AutismKB 2.0

Annotation Detail for GABRG2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:GABRG2 ( CAE2,ECA2,GEFSP3 )
Gene Full Name: gamma-aminobutyric acid (GABA) A receptor, gamma 2
Band: 5q34
Quick LinksEntrez ID:2566; OMIM: 137164; Uniprot ID:GBRG2_HUMAN; ENSEMBL ID: ENSG00000113327; HGNC ID: 4087
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
CHEMDEPENDENCY
methamphetamine abuse
Seizures, Febrile
epilepsy
NEUROLOGICAL
seizures
event-related prefrontal activity
alcohol-dependence
alcohol dependence
prefrontal activity
No data
Desease Name
Epilepsy, childhood absence, susceptibility to, 2
Epilepsy, generalized, with febrile seizures plus, type 3
Febrilel, convulsions, familial, 8
Myoclonic epilepsy, severe, of infancy
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C091518 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]affects binding 14637376
C091518 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]affects binding 14637376
C091518 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane Dieldrin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
C091518 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane Dieldrin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
C091518 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane gamma-Aminobutyric Acid affects the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|affects reaction 14637376
C091518 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane Lindane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
C091518 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane Lindane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
C091518 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
C091518 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
C091518 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
C091518 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
C091518 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane tert-butylbicyclo-2-benzoate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
C091518 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane tert-butylbicyclo-2-benzoate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
C091518 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane tert-butylbicyclophosphorothionate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
C091518 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane tert-butylbicyclophosphorothionate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
C118559 1-bromopropane 1-bromopropane results in increased expression of GABRG2 mRNAincreases expression 19576243
C036531 2,6-xylenol 2,6-xylenol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2]affects binding|increases activity 11399263
C034047 2-cresol 2-cresol results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein]affects binding|increases activity 11399263
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of GABRG2 mRNAdecreases expression 18648102
C006477 alphaxalone alphaxalone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 12939268
C006477 alphaxalone alphaxalone results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]affects binding|increases activity 12939268
D005680 gamma-Aminobutyric Acid 1-Butanol affects the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein]]affects binding|affects reaction|increases activity 11137757
D005680 gamma-Aminobutyric Acid beta-thujone inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction|increases activity 15588619
D005680 gamma-Aminobutyric Acid Camphor promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 15588619
D005680 gamma-Aminobutyric Acid carvone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 15588619
D005680 gamma-Aminobutyric Acid delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]affects binding|increases activity|increases reaction 11156579
D005680 gamma-Aminobutyric Acid Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of GABRG2 protein]increases activity|increases reaction 10797553
D005680 gamma-Aminobutyric Acid Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]affects binding|increases activity|increases reaction 10049148
D005680 gamma-Aminobutyric Acid Flumazenil promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 8632757
D005680 gamma-Aminobutyric Acid GABRA5 protein affects the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRB2 protein binds to GABRG2 protein]]affects binding|affects reaction|increases activity 10987858
D005680 gamma-Aminobutyric Acid gamma-Aminobutyric Acid affects the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|affects reaction 14637376
D005680 gamma-Aminobutyric Acid gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]affects binding|increases activity 11812690
D005680 gamma-Aminobutyric Acid gamma-Aminobutyric Acid binds to and results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein]affects binding|increases activity 11137757
D005680 gamma-Aminobutyric Acid gamma-Aminobutyric Acid results in increased activity of GABRG2 proteinincreases activity 10797553
