AutismKB 2.0

Annotation Detail for FZD2


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Basic Information Top
Gene Symbol:FZD2 ( - )
Gene Full Name: frizzled homolog 2 (Drosophila)
Band: 17q21.31
Quick LinksEntrez ID:2535; OMIM: 600667; Uniprot ID:FZD2_HUMAN; ENSEMBL ID: ENSG00000180340; HGNC ID: 4040
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04916Melanogenesis
hsa04310Wnt signaling pathway
hsa05217Basal cell carcinoma
hsa05200Pathways in cancer
Pathway IDPathway Name
Signaling by GPCR
Pathway IDPathway Name
200016Noncanonical Wnt signaling pathway
200055Wnt signaling network
Pathway IDPathway Name
P00005Angiogenesis
P00004Alzheimer disease-presenilin pathway
P00012Cadherin signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C029955 2-nitrotoluene 2-nitrotoluene results in decreased expression of FZD2 mRNAdecreases expression 16460773
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of FZD2 mRNAdecreases expression 16788091
D000643 Ammonium Chloride Ammonium Chloride affects the expression of FZD2 mRNAaffects expression 16483693
D001205 Ascorbic Acid [Quercetin co-treated with Ascorbic Acid] results in increased expression of FZD2 mRNAaffects cotreatment|increases expression 17639512
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of FZD2 mRNAaffects expression 20382639
C099813 bromochloroacetic acid bromochloroacetic acid results in decreased expression of FZD2 mRNAdecreases expression 16460773
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of FZD2 mRNAaffects expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of FZD2 mRNAincreases expression 16780995
D016572 Cyclosporine Cyclosporine results in increased expression of FZD2 mRNAincreases expression 20106945
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of FZD2 mRNAaffects cotreatment|decreases expression 16054899
D003907 Dexamethasone EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of FZD2 mRNA]affects cotreatment|decreases expression|decreases reaction 16054899
D003907 Dexamethasone Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of FZD2 mRNA]affects cotreatment|decreases expression|decreases reaction 16054899
D004026 Dieldrin Dieldrin results in increased expression of FZD2 mRNAincreases expression 19130878
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of FZD2 mRNAincreases expression 15766595
D004958 Estradiol Estradiol affects the expression of FZD2 mRNAaffects expression 14699072
D005472 Fluorouracil FZD2 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of FZD2 mRNAaffects cotreatment|decreases expression 16054899
D015056 1-Methyl-3-isobutylxanthine EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of FZD2 mRNA]affects cotreatment|decreases expression|decreases reaction 16054899
D015056 1-Methyl-3-isobutylxanthine Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of FZD2 mRNA]affects cotreatment|decreases expression|decreases reaction 16054899
D008942 Mitoxantrone FZD2 protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
C029938 nickel sulfate nickel sulfate results in decreased expression of FZD2 mRNAdecreases expression 16100012
D010126 Ozone Ozone results in decreased expression of FZD2 mRNAdecreases expression 17460151
D010852 Picrotoxin Picrotoxin results in increased expression of FZD2 mRNAincreases expression 15170462
D011794 Quercetin [Quercetin co-treated with Ascorbic Acid] results in increased expression of FZD2 mRNAaffects cotreatment|increases expression 17639512
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of FZD2 mRNAaffects cotreatment|decreases expression 16054899
C089730 rosiglitazone EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of FZD2 mRNA]affects cotreatment|decreases expression|decreases reaction 16054899
C089730 rosiglitazone Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of FZD2 mRNA]affects cotreatment|decreases expression|decreases reaction 16054899
C010327 salinomycin salinomycin results in decreased expression of FZD2 mRNAdecreases expression 19682730
C017947 sodium arsenite TP53 protein affects the reaction [sodium arsenite results in increased expression of FZD2 mRNA]affects reaction|increases expression 16966095
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of FZD2 mRNA]affects cotreatment|decreases expression|decreases reaction 16054899
C081489 valsartan valsartan inhibits the reaction [AGT protein results in decreased expression of FZD2 mRNA]decreases expression|decreases reaction 19225232
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6811752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.3918287403
MESH:D055371 Acute Lung Injury nickel sulfate 4.1519131640 16100012 11954676 12718980
MESH:D000230 Adenocarcinoma Estradiol 4.3011473722
MESH:D000230 Adenocarcinoma Fluorouracil 4.3017638652
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.2116835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.7317306315 16712894
MESH:D000544 Alzheimer Disease Ozone 4.3515513908
MESH:D000544 Alzheimer Disease rosiglitazone 4.3519621015
MESH:D000686 Amyloidosis Diethylstilbestrol 4.3115469931
