AutismKB 2.0

Annotation Detail for IFI6


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Basic Information Top
Gene Symbol:IFI6 ( 6-16,FAM14C,G1P3,IFI-6-16,IFI616 )
Gene Full Name: interferon, alpha-inducible protein 6
Band: 1p35.3
Quick LinksEntrez ID:2537; OMIM: 147572; Uniprot ID:IFI6_HUMAN; ENSEMBL ID: ENSG00000126709; HGNC ID: 4054
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D015081 2-Naphthylamine 2-Naphthylamine results in decreased expression of IFI6 mRNAdecreases expression 18247414
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of IFI6 mRNAdecreases expression 18247414
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of IFI6 mRNAincreases expression 19152381
D001564 Benzo(a)pyrene chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of IFI6 mRNA]decreases reaction|increases expression 19152381
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of IFI6 mRNAincreases expression 20382639
C007020 chlorophyllin chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of IFI6 mRNA]decreases reaction|increases expression 19152381
C423222 cotylenin A cotylenin A results in increased expression of IFI6 mRNAincreases expression 16129123
D003513 Cycloheximide IFI6 protein inhibits the reaction [Cycloheximide results in increased activity of CASP3 protein]decreases reaction|increases activity 15685448
D016572 Cyclosporine Cyclosporine results in decreased expression of IFI6 mRNAdecreases expression 20106945
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of IFI6 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of IFI6 mRNAincreases expression 19619570
D005472 Fluorouracil Fluorouracil results in increased expression of IFI6 mRNAincreases expression 17039268
D005472 Fluorouracil IFI6 protein inhibits the reaction [Fluorouracil results in increased activity of CASP3 protein]decreases reaction|increases activity 15685448
C070081 fulvestrant fulvestrant results in increased expression of IFI6 mRNAincreases expression 16202921
C419708 gefitinib gefitinib results in decreased expression of IFI6 mRNAdecreases expression 16685379
C051890 irinotecan irinotecan analog results in increased expression of IFI6 mRNAincreases expression 18927307
D009538 Nicotine Nicotine results in decreased expression of IFI6 mRNAdecreases expression 18247414
D012643 Selenium Selenium results in increased expression of IFI6 mRNAincreases expression 19244175
D013629 Tamoxifen Tamoxifen results in decreased expression of IFI6 mRNAdecreases expression 16202921
D013629 Tamoxifen Tamoxifen results in increased expression of IFI6 mRNAincreases expression 19155303
C004648 testosterone enanthate testosterone enanthate affects the expression of IFI6 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of IFI6 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of IFI6 mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of IFI6 mRNAincreases expression 20106945
D014212 Tretinoin Tretinoin results in increased expression of IFI6 mRNAincreases expression 16054129
16129123
D014635 Valproic Acid Valproic Acid results in increased expression of IFI6 mRNAincreases expression 19949822
D014810 Vitamin E Vitamin E results in increased expression of IFI6 mRNAincreases expression 19244175
D015215 Zidovudine [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFI6 mRNAaffects cotreatment|increases expression 20370541
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4414745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.9515322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.958875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.8319490988
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.729612607
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.9220127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 6.9211473722
MESH:D000230 Adenocarcinoma Fluorouracil 6.9217638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.596695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.2716835633
MESH:D000505 Alopecia Tretinoin 3.5315955085
MESH:D000544 Alzheimer Disease Nicotine 3.2616627626
MESH:D000550 Amblyopia Valproic Acid 5.1317688650
MESH:D000740 Anemia Fluorouracil 8.3515504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.3511748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.4817497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9619183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.0116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2416292516
MESH:D001249 Asthma Tretinoin 2.3116456186
MESH:D001284 Atrophy fulvestrant 4.7411514358
MESH:D001321 Autistic Disorder Valproic Acid 2.0120603192 18940202 15238991 18177632 18775368 16609825 18985861 19460635 18316065 17157402 18558336 17688650 17507914 18396377 19232924
MESH:D001471 Barrett Esophagus Tretinoin 4.2916935849
MESH:D001714 Bipolar Disorder Valproic Acid 3.0217594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.6012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.6016206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.7915746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.798888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.7020146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 3.7012948864 16675129 17289903 14630087 17261762 19861407 17018787 18497071
MESH:D001943 Breast Neoplasms Fluorouracil 3.7015136595 16110121 19217205 18357371 16595493 18608205 16557594
MESH:D001943 Breast Neoplasms fulvestrant 3.7018984771
MESH:D001943 Breast Neoplasms Tamoxifen 3.7018815881 20390343 19155303 18997820 19084267 18821012 19221464 19289846 19189212 17261762 18855134 20065188 19189210 19103187 19115204 20005174 20544844 19487384 19142967 19066611 15668708 18984771 18629630 17049068 19011961 18425577 17893378 19244106 11161223 17440819 20135344 17242785 18351453 19410462 16202921 19059307 15565566 21138602 19200415 16818667 20859285 16273361 21152245 19288272 16873071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.7020435547
