Annotation Detail for GABRG3
Basic Information Top
| Gene Symbol: | GABRG3 ( - ) |
|---|---|
| Gene Full Name: | gamma-aminobutyric acid (GABA) A receptor, gamma 3 |
| Band: | 15q12 |
| Quick Links | Entrez ID:2567; OMIM: 600233; Uniprot ID:GBRG3_HUMAN; ENSEMBL ID: ENSG00000182256; HGNC ID: 4088 |
| Relate to Another Database: | SFARIGene; denovo-db |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| No data |
| No data |
| No data |
| No data |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of GABRG3 mRNA | affects expression | 16483693 |
| C121718 | dicyclanil | dicyclanil results in increased expression of GABRG3 mRNA | increases expression | 15664270 |
| D011374 | Progesterone | Progesterone results in increased expression of GABRG3 mRNA | increases expression | 16000229 |
| C045950 | propiconazole | propiconazole results in increased expression of GABRG3 mRNA | increases expression | 16643972 |
| C446685 | systhane | systhane results in increased expression of GABRG3 mRNA | increases expression | 16643972 |
| D014050 | Toluene | Toluene affects the expression of GABRG3 mRNA | affects expression | 17108153 |
| C032910 | triadimefon | triadimefon results in increased expression of GABRG3 mRNA | increases expression | 16643972 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000138 | Acidosis | Ammonium Chloride | 3.95 | 18287403 | |
| MESH:D018248 | Adenoma, Liver Cell | dicyclanil | 5.48 | 17162532 | |
| MESH:D020201 | Brain Hemorrhage, Traumatic | Progesterone | 5.78 | 17868700 | |
| MESH:D001930 | Brain Injuries | Progesterone | 4.62 | 15380490 15665606 15845082 | |
| MESH:D001943 | Breast Neoplasms | Progesterone | 2.42 | 15562024 16175315 17614352 | |
| MESH:D006528 | Carcinoma, Hepatocellular | dicyclanil | 3.06 | 17162532 | |
| MESH:D002547 | Cerebral Palsy | Toluene | 6.25 | 9294310 | |
| MESH:D002972 | Cleft Palate | triadimefon | 3.82 | 16781842 | |
| MESH:D019465 | Craniofacial Abnormalities | Toluene | 3.50 | 9294310 | |
| MESH:D019465 | Craniofacial Abnormalities | triadimefon | 3.50 | 16875885 15834900 | |
| MESH:D003643 | Death | Toluene | 6.11 | 6431079 | |
| MESH:D003929 | Diabetic Neuropathies | Progesterone | 4.85 | 17187935 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | Progesterone | 4.11 | 17692515 | |
| MESH:D004715 | Endometriosis | Progesterone | 4.03 | 16134523 | |
| MESH:D006529 | Hepatomegaly | propiconazole | 17.19 | 17178688 17178689 | |
| MESH:D006529 | Hepatomegaly | systhane | 17.19 | 17178688 17178689 | |
| MESH:D006529 | Hepatomegaly | triadimefon | 17.19 | 17178689 17178688 | |
| MESH:D020244 | Infarction, Middle Cerebral Artery | Progesterone | 4.76 | 15869954 | |
| MESH:D007249 | Inflammation | Progesterone | 2.72 | 15869954 | |
| MESH:D007569 | Jaw Abnormalities | triadimefon | 5.24 | 15834900 15992940 | |
| MESH:D008107 | Liver Diseases | propiconazole | 5.09 | 19363144 | |
| MESH:D008107 | Liver Diseases | triadimefon | 5.09 | 19363144 | |
| MESH:D008113 | Liver Neoplasms | dicyclanil | 8.45 | 20118626 | |
| MESH:D008113 | Liver Neoplasms | propiconazole | 8.45 | 19028983 | |
| MESH:D008113 | Liver Neoplasms | triadimefon | 8.45 | 19028983 | |
| MESH:D008114 | Liver Neoplasms, Experimental | propiconazole | 11.31 | 17178689 | |
| MESH:D008114 | Liver Neoplasms, Experimental | systhane | 11.31 | 17178689 | |
