AutismKB 2.0

Annotation Detail for LASS6


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Basic Information Top
Gene Symbol:LASS6 ( CerS6,MGC129949,MGC129950 )
Gene Full Name: LAG1 homolog, ceramide synthase 6
Band: 2q24.3
Quick LinksEntrez ID:253782; OMIM: NA; Uniprot ID:LASS6_HUMAN; ENSEMBL ID: ENSG00000172292; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
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Related Diseases/Disorders Top
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Desease Name
PHARMACOGENOMIC
response to TNF antagonist treatment
Desease Name
Response to TNF antagonist treatment
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of LASS6 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of LASS6 mRNAdecreases expression 20106945
20064835
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of LASS6 mRNAaffects expression 17484886
D004958 Estradiol Estradiol affects the expression of LASS6 mRNAaffects expression 14699072
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of LASS6 mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen Tamoxifen affects the expression of LASS6 mRNAaffects expression 14699072
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of LASS6 mRNAaffects cotreatment|decreases expression 19059307
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of LASS6 mRNAdecreases expression 17101203
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2414514962 15322242 11752688
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4720127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.4711473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D000419 Albuminuria Raloxifene 4.9217451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.5915800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001930 Brain Injuries Raloxifene 4.8316580743
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3920146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 2.3912948864 17261762 17289903 18497071 17018787 14630087 19861407 16675129
MESH:D001943 Breast Neoplasms Raloxifene 2.3915572757 17440819 17893378 16837676 16912660 17261762 15758505 17049068 17242785 15775269 17952589 17595753
MESH:D001943 Breast Neoplasms Tamoxifen 2.3916873071 20135344 20859285 17893378 17440819 19200415 18984771 19189212 17242785 19142967 16818667 15565566 19244106 19155303 17049068 19221464 19487384 19115204 19103187 19189210 20005174 15668708 19066611 11161223 20065188 18629630 18855134 21152245 18821012 16202921 18997820 19011961 18425577 19084267 21138602 18815881 20390343 20544844 17261762 19410462 19289846 16273361 19288272 18351453 19059307
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3920435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.1416011737 15721981 16097048 15700767 16124888 16227642 18705752 15673190 10355542 3786805 16192424 16050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.853084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.8518788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.8516924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.8516924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1120419170
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 10.4017572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 10.4017572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5016120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Raloxifene 3.6315775269
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9518566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2016354765 12621046 8697196 15668235 15340226
MESH:D003072 Cognition Disorders Raloxifene 4.9815800139
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.4117474826
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Estradiol 16.5219279558
MESH:D003928 Diabetic Nephropathies Raloxifene 16.5215920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 16.5219279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5312153990 19085960 11739529 15968718 2444490 11421492 12392966 16227642 17562736 11834606 19370779 14986274 16393943 11287661 12540782 16109766 11529661 17906064 19420014 19416960 18713872 11461765 19164858 10915739 14550746 19739265 10774834 17522070 15619225 14725611 12594235 16081117 16485898 12958197 11743745 12705907 19923254 16177239 10663392 18071297 16781746
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.536884620 19085960 3732212 17522070 15027814 16227642 7179309 4309450 19336974 7440962 7120509 10915739 11566570 2869522 10092053 9327722 3786805 15968718 15998439 16177239 6623471 21278145
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema Raloxifene 7.8015860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.8011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3518230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 10.3615845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.3619031437
MESH:D016889 Endometrial Neoplasms Estradiol 7.9619148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.9616202921 17893378 19155303 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.299294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.9112795759 12631006 15959796 19224547 16045604 16239168 17595544 61145
MESH:D005234 Fatty Liver Raloxifene 14.9117473493
MESH:D005234 Fatty Liver Tamoxifen 14.9119224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D005355 Fibrosis Carbon Tetrachloride 9.8218705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.8220067830
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.8820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8810048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.7211110106
