AutismKB 2.0

Annotation Detail for GABRG1


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Basic Information Top
Gene Symbol:GABRG1 ( DKFZp686H2042,MGC33838 )
Gene Full Name: gamma-aminobutyric acid (GABA) A receptor, gamma 1
Band: 4p12
Quick LinksEntrez ID:2565; OMIM: 137166; Uniprot ID:GBRG1_HUMAN; ENSEMBL ID: ENSG00000163285; HGNC ID: 4086
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D019386 Alendronate Alendronate affects the expression of GABRG1 mRNAaffects expression 16079270
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GABRG1 mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of GABRG1 mRNAaffects cotreatment|decreases expression 18164116
D001640 Bicuculline Bicuculline results in decreased expression of GABRG1 mRNAdecreases expression 9600394
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of GABRG1 mRNAaffects expression 12734012
D004026 Dieldrin Dieldrin results in decreased expression of GABRG1 mRNAdecreases expression 9600394
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of GABRG1 mRNAaffects cotreatment|decreases expression 18164116
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of GABRG1 mRNAaffects expression 16079270
D005419 Flavonoids Flavonoids results in increased expression of GABRG1 mRNAincreases expression 18035473
D020849 Raloxifene Raloxifene affects the expression of GABRG1 mRNAaffects expression 16079270
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D000236 Adenoma beta-Naphthoflavone 7.1919389873
MESH:D000236 Adenoma Diethylnitrosamine 7.196695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.1418056438 17620307 17162532 19061943 16434500 19052882
MESH:D000419 Albuminuria Raloxifene 4.7917451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.5715800139
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001930 Brain Injuries Raloxifene 4.6916580743
MESH:D001943 Breast Neoplasms Dieldrin 2.1015770527 11859874
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1017474063
MESH:D001943 Breast Neoplasms Raloxifene 2.1015758505 15572757 16912660 17049068 17893378 16837676 17440819 17595753 17261762 17242785 17952589 15775269
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9916192424 15721981 18705752 10355542 16050911 16227642 16097048 15700767 16124888 15673190 16011737 3786805
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.0918788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.0921159647 16288022 18971187 19171122 19394651 17138121 19383236 17173139 16540662 17761372 19822196 17978847 18691550 17428255 18978308 17055752 20007298 3084413 20432363 16569478 18665156 18393292 16830150 20214788 16328049 18210153 19335982 19208518 11831363 19919837 18056438 18788625 19418558 20727157 20512989 19701751 18785209 20514400 17162532 19539802 20524982 19052882 18494052 16878318 16698587 10672840 19519916 18506893 10737359 16935385 19107877 16779866 20935162 16807293 20084675 3581430 20101231 16681979 16502159
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.2317572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5615775269
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.9717174075 2727394 7505956 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8419052882
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0017333356 15861022 11677210 17110522 17681005 16105132 16919318
MESH:D003072 Cognition Disorders Raloxifene 4.8315800139
MESH:D003865 Depressive Disorder, Major Raloxifene 4.3117474826
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2220387270
MESH:D003928 Diabetic Nephropathies Raloxifene 4.0917451421 17308373 15920148
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.062869522 6623471 3732212 11566570 17522070 15998439 7440962 3786805 9327722 10092053 15968718 7120509 21278145 6884620 4309450 7179309 10915739 19336974 16227642 15027814 16177239 19085960
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 4.0619107877
MESH:D004487 Edema Raloxifene 3.5115860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.7812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 9.7815845917
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3816302075
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.2819224547 12795759 16239168 12631006 61145 15959796 16045604 17595544
MESH:D005234 Fatty Liver Diethylnitrosamine 20.2821071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.2815345470
MESH:D005234 Fatty Liver Raloxifene 20.2817473493
MESH:D005355 Fibrosis Carbon Tetrachloride 3.6718705752
MESH:D006331 Heart Diseases Raloxifene 3.6511110106
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7919110552 19900420
MESH:D006930 Hyperalgesia Alendronate 4.8516769263
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006973 Hypertension Raloxifene 2.9217577099 15787275
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216945680 16569931
MESH:D007247 Infertility, Female Dieldrin 10.9110630421
MESH:D007247 Infertility, Female Ethinyl Estradiol 10.9112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5917937319
MESH:D007249 Inflammation Diethylnitrosamine 5.4618785209
MESH:D007249 Inflammation Flavonoids 5.4617296493
MESH:D007889 Leiomyoma Raloxifene 4.6816973256
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.9016221502 17157831 17334410 11408273 17174718 16943688 11903743 16239168 21278145
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.9018665156 18407596 20032147 19638242 18522880
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7518418968 15925388 17976157 17481882 12445421 12389079 12958196 18006644 16192424 15370692 17766677 16136751 18705752 12649538 18156304 17698563 11481614 18054572 12586293 14620537 16097048 14724832 15123356 18472094 18205269 17869086 17721639 14512876 18187930 12445418 18166357 15650968 15052691 15893842 18420326 16015684 15818738 17557913 16011737 17714472 17640975 18412020 12667390 15338365 17900296 17805973 17631135 18251166 17525996 18395914 10355542 15931870 12741479 18210741 20821823 16248980 13678700 12666154 12632512 17823541 17565644 18277467 16027843 15673190 15876570 14748882 18429990 14716496 17761835 12546737 16033810 15730626 18279442 18472332 18481824 12898905 18395095 12632514 17944888 17708605 15959796 16638106 15057751 17922224 12609069 18376398 15996030 18263696 18339082 16116963 18317297 14716833 15362042
