AutismKB 2.0

Annotation Detail for GABRA4


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Basic Information Top
Gene Symbol:GABRA4 ( - )
Gene Full Name: gamma-aminobutyric acid (GABA) A receptor, alpha 4
Band: 4p12
Quick LinksEntrez ID:2557; OMIM: 137141; Uniprot ID:GBRA4_HUMAN; ENSEMBL ID: ENSG00000109158; HGNC ID: 4078
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D005680 gamma-Aminobutyric Acid gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]affects cotreatment|increases activity 11123204
D005680 gamma-Aminobutyric Acid [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chloridesaffects cotreatment|increases activity|increases transport 11123204
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GABRA4 mRNAaffects expression 16483693
D001761 Bleomycin Bleomycin results in decreased expression of GABRA4 mRNAdecreases expression 15808516
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of GABRA4 mRNAincreases expression 12832660
D002712 Chlorides [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chloridesaffects cotreatment|increases activity|increases transport 11123204
C086916 delta-hexachlorocyclohexane delta-hexachlorocyclohexane results in decreased activity of [GABRA4 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]affects binding|decreases activity 11156579
D003975 Diazepam Diazepam results in increased expression of GABRA4 mRNAincreases expression 15802192
D004958 Estradiol Estradiol affects the expression of GABRA4 mRNAaffects expression 16000229
D005665 Furosemide Furosemide results in decreased activity of GABRA4 proteindecreases activity 15613639
D007530 Isoflurane [Isoflurane co-treated with Nitrous Oxide] affects the expression of GABRA4 mRNAaffects cotreatment|affects expression 16733821
D007657 Ketone Bodies Ketone Bodies results in decreased expression of GABRA4 mRNAdecreases expression 15469884
D008140 Lorazepam GABRA4 protein affects the susceptibility to Lorazepamaffects response to substance 12522171
D008140 Lorazepam Lorazepam affects the expression of GABRA4 mRNAaffects expression 16107249
D008874 Midazolam Midazolam results in increased expression of GABRA4 mRNAincreases expression 16733821
D009609 Nitrous Oxide [Isoflurane co-treated with Nitrous Oxide] affects the expression of GABRA4 mRNAaffects cotreatment|affects expression 16733821
D010424 Pentobarbital Pentobarbital results in increased expression of GABRA4 mRNAincreases expression 16733821
C033457 phenobarbital quinidine phenobarbital quinidine results in increased expression of GABRA4 mRNAincreases expression 15802192
C006253 pirinixic acid pirinixic acid results in increased expression of GABRA4 mRNAincreases expression 12832660
D011374 Progesterone GABRA4 protein affects the susceptibility to Progesteroneaffects response to substance 12522171
D011374 Progesterone Progesterone affects the expression of GABRA4 proteinaffects expression 12522171
15834956
D015742 Propofol Propofol results in increased expression of GABRA4 mRNAincreases expression 16733821
C042957 Ro 15-4513 Ro 15-4513 results in increased activity of GABRA4 proteinincreases activity 16162846
D013619 Tacrine Tacrine results in increased expression of GABRA4 mRNAincreases expression 12832660
D043343 Testosterone Propionate Testosterone Propionate results in increased expression of GABRA4 mRNAincreases expression 16957604
D014050 Toluene Toluene affects the expression of GABRA4 mRNAaffects expression 17108153
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28492
  • Releated disease ID Related disease Name
    PA447268tardive dyskinesia
    PA443309Alcoholism
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00186 potentiator Lorazepam Anti-anxiety Agents;Hypnotics and Sedatives;Antiemetics;Anticonvulsants;Benzodiazepines;GABA Modulators
    DB00189 agonist Ethchlorvynol Hypnotics and Sedatives
    DB00231 potentiator Temazepam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators
    DB00237 potentiator Butabarbital Anti-anxiety Agents;Hypnotics and Sedatives;Barbiturates
    DB00241 potentiator Trianal-C 1/2 Capsule Analgesics
    DB00306 potentiator Talbutal Analgesics
    DB00312 potentiator Cafergot PB Tab Hypnotics and Sedatives;Adjuvants, Anesthesia;GABA Modulators;Barbiturates
    DB00349 potentiator Clobazam Anticonvulsants;Benzodiazepines
    DB00371 agonist Equagesic Tablets Anti-anxiety Agents;Hypnotics and Sedatives;Anticonvulsants;Muscle Relaxants, Central
    DB00404 potentiator Alprazolam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators
    DB00418 potentiator Secobarbital Hypnotics and Sedatives;Adjuvants, Anesthesia;GABA Modulators;Barbiturates;Adjuvants
    DB00463 potentiator Metharbital Anticonvulsants
    DB00475 potentiator Pro Chlorax Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators
    DB00599 potentiator Thiotal 5g Hypnotics and Sedatives;Anticonvulsants;GABA Modulators;Anesthetics, Intravenous
    DB00628 potentiator Clorazepate Anti-anxiety Agents;Anticonvulsants;GABA Modulators
    DB00683 potentiator Midazolam Anti-anxiety Agents;Hypnotics and Sedatives;Adjuvants, Anesthesia;GABA Modulators;Anesthetics, Intravenous
    DB00690 potentiator Flurazepam Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators
    DB00794 potentiator Primidone Anticonvulsants;Barbiturates
    DB00842 potentiator Oxazepam Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators
    DB00849 potentiator Methylphenobarbital Hypnotics and Sedatives;Anticonvulsants;GABA Modulators
    DB00897 potentiator Triazolam Anti-anxiety Agents;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators
    DB01068 potentiator Clonazepam Anticonvulsants;Benzodiazepines;GABA Modulators
    DB01174 potentiator Phenobarbital Hypnotics and Sedatives;Anticonvulsants;GABA Modulators;Excitatory Amino Acid Antagonists
    DB01351 potentiator Amobarbital Hypnotics and Sedatives;GABA Modulators
    DB01352 potentiator Aprobarbital
    DB01353 potentiator Butethal Anti-anxiety Agents;Hypnotics and Sedatives;Barbiturates
    DB01354 potentiator Heptabarbital Hypnotics and Sedatives;Barbiturates
    DB01355 potentiator Hexobarbital Hypnotics and Sedatives;GABA Modulators;Barbiturates;Adjuvants
    DB01483 potentiator Barbital Hypnotics and Sedatives;GABA Modulators
    DB01496 potentiator Barbituric acid derivative
    DB01544 agonist Flunitrazepam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators
    DB01558 potentiator Bromazepam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators
    DB01595 potentiator Nitrazepam Anti-anxiety Agents;Hypnotics and Sedatives;Anticonvulsants;GABA Modulators

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018