AutismKB 2.0

Annotation Detail for XRCC6


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Basic Information Top
Gene Symbol:XRCC6 ( CTC75,CTCBF,G22P1,KU70,ML8,TLAA )
Gene Full Name: X-ray repair complementing defective repair in Chinese hamster cells 6
Band: 22q13.2
Quick LinksEntrez ID:2547; OMIM: 152690; Uniprot ID:XRCC6_HUMAN; ENSEMBL ID: ENSG00000196419; HGNC ID: 4055
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03450Non-homologous end-joining
Pathway IDPathway Name
DNA Repair
HIV Infection
Pathway IDPathway Name
200038Coregulation of Androgen receptor activity
200020Signaling events mediated by HDAC Class III
200174BARD1 signaling events
200072Regulation of Telomerase
No data
Pathway IDPathway Name
500055Nonhomologous End-joining (NHEJ)
Related Diseases/Disorders Top
No data
No data
Desease Name
Head and Neck Neoplasms
CANCER
Carcinoma, Squamous Cell
Adenocarcinoma
Radiodermatitis
Deglutition Disorders
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of XRCC6 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of XRCC6 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of XRCC6 mRNAdecreases expression 15761015
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of XRCC6 mRNAaffects expression 17331233
D003474 Curcumin Curcumin results in decreased expression of XRCC6 mRNAdecreases expression 17596214
C014347 decitabine decitabine affects the methylation of XRCC6 geneaffects methylation 17630775
D002945 Cisplatin XRCC6 mRNA results in increased susceptibility to [Fluorouracil co-treated with Cisplatin]affects cotreatment|increases response to substance 18546291
D002945 Cisplatin XRCC6 protein results in increased susceptibility to [Fluorouracil co-treated with Cisplatin]affects cotreatment|increases response to substance 18546291
D004052 Diethylnitrosamine MG 262 inhibits the reaction [XRCC6 protein inhibits the reaction [Diethylnitrosamine results in decreased expression of TRP53 protein]]decreases expression|decreases reaction 18506893
D004052 Diethylnitrosamine XRCC6 protein inhibits the reaction [Diethylnitrosamine results in decreased expression of TRP53 protein]decreases expression|decreases reaction 18506893
D004052 Diethylnitrosamine XRCC6 protein inhibits the reaction [Diethylnitrosamine results in increased expression of AURKA mRNA]decreases reaction|increases expression 18506893
D004052 Diethylnitrosamine XRCC6 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 protein]decreases reaction|increases expression 18506893
D004052 Diethylnitrosamine XRCC6 protein inhibits the reaction [Diethylnitrosamine results in increased expression of PCNA protein]decreases reaction|increases expression 18506893
D004052 Diethylnitrosamine XRCC6 protein inhibits the reaction [Diethylnitrosamine results in increased expression of UBA1 mRNA]decreases reaction|increases expression 18506893
D004052 Diethylnitrosamine XRCC6 protein inhibits the reaction [Diethylnitrosamine results in increased expression of UBD mRNA]decreases reaction|increases expression 18506893
D004052 Diethylnitrosamine XRCC6 protein inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of ATM protein]decreases reaction|increases phosphorylation 18506893
D004052 Diethylnitrosamine XRCC6 protein results in decreased susceptibility to Diethylnitrosaminedecreases response to substance 18506893
D002117 Calcitriol Calcitriol results in decreased expression of XRCC6 mRNAdecreases expression 15951637
16847355
C444299 diindolylmethane diindolylmethane inhibits the reaction [Estradiol results in increased expression of XRCC6 mRNA]decreases reaction|increases expression 11179685
D004958 Estradiol diindolylmethane inhibits the reaction [Estradiol results in increased expression of XRCC6 mRNA]decreases reaction|increases expression 11179685
D004958 Estradiol Estradiol results in increased expression of XRCC6 mRNAincreases expression 11179685
D004958 Estradiol Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of XRCC6 mRNA]decreases reaction|increases expression 11179685
D005472 Fluorouracil XRCC6 mRNA results in increased susceptibility to [Fluorouracil co-treated with Cisplatin]affects cotreatment|increases response to substance 18546291
D005472 Fluorouracil XRCC6 protein results in increased susceptibility to [Fluorouracil co-treated with Cisplatin]affects cotreatment|increases response to substance 18546291
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of XRCC6 mRNAdecreases expression 12057914
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to XRCC6 protein]affects binding|increases reaction 17220478
C423917 MG 262 MG 262 inhibits the reaction [XRCC6 protein inhibits the reaction [Diethylnitrosamine results in decreased expression of TRP53 protein]]decreases expression|decreases reaction 18506893
C009277 sodium arsenate sodium arsenate results in increased expression of XRCC6 mRNAincreases expression 16882884
C017947 sodium arsenite sodium arsenite results in increased expression of XRCC6 mRNAincreases expression 12016162