D005680 gamma-Aminobutyric Acid isoborneol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 15588619
D005680 gamma-Aminobutyric Acid Lindane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]affects binding|decreases reaction|increases activity 11156579
D005680 gamma-Aminobutyric Acid Menthol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 15588619
D005680 gamma-Aminobutyric Acid menthone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 15588619
D005680 gamma-Aminobutyric Acid Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]affects binding|increases activity|increases reaction 10049148
D005680 gamma-Aminobutyric Acid Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]affects binding|increases activity|increases reaction 10049148
D005680 gamma-Aminobutyric Acid Ro 15-4513 promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 8632757
D005680 gamma-Aminobutyric Acid Urethane promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 11812690
D005680 gamma-Aminobutyric Acid gamma-Aminobutyric Acid results in increased activity of [GABRR1 protein binds to GABRG2 protein]affects binding|increases activity 12106692
D005680 gamma-Aminobutyric Acid Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRR1 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 12106692
D005680 gamma-Aminobutyric Acid Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 1712603
D005680 gamma-Aminobutyric Acid Ethanol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 1712603
D005680 gamma-Aminobutyric Acid gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]affects binding|increases activity 1712603
D005680 gamma-Aminobutyric Acid Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 1712603
D005680 gamma-Aminobutyric Acid alphaxalone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 12939268
D005680 gamma-Aminobutyric Acid Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 12939268
D005680 gamma-Aminobutyric Acid gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]affects activity|affects binding 17054655
D005680 gamma-Aminobutyric Acid gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]affects binding|increases activity 12939268
D005680 gamma-Aminobutyric Acid gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]affects cotreatment|increases activity 11123204
D005680 gamma-Aminobutyric Acid [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chloridesaffects cotreatment|increases activity|increases transport 11123204
D005680 gamma-Aminobutyric Acid gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]affects cotreatment|increases activity 11123204
D005680 gamma-Aminobutyric Acid [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chloridesaffects cotreatment|increases activity|increases transport 11123204
D005680 gamma-Aminobutyric Acid gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]affects cotreatment|increases activity 11123204
D005680 gamma-Aminobutyric Acid [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chloridesaffects cotreatment|increases activity|increases transport 11123204
D005680 gamma-Aminobutyric Acid gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]affects cotreatment|increases activity 11123204
D005680 gamma-Aminobutyric Acid [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chloridesaffects cotreatment|increases activity|increases transport 11123204
D005680 gamma-Aminobutyric Acid gamma-Aminobutyric Acid results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2]affects binding|increases activity 11399263
D005680 gamma-Aminobutyric Acid gamma-Aminobutyric Acid results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB1 protein]affects binding|increases activity 2165521
D005680 gamma-Aminobutyric Acid Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 12939268
D005680 gamma-Aminobutyric Acid Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects activity|affects binding|decreases reaction 17054655
D005680 gamma-Aminobutyric Acid pregnenolone sulfate inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects activity|affects binding|decreases reaction 17054655
D005680 gamma-Aminobutyric Acid Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 12939268
D005680 gamma-Aminobutyric Acid topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]affects cotreatment|decreases reaction|increases activity|increases transport 11123204
D005680 gamma-Aminobutyric Acid topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]affects cotreatment|decreases reaction|increases activity|increases transport 11123204
D005680 gamma-Aminobutyric Acid topiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]affects cotreatment|increases activity|increases reaction|increases transport 11123204
D005680 gamma-Aminobutyric Acid Zinc inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects activity|affects binding|decreases reaction 17054655
D001569 Benzodiazepines GABRG2 protein affects the susceptibility to Benzodiazepinesaffects response to substance 7644489
C036150 beta-carboline-3-carboxylic acid methyl ester GABRG2 protein mutant form binds to beta-carboline-3-carboxylic acid methyl esteraffects binding 10880692
