Annotation Detail for GABRD
Basic Information Top
| Gene Symbol: | GABRD ( EIG10,EJM7,GEFSP5,MGC45284 ) |
|---|---|
| Gene Full Name: | gamma-aminobutyric acid (GABA) A receptor, delta |
| Band: | 1p36.33 |
| Quick Links | Entrez ID:2563; OMIM: 137163; Uniprot ID:GBRD_HUMAN; ENSEMBL ID: ENSG00000187730; HGNC ID: 4084 |
| Relate to Another Database: | SFARIGene; denovo-db |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| No data |
| No data |
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| Desease Name |
|---|
| Epilepsy, juvenile myoclonic, susceptibility to |
| Generalized epilepsy with febrile seizures plus, type 5, susceptibility to |
| Epilepsy, idiopathic generalized, 10 |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of GABRD mRNA | affects expression | 16483693 |
| D003975 | Diazepam | Diazepam results in increased expression of GABRD mRNA | increases expression | 15802192 |
| D004006 | Dichlorvos | Dichlorvos results in decreased expression of GABRD mRNA | decreases expression | 19146868 |
| D018120 | Finasteride | Finasteride inhibits the reaction [Progesterone affects the expression of GABRD mRNA] | affects expression|decreases reaction | 16914187 16879715 |
| D018120 | Finasteride | Finasteride inhibits the reaction [Progesterone affects the expression of GABRD protein] | affects expression|decreases reaction | 16914187 16879715 |
| D009020 | Morphine | Morphine results in increased expression of GABRD mRNA | increases expression | 15183518 |
| C014707 | nitrosobenzylmethylamine | nitrosobenzylmethylamine results in increased expression of GABRD mRNA | increases expression | 17616710 |
| D010269 | Paraquat | Paraquat results in decreased expression of GABRD mRNA | decreases expression | 19146868 |
| D010278 | Parathion | Parathion results in decreased expression of GABRD mRNA | decreases expression | 19146868 |
| D010424 | Pentobarbital | GABRD protein affects the susceptibility to Pentobarbital | affects response to substance | 15201633 |
| D010424 | Pentobarbital | Pentobarbital results in increased expression of GABRD mRNA | increases expression | 8848253 |
| C033457 | phenobarbital quinidine | phenobarbital quinidine results in increased expression of GABRD mRNA | increases expression | 15802192 |
| C025299 | polyphenols | polyphenols results in decreased expression of GABRD mRNA | decreases expression | 16293270 |
| D011280 | Pregnanolone | Pregnanolone results in decreased expression of GABRD protein | decreases expression | 16914187 |
| D011374 | Progesterone | Finasteride inhibits the reaction [Progesterone affects the expression of GABRD mRNA] | affects expression|decreases reaction | 16879715 16914187 |
| D011374 | Progesterone | Finasteride inhibits the reaction [Progesterone affects the expression of GABRD protein] | affects expression|decreases reaction | 16879715 16914187 |
| D011374 | Progesterone | Progesterone affects the expression of GABRD mRNA | affects expression | 16914187 16879715 |
| D011374 | Progesterone | Progesterone affects the expression of GABRD protein | affects expression | 16879715 15834956 |
| D011374 | Progesterone | Progesterone metabolite affects the expression of GABRD mRNA | affects expression | 16879715 |
