AutismKB 2.0

Annotation Detail for PCSK9


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Basic Information Top
Gene Symbol:PCSK9 ( FH3,HCHOLA3,LDLCQ1,NARC-1,NARC1,PC9 )
Gene Full Name: proprotein convertase subtilisin/kexin type 9
Band: 1p32.3
Quick LinksEntrez ID:255738; OMIM: 607786; Uniprot ID:PCSK9_HUMAN; ENSEMBL ID: ENSG00000169174; HGNC ID: 20001
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Desease IDDesease Name
Inherited disorders of lipid/glycolipid metabolism
H00155Hypercholesterolemia, autosomal dominant
Genetic disorders
Desease IDDesease Name
1740Alzheimer's disease
1848Embryoma
1918Atherosclerosis
1936Hypercholesterolemia
1954Stroke
Desease Name
hypercholesterolemia
cholesterol
CARDIOVASCULAR
cholesterol, LDL
myocardial infarction (early onset)
PHARMACOGENOMIC
atherosclerosis, coronary cholesterol
METABOLIC
heart disease, ischemic hypercholesterolemia
LDL cholesterol
cholesterol heart disease, ischemic
Desease Name
LDL cholesterol
Myocardial infarction (early onset)
Desease Name
Low density lipoprotein cholesterol level QTL 1
Hypercholesterolemia, familial, 3
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PCSK9 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of PCSK9 mRNAaffects expression 18648102
C014949 acetylhydrazine acetylhydrazine results in increased expression of PCSK9 mRNAincreases expression 15282401
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of PCSK9 proteinaffects expression 20106945
D000638 Amiodarone Amiodarone results in increased expression of PCSK9 mRNAincreases expression 19774075
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PCSK9 mRNAaffects cotreatment|increases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PCSK9 mRNAdecreases expression 20106945
C006780 bisphenol A bisphenol A inhibits the reaction [Triiodothyronine results in decreased expression of PCSK9 mRNA]decreases expression|decreases reaction 19228888
D016572 Cyclosporine Cyclosporine results in decreased expression of PCSK9 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of PCSK9 mRNAdecreases expression 18457598
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PCSK9 mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of PCSK9 mRNAdecreases expression 19638242
D004958 Estradiol Estradiol results in decreased expression of PCSK9 mRNAdecreases expression 20106945
C056507 gemcitabine gemcitabine results in increased expression of PCSK9 mRNAincreases expression 17039268
C029424 hydrazine hydrazine results in increased expression of PCSK9 mRNAincreases expression 15282401
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of PCSK9 mRNAincreases expression 18638454
C025462 sulindac sulfide sulindac sulfide results in decreased expression of PCSK9 mRNAdecreases expression 16184548
D014284 Triiodothyronine bisphenol A inhibits the reaction [Triiodothyronine results in decreased expression of PCSK9 mRNA]decreases expression|decreases reaction 19228888
D014284 Triiodothyronine Triiodothyronine results in decreased expression of PCSK9 mRNAdecreases expression 19228888
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PCSK9 mRNAdecreases expression 20106945
D014425 Turpentine Turpentine results in increased expression of PCSK9 mRNAincreases expression 18638454
D015054 Zymosan Zymosan results in increased expression of PCSK9 mRNAincreases expression 18638454
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7615322242 11752688 14514962
MESH:D055371 Acute Lung Injury Lipopolysaccharides 3.9518653653 11850527
MESH:D000210 Acute-Phase Reaction Turpentine 6.0916044259
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2120127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.2111473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 15.563712494
MESH:D000236 Adenoma Benzo(a)pyrene 15.566695378
MESH:D000236 Adenoma beta-Naphthoflavone 15.5619389873
MESH:D000236 Adenoma Diethylnitrosamine 15.5610737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.7717620307 19052882 18056438 16434500 19061943 17162532
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.7716835633
MESH:D000544 Alzheimer Disease sulindac sulfide 3.0718759972
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.7311748828
MESH:D000740 Anemia Zymosan 8.7318664788
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9919183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.7218218290 20041841 18057881
MESH:D001161 Arteriosclerosis Dietary Fats 3.8015238619
MESH:D001169 Arthritis, Experimental Zymosan 4.0715142272 15944321 16872482 15188379 17659584
MESH:D001281 Atrial Fibrillation Amiodarone 3.8419698954 18651412
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.941440618 11289319
MESH:D001778 Blood Coagulation Disorders Amiodarone 8.7719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.7712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7115746008
MESH:D001862 Bone Resorption bisphenol A 3.7811985600
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.7220146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 3.7217123778
MESH:D001943 Breast Neoplasms Dietary Fats 3.7220435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.7217474063
MESH:D001943 Breast Neoplasms Estradiol 3.7212948864 14630087 19861407 16675129 17289903 17261762 17018787 18497071
MESH:D001943 Breast Neoplasms gemcitabine 3.7217039268 18382427
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.7220435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3816111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7316835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.7216705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.723581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 8.7212619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.7218971187 19335982 10737359 19519916 20727157 3581430 11831363 16878318 20514400 19919837 16698587 18506893 16681979 19208518 17428255 18788625 21159647 19701751 20524982 20214788 19107877 20084675 19822196 16807293 18056438 18210153 18494052 16935385 16502159 17761372 16830150 17055752 16779866 3084413 17162532 17978847 16540662 19539802 18978308 18785209 16328049 17138121 20512989 19171122 20935162 10672840 19418558 16569478 20007298 18393292 19383236 19052882 20101231 19394651 20432363 17173139 18665156 16288022 18691550
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.7216924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.9017123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.4212391285
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.637296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0320419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3218850075 16120746 18670907
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8619225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.0018974383
