AutismKB 2.0

Annotation Detail for GABRB1


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Basic Information Top
Gene Symbol:GABRB1 ( - )
Gene Full Name: gamma-aminobutyric acid (GABA) A receptor, beta 1
Band: 4p12
Quick LinksEntrez ID:2560; OMIM: 137190; Uniprot ID:GBRB1_HUMAN; ENSEMBL ID: ENSG00000163288; HGNC ID: 4081
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
CHEMDEPENDENCY
epilepsy
PSYCH
manic-depressive illness
NEUROLOGICAL
alcohol dependence
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C038844 1-octen-3-ol 1-octen-3-ol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|increases activity|increases reaction 14664509
C038844 1-octen-3-ol 1-octen-3-ol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB1 protein]]affects cotreatment|increases activity|increases reaction 16569037
C054511 4,5-dimethyl-3-hydroxy-2(5H)-furanone 4,5-dimethyl-3-hydroxy-2(5H)-furanone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|increases activity|increases reaction 14664509
C534316 7-hydroxy-7-methyl-3-methylene-1-octene 7-hydroxy-7-methyl-3-methylene-1-octene promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB1 protein]]affects cotreatment|increases activity|increases reaction 16569037
D000481 Allantoin Allantoin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|decreases reaction|increases activity 14664509
D005680 gamma-Aminobutyric Acid 1-octen-3-ol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|increases activity|increases reaction 14664509
D005680 gamma-Aminobutyric Acid 1-octen-3-ol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB1 protein]]affects cotreatment|increases activity|increases reaction 16569037
D005680 gamma-Aminobutyric Acid 4,5-dimethyl-3-hydroxy-2(5H)-furanone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|increases activity|increases reaction 14664509
D005680 gamma-Aminobutyric Acid 7-hydroxy-7-methyl-3-methylene-1-octene promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB1 protein]]affects cotreatment|increases activity|increases reaction 16569037
D005680 gamma-Aminobutyric Acid Allantoin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|decreases reaction|increases activity 14664509
D005680 gamma-Aminobutyric Acid benzothiazole promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|increases activity|increases reaction 14664509
D005680 gamma-Aminobutyric Acid catechol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|increases activity|increases reaction 14664509
D005680 gamma-Aminobutyric Acid Chlorogenic Acid inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|decreases reaction|increases activity 14664509
D005680 gamma-Aminobutyric Acid Coffee inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|decreases reaction|increases activity 14664509
D005680 gamma-Aminobutyric Acid Ethanol analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|increases activity|increases reaction 12926865
D005680 gamma-Aminobutyric Acid geraniol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB1 protein]]affects cotreatment|increases activity|increases reaction 16569037
D005680 gamma-Aminobutyric Acid Guaiacol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|increases activity|increases reaction 14664509
D005680 gamma-Aminobutyric Acid linalool promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB1 protein]]affects cotreatment|increases activity|increases reaction 16569037
D005680 gamma-Aminobutyric Acid maltol inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|decreases reaction|increases activity 14664509
D005680 gamma-Aminobutyric Acid Theobromine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|decreases reaction|increases activity 14664509
D005680 gamma-Aminobutyric Acid Theophylline inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|decreases reaction|increases activity 14664509
D005680 gamma-Aminobutyric Acid delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]affects binding|increases activity|increases reaction 11156579
D005680 gamma-Aminobutyric Acid Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]affects binding|increases activity|increases reaction 10049148
D005680 gamma-Aminobutyric Acid Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]affects binding|increases activity|increases reaction 10049148
D005680 gamma-Aminobutyric Acid Lindane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]affects binding|decreases reaction|increases activity 11156579
D005680 gamma-Aminobutyric Acid Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]affects binding|increases activity|increases reaction 10049148
D005680 gamma-Aminobutyric Acid Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]affects binding|increases activity|increases reaction 10049148
D005680 gamma-Aminobutyric Acid Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]affects binding|increases activity|increases reaction 10049148
D005680 gamma-Aminobutyric Acid Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]affects binding|increases activity|increases reaction 10049148
