AutismKB 2.0

Annotation Detail for GABRA2


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Basic Information Top
Gene Symbol:GABRA2 ( FLJ97076 )
Gene Full Name: gamma-aminobutyric acid (GABA) A receptor, alpha 2
Band: 4p12
Quick LinksEntrez ID:2555; OMIM: 137140; Uniprot ID:GBRA2_HUMAN; ENSEMBL ID: ENSG00000151834; HGNC ID: 4076
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
CHEMDEPENDENCY
alcoholism
alcohol effects
alcohol dependence
No data
Desease Name
Alcoholism, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C091518 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]affects binding 14637376
C091518 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane Dieldrin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
C091518 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane Lindane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
C091518 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
C091518 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
C091518 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane tert-butylbicyclo-2-benzoate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
C091518 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane tert-butylbicyclophosphorothionate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
C006477 alphaxalone alphaxalone promotes the reaction [Flunitrazepam binds to GABRA2 protein]affects binding|increases reaction 8397295
D005680 gamma-Aminobutyric Acid gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]affects cotreatment|increases activity 11123204
D005680 gamma-Aminobutyric Acid [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chloridesaffects cotreatment|increases activity|increases transport 11123204
D005680 gamma-Aminobutyric Acid topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]affects cotreatment|decreases reaction|increases activity|increases transport 11123204
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GABRA2 mRNAaffects expression 16483693
C459604 candoxin candoxin results in increased expression of GABRA2 mRNAincreases expression 16309724
D002330 Carmustine Carmustine results in decreased expression of GABRA2 mRNAdecreases expression 15980968
D002712 Chlorides [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chloridesaffects cotreatment|increases activity|increases transport 11123204
D002712 Chlorides topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]affects cotreatment|decreases reaction|increases activity|increases transport 11123204
D003975 Diazepam GABRA2 protein affects the susceptibility to Diazepamaffects response to substance 18313124
D003975 Diazepam GABRA2 protein results in increased susceptibility to Diazepamincreases response to substance 16284244
D003975 Diazepam Diazepam results in increased activity of GABRA2 proteinincreases activity 15613639
D004026 Dieldrin Dieldrin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
D000431 Ethanol Ethanol results in decreased expression of GABRA2 mRNAdecreases expression 1711815
C044610 etizolam etizolam affects the expression of GABRA2 mRNAaffects expression 16107249
D005445 Flunitrazepam alphaxalone promotes the reaction [Flunitrazepam binds to GABRA2 protein]affects binding|increases reaction 8397295
D005445 Flunitrazepam Flunitrazepam binds to GABRA2 proteinaffects binding 8397295
D005445 Flunitrazepam Pentobarbital promotes the reaction [Flunitrazepam binds to GABRA2 protein]affects binding|increases reaction 8397295
D005445 Flunitrazepam Flunitrazepam results in increased activity of GABRA2 proteinincreases activity 16162846
D001556 Lindane Lindane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
D008140 Lorazepam Lorazepam affects the expression of GABRA2 mRNAaffects expression 16107249
D037742 Nanotubes, Carbon Nanotubes, Carbon results in increased expression of GABRA2 mRNAincreases expression 15585362
D010424 Pentobarbital GABRA2 protein affects the susceptibility to Pentobarbitalaffects response to substance 18313124
D010424 Pentobarbital Pentobarbital promotes the reaction [Flunitrazepam binds to GABRA2 protein]affects binding|increases reaction 8397295