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9219900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2516120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D019584 Hot Flashes Estradiol 4.1917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4916354765 15340226 16959395 8697196 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9316899240
MESH:D006973 Hypertension Raloxifene 5.5217577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.5218670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.4515338365
MESH:D007249 Inflammation Tamoxifen 5.3219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3212200463 12878042
MESH:D007333 Insulin Resistance Estradiol 3.1316627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007674 Kidney Diseases Acetaminophen 6.3715629191 12587719
MESH:D007674 Kidney Diseases Estradiol 6.3715618244
MESH:D007680 Kidney Neoplasms Estradiol 8.1815610895
MESH:D007680 Kidney Neoplasms Tamoxifen 8.1818625569
MESH:D007889 Leiomyoma Raloxifene 4.8016973256
MESH:D008064 Lipidoses Tamoxifen 3.3517567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9411408273 17157831 16943688 11903743 16239168 21278145 17334410 16221502 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.1517805973 15673190 18210741 12389079 15338365 15370692 16248980 12649538 12667390 12546737 16192424 17698563 15362042 18472094 18263696 15730626 18420326 18277467 12609069 18251166 17766677 16015684 18429990 18054572 17761835 14716496 16116963 12632514 13678700 12898905 18156304 18376398 15650968 15818738 18418968 16136751 17708605 14748882 12445421 17481882 14724832 17823541 15996030 18006644 17944888 12445418 10355542 14620537 12741479 15925388 12958196 18412020 15893842 17557913 17565644 17869086 18339082 16638106 12632512 12666154 18187930 11481614 18705752 17922224 12586293 18395914 16097048 18472332 18279442 14512876 16033810 20821823 17721639 15931870 15876570 17714472 16011737 16027843 17900296 15057751 18395095 18481824 15123356 17640975 17631135 18166357 15959796 15052691 17525996 17976157 18317297 18205269 14716833
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.1514716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 5.1518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.1512878042
MESH:D008107 Liver Diseases Acetaminophen 4.0919014921 16610002 12969438 16611625 19784758 11587558 19460945 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0915720792 17285989 16246199 15830285 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.3117185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.3116899240 14706259
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.4320195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.4319294768
MESH:D008113 Liver Neoplasms Tamoxifen 11.4316684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.4316984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.3015583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.3012151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4820135361 20464547 18520028 18816296 6695378 20064080 17053015 18569708 20869020
MESH:D008175 Lung Neoplasms Tamoxifen 3.4818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4819555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.5317203775 11807958 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.5316827153 11731420 19196723 14580682 19196722
MESH:D020149 Manganese Poisoning Estradiol 14.1719453300
MESH:D020149 Manganese Poisoning Tamoxifen 14.1719453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 6.0015863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D009101 Multiple Myeloma Raloxifene 3.6316497877
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4916810080
MESH:D009232 Myxoma Raloxifene 6.0016343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2811141357
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009421 Nervous System Malformations Estradiol 10.5811399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.5814600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D010024 Osteoporosis Raloxifene 3.5519059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.5317823083 15758505 15579764 17893378
MESH:D010051 Ovarian Neoplasms Estradiol 2.2919401270
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911399792 11118676 11222880 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1720887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0317292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.0316740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.0316536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0315067354
MESH:D011693 Purpura Raloxifene 6.0015770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.8510029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8516192470
MESH:D013088 Spermatocele Tamoxifen 4.7416709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D020521 Stroke Raloxifene 4.0416837676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013978 Tibial Fractures Estradiol 15.2419048282
MESH:D013978 Tibial Fractures Raloxifene 15.2419048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.8917053015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 8.8917572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.8916712894 17572228 8653321
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.6516837676
MESH:D014846 Vulvar Neoplasms Raloxifene 6.0016343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
Pathway ID Pathway Name
REACT:22258 Metabolism of lipids and lipoproteins
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134925480
    • No data
    Releated disease ID Related disease Name
    PA443434Arthritis, Rheumatoid
    Releated drug ID Related drug Name
    PA10004adalimumab
    PA449515etanercept
    PA452639infliximab
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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