C005790 beta-thujone beta-thujone inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction|increases activity 15588619
D001761 Bleomycin Bleomycin results in decreased expression of GABRG2 mRNAdecreases expression 15808516
C054626 bretazenil bretazenil binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]affects binding|increases activity 8632757
C054626 bretazenil bretazenil binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]affects binding|increases activity 8632757
C015044 bromoform bromoform binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]affects activity|affects binding 12505655
D020001 1-Butanol 1-Butanol affects the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein]]affects binding|affects reaction|increases activity 11137757
D002164 Camphor Camphor promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 15588619
C006923 carvone carvone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 15588619
D002712 Chlorides [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chloridesaffects cotreatment|increases activity|increases transport 11123204
D002712 Chlorides [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chloridesaffects cotreatment|increases activity|increases transport 11123204
D002712 Chlorides [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chloridesaffects cotreatment|increases activity|increases transport 11123204
D002712 Chlorides [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chloridesaffects cotreatment|increases activity|increases transport 11123204
D002712 Chlorides topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]affects cotreatment|decreases reaction|increases activity|increases transport 11123204
D002712 Chlorides topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]affects cotreatment|decreases reaction|increases activity|increases transport 11123204
D002712 Chlorides topiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]affects cotreatment|increases activity|increases reaction|increases transport 11123204
C021604 CL 218872 CL 218872 binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]affects binding|increases activity 8632757
C086916 delta-hexachlorocyclohexane delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]affects binding|increases activity|increases reaction 11156579
C086916 delta-hexachlorocyclohexane delta-hexachlorocyclohexane results in decreased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]affects binding|decreases activity 11156579
C086916 delta-hexachlorocyclohexane delta-hexachlorocyclohexane results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]affects binding|decreases activity 11156579
C086916 delta-hexachlorocyclohexane delta-hexachlorocyclohexane results in decreased activity of [GABRA4 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]affects binding|decreases activity 11156579
D003975 Diazepam Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of GABRG2 protein]increases activity|increases reaction 10797553
D003975 Diazepam GABRG2 protein affects the susceptibility to Diazepamaffects response to substance 10797553
D003975 Diazepam Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 1712603
D003975 Diazepam GABRG2 protein mutant form binds to Diazepamaffects binding 10880692
D003975 Diazepam Diazepam results in increased activity of GABRG2 proteinincreases activity 15613639
D003975 Diazepam GABRG2 protein affects the susceptibility to Diazepamaffects response to substance 7748319
D004026 Dieldrin Dieldrin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
D004026 Dieldrin Dieldrin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
D004026 Dieldrin Dieldrin inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
D004026 Dieldrin Dieldrin results in decreased expression of GABRG2 mRNAdecreases expression 9302086
D007980 Levodopa Levodopa results in decreased expression of GABRG2 mRNAdecreases expression 15837143
D000431 Ethanol Ethanol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 1712603
D000431 Ethanol GABRG2 protein affects the susceptibility to Ethanolaffects response to substance 7748319
C044610 etizolam etizolam results in decreased expression of GABRG2 mRNA alternative formdecreases expression 16107249
D005045 Etomidate Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]affects binding|increases activity|increases reaction 10049148
D005045 Etomidate Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 12939268
D005045 Etomidate Etomidate results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]affects binding|increases activity 12939268
D005442 Flumazenil Flumazenil binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]affects binding|increases activity 8632757
D005442 Flumazenil Flumazenil binds to [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]affects binding 8632757
D005442 Flumazenil Flumazenil promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 8632757
D005445 Flunitrazepam Flunitrazepam binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]affects binding|increases activity 8632757