C017947 sodium arsenite sodium arsenite results in decreased expression of XRCC6 mRNAdecreases expression 16014739
C025462 sulindac sulfide sulindac sulfide results in increased expression of XRCC6 mRNAincreases expression 12734198
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of XRCC6 mRNA]decreases reaction|increases expression 11179685
D014810 Vitamin E Vitamin E results in increased expression of XRCC6 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7614514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.4718287403
MESH:D058186 Acute Kidney Injury Cisplatin 3.8815814532 17670903 12690470
MESH:D055371 Acute Lung Injury Lipopolysaccharides 3.9518653653 11850527
MESH:D000230 Adenocarcinoma arsenic trioxide 10.0411798837 19825857
MESH:D000230 Adenocarcinoma Cisplatin 10.0411798837 17638652
MESH:D000230 Adenocarcinoma Estradiol 10.0411473722
MESH:D000230 Adenocarcinoma Fluorouracil 10.0417638652
MESH:D000236 Adenoma Diethylnitrosamine 2.8010737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.7716434500 19052882 18056438 19061943 17620307 17162532
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.7716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8217306315 16712894
MESH:D019973 Alcohol-Related Disorders Curcumin 5.0017887948
MESH:D000544 Alzheimer Disease Curcumin 4.5715590663
MESH:D000544 Alzheimer Disease sulindac sulfide 4.5718759972
MESH:D000740 Anemia Fluorouracil 8.4217963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.4211748828
MESH:D000799 Angioedema Acetaminophen 3.7610982225
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7216807698
MESH:D050197 Atherosclerosis Curcumin 3.2718704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001327 Autoimmune Diseases Curcumin 4.4019761891
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.6916206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.6912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7115746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.8014601052
MESH:D002545 Brain Ischemia Curcumin 4.2516770732
MESH:D001932 Brain Neoplasms Curcumin 3.8617596214
MESH:D001943 Breast Neoplasms Calcitriol 4.6711237771
MESH:D001943 Breast Neoplasms Cisplatin 4.6719526202 18382427
MESH:D001943 Breast Neoplasms Curcumin 4.6719250217 18462866 16243823 18593918
MESH:D001943 Breast Neoplasms decitabine 4.6719208741 18320071
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.6717474063
MESH:D001943 Breast Neoplasms Estradiol 4.6717018787 19861407 18497071 17261762 17289903 14630087 12948864 16675129
MESH:D001943 Breast Neoplasms Fluorouracil 4.6718357371 15136595 19217205 16110121 16595493 16557594 18608205
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.6720435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2411589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3816111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.8416050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.5916051944
MESH:D002277 Carcinoma Curcumin 13.5618593918
MESH:D002277 Carcinoma Fluorouracil 13.5617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 13.5616835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.883084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 13.8816217749 15553829 15073043 14691202 11135700
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 13.8817982673
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.8818665156 21159647 20214788 19383236 20727157 18978308 10672840 18056438 19208518 20935162 18691550 20432363 17055752 18494052 16935385 20512989 10737359 19539802 16328049 19519916 19418558 17761372 16569478 18506893 20514400 20007298 18971187 16540662 16502159 20101231 16698587 18393292 20524982 17978847 19052882 20084675 19919837 3581430 3084413 17428255 18210153 17162532 19394651 17138121 16830150 16807293 19107877 16288022 19822196 16878318 19335982 19171122 16779866 11831363 19701751 16681979 17173139 18785209 18788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.8816924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 13.8817971768 16799960 17088986 16332177 17045692 18930000
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 13.8815276417 17306315 16507464
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 8.9612023789 16685392
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 8.9618414057
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 8.9612391285
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7919014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.9818695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0412490120
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 17.7711237771
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 17.776189445 17066447 18337622
MESH:D002294 Carcinoma, Squamous Cell Curcumin 17.7718462866
MESH:D002294 Carcinoma, Squamous Cell decitabine 17.7719215824
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 17.7718986760 16757204 16280240 17066447
