AutismKB 2.0

Annotation Detail for GABRR1


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Basic Information Top
Gene Symbol:GABRR1 ( MGC163216 )
Gene Full Name: gamma-aminobutyric acid (GABA) receptor, rho 1
Band: 6q15
Quick LinksEntrez ID:2569; OMIM: 137161; Uniprot ID:GBRR1_HUMAN; ENSEMBL ID: ENSG00000146276; HGNC ID: 4090
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C041597 12-ketoendrin 12-ketoendrin binds to GABRR1 proteinaffects binding 11879973
C091518 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane 1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to GABRR1 proteinaffects binding 11879973
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of GABRR1 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of GABRR1 mRNAaffects expression 17562736
D005680 gamma-Aminobutyric Acid gamma-Aminobutyric Acid results in increased activity of GABRR1 proteinincreases activity 12106692
D005680 gamma-Aminobutyric Acid gamma-Aminobutyric Acid results in increased activity of [GABRR1 protein binds to GABRG2 protein]affects binding|increases activity 12106692
D005680 gamma-Aminobutyric Acid Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRR1 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 12106692
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GABRR1 mRNAaffects expression 16483693
D001761 Bleomycin Bleomycin results in decreased expression of GABRR1 mRNAdecreases expression 15808516
C121718 dicyclanil dicyclanil results in increased expression of GABRR1 mRNAincreases expression 15664270
D004026 Dieldrin Dieldrin binds to GABRR1 proteinaffects binding 11879973
D004041 Dietary Fats Dietary Fats results in decreased expression of GABRR1 mRNAdecreases expression 18042831
D004726 Endosulfan Endosulfan binds to GABRR1 proteinaffects binding 11879973
D001556 Lindane Lindane binds to GABRR1 proteinaffects binding 11879973
C041786 palm oil palm oil results in decreased expression of GABRR1 mRNAdecreases expression 18042831
D010424 Pentobarbital Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRR1 protein binds to GABRG2 protein]]affects binding|increases activity|increases reaction 12106692
D010852 Picrotoxin Picrotoxin results in decreased activity of [GABRR1 protein binds to GABRG2 protein]affects binding|decreases activity 12106692
D020849 Raloxifene ESR2 protein affects the reaction [Raloxifene results in increased expression of GABRR1 mRNA]affects reaction|increases expression 14699072
D020849 Raloxifene Raloxifene affects the expression of GABRR1 mRNAaffects expression 14699072
D015032 Zinc Zinc results in decreased activity of [GABRR1 protein binds to GABRG2 protein]affects binding|decreases activity 12106692
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D000169 Acrodermatitis Zinc 5.3917202136 17190629 16889938
MESH:D055371 Acute Lung Injury Bleomycin 4.8717118201
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.743712494
MESH:D018248 Adenoma, Liver Cell dicyclanil 5.0817162532
MESH:D000382 Agricultural Workers' Diseases Lindane 4.3612661182
MESH:D000419 Albuminuria Raloxifene 4.5817451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 4.4715800139
MESH:D000544 Alzheimer Disease Zinc 4.4716410023 17119284 16580781 16325427
MESH:D000755 Anemia, Sickle Cell Zinc 4.8816916123
MESH:D000799 Angioedema Acetaminophen 3.8410982225
MESH:D000860 Anoxia Bleomycin 5.4015782499
MESH:D001008 Anxiety Disorders Pentobarbital 4.7111141031 18313124
MESH:D001161 Arteriosclerosis Dietary Fats 3.8715238619
MESH:D001249 Asthma Zinc 2.9517085522
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.0211289319 1440618
MESH:D001930 Brain Injuries Raloxifene 11.0816580743
MESH:D001930 Brain Injuries Zinc 11.0817109824
MESH:D001943 Breast Neoplasms Dieldrin 2.0811859874 15770527
MESH:D001943 Breast Neoplasms Dietary Fats 2.0820435547
MESH:D001943 Breast Neoplasms Lindane 2.0814688026
MESH:D001943 Breast Neoplasms Raloxifene 2.0817952589 17242785 15758505 15775269 17893378 16837676 15572757 17261762 16912660 17595753 17440819 17049068
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.667296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.663084413
MESH:D006528 Carcinoma, Hepatocellular dicyclanil 4.6617162532
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.667296757
MESH:D002294 Carcinoma, Squamous Cell Bleomycin 5.346189445
MESH:D002294 Carcinoma, Squamous Cell Zinc 5.3416543248
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.0517572228
MESH:D002318 Cardiovascular Diseases Raloxifene 7.5815775269
MESH:D002318 Cardiovascular Diseases Zinc 7.5816936243
MESH:D002386 Cataract Acetaminophen 2.5710977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.747505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.1319486331 9022650