D005481 Flurothyl Flurothyl results in decreased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]affects binding|decreases activity 11090101
D018682 GABA Agents GABA Agents binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]affects binding|increases activity 8632757
D018682 GABA Agents GABA Agents binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]affects binding|increases activity 8632757
D006591 Hexobarbital Hexobarbital affects the expression of GABRG2 mRNAaffects expression 9336343
C022871 isoborneol isoborneol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 15588619
C063822 L 663581 L 663581 binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]affects binding|increases activity 8632757
C063822 L 663581 L 663581 binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]affects binding|increases activity 8632757
D001556 Lindane Lindane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
D001556 Lindane Lindane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
D001556 Lindane Lindane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]affects binding|decreases reaction|increases activity 11156579
D008140 Lorazepam Lorazepam results in decreased expression of GABRG2 mRNA alternative formdecreases expression 16107249
D008345 Manganese Manganese results in increased expression of GABRG2 mRNAincreases expression 17175027
C025340 manganese chloride manganese chloride results in increased expression of GABRG2 mRNAincreases expression 17175027
D008610 Menthol Menthol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 15588619
C019466 menthone menthone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 15588619
D008874 Midazolam GABRG2 protein alternative form affects the susceptibility to Midazolamaffects response to substance 10880692
D008874 Midazolam GABRG2 protein mutant form binds to Midazolamaffects binding 10880692
D009151 Mustard Gas Mustard Gas results in increased expression of GABRG2 mRNAincreases expression 15674844
D010424 Pentobarbital Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]affects binding|increases activity|increases reaction 10049148
D010424 Pentobarbital Pentobarbital results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]affects binding|increases activity 10049148
D010424 Pentobarbital GABRG2 protein affects the susceptibility to Pentobarbitalaffects response to substance 12106692
D010424 Pentobarbital Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRR1 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 12106692
D010424 Pentobarbital Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 1712603
D010424 Pentobarbital Pentobarbital affects the expression of GABRG2 mRNAaffects expression 8787126
9336343
D010424 Pentobarbital Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 12939268
D010424 Pentobarbital Pentobarbital results in decreased expression of GABRG2 mRNAdecreases expression 8412506
D010424 Pentobarbital Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]affects binding|increases activity 12939268
D010424 Pentobarbital Pentobarbital results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB1 protein]affects binding|increases activity 2165521
D010433 Pentylenetetrazole Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
D010433 Pentylenetetrazole Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
D010433 Pentylenetetrazole Pentylenetetrazole inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
D010852 Picrotoxin Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
D010852 Picrotoxin Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
D010852 Picrotoxin Picrotoxin inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
D010852 Picrotoxin Picrotoxin results in decreased activity of [GABRR1 protein binds to GABRG2 protein]affects binding|decreases activity 12106692
D010852 Picrotoxin Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects activity|affects binding|decreases reaction 17054655
D010852 Picrotoxin Picrotoxin results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]affects binding|decreases activity 17054655
C018370 pregnenolone sulfate pregnenolone sulfate inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects activity|affects binding|decreases reaction 17054655
C018370 pregnenolone sulfate pregnenolone sulfate results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]affects binding|decreases activity 17054655
D015742 Propofol Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]affects binding|increases activity|increases reaction 10049148
D015742 Propofol Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 12939268
D015742 Propofol Propofol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]affects binding|increases activity 12939268
D015742 Propofol Propofol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2]affects binding|increases activity 11399263
C042957 Ro 15-4513 Ro 15-4513 binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]affects binding|increases activity 8632757
C042957 Ro 15-4513 Ro 15-4513 promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 8632757
C042957 Ro 15-4513 GABRG2 protein mutant form binds to Ro 15-4513affects binding 10880692
