D011472 Prostatitis vinclozolin 4.6118629315
MESH:D011537 Pruritus Mustard Gas 3.7718058305
MESH:D019310 Pseudolymphoma Phenobarbital 4.1612752131
MESH:D011565 Psoriasis Cyclosporine 2.1116882103
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 8.6416636934
MESH:D011658 Pulmonary Fibrosis Mustard Gas 8.6417894541 17720292 17266442 10334151 17620002
MESH:D011658 Pulmonary Fibrosis Paraquat 8.6416324872 17997886
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7418722050 16160472 18286688 15538739
MESH:D015427 Reperfusion Injury pirinixic acid 2.2319058328
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.6111700416
MESH:D012135 Respiratory Sounds alachlor 9.0011874814
MESH:D012135 Respiratory Sounds Paraquat 9.0011874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5318990726
MESH:D012162 Retinal Degeneration Paraquat 3.6316458197
MESH:D012208 Rhabdomyosarcoma decitabine 4.1019155313
MESH:D012512 Sarcoma, Ewing's Etoposide 4.4014601052
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.5216636934
MESH:D012640 Seizures Ethanol 5.439754883
MESH:D012640 Seizures Phenobarbital 5.433137016 4039156 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.506407741
MESH:D012871 Skin Diseases Mustard Gas 2.6315451306 12880345 16961503
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.4819755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 8.4818572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.4816192470
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.1916517039
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5512854658
MESH:D013274 Stomach Neoplasms marker/mechanism 16367923
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.462093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 4.4619037991
MESH:D013274 Stomach Neoplasms Ethanol 4.4618456281
MESH:D013274 Stomach Neoplasms Fluorouracil 4.4616424979 17498489 17172411 16951190 18396642 19015929 17522103 15786421 19084572 18567086
MESH:D013276 Stomach Ulcer Ethanol 3.2516755016 17918041 9562338 11906479 17189318 9211565
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.979754883
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.7312837982
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5712697716
MESH:D013964 Thyroid Neoplasms alachlor 10.778812207
MESH:D013964 Thyroid Neoplasms decitabine 10.7717967635
MESH:D013964 Thyroid Neoplasms Phenobarbital 10.771399818
MESH:D013978 Tibial Fractures Estradiol 4.3519048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.7116280240
MESH:D014202 Tremor Lead 5.1621145352
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 10.8717053015
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 10.8714692829
MESH:D001749 Urinary Bladder Neoplasms decitabine 10.8717616700 19087683
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 10.8717306315 16452187 16712894 11723127
MESH:D014581 Urticaria Acetaminophen 2.6810982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.5516803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.5511813266
MESH:D014604 Uveal Neoplasms decitabine 4.5817785578
MESH:D014605 Uveitis Cyclosporine 3.651336536
MESH:D014652 Vascular Diseases sodium arsenite 4.1017056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.1117120751
Pathway ID Pathway Name
KEGG:04520 Adherens junction
KEGG:04360 Axon guidance
REACT:18266 Axon guidance
KEGG:04664 Fc epsilon RI signaling pathway
KEGG:04510 Focal adhesion
REACT:604 Hemostasis
REACT:6185 HIV Infection
REACT:23853 Interactions of the immunoglobulin superfamily (IgSF) member proteins
KEGG:05162 Measles
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:04380 Osteoclast differentiation
KEGG:05130 Pathogenic Escherichia coli infection
KEGG:05020 Prion diseases
REACT:6900 Signaling in Immune system
KEGG:04660 T cell receptor signaling pathway
KEGG:05416 Viral myocarditis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28454
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA449167cyclosporine
    PA451578tacrolimus
    PA448976choline
    PA152241909PP2
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01254 multitarget Dasatinib Protein Kinase Inhibitors
    DB02078 - 1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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