MESH:D000740 Anemia Fluorouracil 8.1817963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.1811748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.0817084956
MESH:D001169 Arthritis, Experimental Dexamethasone 3.4317659584
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5215570426
MESH:D001249 Asthma Ozone 2.5917854713 16373670
MESH:D001260 Ataxia Telangiectasia Quercetin 4.8015336622
MESH:D001327 Autoimmune Diseases Quercetin 4.2419761891
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.8912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6515746008
MESH:D001943 Breast Neoplasms Ascorbic Acid 4.6016443354
MESH:D001943 Breast Neoplasms Dieldrin 4.6015770527 11859874
MESH:D001943 Breast Neoplasms Diethylstilbestrol 4.6015324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 4.6018497071 17289903 17261762 12948864 17018787 16675129 19861407 14630087
MESH:D001943 Breast Neoplasms Fluorouracil 4.6018608205 16110121 15136595 16557594 19217205 18357371 16595493
MESH:D001943 Breast Neoplasms Quercetin 4.6018628248
MESH:D001943 Breast Neoplasms salinomycin 4.6019682730
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.6020435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5418417511 19059883 15516495 17626835 16777450 14754758 18315731
MESH:D002100 Cachexia Ozone 4.5716183385
MESH:D002105 Cadmium Poisoning Quercetin 5.3716962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2916111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6118705752 16192424 3786805 15673190 10355542 15721981 16124888 16050911 16097048 16227642 16011737 15700767
MESH:D002276 Carcinoid Tumor Fluorouracil 4.5016051944
MESH:D002277 Carcinoma Fluorouracil 7.7317121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.7316835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 11.0318788625
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 11.0316924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.0316924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 11.0318930000 16332177 17971768 17045692 17088986 16799960
MESH:D006528 Carcinoma, Hepatocellular Quercetin 11.0312508355 19519916
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 11.0317306315 16507464 15276417
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.7817234771
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.9418695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.5917066447 16757204 16280240 18986760
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.5918572023
MESH:D006332 Cardiomegaly Quercetin 11.0219794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 11.0218670907 18850075 16120746
MESH:D006332 Cardiomegaly valsartan 11.0219597038
MESH:D009202 Cardiomyopathies valsartan 4.3316247790
MESH:D002318 Cardiovascular Diseases valsartan 4.1811230374
MESH:D002430 Cecal Neoplasms 2-nitrotoluene 5.5214688030
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 15.0520889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.0512371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.0518566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 15.0520056578 19524636
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D002779 Cholestasis Cyclosporine 2.7919486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0316354765 12621046 8697196 15668235 15340226
MESH:D003110 Colonic Neoplasms Dexamethasone 5.7315824018
MESH:D003110 Colonic Neoplasms Fluorouracil 5.7318772588 16340194 17016597 15001691 17287894 17725105 17172411 16510598 17018589 17169374
MESH:D003110 Colonic Neoplasms Quercetin 5.7316640504 15741050 11134977 19056647 17191121 17148506 19440933
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.6217016601 18802399 18448328 17454858 17094418 16524972 18949393 16331619 17594712 20501625 15289873 17695437 14970324 16282729 18288408 18509181 16391804 16303861 17255274 18383874 15148649 17401013
MESH:D015179 Colorectal Neoplasms Quercetin 2.6218095365 18852136
MESH:D003139 Common Cold Ascorbic Acid 5.3017323712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9114669216 17141729
MESH:D003324 Coronary Artery Disease valsartan 3.8417719468
MESH:D003384 Coxsackievirus Infections valsartan 5.6720392896
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.5617728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5610048152 20055451 15322242
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.3916002989 12952375
MESH:D007644 Darier Disease Fluorouracil 4.6216733453
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 6.8112438553
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 6.8116780908 11298694 16823706
MESH:D003920 Diabetes Mellitus rosiglitazone 4.1517446233
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 8.3919496084
MESH:D003921 Diabetes Mellitus, Experimental valsartan 8.3911508273
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 7.0416506275
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 7.0412642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.0417107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.8419279558