C009250 sevoflurane sevoflurane affects the expression of GABRG2 mRNAaffects expression 15967596
C017947 sodium arsenite sodium arsenite results in increased expression of GABRG2 mRNAincreases expression 17879257
C046308 tert-butylbicyclo-2-benzoate tert-butylbicyclo-2-benzoate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
C046308 tert-butylbicyclo-2-benzoate tert-butylbicyclo-2-benzoate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
C037476 tert-butylbicyclophosphorothionate Dieldrin inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
C037476 tert-butylbicyclophosphorothionate Pentylenetetrazole inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
C037476 tert-butylbicyclophosphorothionate Picrotoxin inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
C037476 tert-butylbicyclophosphorothionate tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]affects binding 14637376
C037476 tert-butylbicyclophosphorothionate tert-butylbicyclophosphorothionate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
C037476 tert-butylbicyclophosphorothionate tert-butylbicyclophosphorothionate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|decreases reaction 14637376
D043343 Testosterone Propionate Testosterone Propionate results in decreased expression of GABRG2 mRNAdecreases expression 16957604
D013943 Thymol Thymol results in increased activity of [GABRG2 binds to GABRA1 binds to GABRB2]affects binding|increases activity 11399263
D014050 Toluene Toluene affects the expression of GABRG2 mRNA alternative formaffects expression 17108153
C052342 topiramate topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]affects cotreatment|decreases reaction|increases activity|increases transport 11123204
C052342 topiramate topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]affects cotreatment|decreases reaction|increases activity|increases transport 11123204
C052342 topiramate topiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]affects cotreatment|increases activity|increases reaction|increases transport 11123204
D014520 Urethane Urethane promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 11812690
D015032 Zinc Zinc results in decreased activity of [GABRR1 protein binds to GABRG2 protein]affects binding|decreases activity 12106692
D015032 Zinc GABRG2 protein affects the susceptibility to Zincaffects response to substance 10797553
D015032 Zinc Zinc inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]affects activity|affects binding|decreases reaction 17054655
D015032 Zinc Zinc results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]affects binding|decreases activity 17054655
C049109 zolpidem zolpidem binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]affects binding|increases activity 8632757
C049109 zolpidem GABRG2 protein alternative form affects the susceptibility to zolpidemaffects response to substance 10880692
C049109 zolpidem GABRG2 protein mutant form binds to zolpidemaffects binding 10880692
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 3.3418926900 17676605
MESH:D000138 Acidosis Ethanol 3.9111192467
MESH:D000169 Acrodermatitis Zinc 4.8116889938 17202136 17190629
MESH:D055371 Acute Lung Injury Bleomycin 4.3417118201
MESH:D000230 Adenocarcinoma Urethane 3.1618316556
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Urethane 5.1115814487
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 5.853712494
MESH:D000236 Adenoma Urethane 5.8516926031 11497255 6695378 10530776 10822126 17093202 17195641
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.1015276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.3017306315 16712894
MESH:D000382 Agricultural Workers' Diseases Lindane 3.7912661182
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.7115451040 15451039
MESH:D000437 Alcoholism topiramate 4.5617925516 18552399 19331489
MESH:D000544 Alzheimer Disease Zinc 2.6116325427 16410023 17119284 16580781
MESH:D000755 Anemia, Sickle Cell Zinc 4.3416916123
MESH:D000756 Anemia, Sideroblastic Manganese 9.2616910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 9.2616910769
MESH:D000853 Anophthalmos Ethanol 4.2415513904
MESH:D000860 Anoxia Bleomycin 4.8215782499
MESH:D001008 Anxiety Disorders Diazepam 12.4718313124 16284244
MESH:D001008 Anxiety Disorders Ethanol 12.4711141031
MESH:D001008 Anxiety Disorders Pentobarbital 12.4718313124 11141031
MESH:D001249 Asthma Mustard Gas 4.4710378619
MESH:D001249 Asthma Zinc 4.4717085522
MESH:D001259 Ataxia 1-Butanol 5.037820390
MESH:D001321 Autistic Disorder Benzodiazepines 4.7717630868
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.411440618 11289319
MESH:D001768 Blister Mustard Gas 4.5719167455
MESH:D001836 Body Weight Changes 2-cresol 6.1112820538
MESH:D001930 Brain Injuries Zinc 4.1117109824
MESH:D001943 Breast Neoplasms Dieldrin 3.0911859874 15770527
MESH:D001943 Breast Neoplasms Lindane 3.0914688026
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.5715286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.3717687719 10378619
MESH:D002056 Burns Ethanol 4.0716374292