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 15.507505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.5012371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 15.5017174075 7505956 2727394 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.5018566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.0719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.0716835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.669022650 19486331
MESH:D002779 Cholestasis Cyclosporine 7.6619486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.078697196 16354765 12621046 15340226 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9814669216 17141729
MESH:D003324 Coronary Artery Disease marker/mechanism 21378990
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2515322242 20055451 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.9318551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7211298694 18759878 8970840 8156756 12868966 14531868 11906362 2524372
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.413621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.1520387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1517107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.3319279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 11.7421346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 11.7418289764 7440962 18692083 6679447 9653073 1440618 6482804 9022650 11289319 16192314 18648102 8291058 9328219
MESH:D056486 Drug-Induced Liver Injury Amiodarone 11.7415265979 18218290
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.7419107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.7420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6911462148
MESH:D050171 Dyslipidemias Dietary Fats 3.3918367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8212711302 11000095
MESH:D004487 Edema Zymosan 6.827907874
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8215322242 16714409 18230668
MESH:D016889 Endometrial Neoplasms Estradiol 2.9219148513 18566989 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9410568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.3115821434 17637181 15328337
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0416302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.293581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2916530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9511564622
MESH:D005234 Fatty Liver Amiodarone 18.1214986274
MESH:D005234 Fatty Liver Cyclosporine 18.1219224547
MESH:D005234 Fatty Liver Dietary Fats 18.1219004024 19551842 17967931 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 18.1221071580 20387270
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3711858732
MESH:D005334 Fever Lipopolysaccharides 3.939205823 11852909
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.946705139
MESH:D005355 Fibrosis Cyclosporine 14.2212639820 12168785
MESH:D005355 Fibrosis Dietary Fats 14.2218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.2220067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.138708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.957505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.2920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.2910048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3415720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.3016366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2511000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.346705139
MESH:D006505 Hepatitis Zymosan 9.3419110552
MESH:D006529 Hepatomegaly Amiodarone 8.2515265979
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.2512621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.9515709030
MESH:D019584 Hot Flashes Estradiol 3.6717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9615340226 8697196 18606429 16959395 16354765
MESH:D006937 Hypercholesterolemia Amiodarone 8.898137927 9751232
MESH:D006937 Hypercholesterolemia Dietary Fats 8.8921332399
OMIM:603776 HYPERCHOLESTEROLEMIA, AUTOSOMAL DOMINANT, 3 marker/mechanism
MESH:D006949 Hyperlipidemias Dietary Fats 3.5321332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8515034207
MESH:D006973 Hypertension Cyclosporine 4.8310903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8318670907 18850075
MESH:D007037 Hypothyroidism Amiodarone 4.4318020914 17991464
MESH:D007249 Inflammation Dietary Fats 15.4020412841
MESH:D007249 Inflammation Diethylnitrosamine 15.4018785209
MESH:D007249 Inflammation Lipopolysaccharides 15.4017237260 17255318 9205823 12878042 17963957
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 15.4012878042 12200463
MESH:D007249 Inflammation Zymosan 15.4011289658 8014878
MESH:D007333 Insulin Resistance bisphenol A 12.0416393666
MESH:D007333 Insulin Resistance Dietary Fats 12.0411836018 18457598
MESH:D007333 Insulin Resistance Estradiol 12.0416627594 16393666
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.5517255318
MESH:D043183 Irritable Bowel Syndrome Zymosan 5.7517553498
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.949022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2516580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3615604871
MESH:D007674 Kidney Diseases Cyclosporine 5.778314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 5.7715618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 17.1316705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 17.136582329
MESH:D007680 Kidney Neoplasms Cyclosporine 17.1312371664
MESH:D007680 Kidney Neoplasms Estradiol 17.1315610895
MESH:D007970 Leukopenia Lipopolysaccharides 4.6115821434
MESH:D008064 Lipidoses Amiodarone 3.4515342952 17567588
MESH:D008103 Liver Cirrhosis Dietary Fats 6.4718296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.4718665156 19638242 20032147 18522880 18407596
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1415034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.4414716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 3.4412878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4412878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.0817034775
MESH:D008113 Liver Neoplasms Aflatoxin B1 13.8918177683 2125692 15890375 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 13.8921137059 20195826
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 13.8919389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 13.8915175105 20583210 12771043 19090486 18754104 19256749 20137499 15885732 19638242 2422723 10737359 21071580 19499222 16942905 19254457 19850985 19426721 18978307 19812893 2862719 21278145 19427195 18977376 19294768 20452335 20434301 20492335 19996281 20101389 20118626 18644402 19255062 12112319 20501860 18648771 19833225 20405173 19551842 19690152 21167192 21047994 9163691 19073162 19642983