MESH:D003928 Diabetic Nephropathies valsartan 8.8411427623 18630688
MESH:D003967 Diarrhea Dexamethasone 3.537237001
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.5615027814 7120509 10092053 3732212 10915739 19336974 21278145 11566570 4309450 6884620 16177239 3786805 16227642 15998439 2869522 7179309 7440962 6623471 19085960 9327722 17522070 15968718
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.5620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6311462148
MESH:C538011 Eales disease Ascorbic Acid 5.309068938
MESH:D004485 Eczema Dexamethasone 4.2912438553
MESH:D004487 Edema Dexamethasone 10.7019703484
MESH:D004487 Edema rosiglitazone 10.7012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.7011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7316714409 15322242 18230668
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.5216402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 7.1816804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 7.1819148513 11473722 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8710568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.3620426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.3617638652 16337965 15173087 16481741 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8911564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 12.3012631006 19224547 15959796 12795759 16239168 61145 16045604 17595544
MESH:D005234 Fatty Liver Cyclosporine 12.3019224547
MESH:D005234 Fatty Liver rosiglitazone 12.3019196556
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.5516611131 15751030 16513791 16002989 16534752
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2911858732
MESH:D005355 Fibrosis Carbon Tetrachloride 25.9418705752
MESH:D005355 Fibrosis Cyclosporine 25.9412639820 12168785
MESH:D005355 Fibrosis Quercetin 25.9419474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 25.9420067830
MESH:D005355 Fibrosis valsartan 25.9416893502
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 12.2416452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 12.2416452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.058708960
MESH:D005909 Glioblastoma Quercetin 3.2819804834
MESH:D005910 Glioma Fluorouracil 5.9616145905
MESH:D005910 Glioma Quercetin 5.9617643826
MESH:D015432 Glomerulonephritis, Membranoproliferative valsartan 5.3816928621
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4210696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.2718337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 6.5616080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5610048152 11294989
MESH:D006331 Heart Diseases Mitoxantrone 4.0316019553
MESH:D006333 Heart Failure valsartan 4.1519027736
MESH:D006394 Hemangiosarcoma 2-nitrotoluene 4.9213678655
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2515720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4319900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7216120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 6.0616490937 16863852
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 6.067520565
MESH:D006558 Herpes Genitalis Estradiol 4.8615709030
MESH:D006689 Hodgkin Disease sodium arsenite 3.0112676792
MESH:D019584 Hot Flashes Estradiol 3.5817088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.878697196 18606429 15340226 16354765 16959395
MESH:D006930 Hyperalgesia rosiglitazone 3.7812083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3616899240
MESH:D006943 Hyperglycemia Quercetin 3.8811834736 18262572
MESH:D006965 Hyperplasia Diethylstilbestrol 4.2714722030 12960047
MESH:D006973 Hypertension Cyclosporine 15.7210903974
MESH:D006973 Hypertension Dexamethasone 15.7217042910
MESH:D006973 Hypertension Quercetin 15.7218356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 15.7218850075 18670907
MESH:D006973 Hypertension valsartan 15.7218344623 12692753 16475468 12850387 20102058 18390891 10903974 11427623
MESH:D006974 Hypertension, Malignant valsartan 6.2411560862
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9215338365
MESH:D007021 Hypospadias Diethylstilbestrol 4.4116002989
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.2718306037
MESH:D007246 Infertility Diethylstilbestrol 4.1915036965
MESH:D007247 Infertility, Female Dieldrin 4.7810630421
MESH:D007248 Infertility, Male sodium arsenite 2.8815346721 12646999
MESH:D007249 Inflammation Dexamethasone 7.928960868 11099482
MESH:D007249 Inflammation rosiglitazone 7.9212083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.9212200463 12878042
MESH:D007251 Influenza, Human Quercetin 4.3416624496
MESH:D007333 Insulin Resistance Estradiol 7.2616393666 16627594
MESH:D007333 Insulin Resistance rosiglitazone 7.2616306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1816580747
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.2718306037
MESH:D007627 Keloid Quercetin 4.7817086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2715604871
MESH:D007674 Kidney Diseases Cyclosporine 18.048314463 18776723 10903974