| D011374 | Progesterone | Progesterone results in decreased expression of GABRD protein | decreases expression | 16914187 |
| C009413 | tetrahydrodeoxycorticosterone | tetrahydrodeoxycorticosterone results in decreased expression of GABRD protein | decreases expression | 16914187 |
| D014050 | Toluene | Toluene affects the expression of GABRD mRNA | affects expression | 17108153 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000138 | Acidosis | Ammonium Chloride | 3.61 | 18287403 | |
| MESH:D000382 | Agricultural Workers' Diseases | Dichlorvos | 15.04 | 17119214 16611668 12661182 | |
| MESH:D000382 | Agricultural Workers' Diseases | Paraquat | 15.04 | 11874814 | |
| MESH:D000382 | Agricultural Workers' Diseases | Parathion | 15.04 | 17119214 11874814 | |
| MESH:D001008 | Anxiety Disorders | Diazepam | 9.92 | 18313124 16284244 | |
| MESH:D001008 | Anxiety Disorders | Pentobarbital | 9.92 | 11141031 18313124 | |
| MESH:D001480 | Basal Ganglia Diseases | Dichlorvos | 6.03 | 15303389 | |
| MESH:D020201 | Brain Hemorrhage, Traumatic | Progesterone | 5.40 | 17868700 | |
| MESH:D001930 | Brain Injuries | Pregnanolone | 11.75 | 15380490 15665606 | |
| MESH:D001930 | Brain Injuries | Progesterone | 11.75 | 15665606 15845082 15380490 | |
| MESH:D002545 | Brain Ischemia | Morphine | 5.19 | 19211983 | |
| MESH:D001943 | Breast Neoplasms | Parathion | 2.84 | 12762645 | |
| MESH:D001943 | Breast Neoplasms | Progesterone | 2.84 | 16175315 15562024 17614352 | |
| MESH:D002418 | Cattle Diseases | Dichlorvos | 5.71 | 14651886 | |
| MESH:D002493 | Central Nervous System Diseases | Dichlorvos | 5.80 | 12670839 | |
| MESH:D002547 | Cerebral Palsy | Toluene | 5.90 | 9294310 | |
| MESH:D002972 | Cleft Palate | Diazepam | 4.37 | 3629520 | |
| MESH:D003110 | Colonic Neoplasms | polyphenols | 2.68 | 16293270 | |
| MESH:D003128 | Coma | Dichlorvos | 6.06 | 15303389 | |
| MESH:D019465 | Craniofacial Abnormalities | Toluene | 2.88 | 9294310 | |
| MESH:D003643 | Death | Toluene | 5.73 | 6431079 | |
| MESH:D003929 | Diabetic Neuropathies | Pregnanolone | 12.59 | 17187935 | |
| MESH:D003929 | Diabetic Neuropathies | Progesterone | 12.59 | 17187935 | |
| MESH:D003967 | Diarrhea | Morphine | 4.56 | 2540324 | |
| MESH:D056486 | Drug-Induced Liver Injury | polyphenols | 2.75 | 19370779 | |
| MESH:D004421 | Dystonia | Diazepam | 5.70 | 1851702 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | Progesterone | 3.82 | 17692515 | |
| MESH:D004715 | Endometriosis | Progesterone | 3.79 | 16134523 | |
| MESH:D004828 | Epilepsies, Partial | Diazepam | 5.60 | 3922381 | |
| MESH:D004827 | Epilepsy | Diazepam | 4.57 | 821787 | |
| MESH:D004832 | Epilepsy, Absence | Diazepam | 5.23 | 6401628 6426943 | |
| MESH:D004829 | Epilepsy, Generalized | marker/mechanism | |||
| MESH:D004938 | Esophageal Neoplasms | nitrosobenzylmethylamine | 2.78 | 15264214 15150132 15878914 15623463 16510608 15547721 16805852 16704527 15547733 | |
| OMIM:604233 | GENERALIZED EPILEPSY WITH FEBRILE SEIZURES PLUS, TYPE 1 | marker/mechanism | |||
| MESH:D005911 | Gliosis | Paraquat | 5.23 | 11124998 | |
| MESH:D006734 | Horse Diseases | Dichlorvos | 6.06 | 16402567 | |
| MESH:D006941 | Hyperesthesia | Dichlorvos | 6.75 | 12563396 | |
| MESH:D020244 | Infarction, Middle Cerebral Artery | Progesterone | 4.44 | 15869954 | |
| MESH:D007248 | Infertility, Male | Paraquat | 7.54 | 4850670 | |