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.2016964402 16246199 15830285 15720792 17285989
MESH:D008107 Liver Diseases Diethylnitrosamine 4.2017034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8516899240 14706259
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 11.2821295105 19389873
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.2819294768
MESH:D008113 Liver Neoplasms Dieldrin 11.288742319 9539021
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.2819638242 19255062 19499222 20501860 18644402 20583210 19690152 20101389 15175105 19996281 18977376 18978307 21278145 15885732 19294768 20118626 19426721 20434301 18754104 21071580 9163691 19256749 19833225 19254457 19812893 19090486 20452335 10737359 20137499 21167192 12771043 2862719 12112319 2422723 19642983 19073162 19551842 21047994 20492335 18648771 16942905 19427195 19850985 20405173
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.5318164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.5312014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.532563599 18775883 19519916 18093689 19126423 18079962 17854601 18544905 9362446 19009564 16842330 19539802 17174075 16267830 18164116 21159647 3124819 18308698 17942915 18253720 19004024 18282651
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.766695378 20970405 21163286 20512841
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.8215863610
MESH:D009101 Multiple Myeloma Raloxifene 3.5616497877
MESH:D009232 Myxoma Raloxifene 5.8216343187
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.629029167 3581430
MESH:D009369 Neoplasms Dieldrin 3.548820588
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3820387270
MESH:D010024 Osteoporosis Alendronate 8.1217882678
MESH:D010024 Osteoporosis Raloxifene 8.1217882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.4117823083 17893378 15758505 15579764
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4716540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010300 Parkinson Disease Dieldrin 3.5816112328 11181820 11445065 17291500 16809432
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.702563599
MESH:D011471 Prostatic Neoplasms Raloxifene 3.5816536755 15731164 16220300
MESH:D011537 Pruritus Ethinyl Estradiol 3.5515861022 16919318
MESH:D011693 Purpura Raloxifene 5.8215770314
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D020521 Stroke Raloxifene 3.9616837676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.117505956
MESH:D013978 Tibial Fractures Raloxifene 5.4719048282
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 2.8717572228
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D054556 Venous Thromboembolism Raloxifene 5.4716837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.8216343187
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28500
    • No data
    Releated disease ID Related disease Name
    PA153906318Autism Spectrum Disorder
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00186 potentiator Lorazepam Anti-anxiety Agents;Hypnotics and Sedatives;Antiemetics;Anticonvulsants;Benzodiazepines;GABA Modulators
    DB00231 potentiator Temazepam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators
    DB00349 potentiator Clobazam Anticonvulsants;Benzodiazepines
    DB00404 potentiator Alprazolam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators
    DB00475 potentiator Pro Chlorax Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators
    DB00546 potentiator Adinazolam Anti-anxiety Agents;Antidepressive Agents
    DB00628 potentiator Clorazepate Anti-anxiety Agents;Anticonvulsants;GABA Modulators
    DB00683 potentiator Midazolam Anti-anxiety Agents;Hypnotics and Sedatives;Adjuvants, Anesthesia;GABA Modulators;Anesthetics, Intravenous
    DB00690 potentiator Flurazepam Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators
    DB00801 potentiator Halazepam Anti-anxiety Agents;Muscle Relaxants;Benzodiazepines;Sedative
    DB00829 potentiator Diazepam Anti-anxiety Agents;Hypnotics and Sedatives;Antiemetics;Anticonvulsants;Adjuvants, Anesthesia;GABA Modulators;Anesthetics, Intravenous;Muscle Relaxants, Central
    DB00842 potentiator Oxazepam Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators
    DB00897 potentiator Triazolam Anti-anxiety Agents;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators
    DB01068 potentiator Clonazepam Anticonvulsants;Benzodiazepines;GABA Modulators
    DB01215 potentiator Estazolam Anti-anxiety Agents;Anticonvulsants;GABA Modulators
    DB01558 potentiator Bromazepam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators
    DB01559 potentiator Clotiazepam Anti-anxiety Agents;Hypnotics and Sedatives;Anticonvulsants;Benzodiazepines
    DB01567 potentiator Fludiazepam Anti-anxiety Agents;Benzodiazepines
    DB01587 potentiator Ketazolam Anti-anxiety Agents;Benzodiazepines
    DB01588 potentiator Prazepam Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators
    DB01589 potentiator Quazepam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators
    DB01594 potentiator Cinolazepam Anticonvulsants;Benzodiazepines;Sedatives and Hypnotics
    DB01595 potentiator Nitrazepam Anti-anxiety Agents;Hypnotics and Sedatives;Anticonvulsants;GABA Modulators
    No data
    No data
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    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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