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 17.7718572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3218850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.5310977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.867505956 21159647 2727394 17174075
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.8618566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 10.8620056578 19524636
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.0719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.0716835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.078697196 15340226 16354765 12621046 15668235
MESH:D003092 Colitis Curcumin 4.0918200517 16782535 16804969
MESH:D003103 Coloboma Curcumin 4.4718809619
MESH:D003110 Colonic Neoplasms Curcumin 5.8216340194 19359593
MESH:D003110 Colonic Neoplasms decitabine 5.8217616700
MESH:D003110 Colonic Neoplasms Fluorouracil 5.8217169374 15001691 16340194 17725105 17018589 16510598 17287894 18772588 17016597 17172411
MESH:D015179 Colorectal Neoplasms arsenic trioxide 4.7520501625
MESH:D015179 Colorectal Neoplasms Cisplatin 4.7515273666
MESH:D015179 Colorectal Neoplasms decitabine 4.7518981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 4.7516391804 16331619 20501625 18448328 18802399 15148649 17695437 17594712 16524972 16282729 17401013 17094418 16303861 18288408 18383874 18949393 15289873 17255274 17454858 14970324 17016601 18509181
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9814669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.8118497527
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1012609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.3710525206
MESH:D019465 Craniofacial Abnormalities sodium arsenate 5.3710525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.3715322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Vitamin E 5.3719769572
MESH:D007644 Darier Disease Fluorouracil 4.7116733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.0115213294
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 7.0118403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.0120387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.0117107852
MESH:D003928 Diabetic Nephropathies Curcumin 8.7818204486
MESH:D003928 Diabetic Nephropathies Estradiol 8.7819279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.7818713872 16485898 10663392 12958197 14550746 2444490 19739265 10774834 19416960 11287661 12540782 12594235 11461765 15968718 11529661 12705907 11743745 16081117 11739529 11421492 12153990 17522070 17562736 16109766 16177239 19085960 19420014 18071297 17906064 16781746 14725611 12392966 19923254 16227642 11834606 19370779 14986274 19164858 15619225 16393943 10915739
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.7819107877
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 8.7818186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.7820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0219426721
MESH:D004362 Drug Toxicity Cisplatin 7.9619839026 15033597 12231392 12649298
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.9611462148
MESH:D004381 Duodenal Ulcer Curcumin 3.9617351913
MESH:C538011 Eales disease Vitamin E 4.629068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8218230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 3.8515138306
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.0319294695
MESH:D016889 Endometrial Neoplasms Estradiol 2.9218566989 19148513 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9410568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.3115821434 15328337 17637181
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0416302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.2312903497
MESH:D004938 Esophageal Neoplasms Cisplatin 7.2316481741 15173087 16785472 17638652 15464296
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.2316481741 16337965 17638652 16785472 15173087
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9511564622
MESH:D005234 Fatty Liver arsenic trioxide 12.7615073043
MESH:D005234 Fatty Liver Curcumin 12.7619297423
MESH:D005234 Fatty Liver Diethylnitrosamine 12.7620387270 21071580
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3711858732
MESH:D005334 Fever Lipopolysaccharides 3.9311852909 9205823
MESH:D005355 Fibrosis Curcumin 8.5018705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.5020067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1816904648
MESH:D005756 Gastritis Acetaminophen 3.5916983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.6118462866
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5916452187
MESH:D005909 Glioblastoma Curcumin 3.4217596214
MESH:D005910 Glioma Fluorouracil 2.8316145905
MESH:D018149 Glucose Intolerance sodium arsenate 5.0019446573
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5110696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 18.0015102660 15464296
MESH:D006258 Head and Neck Neoplasms Curcumin 18.0018829502 18462866
MESH:D006258 Head and Neck Neoplasms decitabine 18.0019215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 18.0018337622 15102660 15162350