MESH:D001943 Breast Neoplasms Tretinoin 3.7016166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4816813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3516111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.8216050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.5616051944
MESH:D002277 Carcinoma Fluorouracil 7.8917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.8916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4019066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0516168501
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.4416924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.4416799960 16332177 17971768 17045692 18930000 17088986
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.4416924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.441917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung gefitinib 3.9115496427 18347146 17290066 20005069 16230376 19233551
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.9718695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.3420419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.3416757204 17066447 16280240 18986760
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.3416096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3118850075 18670907 16120746
MESH:D002386 Cataract Tretinoin 3.0317460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.7020889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.7012371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.7018566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4816129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6720734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0716835633
MESH:D002779 Cholestasis Cyclosporine 2.8319486331
MESH:D002822 Choriocarcinoma Tretinoin 5.0516461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.6116354765 8697196 12621046 15340226 15668235
MESH:D002972 Cleft Palate Tretinoin 5.619407595
MESH:D003092 Colitis Selenium 9.1317936198
MESH:D003092 Colitis Tretinoin 9.1317035595
MESH:D003110 Colonic Neoplasms Fluorouracil 3.9017172411 17725105 17287894 15001691 16340194 16510598 18772588 17169374 17018589 17016597
MESH:D003110 Colonic Neoplasms irinotecan 3.9017287894 17725105
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.6418802399 17594712 17454858 18288408 16331619 14970324 18509181 17016601 20501625 17094418 17401013 18448328 18383874 18949393 16303861 16391804 15148649 17255274 16282729 15289873 17695437 16524972
MESH:D015179 Colorectal Neoplasms gefitinib 3.6417594712
MESH:D015179 Colorectal Neoplasms irinotecan 3.6416391804 16303861 18259882 18509181 17159606 15273666 17454858
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.3020055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.308800419 16925845 10589399 17551590 9142499 9211117 9664655 9224671 9125849 14991402
MESH:D019465 Craniofacial Abnormalities Valproic Acid 5.3016575769 17688650 8888407
MESH:D019465 Craniofacial Abnormalities Vitamin E 5.3019769572
MESH:D007644 Darier Disease Fluorouracil 4.6816733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.2519031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6417107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.5219279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.5219279558
MESH:D056486 Drug-Induced Liver Injury Selenium 6.0315131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.0320420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.031733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.9611462148
MESH:D004362 Drug Toxicity Zidovudine 7.9615040536
MESH:D004421 Dystonia Valproic Acid 3.941851702
MESH:D020821 Dystonic Disorders Nicotine 5.8217881519
MESH:C538011 Eales disease Vitamin E 4.609068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.2812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.5915322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.5918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 3.4319031437
MESH:D016889 Endometrial Neoplasms Estradiol 12.0118566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 12.0116202921 19155303 17893378 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 12.0116569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.929294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.043659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.8116628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.8818234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.497562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.197750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.963659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.0620426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.0616530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.0616337965 16785472 15173087 17638652 16481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.5611564622
MESH:D005124 Eye Abnormalities Tretinoin 8.5616938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 17.9819224547
MESH:D005234 Fatty Liver Tamoxifen 17.9814986274 19224547
MESH:D005234 Fatty Liver Valproic Acid 17.9814986274 19224547
MESH:D005234 Fatty Liver Zidovudine 17.9818299183
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3511858732
MESH:D005315 Fetal Diseases Valproic Acid 4.7816575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.028888407 18558336
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.0719069698
MESH:D005355 Fibrosis Cyclosporine 14.0912639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.0920067830
MESH:D005355 Fibrosis Tretinoin 14.0917994277
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.118708960
MESH:D005909 Glioblastoma Tretinoin 2.9317312396