D005680 gamma-Aminobutyric Acid Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 1712603
D005680 gamma-Aminobutyric Acid Ethanol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 1712603
D005680 gamma-Aminobutyric Acid gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]affects binding|increases activity 1712603
D005680 gamma-Aminobutyric Acid Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 1712603
D005680 gamma-Aminobutyric Acid Bicuculline inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|decreases reaction|increases activity 1977069
D005680 gamma-Aminobutyric Acid Flumazenil promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|increases activity|increases reaction 1977069
D005680 gamma-Aminobutyric Acid gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]affects binding|increases activity 1977069
D005680 gamma-Aminobutyric Acid gamma-Aminobutyric Acid results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB1 protein]affects binding|increases activity 2165521
D005680 gamma-Aminobutyric Acid methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|increases activity|increases reaction 1977069
D005680 gamma-Aminobutyric Acid Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|increases activity|increases reaction 1977069
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GABRB1 mRNAaffects expression 16483693
D001374 Azacitidine Azacitidine results in increased expression of GABRB1 mRNAincreases expression 19194470
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GABRB1 mRNAdecreases expression 20382639
C005465 benzothiazole benzothiazole promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|increases activity|increases reaction 14664509
D001640 Bicuculline Bicuculline inhibits the reaction [Ethanol analog results in increased activity of [GABRA1 protein co-treated with GABRB1 protein]]affects cotreatment|decreases reaction|increases activity 16569037
D001640 Bicuculline Bicuculline inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|decreases reaction|increases activity 1977069
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of GABRB1 mRNAdecreases expression 16644059
C034221 catechol catechol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|increases activity|increases reaction 14664509
D002726 Chlorogenic Acid Chlorogenic Acid inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|decreases reaction|increases activity 14664509
D003069 Coffee Coffee inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|decreases reaction|increases activity 14664509
C086916 delta-hexachlorocyclohexane delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]affects binding|increases activity|increases reaction 11156579
C086916 delta-hexachlorocyclohexane delta-hexachlorocyclohexane results in decreased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]affects binding|decreases activity 11156579
D003975 Diazepam Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 1712603
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of GABRB1 mRNAdecreases expression 12807726
D004726 Endosulfan Endosulfan binds to GABRB1 proteinaffects binding 11489356
D000431 Ethanol Bicuculline inhibits the reaction [Ethanol analog results in increased activity of [GABRA1 protein co-treated with GABRB1 protein]]affects cotreatment|decreases reaction|increases activity 16569037
D000431 Ethanol Ethanol analog promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|increases activity|increases reaction 12926865
D000431 Ethanol Ethanol analog results in increased activity of [GABRA1 protein co-treated with GABRB1 protein]affects cotreatment|increases activity 16569037
D000431 Ethanol Ethanol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 1712603
D005045 Etomidate Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]affects binding|increases activity|increases reaction 10049148
D005045 Etomidate Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]affects binding|increases activity|increases reaction 10049148
C082360 fipronil fipronil binds to GABRB1 proteinaffects binding 11489356
D005442 Flumazenil Flumazenil promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|increases activity|increases reaction 1977069
D005481 Flurothyl Flurothyl results in decreased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]affects binding|decreases activity 11090101
C007836 geraniol geraniol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB1 protein]]affects cotreatment|increases activity|increases reaction 16569037
D006139 Guaiacol Guaiacol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|increases activity|increases reaction 14664509
C018584 linalool linalool promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB1 protein]]affects cotreatment|increases activity|increases reaction 16569037
D001556 Lindane Lindane binds to GABRB1 proteinaffects binding 11489356
D001556 Lindane Lindane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]affects binding|decreases reaction|increases activity 11156579
