AutismKB 2.0

Annotation Detail for GABRP


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Basic Information Top
Gene Symbol:GABRP ( MGC126386,MGC126387 )
Gene Full Name: gamma-aminobutyric acid (GABA) A receptor, pi
Band: 5q35.1
Quick LinksEntrez ID:2568; OMIM: 602729; Uniprot ID:GBRP_HUMAN; ENSEMBL ID: ENSG00000094755; HGNC ID: 4089
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
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Related Diseases/Disorders Top
No data
Desease IDDesease Name
1944Breast cancer
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GABRP mRNAaffects expression 16483693
C006780 bisphenol A bisphenol A affects the expression of GABRP mRNAaffects expression 20170705
C006780 bisphenol A bisphenol A results in decreased expression of GABRP mRNAdecreases expression 20678512
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of GABRP mRNAincreases expression 17010207
D004958 Estradiol Estradiol affects the expression of GABRP mRNAaffects expression 16000229
D004958 Estradiol Estradiol results in increased expression of GABRP mRNAincreases expression 17010207
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of GABRP mRNAaffects expression 20170705
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of GABRP mRNAaffects expression 20170705
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of GABRP mRNAdecreases expression 17351261
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of GABRP mRNAincreases expression 17557909
C474055 octylphenol octylphenol results in increased expression of GABRP mRNAincreases expression 17010207
D014212 Tretinoin Tretinoin results in increased expression of GABRP mRNAincreases expression 16249480
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D000230 Adenocarcinoma Estradiol 4.4111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4114692618
MESH:D000505 Alopecia Tretinoin 3.8415955085
MESH:D000686 Amyloidosis Diethylstilbestrol 4.8115469931
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.7315885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.7316412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Tretinoin 2.4116456186
MESH:D001471 Barrett Esophagus Tretinoin 4.7316935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.8916206674 16197459
MESH:D001862 Bone Resorption bisphenol A 4.1411985600
MESH:D001943 Breast Neoplasms bisphenol A 2.0217123778
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.0217129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 2.0216675129 12948864 17261762 18497071 14630087 19861407 17289903 17018787
MESH:D001943 Breast Neoplasms Tretinoin 2.0216443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9916813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6016168501
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 4.8415948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.8416924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.841917145
MESH:D002278 Carcinoma in Situ bisphenol A 5.3817123778
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3516096774 16051514
MESH:D002386 Cataract Tretinoin 3.2417460283
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9518566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9916129372
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0717110522 17681005 17333356 16919318 11677210 16105132 15861022
MESH:D002822 Choriocarcinoma Tretinoin 5.6016461808
MESH:D002972 Cleft Palate Tretinoin 2.769407595
MESH:D003092 Colitis Tretinoin 4.0617035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.839142499 9224671 10589399 9125849 17551590 9664655 16925845 14991402 9211117 8800419
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.8916002989 12952375
MESH:D003928 Diabetic Nephropathies Estradiol 3.6619279558
MESH:D004489 Edema, Cardiac Tretinoin 4.9118230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5212538720
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 5.0916402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 13.4915700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 13.4918566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 13.4916569247
MESH:D005124 Eye Abnormalities Tretinoin 3.7816938888 9664655
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.0915345470
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.8116534752 16611131 16002989 16513791 15751030
MESH:D005355 Fibrosis Tretinoin 3.8717994277
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.3416452187
MESH:D005909 Glioblastoma Tretinoin 3.1717312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6016084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0214991402 9664655
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D019584 Hot Flashes Estradiol 4.1917088409
MESH:D006930 Hyperalgesia Tretinoin 3.4316870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9316778211
MESH:D006965 Hyperplasia Diethylstilbestrol 4.7912960047 14722030
MESH:D007021 Hypospadias Diethylstilbestrol 12.4716002989
MESH:D007021 Hypospadias Ethinyl Estradiol 12.4716945680 16569931
MESH:D007246 Infertility Diethylstilbestrol 4.6815036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007333 Insulin Resistance bisphenol A 8.0116393666
MESH:D007333 Insulin Resistance Estradiol 8.0116393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 4.1217994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.1815992940 17551590
MESH:D007674 Kidney Diseases Estradiol 2.7215618244
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 8.3316762066 15003126 14681315
MESH:D007680 Kidney Neoplasms Estradiol 8.3315610895
MESH:D007859 Learning Disorders Diethylstilbestrol 4.4217184923
MESH:D007938 Leukemia Tretinoin 2.8917143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9816482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1117596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3219075265 17712046 16891316 17361223 17301526 17107899 16766008 17649720 12679006 17294898 19225113 16823087 17506722 17339181 16140955 19642359 16935935 16788101 15748426 19035177 16331271 9834237 19029980 17217047 17368321