MESH:D034381 Hearing Loss Cisplatin 4.2219898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.3415464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4211294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 6.4216080930
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.3016366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2511000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8116120746 15340226 12621046
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.9517701891
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6716490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.9515709030
MESH:D006689 Hodgkin Disease Cisplatin 7.2916200630 16170182
MESH:D006689 Hodgkin Disease sodium arsenite 7.2912676792
MESH:D019584 Hot Flashes Estradiol 9.7817088409
MESH:D019584 Hot Flashes Vitamin E 9.7814716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9618606429 16354765 15340226 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.6316870215
MESH:D006937 Hypercholesterolemia Curcumin 3.9718704882
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8718850075 18670907
MESH:D007248 Infertility, Male decitabine 6.7117581917
MESH:D007248 Infertility, Male sodium arsenite 6.7112646999 15346721
MESH:D007249 Inflammation Curcumin 11.6218403477 16956363 17151092
MESH:D007249 Inflammation Diethylnitrosamine 11.6218785209
MESH:D007249 Inflammation Lipopolysaccharides 11.6217255318 9205823 17963957 12878042 17237260
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.6212878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1718596194 18200517
MESH:D007251 Influenza, Human Vitamin E 4.1316624496
MESH:D007333 Insulin Resistance Estradiol 2.9116627594 16393666
MESH:D007414 Intestinal Neoplasms Curcumin 4.1410783313
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.5517255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2516580747
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.0615464296
MESH:D007674 Kidney Diseases Acetaminophen 18.5215629191 12587719
MESH:D007674 Kidney Diseases Cisplatin 18.5212649298 18289764 15190930 12231392 19839026
MESH:D007674 Kidney Diseases Estradiol 18.5215618244
MESH:D007674 Kidney Diseases sodium arsenite 18.5220008137
MESH:D007674 Kidney Diseases Vitamin E 18.5212488133
MESH:D007680 Kidney Neoplasms Estradiol 7.2415610895
MESH:D007680 Kidney Neoplasms Fluorouracil 7.2416985049
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.7111231351
MESH:D007889 Leiomyoma Curcumin 4.4918555241
MESH:D007938 Leukemia arsenic trioxide 10.3215070760
MESH:D007938 Leukemia Curcumin 10.3218462866
MESH:D007938 Leukemia decitabine 10.3219235587 18980019
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 9.4917077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 9.4916106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.2216972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.3119077051
MESH:D007951 Leukemia, Myeloid decitabine 9.3117236224 19117987 18454857
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.9417050201 16968895 20471514 19850784 16467208
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.9418206229 18704418 19387464 19010910 18460780 17679729
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.3818055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.1615213294 17869043 12679006 16330433 19225113 16823087 11161223 15336539 16966277 17107899 16891316 12018890 11468182 16331271 15748426 17712046 19075265 17649720 19642359 17217047 19035177 15622746 16112521 12712474 9834237
MESH:D015458 Leukemia, T-Cell arsenic trioxide 11.4316882451
MESH:D015458 Leukemia, T-Cell Curcumin 11.4316106398
MESH:D007970 Leukopenia Lipopolysaccharides 4.6115821434
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.7818665156 20032147 19638242 18522880 18407596
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 6.6317355460 18705752 18006644
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.6314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 6.6312878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.6312878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.6316169303
MESH:D008107 Liver Diseases Acetaminophen 6.4116610002 12969438 19014921 12587719 11587558 19460945 16611625 19784758
MESH:D008107 Liver Diseases Curcumin 6.4116956363
MESH:D008107 Liver Diseases Diethylnitrosamine 6.4117034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1616871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 13.8914682389
MESH:D008113 Liver Neoplasms Diethylnitrosamine 13.8919294768 18644402 19090486 15885732 19642983 21047994 18977376 19638242 18648771 12771043 2422723 19427195 2862719 20492335 19551842 10737359 20101389 18978307 21071580 20452335 15175105 12112319 19254457 16942905 21278145 19690152 19850985 20405173 19996281 20501860 20434301 19256749 19426721 19812893 20118626 19833225 19499222 20583210 21167192 19073162 9163691 19255062 18754104 20137499
MESH:D008113 Liver Neoplasms Fluorouracil 13.8917045692 18383874 15113037 16603448