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.8916984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 18.06598648 3712494 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 18.068603461
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 18.0618164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 18.069362446 18079962 18282651 18775883 19126423 16267830 17854601 17942915 19004024 18093689 2563599 19009564 19519916 18544905 18253720 3124819 17174075 16842330 18164116 19539802 18308698 21159647
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 18.0612151625
MESH:D008133 Long QT Syndrome Amiodarone 3.5111989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 3.3112587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.4018516814
MESH:D055370 Lung Injury Lipopolysaccharides 3.9221114838
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.7414755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.7420464547 20869020 18569708 17053015 18816296 6695378 20064080 18520028 20135361
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.7420970405 20512841 21163286 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.7419555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.5016891317 11408345 11807958 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.4019453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1216381670
MESH:D009102 Multiple Organ Failure Zymosan 5.1210890648 12130978 15241586 17724436 15213630 10479408 12879239 18160304 15259001 15834315
MESH:D009181 Mycoses Amiodarone 4.8212754197 17974566
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.2116810080
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.7718551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.593581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.593581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1311141357
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2118481113 19348381
MESH:D009421 Nervous System Malformations bisphenol A 15.8616427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 15.8611399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.8614600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.866679447
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.2720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0420387270
MESH:D009765 Obesity Dietary Fats 2.2711836018 21332399 18457598 17217161 20518802 19632207 18674790 16723640 20132043
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.6216049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.624026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.943988306
MESH:D010049 Ovarian Diseases bisphenol A 4.9011985600
MESH:D010051 Ovarian Neoplasms Estradiol 2.1919401270
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.5416540662
MESH:D010190 Pancreatic Neoplasms gemcitabine 5.5411504793 16929163 17440100 18992248 18383843
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.407296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1712520081
MESH:D010538 Peritonitis Zymosan 4.8017826846 14761945 19088179 18760300 19641140 18977430 15259001 17371808 15979727 18557954 11985352
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.396228378
MESH:D011014 Pneumonia Lipopolysaccharides 4.4711605937 12224865
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4718163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.6912371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.692563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.2210548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.2211896295 11118676 11399792 11222880
OMIM:607786 PROPROTEIN CONVERTASE, SUBTILISIN/KEXIN-TYPE, 9 marker/mechanism
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.2820887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.2820887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5617292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.5616740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.5616740699
MESH:D011565 Psoriasis Cyclosporine 2.2016882103
MESH:D011629 Puberty, Precocious bisphenol A 4.7010548101
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8212490602 12832656 11597910
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.6710835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7518990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.313692021
MESH:D012640 Seizures 2,4-dinitrotoluene 2.4718551238
MESH:D018805 Sepsis Zymosan 4.5711441115
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.0018724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.3319755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.3316192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.312093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3118456281
MESH:D013276 Stomach Ulcer Amiodarone 3.2418087811
MESH:D019966 Substance-Related Disorders bisphenol A 3.9016045194 16684133
MESH:D013610 Tachycardia Amiodarone 4.2011238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.1019225199
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.0815821434
MESH:D013959 Thyroid Diseases Amiodarone 11.7819731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.7812697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.897505956 3712494 6587162 6582329 1399818
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.897505956
MESH:D013971 Thyrotoxicosis Amiodarone 4.7718020914 19584973
MESH:D013978 Tibial Fractures Estradiol 4.6019048282
MESH:D016171 Torsades de Pointes Amiodarone 4.1111989578 17467628
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.0616049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.068074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.0617053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.2310091137
MESH:D014591 Uterine Diseases bisphenol A 4.9314652134
MESH:D014594 Uterine Neoplasms sulindac sulfide 4.5718645019
MESH:D014605 Uveitis Cyclosporine 11.711336536
MESH:D014605 Uveitis Zymosan 11.7111006244
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1715886252
MESH:D015430 Weight Gain Dietary Fats 3.6616723640
MESH:D014985 Xerophthalmia Cyclosporine 4.3617120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA38617
    • No data
    Releated disease ID Related disease Name
    PA443635Cardiovascular Diseases
    PA445019Myocardial Infarction
    PA445019Myocardial Infarction
    PA443797Coronary Disease
    PA444567Hypobetalipoproteinemias
    PA446414Carotid Stenosis
    Releated drug ID Related drug Name
    PA133950441hmg coa reductase inhibitors
    PA449688fluvastatin
    PA450480metoprolol
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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