D010433 Pentylenetetrazole Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
D010852 Picrotoxin Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
D011374 Progesterone Progesterone results in increased expression of GABRA2 mRNAincreases expression 16000229
C042957 Ro 15-4513 GABRA2 protein affects the susceptibility to Ro 15-4513affects response to substance 15850489
C446685 systhane systhane results in decreased expression of GABRA2 mRNAdecreases expression 16730040
C046308 tert-butylbicyclo-2-benzoate tert-butylbicyclo-2-benzoate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
C037476 tert-butylbicyclophosphorothionate tert-butylbicyclophosphorothionate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
D043343 Testosterone Propionate Testosterone Propionate results in decreased expression of GABRA2 mRNAdecreases expression 16957604
D014050 Toluene Toluene affects the expression of GABRA2 mRNAaffects expression 17108153
C052342 topiramate topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]affects cotreatment|decreases reaction|increases activity|increases transport 11123204
C032910 triadimefon triadimefon results in decreased expression of GABRA2 mRNAdecreases expression 16730040
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 3.6918926900 17676605
MESH:D000138 Acidosis Ammonium Chloride 9.7118287403
MESH:D000138 Acidosis Ethanol 9.7111192467
MESH:D000382 Agricultural Workers' Diseases Lindane 4.1512661182
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.0915451039 15451040
MESH:D000437 Alcoholism marker/mechanism
MESH:D000437 Alcoholism topiramate 4.8517925516 18552399 19331489
MESH:D000853 Anophthalmos Ethanol 4.5915513904
MESH:D001008 Anxiety Disorders marker/mechanism 18313124
MESH:D001008 Anxiety Disorders Diazepam 14.1916284244 18313124
MESH:D001008 Anxiety Disorders Ethanol 14.1911141031
MESH:D001008 Anxiety Disorders Pentobarbital 14.1918313124 11141031
MESH:D001321 Autistic Disorder marker/mechanism 18821008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1117868700
MESH:D001930 Brain Injuries Progesterone 4.0315665606 15845082 15380490
MESH:D001932 Brain Neoplasms Carmustine 4.1916187019
MESH:D001943 Breast Neoplasms Dieldrin 2.2215770527 11859874
MESH:D001943 Breast Neoplasms Lindane 2.2214688026
MESH:D001943 Breast Neoplasms Progesterone 2.2217614352 15562024 16175315
MESH:D002056 Burns Ethanol 4.4316374292
MESH:D006528 Carcinoma, Hepatocellular Ethanol 2.3715763234 18788625 15289165
MESH:D006332 Cardiomegaly Ethanol 3.3119332462
MESH:D002547 Cerebral Palsy Toluene 5.629294310
MESH:D002659 Child Development Disorders, Pervasive topiramate 4.0115650499
MESH:D002971 Cleft Lip Ethanol 3.4715513904
MESH:D002972 Cleft Palate Diazepam 9.743629520
MESH:D002972 Cleft Palate Ethanol 9.7415513904
MESH:D002972 Cleft Palate triadimefon 9.7416781842
MESH:D019465 Craniofacial Abnormalities Ethanol 4.0411198716 15451040 10194807 11873399 19302082 15513904 15451039
MESH:D019465 Craniofacial Abnormalities Toluene 4.049294310
MESH:D019465 Craniofacial Abnormalities triadimefon 4.0416875885 15834900
MESH:D003643 Death Pentylenetetrazole 13.126431079
MESH:D003643 Death Toluene 13.126431079
MESH:D003924 Diabetes Mellitus, Type 2 topiramate 3.6416979414
MESH:D003929 Diabetic Neuropathies Progesterone 4.2717187935
MESH:D056486 Drug-Induced Liver Injury Ethanol 2.5511566570
MESH:D004421 Dystonia Diazepam 5.461851702
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.5617692515
MESH:D004715 Endometriosis Progesterone 3.5716134523
MESH:D004828 Epilepsies, Partial Diazepam 5.313922381
MESH:D004827 Epilepsy Diazepam 7.40821787
MESH:D004827 Epilepsy topiramate 7.4019148780
MESH:D004832 Epilepsy, Absence Diazepam 9.606426943 6401628
MESH:D004832 Epilepsy, Absence Pentylenetetrazole 9.606426943
MESH:D004833 Epilepsy, Temporal Lobe topiramate 6.0416499746
MESH:D004938 Esophageal Neoplasms Ethanol 2.7016704527
MESH:D005234 Fatty Liver Ethanol 3.5319236843 18620774 16409862