MESH:D008113 Liver Neoplasms sodium arsenite 13.8916712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.8916984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 9.4920377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 9.4916842330 9362446 17174075 2563599 18544905 19004024 16267830 19519916 18253720 18164116 19126423 19009564 18282651 18079962 19539802 21159647 17854601 18775883 18308698 17942915 3124819 18093689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.4912151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2815213294
MESH:D008171 Lung Diseases sodium arsenite 7.2419095001
MESH:D008171 Lung Diseases Vitamin E 7.2416863852
MESH:D055370 Lung Injury Asbestos, Crocidolite 9.0117365036
MESH:D055370 Lung Injury Lipopolysaccharides 9.0121114838
MESH:D008175 Lung Neoplasms arsenic trioxide 12.8311798837 19825857
MESH:D008175 Lung Neoplasms Cisplatin 12.8311798837 17225452 6189445
MESH:D008175 Lung Neoplasms Curcumin 12.8318462866 16243823 19359593
MESH:D008175 Lung Neoplasms Diethylnitrosamine 12.836695378 20970405 21163286 20512841
MESH:D008175 Lung Neoplasms Fluorouracil 12.8315246190
MESH:D008175 Lung Neoplasms sodium arsenite 12.8316712894 15276417 17306315 17077188 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 12.8319555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 12.8311062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.7115086387
MESH:D008223 Lymphoma Curcumin 7.5618462866
MESH:D008223 Lymphoma decitabine 7.5619470736
MESH:D016399 Lymphoma, T-Cell Curcumin 4.6116173963
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.5011408345 17203775 11807958 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.4019453300
MESH:D008545 Melanoma Cisplatin 7.2318332650 18505091 11135225 18176117 12374674 16432458 16809738 12393984 12883367 17023156 17761969 16248763 15577323
MESH:D008545 Melanoma Curcumin 7.2317885582 18462866
MESH:D008545 Melanoma decitabine 7.2317785578 16505122
MESH:D008545 Melanoma sodium arsenite 7.2316487513 19082730
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.6915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4819513568
MESH:D008569 Memory Disorders Curcumin 4.0717263510
MESH:D008654 Mesothelioma Asbestos, Crocidolite 6.3916966607 18303189 16166281
MESH:D008654 Mesothelioma Cisplatin 6.3917638057
MESH:D009062 Mouth Neoplasms Fluorouracil 3.5616757204 18986760
MESH:D009101 Multiple Myeloma arsenic trioxide 11.8214977855 19549372 15949261 19417148 11468182
MESH:D009101 Multiple Myeloma Curcumin 11.8219372569
MESH:D009101 Multiple Myeloma decitabine 11.8218172295
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.8317962980
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.7718186108
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.3316882451 16105982
MESH:D009190 Myelodysplastic Syndromes decitabine 7.3319157545 16882708 19010910 18608210
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.2116810080
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 10.0416624393
MESH:D009361 Neoplasm Invasiveness Curcumin 10.0418495463
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.539029167 3581430
MESH:D009369 Neoplasms Cisplatin 11.5716773208
MESH:D009369 Neoplasms decitabine 11.5717925555 19470736 19116145
MESH:D009369 Neoplasms Fluorouracil 11.5718600527 18239605 16928823
MESH:D009369 Neoplasms sodium arsenite 11.5711559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5820056578
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.4512497104
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6517289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.4115464296
MESH:D009421 Nervous System Malformations Estradiol 9.1816427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.1814600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.5518462866
MESH:D009436 Neural Tube Defects arsenic trioxide 11.9410525206
MESH:D009436 Neural Tube Defects sodium arsenate 11.9410525206 11749123 18186108 19446573
MESH:D009436 Neural Tube Defects sodium arsenite 11.9412854658
MESH:D009447 Neuroblastoma Cisplatin 3.408761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.9318514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.9320387270
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.618761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0420387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3816436463
MESH:D009765 Obesity Curcumin 2.7319297423
MESH:D010024 Osteoporosis Curcumin 3.4218719352
MESH:D010051 Ovarian Neoplasms arsenic trioxide 18.5212452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Cisplatin 18.5215464296 6897625 17225452 19769630
MESH:D010051 Ovarian Neoplasms Curcumin 18.5219020741 18462866
MESH:D010051 Ovarian Neoplasms decitabine 18.5219259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 18.5219401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 18.5215276417 17306315
MESH:D010146 Pain Acetaminophen 2.3216870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 20.1115580305
MESH:D010190 Pancreatic Neoplasms Cisplatin 20.1119003803