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.977296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Ethanol 3.9718788625 15763234 15289165
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.9717306315 16507464 15276417
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.377296757
MESH:D002294 Carcinoma, Squamous Cell Bleomycin 6.556189445
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 6.5518572023
MESH:D002294 Carcinoma, Squamous Cell Zinc 6.5516543248
MESH:D006332 Cardiomegaly Ethanol 3.0919332462
MESH:D002318 Cardiovascular Diseases Zinc 3.2416936243
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 9.107505956
MESH:D002471 Cell Transformation, Neoplastic bromoform 9.1018075178
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 9.1019524636 20056578
MESH:D002547 Cerebral Palsy Toluene 5.269294310
MESH:D002659 Child Development Disorders, Pervasive topiramate 3.8515650499
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 2.7019486331 9022650
MESH:D002971 Cleft Lip Ethanol 3.2515513904
MESH:D002972 Cleft Palate Diazepam 8.633629520
MESH:D002972 Cleft Palate Ethanol 8.6315513904
MESH:D002972 Cleft Palate Urethane 8.6312810352
MESH:D019465 Craniofacial Abnormalities Ethanol 3.6315451040 19302082 10194807 15513904 11198716 11873399 15451039
MESH:D019465 Craniofacial Abnormalities Toluene 3.639294310
MESH:D019465 Craniofacial Abnormalities Zinc 3.6319302082
MESH:D003643 Death Pentylenetetrazole 11.886431079
MESH:D003643 Death Toluene 11.886431079
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.268970840 18759878 2524372 12868966 11906362 8156756 14531868 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 2.953621924 2952479
MESH:D003920 Diabetes Mellitus Zinc 3.7016479319
MESH:D003924 Diabetes Mellitus, Type 2 topiramate 3.5316979414
OMIM:607208 DRAVET SYNDROME marker/mechanism
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.419022650 18692083 9653073 18289764 8291058 7440962 1440618 18648102 9328219 11289319 6482804 6679447 16192314
MESH:D056486 Drug-Induced Liver Injury Ethanol 3.4111566570
MESH:D004409 Dyskinesia, Drug-Induced Levodopa 5.7615893579 3690436
MESH:D004421 Dystonia Diazepam 5.121851702
MESH:D004487 Edema Bleomycin 5.8117118201
MESH:D004487 Edema Mustard Gas 5.8111402378 11428647 11428631 9260866
MESH:D004828 Epilepsies, Partial Diazepam 4.943922381
MESH:D004827 Epilepsy Diazepam 6.67821787
MESH:D004827 Epilepsy topiramate 6.6719148780
MESH:D004832 Epilepsy, Absence Diazepam 8.566426943 6401628
MESH:D004832 Epilepsy, Absence Pentylenetetrazole 8.566426943
OMIM:607681 EPILEPSY, CHILDHOOD ABSENCE, SUSCEPTIBILITY TO, 2 marker/mechanism
MESH:D004833 Epilepsy, Temporal Lobe topiramate 5.6716499746
MESH:D004890 Erythema Mustard Gas 4.579357497
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.253581430
MESH:D004938 Esophageal Neoplasms Ethanol 6.2516704527
MESH:D004938 Esophageal Neoplasms Zinc 6.2516543248
MESH:D005234 Fatty Liver Ethanol 3.2218620774 19236843 16409862
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.0617920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.7115513904 10194807 16946407 15451040
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.416705139
MESH:D005756 Gastritis Ethanol 9.5415046732
MESH:D005756 Gastritis Zinc 9.5417241300
OMIM:604233 GENERALIZED EPILEPSY WITH FEBRILE SEIZURES PLUS, TYPE 1 marker/mechanism
OMIM:611277 GENERALIZED EPILEPSY WITH FEBRILE SEIZURES PLUS, TYPE 3 marker/mechanism
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.0916452187
MESH:D005909 Glioblastoma Manganese 3.5217043766
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.497505956
MESH:D006130 Growth Disorders Zinc 3.5617217573
MESH:D006331 Heart Diseases Urethane 3.8216046796
MESH:D006333 Heart Failure Zinc 3.2317162251
MESH:D006335 Heart Injuries Zinc 5.1617074742
MESH:D016481 Helicobacter Infections Zinc 3.9917241300
MESH:D006501 Hepatic Encephalopathy marker/mechanism 15929193
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 2.966705139
MESH:D006527 Hepatolenticular Degeneration Zinc 4.1117276780
MESH:D006689 Hodgkin Disease Bleomycin 6.1915147373 17606976 18501091
MESH:D006689 Hodgkin Disease sodium arsenite 6.1912676792
MESH:D006930 Hyperalgesia Ethanol 3.2518783367
MESH:D020138 Hyperhomocysteinemia Levodopa 5.1916787708 16275827
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.3615034207
MESH:D007247 Infertility, Female Dieldrin 4.3910630421
MESH:D007248 Infertility, Male sodium arsenite 2.5915346721 12646999
MESH:D007249 Inflammation Bleomycin 4.6317118201
MESH:D007249 Inflammation Mustard Gas 4.638975870 16001271 9260866 11402378 17524151 11428631 11428647 11428620 9357497
MESH:D007511 Ischemia Zinc 4.0516584753
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.418074119 9022650
MESH:D007569 Jaw Abnormalities Ethanol 3.8715513904
MESH:D007674 Kidney Diseases sodium arsenite 5.1620008137
MESH:D007674 Kidney Diseases Zinc 5.1616960431
MESH:D007676 Kidney Failure, Chronic Zinc 3.8916518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 2.496582329
MESH:D007859 Learning Disorders Ethanol 8.1415451040
MESH:D007859 Learning Disorders sevoflurane 8.1419212262
MESH:D017880 Limb Deformities, Congenital Ethanol 3.3817676605