MESH:D005910 Glioma Fluorouracil 2.8316145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4910696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.5515102660 15162350 18337622
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.5516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0516084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 15.4920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 15.4911294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 15.4914991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin E 15.4916080930
MESH:D006333 Heart Failure Selenium 3.0117162251
MESH:D006402 Hematologic Diseases Zidovudine 4.6112579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2311000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7812621046 16120746 15340226
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6616863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.9315709030
MESH:D015658 HIV Infections Zidovudine 3.4311698656 11363243 20032539 11141242 17358032
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.6417440010
MESH:D019584 Hot Flashes Estradiol 9.7017088409
MESH:D019584 Hot Flashes Vitamin E 9.7014716179
MESH:D006849 Hydrocephalus Valproic Acid 4.7617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.948697196 16354765 15340226 18606429 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.1216870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4616778211
MESH:D006973 Hypertension Cyclosporine 4.8110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8118670907 18850075
MESH:D006976 Hypertension, Pulmonary gefitinib 4.6218424623
MESH:D017380 Hypertrophy, Right Ventricular gefitinib 6.1318424623
MESH:D007248 Infertility, Male fulvestrant 3.6811514358
MESH:D007249 Inflammation Tamoxifen 4.7019457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.7012200463 12878042
MESH:D007251 Influenza, Human Selenium 10.6116624496
MESH:D007251 Influenza, Human Vitamin E 10.6116624496
MESH:D007333 Insulin Resistance Estradiol 2.8916627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 3.6617994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.5916580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.5915992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3415604871
MESH:D007674 Kidney Diseases Cyclosporine 9.698314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 9.6915618244
MESH:D007674 Kidney Diseases Vitamin E 9.6912488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.7816518626
MESH:D007680 Kidney Neoplasms Cyclosporine 27.9412371664
MESH:D007680 Kidney Neoplasms Estradiol 27.9415610895
MESH:D007680 Kidney Neoplasms Fluorouracil 27.9416985049
MESH:D007680 Kidney Neoplasms gefitinib 27.9418625569
MESH:D007680 Kidney Neoplasms Tamoxifen 27.9418625569
MESH:D007680 Kidney Neoplasms Zidovudine 27.9412579204
MESH:D007938 Leukemia Tretinoin 2.7217143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.3120370541
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6019285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.8219850784 16294345 17596541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.8216294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0819225113 16891316 16331271 16788101 16935935 16823087 15748426 17649720 17217047 17107899 16140955 19075265 16766008 17339181 12679006 17361223 17301526 19035177 19029980 9834237 17506722 17294898 17368321 19642359 17712046
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.239224671
MESH:D008064 Lipidoses Tamoxifen 3.0817567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.5914659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.5918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.5912878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.5916248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.5916169303
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.3521137059 20195826
MESH:D008113 Liver Neoplasms Fluorouracil 10.3517045692 16603448 18383874 15113037
MESH:D008113 Liver Neoplasms Tamoxifen 10.3516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.3516984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.0412151625
MESH:D008171 Lung Diseases Vitamin E 3.1016863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.1617228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.3818816296 18520028 20464547 20135361 18569708 17053015 20064080 6695378 20869020
MESH:D008175 Lung Neoplasms Fluorouracil 8.3815246190
MESH:D008175 Lung Neoplasms Tamoxifen 8.3818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.3819555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 8.3811062179
MESH:D008175 Lung Neoplasms Zidovudine 8.3818800350
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.6815086387
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.6519428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 13.7511408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental gefitinib 13.7518375820
MESH:D008325 Mammary Neoplasms, Experimental Selenium 13.7515318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 13.7511731420 19196722 14580682 16827153 19196723
MESH:D020149 Manganese Poisoning Estradiol 12.2919453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.2919453300
MESH:D008527 Medulloblastoma Tretinoin 2.7417453147
MESH:D008545 Melanoma Tamoxifen 3.2219393235 12393984
MESH:D008545 Melanoma Tretinoin 3.2216752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.0715990972
MESH:D008591 Meningomyelocele Tretinoin 4.3216940565
MESH:D008654 Mesothelioma Selenium 2.7515107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6816801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.7317358032
MESH:D008881 Migraine Disorders Valproic Acid 3.1118803445 18765137
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.2516381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.2516757204 18986760