MESH:D007674 Kidney Diseases Estradiol 18.0415618244
MESH:D007674 Kidney Diseases Quercetin 18.0416962696
MESH:D007674 Kidney Diseases sodium arsenite 18.0420008137
MESH:D007674 Kidney Diseases valsartan 18.0410903974 16893502 12164870
MESH:D007680 Kidney Neoplasms Cyclosporine 16.6312371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 16.6315003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 16.6315610895
MESH:D007680 Kidney Neoplasms Fluorouracil 16.6316985049
MESH:D007859 Learning Disorders Diethylstilbestrol 3.8917184923
MESH:D007938 Leukemia Quercetin 3.0717468513
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.7218172266
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.7116943688 21278145 11408273 17174718 17157831 16239168 16221502 17334410 11903743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 10.6015931870 16248980 18054572 17698563 12609069 15673190 16136751 15818738 18395095 15925388 17869086 17761835 16638106 18210741 12445418 12546737 17922224 12632514 17481882 14620537 18472094 18006644 15959796 14716496 14716833 14748882 12649538 18395914 18420326 18472332 18263696 16015684 16116963 17708605 17631135 15730626 12586293 12898905 12667390 14512876 18481824 15370692 18339082 12666154 15338365 17823541 18412020 17557913 10355542 18251166 18429990 18376398 12958196 17714472 15362042 18277467 18279442 12389079 17900296 18187930 15123356 15052691 18166357 17944888 15057751 18205269 13678700 17976157 14724832 20821823 15876570 16033810 17565644 11481614 12445421 16097048 17721639 15996030 12632512 15893842 15650968 16192424 18705752 18418968 16011737 12741479 18156304 16027843 17766677 17525996 17805973 17640975 18317297
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 10.6016718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.6014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 10.6012741479
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 10.6017347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.6012878042
MESH:D008106 Liver Cirrhosis, Experimental valsartan 10.6015619341 16872305 15504291
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0416964402 16246199 15830285 15720792 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9915123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.5414706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 20.9219294768
MESH:D008113 Liver Neoplasms Dieldrin 20.928742319 9539021
MESH:D008113 Liver Neoplasms Diethylstilbestrol 20.9216712894 15890375
MESH:D008113 Liver Neoplasms Fluorouracil 20.9218383874 17045692 15113037 16603448
MESH:D008113 Liver Neoplasms Quercetin 20.9218980244
MESH:D008113 Liver Neoplasms sodium arsenite 20.9215276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.9216984957
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 13.3018544905
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 13.3015583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Quercetin 13.3019519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.3012151625
MESH:D008171 Lung Diseases Ascorbic Acid 11.8116863852
MESH:D008171 Lung Diseases Ozone 11.8119066396 8266340
MESH:D008171 Lung Diseases sodium arsenite 11.8119095001
MESH:D055370 Lung Injury Ozone 3.6820417186
MESH:D008175 Lung Neoplasms Ascorbic Acid 10.3816401635
MESH:D008175 Lung Neoplasms Dexamethasone 10.3815824018 11195469
MESH:D008175 Lung Neoplasms Fluorouracil 10.3815246190
MESH:D008175 Lung Neoplasms Ozone 10.387614698 8597069
MESH:D008175 Lung Neoplasms Quercetin 10.3816280456
MESH:D008175 Lung Neoplasms sodium arsenite 10.3817306315 15276417 16712894 19931552 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.3811884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.6215086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.9815166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.3515700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.3416002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.5616891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 9.5616827153
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 9.5619682730
MESH:D020149 Manganese Poisoning Estradiol 4.3119453300
MESH:D008545 Melanoma sodium arsenite 2.0116487513 19082730
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.2317261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6216801185
MESH:D008679 Metaplasia Ozone 4.9310496685
MESH:D009062 Mouth Neoplasms Fluorouracil 3.5016757204 18986760
MESH:D009101 Multiple Myeloma Dexamethasone 3.3815744524 15867202 16118317
MESH:D019042 Muscle Neoplasms 2-nitrotoluene 6.5113678655
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.449809623
MESH:D009203 Myocardial Infarction Quercetin 2.9219595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.1316810080
MESH:D015428 Myocardial Reperfusion Injury Quercetin 8.1319207477
MESH:D009369 Neoplasms Dieldrin 18.738820588
MESH:D009369 Neoplasms Diethylstilbestrol 18.7315313581
MESH:D009369 Neoplasms Fluorouracil 18.7318239605 18600527 16928823
MESH:D009369 Neoplasms Mitoxantrone 18.7316640825
MESH:D009369 Neoplasms Quercetin 18.7315185748