| MESH:D007248 | Infertility, Male | Parathion | 7.54 | 16029889 | |
| MESH:D007249 | Inflammation | polyphenols | 5.47 | 16366677 | |
| MESH:D007249 | Inflammation | Progesterone | 5.47 | 15869954 | |
| MESH:D007674 | Kidney Diseases | Dichlorvos | 4.26 | 16798900 | |
| MESH:D008107 | Liver Diseases | polyphenols | 2.79 | 16698588 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Progesterone | 2.88 | 17203775 11408345 | |
| MESH:D008607 | Mental Retardation | Toluene | 3.66 | 9294310 | |
| MESH:D016472 | Motor Neuron Disease | Dichlorvos | 6.37 | 11282359 | |
| MESH:D019957 | Motor Skills Disorders | Toluene | 5.27 | 9294310 | |
| MESH:D009349 | Nematode Infections | Dichlorvos | 6.20 | 16402567 | |
| MESH:D009410 | Nerve Degeneration | Dichlorvos | 9.09 | 17850875 11282359 | |
| MESH:D009410 | Nerve Degeneration | Paraquat | 9.09 | 16893418 | |
| MESH:D019636 | Neurodegenerative Diseases | Dichlorvos | 4.94 | 16635102 | |
| MESH:D020258 | Neurotoxicity Syndromes | Dichlorvos | 4.78 | 12186780 | |
| MESH:D010051 | Ovarian Neoplasms | Progesterone | 2.53 | 17393432 16525653 | |
| MESH:D010146 | Pain | Morphine | 4.21 | 20225289 16273134 6776300 15275824 18699797 15215642 | |
| MESH:D010195 | Pancreatitis | Dichlorvos | 4.92 | 16258382 | |
| MESH:D010300 | Parkinson Disease | Paraquat | 2.82 | 15824117 15451049 16140633 16510128 11124998 11445065 11181820 12911755 | |
| MESH:D010302 | Parkinson Disease, Secondary | Dichlorvos | 11.59 | 12645970 | |
| MESH:D010302 | Parkinson Disease, Secondary | Paraquat | 11.59 | 16190885 | |
| MESH:D011014 | Pneumonia | Paraquat | 4.50 | 12504350 | |
| MESH:D011041 | Poisoning | Dichlorvos | 4.99 | 15303389 12460839 17157343 18072136 17603234 16036766 | |
| MESH:D011115 | Polyneuropathies | Dichlorvos | 5.68 | 12563396 | |
| MESH:D011471 | Prostatic Neoplasms | Dichlorvos | 4.74 | 12661182 | |
| MESH:D011471 | Prostatic Neoplasms | Finasteride | 4.74 | 12597149 | |
| MESH:D011658 | Pulmonary Fibrosis | Paraquat | 2.92 | 16324872 17997886 | |
| MESH:D012021 | Reflex, Abnormal | Pentobarbital | 6.07 | 10930210 | |
| MESH:D015427 | Reperfusion Injury | Morphine | 4.14 | 19211983 | |
| MESH:D012128 | Respiratory Distress Syndrome, Adult | Paraquat | 3.94 | 11700416 | |
| MESH:D012131 | Respiratory Insufficiency | Dichlorvos | 5.66 | 17350689 15303389 | |
| MESH:D012135 | Respiratory Sounds | Dichlorvos | 16.71 | 17119214 16611668 | |
| MESH:D012135 | Respiratory Sounds | Paraquat | 16.71 | 11874814 | |
| MESH:D012135 | Respiratory Sounds | Parathion | 16.71 | 17119214 11874814 | |
| MESH:D012140 | Respiratory Tract Diseases | Dichlorvos | 11.71 | 16611668 17119214 | |
| MESH:D012140 | Respiratory Tract Diseases | Parathion | 11.71 | 17119214 | |
| MESH:D012162 | Retinal Degeneration | Paraquat | 3.89 | 16458197 | |
| MESH:D012468 | Salivary Gland Neoplasms | Progesterone | 2.86 | 18045962 | |
| MESH:D012559 | Schizophrenia | marker/mechanism | 18923069 | ||
| MESH:D012640 | Seizures | Diazepam | 14.52 | 10087439 9754883 15946322 | |
| MESH:D012640 | Seizures | Dichlorvos | 14.52 | 12660363 17157343 | |
| MESH:D012640 | Seizures | Pentobarbital | 14.52 | 9754883 10087439 | |
| MESH:D012640 | Seizures | Toluene | 14.52 | 9294310 6431079 | |