MESH:D010190 Pancreatic Neoplasms Curcumin 20.1119196508 17440100 19401701
MESH:D010190 Pancreatic Neoplasms decitabine 20.1119294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 20.1116540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 20.1116500647 15113037 19003803 16929163
MESH:D010235 Paraganglioma arsenic trioxide 4.0819927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1712520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.2215464296
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.8110923243
MESH:D010997 Pleural Neoplasms Cisplatin 5.2617638057
MESH:D011014 Pneumonia Lipopolysaccharides 4.4711605937 12224865
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4718163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.472563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1111118676 11222880 11399792 11896295
MESH:D055728 Primary Myelofibrosis decitabine 4.6417616702
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.6915572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8020887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0919131511
MESH:D011471 Prostatic Neoplasms Calcitriol 2.0918247401 12479363 15754350 16289102 16644109
MESH:D011471 Prostatic Neoplasms Curcumin 2.0912497104 10851300 18769126 15129424 18226269 18156803 11398177
MESH:D011471 Prostatic Neoplasms Estradiol 2.0916740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0919082440 18626508
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0916039940
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0915084515
MESH:D011656 Pulmonary Emphysema Curcumin 4.4519168576
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0015814490 17975199 17365031 17322281
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9315538739 18722050 18286688 16160472
MESH:D051437 Renal Insufficiency Cisplatin 4.3215464296
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.9418379247 10666014
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.6710835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7518990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.3219155313
MESH:D012509 Sarcoma Curcumin 4.0418462866
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 10.0616646077
MESH:D012512 Sarcoma, Ewing's Cisplatin 10.0614601052
MESH:D018805 Sepsis Curcumin 4.0018389075
MESH:D012871 Skin Diseases Vitamin E 2.4218709164
MESH:D012878 Skin Neoplasms sodium arsenite 5.4618572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.4616192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.2615464296
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7312854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 6.3217007042
MESH:D013274 Stomach Neoplasms Cisplatin 6.3217522103 15958060 18396642
MESH:D013274 Stomach Neoplasms decitabine 6.3219037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 6.3218456281
MESH:D013274 Stomach Neoplasms Fluorouracil 6.3218396642 19015929 16951190 17498489 18567086 17522103 17172411 19084572 16424979 15786421
MESH:D013276 Stomach Ulcer Curcumin 3.4216631530 19188055
MESH:D020521 Stroke Vitamin E 3.4516517955
MESH:D013736 Testicular Neoplasms Cisplatin 4.5517225452 15464296
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.0815821434
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 11.6219014326
MESH:D013964 Thyroid Neoplasms decitabine 11.6217967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.627505956
MESH:D013978 Tibial Fractures Estradiol 4.6019048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.9116280240
MESH:D016171 Torsades de Pointes arsenic trioxide 3.8815213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 15.4712973940 20435036 11780464 12845720
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 15.4712973940 17225452 15464296
MESH:D001749 Urinary Bladder Neoplasms Curcumin 15.4718593936
MESH:D001749 Urinary Bladder Neoplasms decitabine 15.4719087683 17616700
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 15.4711723127 17306315 16452187 16712894
MESH:D014565 Urogenital Neoplasms Curcumin 5.1818462866
MESH:D014581 Urticaria Acetaminophen 2.8910982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 15.4716803524
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 15.4716803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 15.4711813266
MESH:D014594 Uterine Neoplasms sulindac sulfide 4.5718645019
MESH:D014604 Uveal Neoplasms decitabine 4.8317785578
MESH:D014625 Vaginal Neoplasms Cisplatin 4.5215577323
MESH:D014652 Vascular Diseases sodium arsenite 4.3417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5112125929
MESH:D014839 Vomiting Cisplatin 4.6411897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1715886252
Pathway ID Pathway Name
REACT:216 DNA Repair
REACT:6185 HIV Infection
KEGG:03450 Non-homologous end-joining
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28467
    • No data
    No data
    Releated drug ID Related drug Name
    PA451581tamoxifen
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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