C008316 maltol maltol inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|decreases reaction|increases activity 14664509
C034818 methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|increases activity|increases reaction 1977069
D009118 Muscimol Muscimol binds to GABRB1 proteinaffects binding 9661255
D010424 Pentobarbital Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]affects binding|increases activity|increases reaction 10049148
D010424 Pentobarbital Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]affects binding|increases activity|increases reaction 10049148
D010424 Pentobarbital Pentobarbital results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]affects binding|increases activity 10049148
D010424 Pentobarbital Pentobarbital results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]affects binding|increases activity 10049148
D010424 Pentobarbital Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 1712603
D010424 Pentobarbital Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|increases activity|increases reaction 1977069
D010424 Pentobarbital Pentobarbital results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB1 protein]affects binding|increases activity 2165521
D010424 Pentobarbital Pentobarbital results in increased expression of GABRB1 mRNAincreases expression 9661255
D011374 Progesterone Progesterone affects the expression of GABRB1 proteinaffects expression 15834956
D015742 Propofol Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]affects binding|increases activity|increases reaction 10049148
D015742 Propofol Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]affects binding|increases activity|increases reaction 10049148
D013805 Theobromine Theobromine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|decreases reaction|increases activity 14664509
D013806 Theophylline Theophylline inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]affects binding|decreases reaction|increases activity 14664509
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 3.5718926900 17676605
MESH:D000138 Acidosis Ammonium Chloride 9.2918287403
MESH:D000138 Acidosis Ethanol 9.2911192467
MESH:D000236 Adenoma Diethylnitrosamine 2.656695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 3.5519061943 17620307 16434500 17162532 18056438 19052882
MESH:D000382 Agricultural Workers' Diseases Lindane 4.0212661182
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.9615451040 15451039
MESH:D000853 Anophthalmos Ethanol 4.4715513904
MESH:D001008 Anxiety Disorders Diazepam 13.6118313124 16284244
MESH:D001008 Anxiety Disorders Ethanol 13.6111141031
MESH:D001008 Anxiety Disorders Pentobarbital 13.6118313124 11141031
MESH:D001249 Asthma Theophylline 3.759701106 12113382
MESH:D001321 Autistic Disorder marker/mechanism 16770606 16080114
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9817868700
MESH:D001930 Brain Injuries Progesterone 3.9115665606 15845082 15380490
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.0717474063
MESH:D001943 Breast Neoplasms Lindane 2.0714688026
MESH:D001943 Breast Neoplasms Progesterone 2.0716175315 15562024 17614352
MESH:D002056 Burns Ethanol 4.3116374292
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4315673190 18705752 15721981 3786805 15700767 10355542 16227642 16124888 16050911 16192424 16097048 16011737
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.3118788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.3116935385 19208518 18971187 19539802 19418558 17173139 10737359 3084413 20214788 19394651 16569478 19171122 18665156 18506893 17162532 16807293 16540662 16878318 19383236 20727157 19107877 19335982 16830150 20514400 20007298 17978847 19519916 17138121 20524982 3581430 20432363 18393292 16698587 19919837 17428255 10672840 20084675 17055752 18691550 19701751 16681979 19052882 18056438 18785209 20935162 17761372 21159647 16288022 11831363 16328049 16779866 18788625 20512989 16502159 18494052 18210153 18978308 19822196 20101231
MESH:D006528 Carcinoma, Hepatocellular Ethanol 4.3118788625 15763234 15289165
MESH:D006332 Cardiomegaly Ethanol 3.2419332462
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 5.8720889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 5.8717174075 7505956 21159647 2727394
MESH:D002637 Chest Pain Theophylline 5.5115238202
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.3919052882
MESH:D002971 Cleft Lip Ethanol 3.4015513904
MESH:D002972 Cleft Palate Diazepam 6.273629520
MESH:D002972 Cleft Palate Ethanol 6.2715513904
MESH:D003110 Colonic Neoplasms geraniol 4.6115374632
MESH:D015179 Colorectal Neoplasms Azacitidine 2.7219934284
MESH:D019465 Craniofacial Abnormalities Ethanol 2.3115451040 19302082 15513904 15451039 11873399 10194807 11198716
MESH:D003490 Cyanosis Endosulfan 5.207900959
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.1020387270
MESH:D003929 Diabetic Neuropathies Progesterone 4.1517187935
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 5.6710915739 3732212 16177239 2869522 19085960 7179309 15968718 11566570 21278145 15027814 16227642 10092053 7440962 19336974 4309450 6623471 3786805 6884620 9327722 17522070 7120509 15998439