MESH:D008103 Liver Cirrhosis Ethanol 3.0215289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.5018295389
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.8015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 2.3018166357
MESH:D008107 Liver Diseases Lindane 2.941715830
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.0717207112 17347304
MESH:D008113 Liver Neoplasms Dieldrin 6.269539021 8742319
MESH:D008113 Liver Neoplasms sodium arsenite 6.2616712894 15276417
MESH:D008113 Liver Neoplasms Urethane 6.2617559639 17093202 16391232
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.163712494 1399818 598648 6587162
MESH:D008171 Lung Diseases Mustard Gas 6.1618161513 18702808
MESH:D008171 Lung Diseases sodium arsenite 6.1619095001
MESH:D008175 Lung Neoplasms Bleomycin 4.236189445
MESH:D008175 Lung Neoplasms Mustard Gas 4.233148597 8781369
MESH:D008175 Lung Neoplasms sodium arsenite 4.2319931552 16712894 15276417 17306315 17077188
MESH:D008175 Lung Neoplasms Urethane 4.237750092 11323394 17093202 11992545 11062179 11893704 16788158 16289808 11246140 17255336 12117781 10822126 11074608 16926031 16007126 10997738 16391232 15166089 11307925 12765245 10530776 12957351 15136453 6695378 10779650 11807781 11552296 16204055 14587096 11497255 17195641 16337739 15902970 12466968 11544531
MESH:D008325 Mammary Neoplasms, Experimental Zinc 2.9212773700
MESH:D020149 Manganese Poisoning Manganese 4.9216551646 16568477 19453300
MESH:D008545 Melanoma Bleomycin 3.4015577320
MESH:D008545 Melanoma sodium arsenite 3.4016487513 19082730
MESH:D008569 Memory Disorders Ethanol 8.1118411066 15451040
MESH:D008569 Memory Disorders sevoflurane 8.1119212262
MESH:D008607 Mental Retardation Toluene 3.429294310
MESH:D008881 Migraine Disorders topiramate 4.1518759728 18765137 16942474 18803445
MESH:D019957 Motor Skills Disorders Toluene 4.699294310
MESH:D009069 Movement Disorders Manganese 4.4616551646
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.203581430
MESH:D009369 Neoplasms Dieldrin 9.348820588
MESH:D009369 Neoplasms Lindane 9.3416818664 12807735
MESH:D009369 Neoplasms sodium arsenite 9.3411559025
MESH:D009369 Neoplasms Urethane 9.3415625555
MESH:D009374 Neoplasms, Experimental sodium arsenite 7.5720056578
MESH:D009374 Neoplasms, Experimental Urethane 7.5715582191
MESH:D009410 Nerve Degeneration Manganese 3.8116551646
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 5.916679447
MESH:D009436 Neural Tube Defects sodium arsenite 5.9112854658
MESH:D009503 Neutropenia Mustard Gas 3.4316761898 7688884
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 2.914026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.413988306
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.5415276417 17306315
MESH:D010051 Ovarian Neoplasms Urethane 4.5416391232
MESH:D010190 Pancreatic Neoplasms Ethanol 2.7312384795
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 2.917296757
MESH:D010300 Parkinson Disease Dieldrin 7.6316112328 17291500 11445065 16809432 11181820
MESH:D010300 Parkinson Disease Levodopa 7.6319594199 20334432 7566641 18328768 11432539
MESH:D010300 Parkinson Disease Manganese 7.6311181820
MESH:D020734 Parkinsonian Disorders Levodopa 8.378817341 11246459 18722529
MESH:D020734 Parkinsonian Disorders Manganese 8.3716140633
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 3.876228378
MESH:D010911 Pituitary Neoplasms Urethane 4.8316391232
MESH:D011014 Pneumonia Bleomycin 4.8216317386 17071938 18024389
MESH:D011041 Poisoning Mustard Gas 3.2615727166
MESH:D011225 Pre-Eclampsia Zinc 3.7117114810
MESH:D011471 Prostatic Neoplasms Lindane 3.0414688026 12661182
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.0416039940
MESH:D011471 Prostatic Neoplasms Zinc 3.0416606632 16517595 16700911 12429649
MESH:D011537 Pruritus Mustard Gas 3.5118058305
MESH:D011595 Psychomotor Agitation Benzodiazepines 6.3220581379
MESH:D011654 Pulmonary Edema Bleomycin 4.7215808516
MESH:D011658 Pulmonary Fibrosis Bleomycin 5.3318162602 16115399 17177178 16314464 21435439 14609568 17434272 11554783 15322207 17241526 12624602 15541506 18008008 12574379
MESH:D011658 Pulmonary Fibrosis Mustard Gas 5.3317894541 17620002 17266442 10334151 17720292
MESH:D012004 Rectal Neoplasms bromoform 5.7817535441
MESH:D012021 Reflex, Abnormal Pentobarbital 5.4310930210
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 7.503692021
MESH:D012162 Retinal Degeneration Zinc 7.5016584753
MESH:C537537 Segawa syndrome, autosomal recessive Levodopa 6.108817341
MESH:D012640 Seizures Diazepam 48.029754883 15946322 10087439
MESH:D012640 Seizures Ethanol 48.029754883
MESH:D012640 Seizures etizolam 48.0216107249
MESH:D012640 Seizures Flurothyl 48.023352866
MESH:D012640 Seizures Lindane 48.0215475178 12842176 7539098
MESH:D012640 Seizures Lorazepam 48.0216107249 10087439
MESH:D012640 Seizures Midazolam 48.0210087439
MESH:D012640 Seizures Pentobarbital 48.0210087439 9754883
MESH:D012640 Seizures Pentylenetetrazole 48.0218164287 19660546 8954991 2616065 18657176 3352866 3037702 15475178 16054440 6431079
MESH:D012640 Seizures Picrotoxin 48.028635557 8954991