| MESH:D008114 | Liver Neoplasms, Experimental | triadimefon | 11.31 | 17178689 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Progesterone | 3.03 | 17203775 11408345 | |
| MESH:D008607 | Mental Retardation | Toluene | 3.72 | 9294310 | |
| MESH:D019957 | Motor Skills Disorders | Toluene | 5.54 | 9294310 | |
| MESH:D010051 | Ovarian Neoplasms | Progesterone | 2.59 | 16525653 17393432 | |
| MESH:D012468 | Salivary Gland Neoplasms | Progesterone | 2.93 | 18045962 | |
| MESH:D012640 | Seizures | Toluene | 3.90 | 9294310 6431079 | |
| MESH:D013119 | Spinal Cord Injuries | Progesterone | 4.68 | 16503802 15862959 | |
| MESH:D013733 | Testicular Diseases | Toluene | 5.35 | 10048760 10514026 | |
| MESH:D013964 | Thyroid Neoplasms | triadimefon | 4.29 | 17178689 |
| Pathway ID | Pathway Name |
|---|---|
| KEGG:04080 | Neuroactive ligand-receptor interaction |
| REACT:13685 | Synaptic Transmission |
| REACT:15518 | Transmembrane transport of small molecules |
| Drugbank ID | Action | Drug Name | Description |
|---|---|---|---|
| DB00186 | potentiator | Lorazepam | Anti-anxiety Agents;Hypnotics and Sedatives;Antiemetics;Anticonvulsants;Benzodiazepines;GABA Modulators |
| DB00231 | potentiator | Temazepam | Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators |
| DB00349 | potentiator | Clobazam | Anticonvulsants;Benzodiazepines |
| DB00404 | potentiator | Alprazolam | Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators |
| DB00475 | potentiator | Pro Chlorax | Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators |
| DB00546 | potentiator | Adinazolam | Anti-anxiety Agents;Antidepressive Agents |
| DB00628 | potentiator | Clorazepate | Anti-anxiety Agents;Anticonvulsants;GABA Modulators |
| DB00683 | potentiator | Midazolam | Anti-anxiety Agents;Hypnotics and Sedatives;Adjuvants, Anesthesia;GABA Modulators;Anesthetics, Intravenous |
| DB00690 | potentiator | Flurazepam | Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators |
| DB00801 | potentiator | Halazepam | Anti-anxiety Agents;Muscle Relaxants;Benzodiazepines;Sedative |
| DB00829 | potentiator | Diazepam | Anti-anxiety Agents;Hypnotics and Sedatives;Antiemetics;Anticonvulsants;Adjuvants, Anesthesia;GABA Modulators;Anesthetics, Intravenous;Muscle Relaxants, Central |
| DB00842 | potentiator | Oxazepam | Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators |
| DB00897 | potentiator | Triazolam | Anti-anxiety Agents;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators |
| DB01068 | potentiator | Clonazepam | Anticonvulsants;Benzodiazepines;GABA Modulators |
| DB01215 | potentiator | Estazolam | Anti-anxiety Agents;Anticonvulsants;GABA Modulators |
| DB01558 | potentiator | Bromazepam | Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators |
| DB01559 | potentiator | Clotiazepam | Anti-anxiety Agents;Hypnotics and Sedatives;Anticonvulsants;Benzodiazepines |
| DB01567 | potentiator | Fludiazepam | Anti-anxiety Agents;Benzodiazepines |
| DB01588 | potentiator | Prazepam | Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators |
| DB01589 | potentiator | Quazepam | Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators |
| DB01594 | potentiator | Cinolazepam | Anticonvulsants;Benzodiazepines;Sedatives and Hypnotics |
| DB01595 | potentiator | Nitrazepam | Anti-anxiety Agents;Hypnotics and Sedatives;Anticonvulsants;GABA Modulators |
| No data |
| No data |
| No data |