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 5.6719107877
MESH:D056486 Drug-Induced Liver Injury Ethanol 5.6711566570
MESH:D004417 Dyspnea Endosulfan 4.923388749 7900959
MESH:D004421 Dystonia Diazepam 5.341851702
MESH:D004646 Emphysema Endosulfan 6.197900959
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.4517692515
MESH:D004715 Endometriosis Progesterone 3.4616134523
MESH:D004828 Epilepsies, Partial Diazepam 5.183922381
MESH:D004827 Epilepsy Diazepam 4.37821787
MESH:D004832 Epilepsy, Absence Diazepam 4.916426943 6401628
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7616302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.2920426865
MESH:D004938 Esophageal Neoplasms Ethanol 4.2916704527
MESH:D005234 Fatty Liver Carbon Tetrachloride 11.4016239168 12795759 16045604 12631006 17595544 15959796 61145 19224547
MESH:D005234 Fatty Liver Diethylnitrosamine 11.4021071580 20387270
MESH:D005234 Fatty Liver Ethanol 11.4016409862 19236843 18620774
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.3017920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.9416946407 15451040 10194807 15513904
MESH:D005355 Fibrosis Carbon Tetrachloride 3.1118705752
MESH:D005756 Gastritis Ethanol 4.3315046732
MESH:D006470 Hemorrhage Endosulfan 4.987900959
MESH:D006501 Hepatic Encephalopathy marker/mechanism 15929193
MESH:D006505 Hepatitis Carbon Tetrachloride 3.2619110552 19900420
MESH:D006930 Hyperalgesia Ethanol 3.4418783367
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1816899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7415338365
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.0615869954
MESH:D007248 Infertility, Male Endosulfan 7.058588293 9432128
MESH:D007248 Infertility, Male Theophylline 7.0516988215
MESH:D007249 Inflammation Diethylnitrosamine 4.5518785209
MESH:D007249 Inflammation Progesterone 4.5515869954
MESH:D007569 Jaw Abnormalities Ethanol 4.0915513904
MESH:D007859 Learning Disorders Endosulfan 9.028157075
MESH:D007859 Learning Disorders Ethanol 9.0215451040
MESH:D007938 Leukemia Azacitidine 3.5119148494
MESH:D007951 Leukemia, Myeloid Azacitidine 4.3119077051
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 2.9418720364 17596541
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 4.8619299654
MESH:D017880 Limb Deformities, Congenital Ethanol 3.5617676605
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 9.9316943688 11903743 11408273 16239168 16221502 17334410 21278145 17157831 17174718
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 9.9318665156 18407596 18522880 19638242 20032147
MESH:D008103 Liver Cirrhosis Ethanol 9.9315289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.7418295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.5618472094 18205269 14620537 18395095 12632514 12609069 14512876 16097048 14748882 17900296 12666154 12741479 18210741 14724832 16015684 15057751 15931870 15362042 14716496 16033810 15925388 15052691 16136751 18339082 18472332 18317297 12546737 20821823 17481882 17944888 12898905 16027843 12649538 18279442 12389079 15893842 18395914 18705752 17708605 15996030 18166357 10355542 17557913 18429990 17761835 11481614 15818738 17721639 17805973 14716833 16638106 18263696 16248980 15959796 17869086 15650968 17823541 12586293 15370692 17976157 17565644 16116963 12445418 16011737 15730626 13678700 18412020 15123356 17922224 18420326 15338365 16192424 17698563 17525996 18006644 15876570 18481824 18376398 18277467 12667390 15673190 18251166 18054572 18418968 18187930 18156304 12445421 17766677 17714472 17631135 17640975 12632512 12958196
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 2.5618166357
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.0815720792 17285989 16964402 15830285 16246199
MESH:D008107 Liver Diseases Diethylnitrosamine 6.0817034775
MESH:D008107 Liver Diseases Lindane 6.081715830
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.3117207112 17347304
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.3814706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.1319294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 4.1316942905 19254457 9163691 18648771 21167192 20137499 10737359 19638242 19255062 19426721 19256749 21278145 20118626 19690152 18978307 12112319 19427195 20452335 20492335 18754104 20405173 20101389 19833225 12771043 15885732 19812893 19850985 19499222 20583210 18977376 20434301 21047994 19073162 18644402 20501860 15175105 19996281 19090486 2862719 21071580 2422723 19642983 19294768 19551842
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.2212014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 5.2217174075 18544905 21159647 19539802 19126423 3124819 18164116 16267830 18253720 18079962 19004024 18775883 16842330 17942915 18093689 19009564 17854601 9362446 18282651 2563599 18308698 19519916
MESH:D008175 Lung Neoplasms Azacitidine 2.6921224363
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.6921163286 20512841 20970405 6695378