MESH:D012640 Seizures Toluene 48.029294310 6431079
MESH:D012640 Seizures topiramate 48.0216499746
MESH:D012640 Seizures zolpidem 48.029754883
MESH:D012871 Skin Diseases Mustard Gas 2.5412880345 16961503 15451306
MESH:D012878 Skin Neoplasms sodium arsenite 5.1718572023 19524636
MESH:D012878 Skin Neoplasms Urethane 5.1711807781
MESH:D012893 Sleep Disorders Midazolam 10.096138072
MESH:D012893 Sleep Disorders zolpidem 10.0919395429
MESH:D007319 Sleep Initiation and Maintenance Disorders Lorazepam 13.8515341891
MESH:D007319 Sleep Initiation and Maintenance Disorders Midazolam 13.856138071
MESH:D007319 Sleep Initiation and Maintenance Disorders zolpidem 13.8515341891 9066939 17225163
MESH:D016135 Spinal Dysraphism sodium arsenite 3.3312854658
MESH:D013274 Stomach Neoplasms Ethanol 2.3018456281
MESH:D013276 Stomach Ulcer Ethanol 3.039211565 11906479 9562338 17918041 17189318 16755016
MESH:D013375 Substance Withdrawal Syndrome Diazepam 19.289754883
MESH:D013375 Substance Withdrawal Syndrome Ethanol 19.289754883
MESH:D013375 Substance Withdrawal Syndrome Pentobarbital 19.2811529278 9754883
MESH:D013375 Substance Withdrawal Syndrome zolpidem 19.289754883
MESH:D013733 Testicular Diseases Toluene 4.3710514026 10048760
MESH:D013742 Tetanus Midazolam 12.122903605
MESH:D013742 Tetanus Propofol 12.122903605
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.446587162 6582329 7505956 1399818 3712494
MESH:D014062 Tongue Neoplasms Zinc 3.8816543248
MESH:D014202 Tremor 2-cresol 5.7712820538
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 4.208074119
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 4.2011723127 17306315 16452187 16712894
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.2511813266
MESH:D014652 Vascular Diseases sodium arsenite 3.8317056641
MESH:D019043 Vascular Neoplasms Urethane 5.3110620525
MESH:D015431 Weight Loss Bleomycin 5.0512624602
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:13685 Synaptic Transmission
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28501
    • No data
    Releated disease ID Related disease Name
    PA443309Alcoholism
    Releated drug ID Related drug Name
    PA449283diazepam
    PA164781320flunitrazepam
    PA164743987etomidate
    PA164783813adinazolam
    PA448333alprazolam
    PA10402benzodiazepine derivatives
    PA10035bromazepam
    PA448932chlordiazepoxide
    PA164748034cinolazepam
    PA10888clobazam
    PA449050clonazepam
    PA164749297clorazepate
    PA449502estazolam
    PA449681flurazepam
    PA164746526halazepam
    PA164749385ketazolam
    PA450267lorazepam
    PA450496midazolam
    PA10242nitrazepam
    PA450731oxazepam
    PA164776668prazepam
    PA164744373quazepam
    PA451608temazepam
    PA451753triazolam
    PA449659flumazenil
    PA450403methamphetamine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00186 potentiator Lorazepam Anti-anxiety Agents;Hypnotics and Sedatives;Antiemetics;Anticonvulsants;Benzodiazepines;GABA Modulators
    DB00231 potentiator Temazepam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators
    DB00349 potentiator Clobazam Anticonvulsants;Benzodiazepines
    DB00404 potentiator Alprazolam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators
    DB00475 potentiator Pro Chlorax Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators
    DB00546 potentiator Adinazolam Anti-anxiety Agents;Antidepressive Agents
    DB00628 potentiator Clorazepate Anti-anxiety Agents;Anticonvulsants;GABA Modulators
    DB00683 potentiator Midazolam Anti-anxiety Agents;Hypnotics and Sedatives;Adjuvants, Anesthesia;GABA Modulators;Anesthetics, Intravenous
    DB00690 potentiator Flurazepam Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators
    DB00801 potentiator Halazepam Anti-anxiety Agents;Muscle Relaxants;Benzodiazepines;Sedative
    DB00829 potentiator Diazepam Anti-anxiety Agents;Hypnotics and Sedatives;Antiemetics;Anticonvulsants;Adjuvants, Anesthesia;GABA Modulators;Anesthetics, Intravenous;Muscle Relaxants, Central
    DB00842 partial agonist Oxazepam Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators
    DB00897 potentiator Triazolam Anti-anxiety Agents;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators
    DB01068 potentiator Clonazepam Anticonvulsants;Benzodiazepines;GABA Modulators
    DB01215 potentiator Estazolam Anti-anxiety Agents;Anticonvulsants;GABA Modulators
    DB01381 negative modulator Ginkgo biloba
    DB01558 potentiator Bromazepam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators
    DB01559 potentiator Clotiazepam Anti-anxiety Agents;Hypnotics and Sedatives;Anticonvulsants;Benzodiazepines
    DB01567 potentiator Fludiazepam Anti-anxiety Agents;Benzodiazepines
    DB01588 potentiator Prazepam Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators
    DB01589 potentiator Quazepam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators
    DB01594 potentiator Cinolazepam Anticonvulsants;Benzodiazepines;Sedatives and Hypnotics
    DB01595 potentiator Nitrazepam Anti-anxiety Agents;Hypnotics and Sedatives;Anticonvulsants;GABA Modulators
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved