AutismKB 2.0

Annotation Detail for PAN3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PAN3 ( - )
Gene Full Name: PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
Band: 13q12.2
Quick LinksEntrez ID:255967; OMIM: NA; Uniprot ID:PAN3_HUMAN; ENSEMBL ID: ENSG00000152520; HGNC ID: 29991
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Metabolism of RNA
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PAN3 mRNAdecreases expression 19150397
C051890 irinotecan irinotecan analog results in decreased expression of PAN3 mRNAdecreases expression 18927307
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 3.0420889678
MESH:D003110 Colonic Neoplasms irinotecan 2.6517725105 17287894
MESH:D015179 Colorectal Neoplasms irinotecan 2.3718509181 16391804 17454858 17159606 16303861 18259882 15273666
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1620426865
MESH:D052016 Mucositis irinotecan 5.8917159606
MESH:D009362 Neoplasm Metastasis irinotecan 3.3218259882
MESH:D009447 Neuroblastoma irinotecan 3.698761367
MESH:D017599 Neuroectodermal Tumors irinotecan 5.628761367
MESH:D013274 Stomach Neoplasms irinotecan 2.3615723263
Pathway ID Pathway Name
REACT:21257 Metabolism of RNA
KEGG:03018 RNA degradation
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA144596398
  • Releated gene ID Related gene Name
    PA144596398PAN3
    No data
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018