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.6511408345 17203775
MESH:D008569 Memory Disorders Ethanol 3.8518411066 15451040
MESH:D008924 Mite Infestations fipronil 6.6116884176
MESH:D009006 Monosomy Azacitidine 5.7219299654
MESH:D009101 Multiple Myeloma Azacitidine 3.7218443271 19549372
MESH:D009190 Myelodysplastic Syndromes Azacitidine 3.8017611569 19805378 17596541 18720364
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.423581430 9029167
MESH:D009369 Neoplasms Lindane 3.2016818664 12807735
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.0620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7620387270
MESH:D010051 Ovarian Neoplasms Progesterone 2.4117393432 16525653
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 4.9916540662
MESH:D010190 Pancreatic Neoplasms Ethanol 4.9912384795
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.262563599
MESH:D011471 Prostatic Neoplasms Azacitidine 4.0718324645
MESH:D011471 Prostatic Neoplasms Lindane 4.0712661182 14688026
MESH:D029424 Pulmonary Disease, Chronic Obstructive Theophylline 4.8718983928
MESH:D012021 Reflex, Abnormal Pentobarbital 5.6710930210
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7318045962
MESH:D012640 Seizures Diazepam 24.509754883 15946322 10087439
MESH:D012640 Seizures Endosulfan 24.507539098 10698677
MESH:D012640 Seizures Ethanol 24.509754883
MESH:D012640 Seizures fipronil 24.5010698677
MESH:D012640 Seizures Flurothyl 24.503352866
MESH:D012640 Seizures Lindane 24.5015475178 12842176 7539098
MESH:D012640 Seizures Pentobarbital 24.5010087439 9754883
MESH:D013119 Spinal Cord Injuries Progesterone 3.9315862959 16503802
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.5118456281
MESH:D013274 Stomach Neoplasms Ethanol 2.5118456281
MESH:D013276 Stomach Ulcer Ethanol 3.2317189318 17918041 9562338 11906479 9211565 16755016
MESH:D013375 Substance Withdrawal Syndrome Diazepam 14.959754883
MESH:D013375 Substance Withdrawal Syndrome Ethanol 14.959754883
MESH:D013375 Substance Withdrawal Syndrome Pentobarbital 14.9511529278 9754883
MESH:D013742 Tetanus Propofol 6.072903605
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.727505956
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:13685 Synaptic Transmission
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28495
    • No data
    Releated disease ID Related disease Name
    PA443309Alcoholism
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00186 potentiator Lorazepam Anti-anxiety Agents;Hypnotics and Sedatives;Antiemetics;Anticonvulsants;Benzodiazepines;GABA Modulators
    DB00189 agonist Ethchlorvynol Hypnotics and Sedatives
    DB00231 potentiator Temazepam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators
    DB00349 potentiator Clobazam Anticonvulsants;Benzodiazepines
    DB00404 potentiator Alprazolam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators
    DB00431 antagonist Dermadex Crm Antiscabies Agent;Scabicide;Insecticides
    DB00475 potentiator Pro Chlorax Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators
    DB00546 potentiator Adinazolam Anti-anxiety Agents;Antidepressive Agents
    DB00628 potentiator Clorazepate Anti-anxiety Agents;Anticonvulsants;GABA Modulators
    DB00683 potentiator Midazolam Anti-anxiety Agents;Hypnotics and Sedatives;Adjuvants, Anesthesia;GABA Modulators;Anesthetics, Intravenous
    DB00690 potentiator Flurazepam Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators
    DB00801 potentiator Halazepam Anti-anxiety Agents;Muscle Relaxants;Benzodiazepines;Sedative
    DB00829 potentiator Diazepam Anti-anxiety Agents;Hypnotics and Sedatives;Antiemetics;Anticonvulsants;Adjuvants, Anesthesia;GABA Modulators;Anesthetics, Intravenous;Muscle Relaxants, Central
    DB00842 potentiator Oxazepam Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators
    DB00897 potentiator Triazolam Anti-anxiety Agents;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators
    DB01068 potentiator Clonazepam Anticonvulsants;Benzodiazepines;GABA Modulators
    DB01215 potentiator Estazolam Anti-anxiety Agents;Anticonvulsants;GABA Modulators
    DB01440 partial agonist Gamma Hydroxybutyric Acid Adjuvants, Anesthesia;Anesthetics, Intravenous
    DB01558 potentiator Bromazepam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators
    DB01559 potentiator Clotiazepam Anti-anxiety Agents;Hypnotics and Sedatives;Anticonvulsants;Benzodiazepines
    DB01567 potentiator Fludiazepam Anti-anxiety Agents;Benzodiazepines
    DB01587 potentiator Ketazolam Anti-anxiety Agents;Benzodiazepines
    DB01588 potentiator Prazepam Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators
    DB01589 potentiator Quazepam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators
    DB01594 potentiator Cinolazepam Anticonvulsants;Benzodiazepines;Sedatives and Hypnotics
    DB01595 potentiator Nitrazepam Anti-anxiety Agents;Hypnotics and Sedatives;Anticonvulsants;GABA Modulators
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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