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.4317920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.0716946407 15513904 10194807 15451040
MESH:D005756 Gastritis Ethanol 4.4615046732
MESH:D005909 Glioblastoma Carmustine 3.7816187019
MESH:D006529 Hepatomegaly systhane 8.7717178688 17178689
MESH:D006529 Hepatomegaly triadimefon 8.7717178688 17178689
MESH:D006930 Hyperalgesia Ethanol 3.5418783367
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1815869954
MESH:D007247 Infertility, Female Dieldrin 4.7310630421
MESH:D007249 Inflammation Progesterone 2.4915869954
MESH:D007569 Jaw Abnormalities Ethanol 10.0315513904
MESH:D007569 Jaw Abnormalities triadimefon 10.0315834900 15992940
MESH:D007859 Learning Disorders Ethanol 3.9915451040
MESH:D017880 Limb Deformities, Congenital Ethanol 3.6517676605
MESH:D008103 Liver Cirrhosis Ethanol 3.2515289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.8718295389
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 2.3018166357
MESH:D008107 Liver Diseases Lindane 4.651715830
MESH:D008107 Liver Diseases triadimefon 4.6519363144
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.4317347304 17207112
MESH:D008113 Liver Neoplasms Dieldrin 5.129539021 8742319
MESH:D008113 Liver Neoplasms triadimefon 5.1219028983
MESH:D008114 Liver Neoplasms, Experimental systhane 6.4017178689
MESH:D008114 Liver Neoplasms, Experimental triadimefon 6.4017178689
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.7317203775 11408345
MESH:D008545 Melanoma Carmustine 2.8412393984
MESH:D008569 Memory Disorders Ethanol 3.9718411066 15451040
MESH:D008607 Mental Retardation Toluene 3.579294310
MESH:D008881 Migraine Disorders topiramate 4.4218759728 18803445 16942474 18765137
MESH:D019957 Motor Skills Disorders Toluene 5.029294310
MESH:D009369 Neoplasms Dieldrin 5.458820588
MESH:D009369 Neoplasms Lindane 5.4516818664 12807735
MESH:D010051 Ovarian Neoplasms Progesterone 2.4616525653 17393432
MESH:D010190 Pancreatic Neoplasms Ethanol 2.8912384795
MESH:D010300 Parkinson Disease Dieldrin 3.4411445065 11181820 16809432 17291500 16112328
MESH:D011471 Prostatic Neoplasms Lindane 4.2312661182 14688026
MESH:D012021 Reflex, Abnormal Pentobarbital 5.7910930210
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7818045962
MESH:D012640 Seizures Diazepam 40.4015946322 9754883 10087439
MESH:D012640 Seizures Ethanol 40.409754883
MESH:D012640 Seizures etizolam 40.4016107249
MESH:D012640 Seizures Lindane 40.4012842176 15475178 7539098
MESH:D012640 Seizures Lorazepam 40.4016107249 10087439
MESH:D012640 Seizures Pentobarbital 40.409754883 10087439
MESH:D012640 Seizures Pentylenetetrazole 40.4019660546 16054440 6431079 8954991 2616065 3037702 3352866 18657176 15475178 18164287
MESH:D012640 Seizures Picrotoxin 40.408635557 8954991
MESH:D012640 Seizures Toluene 40.406431079 9294310
MESH:D012640 Seizures topiramate 40.4016499746
MESH:D007319 Sleep Initiation and Maintenance Disorders Lorazepam 6.0315341891
MESH:D013119 Spinal Cord Injuries Progesterone 4.0516503802 15862959
MESH:D013274 Stomach Neoplasms Ethanol 2.3018456281
MESH:D013276 Stomach Ulcer Ethanol 3.3317189318 11906479 9562338 17918041 16755016 9211565
MESH:D013375 Substance Withdrawal Syndrome Diazepam 15.579754883
MESH:D013375 Substance Withdrawal Syndrome Ethanol 15.579754883
MESH:D013375 Substance Withdrawal Syndrome Pentobarbital 15.5711529278 9754883
MESH:D013733 Testicular Diseases Toluene 4.7310514026 10048760
MESH:D013964 Thyroid Neoplasms triadimefon 3.9217178689
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:13685 Synaptic Transmission
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28490
    • No data
    Releated disease ID Related disease Name
    PA446879Alcohol-Related Disorders
    PA443309Alcoholism
    Releated drug ID Related drug Name
    PA164743471adenosine triphosphate
    PA449659flumazenil
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00186 potentiator Lorazepam Anti-anxiety Agents;Hypnotics and Sedatives;Antiemetics;Anticonvulsants;Benzodiazepines;GABA Modulators
    DB00189 agonist Ethchlorvynol Hypnotics and Sedatives