MESH:D009369 Neoplasms sodium arsenite 18.7311559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5020056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5617289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1419348381 18481113
MESH:D009421 Nervous System Malformations Diethylstilbestrol 15.4211399458
MESH:D009421 Nervous System Malformations Estradiol 15.4211399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.4214600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.0312854658
MESH:D020078 Neurogenic Inflammation Quercetin 4.2017929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3216436463
MESH:D009765 Obesity Ascorbic Acid 3.1017217161
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.0619495926
MESH:D010051 Ovarian Neoplasms Estradiol 7.6119401270
MESH:D010051 Ovarian Neoplasms Quercetin 7.6119005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.6115276417 17306315
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.2819003803 16500647 15113037 16929163
MESH:D010190 Pancreatic Neoplasms Quercetin 5.2816965848
MESH:D010300 Parkinson Disease Dieldrin 3.4611445065 11181820 16809432 17291500 16112328
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0812520081
MESH:D010538 Peritonitis Ozone 3.9616369182
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.0014722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.5015687265 16977796
MESH:D011014 Pneumonia Ozone 4.2218381685 18007984 18929643
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3918163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.6212371664
MESH:D011230 Precancerous Conditions Quercetin 8.6219056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.4521297632
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 8.9917184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.9911222880 11399792 11896295 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7320887781
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.8817136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8819082440 18626508
MESH:D011471 Prostatic Neoplasms Quercetin 1.8817292933 14715546
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8816039940
MESH:D011507 Proteinuria valsartan 4.7012164870 17664856 18344623
MESH:D011565 Psoriasis Cyclosporine 2.1716882103
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 5.1614606601
MESH:D011658 Pulmonary Fibrosis valsartan 3.7517241526
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8618286688 16160472 18722050 15538739
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.8618379247 11700416
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6718990726
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.2616849425
MESH:D012554 Schistosomiasis japonica Quercetin 5.3716862918
MESH:D012640 Seizures Picrotoxin 3.888954991 8635557
MESH:D012871 Skin Diseases Ascorbic Acid 3.1718709164
MESH:D012878 Skin Neoplasms sodium arsenite 5.3318572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.3316192470
MESH:D013088 Spermatocele Diethylstilbestrol 4.5416709447 16002989
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6612854658
MESH:D013272 Stomach Diseases Dexamethasone 4.1515472012
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0018396642 17498489 17522103 15786421 16424979 18567086 17172411 19084572 16951190 19015929
MESH:D013276 Stomach Ulcer Ascorbic Acid 7.1718726076
MESH:D013276 Stomach Ulcer Dexamethasone 7.1715138204
MESH:D020521 Stroke Ascorbic Acid 4.1616517955 16403987
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7312697716
MESH:D013978 Tibial Fractures Estradiol 4.5119048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.8416280240
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 8.0516452187 17306315 16712894
MESH:D001749 Urinary Bladder Neoplasms Quercetin 8.0516720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.0511723127 17306315 16452187 16712894
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 15.0416175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 15.0416803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 15.0411813266
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.0014652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 3.9015809267 16690809
MESH:D014605 Uveitis Cyclosporine 11.191336536
MESH:D014605 Uveitis Dexamethasone 11.191336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.2716002989 16513791
MESH:D014652 Vascular Diseases sodium arsenite 4.2517056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4212125929
MESH:D020257 Ventricular Remodeling valsartan 5.5319027736
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.2717120751
Pathway ID Pathway Name
KEGG:05217 Basal cell carcinoma
KEGG:04916 Melanogenesis
KEGG:05200 Pathways in cancer
REACT:14797 Signaling by GPCR
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28457
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450379mercaptopurine
    PA450428methotrexate
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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