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.509224671
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.5314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.5318397230 16248980
MESH:D008113 Liver Neoplasms Diethylstilbestrol 2.7215890375 16712894
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.5515166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.6615700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.9616002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7216891317 11807958 11408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.9319453300
MESH:D008527 Medulloblastoma Tretinoin 2.8717453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008591 Meningomyelocele Tretinoin 4.7816940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2217596541
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4916810080
MESH:D009369 Neoplasms Diethylstilbestrol 5.6115313581
MESH:D009369 Neoplasms Tretinoin 5.6116594593 16946489
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009421 Nervous System Malformations bisphenol A 26.4216427766 11399458
MESH:D009421 Nervous System Malformations Diethylstilbestrol 26.4211399458
MESH:D009421 Nervous System Malformations Estradiol 26.4216427766 11399458
MESH:D009421 Nervous System Malformations Tretinoin 26.429125849
MESH:D009436 Neural Tube Defects Tretinoin 3.229142499
MESH:D010049 Ovarian Diseases bisphenol A 5.3811985600
MESH:D010051 Ovarian Neoplasms Estradiol 5.0419401270
MESH:D010051 Ovarian Neoplasms Tretinoin 5.0416936753
MESH:D010146 Pain Tretinoin 3.1316870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5415976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.6114722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 5.0316977796 15687265
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 11.2010548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 11.2017184923
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 11.5120887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 11.5120887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.5716740699
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.5715046698 15846301 17136230
MESH:D011471 Prostatic Neoplasms Estradiol 2.5716740699
MESH:D011507 Proteinuria Tretinoin 3.9116636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.7115861022 16919318
MESH:D011625 Pterygium Tretinoin 5.1916723453
MESH:D011629 Puberty, Precocious bisphenol A 5.1810548101
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4016283617 16116481
MESH:D012878 Skin Neoplasms Tretinoin 2.7216467112
MESH:D013088 Spermatocele Diethylstilbestrol 13.2416709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 13.2416709447
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D019966 Substance-Related Disorders bisphenol A 4.3816045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2316026305 17045167
MESH:D013978 Tibial Fractures Estradiol 5.1319048282
MESH:D014062 Tongue Neoplasms Tretinoin 4.0516051514
MESH:D014376 Tuberculosis Tretinoin 3.3816040207
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 2.8616452187 16712894 17306315
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 10.4016175088
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 10.4016129372
MESH:D014591 Uterine Diseases bisphenol A 15.3414652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 15.3414652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 10.5915809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 10.5914692618
MESH:D014604 Uveal Neoplasms Tretinoin 5.0516752155
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.7916002989 16513791
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.3916761959
MESH:D009396 Wilms Tumor Tretinoin 4.2216287080
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00186 potentiator Lorazepam Anti-anxiety Agents;Hypnotics and Sedatives;Antiemetics;Anticonvulsants;Benzodiazepines;GABA Modulators
DB00231 potentiator Temazepam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators
DB00349 potentiator Clobazam Anticonvulsants;Benzodiazepines
DB00404 potentiator Alprazolam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators
DB00475 potentiator Pro Chlorax Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators
DB00546 potentiator Adinazolam Anti-anxiety Agents;Antidepressive Agents
DB00628 potentiator Clorazepate Anti-anxiety Agents;Anticonvulsants;GABA Modulators
DB00683 potentiator Midazolam Anti-anxiety Agents;Hypnotics and Sedatives;Adjuvants, Anesthesia;GABA Modulators;Anesthetics, Intravenous
DB00690 potentiator Flurazepam Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators
DB00801 potentiator Halazepam Anti-anxiety Agents;Muscle Relaxants;Benzodiazepines;Sedative
DB00829 potentiator Diazepam Anti-anxiety Agents;Hypnotics and Sedatives;Antiemetics;Anticonvulsants;Adjuvants, Anesthesia;GABA Modulators;Anesthetics, Intravenous;Muscle Relaxants, Central
DB00842 potentiator Oxazepam Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators
DB00897 potentiator Triazolam Anti-anxiety Agents;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators
DB01068 potentiator Clonazepam Anticonvulsants;Benzodiazepines;GABA Modulators
DB01215 potentiator Estazolam Anti-anxiety Agents;Anticonvulsants;GABA Modulators
DB01558 potentiator Bromazepam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators
DB01559 potentiator Clotiazepam Anti-anxiety Agents;Hypnotics and Sedatives;Anticonvulsants;Benzodiazepines
DB01567 potentiator Fludiazepam Anti-anxiety Agents;Benzodiazepines
DB01588 potentiator Prazepam Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators
DB01589 potentiator Quazepam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators
DB01594 potentiator Cinolazepam Anticonvulsants;Benzodiazepines;Sedatives and Hypnotics
DB01595 potentiator Nitrazepam Anti-anxiety Agents;Hypnotics and Sedatives;Anticonvulsants;GABA Modulators
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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