    DB00231 potentiator Temazepam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators
    DB00237 potentiator Butabarbital Anti-anxiety Agents;Hypnotics and Sedatives;Barbiturates
    DB00241 potentiator Trianal-C 1/2 Capsule Analgesics
    DB00306 potentiator Talbutal Analgesics
    DB00312 potentiator Cafergot PB Tab Hypnotics and Sedatives;Adjuvants, Anesthesia;GABA Modulators;Barbiturates
    DB00349 potentiator Clobazam Anticonvulsants;Benzodiazepines
    DB00371 agonist Equagesic Tablets Anti-anxiety Agents;Hypnotics and Sedatives;Anticonvulsants;Muscle Relaxants, Central
    DB00402 agonist Eszopiclone Hypnotics and Sedatives
    DB00404 potentiator Alprazolam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators
    DB00418 potentiator Secobarbital Hypnotics and Sedatives;Adjuvants, Anesthesia;GABA Modulators;Barbiturates;Adjuvants
    DB00425 agonist Zolpidem GABA Agonists;Hypnotics and Sedatives
    DB00463 potentiator Metharbital Anticonvulsants
    DB00475 potentiator Pro Chlorax Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators
    DB00546 potentiator Adinazolam Anti-anxiety Agents;Antidepressive Agents
    DB00599 potentiator Thiotal 5g Hypnotics and Sedatives;Anticonvulsants;GABA Modulators;Anesthetics, Intravenous
    DB00628 potentiator Clorazepate Anti-anxiety Agents;Anticonvulsants;GABA Modulators
    DB00683 potentiator Midazolam Anti-anxiety Agents;Hypnotics and Sedatives;Adjuvants, Anesthesia;GABA Modulators;Anesthetics, Intravenous
    DB00690 potentiator Flurazepam Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators
    DB00794 potentiator Primidone Anticonvulsants;Barbiturates
    DB00801 potentiator Halazepam Anti-anxiety Agents;Muscle Relaxants;Benzodiazepines;Sedative
    DB00829 potentiator Diazepam Anti-anxiety Agents;Hypnotics and Sedatives;Antiemetics;Anticonvulsants;Adjuvants, Anesthesia;GABA Modulators;Anesthetics, Intravenous;Muscle Relaxants, Central
    DB00842 other/unknown Oxazepam Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators
    DB00849 potentiator Methylphenobarbital Hypnotics and Sedatives;Anticonvulsants;GABA Modulators
    DB00897 potentiator Triazolam Anti-anxiety Agents;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators
    DB01068 potentiator Clonazepam Anticonvulsants;Benzodiazepines;GABA Modulators
    DB01174 potentiator Phenobarbital Hypnotics and Sedatives;Anticonvulsants;GABA Modulators;Excitatory Amino Acid Antagonists
    DB01198 agonist Zopiclone Hypnotics and Sedatives
    DB01205 - Flumazenil GABA Modulators;Antidotes
    DB01215 potentiator Estazolam Anti-anxiety Agents;Anticonvulsants;GABA Modulators
    DB01346 agonist Quinidine barbiturate
    DB01351 potentiator Amobarbital Hypnotics and Sedatives;GABA Modulators
    DB01352 potentiator Aprobarbital
    DB01353 potentiator Butethal Anti-anxiety Agents;Hypnotics and Sedatives;Barbiturates
    DB01354 potentiator Heptabarbital Hypnotics and Sedatives;Barbiturates
    DB01355 potentiator Hexobarbital Hypnotics and Sedatives;GABA Modulators;Barbiturates;Adjuvants
    DB01483 potentiator Barbital Hypnotics and Sedatives;GABA Modulators
    DB01496 potentiator Barbituric acid derivative
    DB01544 agonist Flunitrazepam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators
    DB01558 potentiator Bromazepam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators
    DB01559 potentiator Clotiazepam Anti-anxiety Agents;Hypnotics and Sedatives;Anticonvulsants;Benzodiazepines
    DB01567 agonist Fludiazepam Anti-anxiety Agents;Benzodiazepines
    DB01588 potentiator Prazepam Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators
    DB01589 potentiator Quazepam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators
    DB01594 potentiator Cinolazepam Anticonvulsants;Benzodiazepines;Sedatives and Hypnotics
    DB01595 potentiator Nitrazepam Anti-anxiety Agents;Hypnotics and Sedatives;Anticonvulsants;GABA Modulators
    No data
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    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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