| MESH:D013119 | Spinal Cord Injuries | Progesterone | 4.33 | 16503802 15862959 | |
| MESH:D013274 | Stomach Neoplasms | Dichlorvos | 3.20 | 11397402 | |
| MESH:D013274 | Stomach Neoplasms | nitrosobenzylmethylamine | 3.20 | 17575124 12958204 | |
| MESH:D013322 | Strongyloidiasis | Dichlorvos | 6.20 | 14651886 | |
| MESH:D013375 | Substance Withdrawal Syndrome | Diazepam | 10.78 | 9754883 | |
| MESH:D013375 | Substance Withdrawal Syndrome | Pentobarbital | 10.78 | 9754883 11529278 | |
| MESH:D013705 | Temporomandibular Joint Disorders | polyphenols | 5.31 | 17997062 | |
| MESH:D013733 | Testicular Diseases | Toluene | 5.01 | 10514026 10048760 |
| Pathway ID | Pathway Name |
|---|---|
| KEGG:04080 | Neuroactive ligand-receptor interaction |
Pharmacogenomics Knowledge Base | Drugbank ID | Action | Drug Name | Description |
|---|---|---|---|
| DB00186 | potentiator | Lorazepam | Anti-anxiety Agents;Hypnotics and Sedatives;Antiemetics;Anticonvulsants;Benzodiazepines;GABA Modulators |
| DB00231 | potentiator | Temazepam | Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators |
| DB00349 | potentiator | Clobazam | Anticonvulsants;Benzodiazepines |
| DB00404 | potentiator | Alprazolam | Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators |
| DB00475 | potentiator | Pro Chlorax | Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators |
| DB00546 | potentiator | Adinazolam | Anti-anxiety Agents;Antidepressive Agents |
| DB00628 | potentiator | Clorazepate | Anti-anxiety Agents;Anticonvulsants;GABA Modulators |
| DB00683 | potentiator | Midazolam | Anti-anxiety Agents;Hypnotics and Sedatives;Adjuvants, Anesthesia;GABA Modulators;Anesthetics, Intravenous |
| DB00690 | potentiator | Flurazepam | Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators |
| DB00801 | potentiator | Halazepam | Anti-anxiety Agents;Muscle Relaxants;Benzodiazepines;Sedative |
| DB00829 | potentiator | Diazepam | Anti-anxiety Agents;Hypnotics and Sedatives;Antiemetics;Anticonvulsants;Adjuvants, Anesthesia;GABA Modulators;Anesthetics, Intravenous;Muscle Relaxants, Central |
| DB00842 | potentiator | Oxazepam | Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators |
| DB00897 | potentiator | Triazolam | Anti-anxiety Agents;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators |
| DB01068 | potentiator | Clonazepam | Anticonvulsants;Benzodiazepines;GABA Modulators |
| DB01215 | potentiator | Estazolam | Anti-anxiety Agents;Anticonvulsants;GABA Modulators |
| DB01558 | potentiator | Bromazepam | Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators |
| DB01559 | potentiator | Clotiazepam | Anti-anxiety Agents;Hypnotics and Sedatives;Anticonvulsants;Benzodiazepines |
| DB01567 | potentiator | Fludiazepam | Anti-anxiety Agents;Benzodiazepines |
| DB01587 | potentiator | Ketazolam | Anti-anxiety Agents;Benzodiazepines |
| DB01588 | potentiator | Prazepam | Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators |
| DB01589 | potentiator | Quazepam | Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators |
| DB01594 | potentiator | Cinolazepam | Anticonvulsants;Benzodiazepines;Sedatives and Hypnotics |
| DB01595 | potentiator | Nitrazepam | Anti-anxiety Agents;Hypnotics and Sedatives;Anticonvulsants;GABA Modulators |
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