MESH:D052016 Mucositis irinotecan 4.9017159606
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.928888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.1917596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.1917596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.1916810080
MESH:D009362 Neoplasm Metastasis irinotecan 5.8118259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.8119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4819410462
MESH:D009369 Neoplasms Benzo(a)pyrene 11.4811141357
MESH:D009369 Neoplasms Fluorouracil 11.4818600527 18239605 16928823
MESH:D009369 Neoplasms Nicotine 11.4816365874
MESH:D009369 Neoplasms Tretinoin 11.4816946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8919196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 10.0017289903
MESH:D009389 Neovascularization, Pathologic Nicotine 10.0016365874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1918481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 15.7116427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.7114600291
MESH:D009421 Nervous System Malformations Tretinoin 15.719125849
MESH:D009436 Neural Tube Defects Tretinoin 7.079142499
MESH:D009436 Neural Tube Defects Valproic Acid 7.0716359493 8888407
MESH:D009447 Neuroblastoma irinotecan 3.428761367
MESH:D017599 Neuroectodermal Tumors irinotecan 4.628761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3616436463
MESH:D010051 Ovarian Neoplasms Estradiol 4.6919401270
MESH:D010051 Ovarian Neoplasms Tretinoin 4.6916936753
MESH:D010146 Pain Tretinoin 2.8116870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.2119003803 16929163 15113037 16500647
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.2115976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1412520081
MESH:D010954 Plasmacytoma Selenium 4.7815087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4518163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1312371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.1011896295 11118676 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.1020603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7820887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8917292933
MESH:D011471 Prostatic Neoplasms Estradiol 1.8916740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8918626508 19082440
MESH:D011471 Prostatic Neoplasms gefitinib 1.8917914592 15651060 16685379
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8915067354
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8915084515
MESH:D011507 Proteinuria Tretinoin 3.5016636307
MESH:D019310 Pseudolymphoma Valproic Acid 4.4412752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.1916882103
MESH:D011625 Pterygium Tretinoin 4.6816723453
MESH:D011658 Pulmonary Fibrosis gefitinib 3.9618424623
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9218722050 18286688 16160472 15538739
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7318990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.5116116481 16283617
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.5119155313
MESH:D012559 Schizophrenia Valproic Acid 2.0519110320 15737665
MESH:D012640 Seizures Nicotine 6.1617873105
MESH:D012640 Seizures Valproic Acid 6.1611738929 1511512 15475178 3137016 17978042 11044598 16876388 14763951
MESH:D012871 Skin Diseases Vitamin E 2.4118709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.0919755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.0916192470
MESH:D012878 Skin Neoplasms Tretinoin 9.0916467112
MESH:D013088 Spermatocele Tamoxifen 4.1916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.9319457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.6919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.4412833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 6.302093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 6.3017522103 19084572 16424979 19015929 18396642 17498489 18567086 15786421 17172411 16951190
MESH:D013274 Stomach Neoplasms irinotecan 6.3015723263
MESH:D013274 Stomach Neoplasms Tretinoin 6.3017261132
MESH:D013274 Stomach Neoplasms Zidovudine 6.3017696246
MESH:D020521 Stroke Vitamin E 3.4316517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8012697716
MESH:D013964 Thyroid Neoplasms gefitinib 7.4316940797
MESH:D013964 Thyroid Neoplasms Tretinoin 7.4316026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.5819048282
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 4.6511259349 16720336 16785264
MESH:D014029 Tobacco Use Disorder Nicotine 5.3417979512 18305452 15735609 18041664
MESH:D014062 Tongue Neoplasms Fluorouracil 9.5016280240
MESH:D014062 Tongue Neoplasms Tretinoin 9.5016051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.1317262798
MESH:D014376 Tuberculosis Tretinoin 3.1616040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.413119515
MESH:D001749 Urinary Bladder Neoplasms 2-Naphthylamine 8.2211144890
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.2217053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.2216712894 17572228 8653321
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.538888407
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.1216803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.1216129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.5016752155
MESH:D014605 Uveitis Cyclosporine 3.881336536
MESH:D014625 Vaginal Neoplasms Zidovudine 4.6512579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4912125929
MESH:D014820 Vitiligo Tretinoin 3.9516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1415886252
MESH:D009396 Wilms Tumor Tretinoin 3.8716287080
MESH:D014985 Xerophthalmia Cyclosporine 4.3417120751
Pathway ID Pathway Name
REACT:6900 Signaling in Immune system
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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