MESH:D003072 Cognition Disorders Raloxifene 4.6015800139
MESH:D019465 Craniofacial Abnormalities Zinc 2.4319302082
MESH:D003490 Cyanosis Endosulfan 5.537900959
MESH:D003865 Depressive Disorder, Major Raloxifene 4.1417474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7912868966 11298694 18759878 2524372 8156756 14531868 11906362 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.472952479 3621924
MESH:D003920 Diabetes Mellitus Zinc 4.1916479319
MESH:D003928 Diabetic Nephropathies Raloxifene 3.9217308373 17451421 15920148
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.691440618 18692083 6679447 18289764 9328219 6482804 16192314 11289319 9653073 9022650 7440962 8291058 18648102
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.6916177239 17522070 16109766 12705907 11834606 11421492 16227642 16781746 14986274 14725611 16081117 18071297 10774834 11461765 19085960 19416960 19739265 15968718 19370779 12958197 17562736 17906064 12540782 16393943 19164858 10915739 11743745 18713872 2444490 16485898 11287661 12594235 10663392 19420014 14550746 19923254 11529661 12392966 15619225 12153990 11739529
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1019426721
MESH:D050171 Dyslipidemias Dietary Fats 3.4418367378
MESH:D004417 Dyspnea Endosulfan 5.287900959 3388749
MESH:D004487 Edema Bleomycin 7.4817118201
MESH:D004487 Edema Raloxifene 7.4815860553
MESH:D004646 Emphysema Endosulfan 6.567900959
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 3.9815845917
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.663581430
MESH:D004938 Esophageal Neoplasms Zinc 4.6616543248
MESH:D005234 Fatty Liver Dietary Fats 7.9518296743 17967931 19551842 19004024
MESH:D005234 Fatty Liver Raloxifene 7.9517473493
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.026705139
MESH:D005355 Fibrosis Dietary Fats 3.5118296743
MESH:D005756 Gastritis Acetaminophen 11.1716983495
MESH:D005756 Gastritis Zinc 11.1717241300
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.027505956
MESH:D006130 Growth Disorders Zinc 3.9517217573
MESH:D006331 Heart Diseases Raloxifene 3.5211110106
MESH:D006333 Heart Failure Zinc 3.5917162251
MESH:D006335 Heart Injuries Zinc 5.7717074742
MESH:D016481 Helicobacter Infections Zinc 4.5117241300
MESH:D006470 Hemorrhage Endosulfan 5.287900959
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.506705139
MESH:D006527 Hepatolenticular Degeneration Zinc 4.6817276780
MESH:D006689 Hodgkin Disease Bleomycin 4.3518501091 17606976 15147373
MESH:D006930 Hyperalgesia Acetaminophen 2.6816870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.5721332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.6021332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9215034207
MESH:D006973 Hypertension Raloxifene 2.8617577099 15787275
MESH:D007247 Infertility, Female Dieldrin 4.9210630421
MESH:D007248 Infertility, Male Endosulfan 4.288588293 9432128
MESH:D007249 Inflammation Bleomycin 5.5717118201
MESH:D007249 Inflammation Dietary Fats 5.5720412841
MESH:D007333 Insulin Resistance Dietary Fats 3.0911836018 18457598
MESH:D007511 Ischemia Zinc 4.6216584753
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.028074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 6.1115629191 12587719
MESH:D007674 Kidney Diseases Zinc 6.1116960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.4016518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 2.956582329
MESH:D007859 Learning Disorders Endosulfan 5.098157075
MESH:D007889 Leiomyoma Raloxifene 4.4816973256
MESH:D008103 Liver Cirrhosis Dietary Fats 2.8618296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1815034207 9327722
MESH:D008107 Liver Diseases Acetaminophen 4.2519460945 16611625 19784758 16610002 19014921 12587719 12969438 11587558
MESH:D008107 Liver Diseases Lindane 4.251715830
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2216871587 17185352
MESH:D008113 Liver Neoplasms dicyclanil 5.4120118626
MESH:D008113 Liver Neoplasms Dieldrin 5.418742319 9539021
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.52598648 3712494 6587162 1399818
MESH:D008175 Lung Neoplasms Bleomycin 3.116189445
MESH:D008325 Mammary Neoplasms, Experimental Zinc 3.2812773700
MESH:D008545 Melanoma Bleomycin 3.2515577320
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5519513568
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.5515863610
MESH:D009101 Multiple Myeloma Raloxifene 3.4216497877
MESH:D009232 Myxoma Raloxifene 5.5516343187
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.463581430
MESH:D009369 Neoplasms Dieldrin 5.798820588
MESH:D009369 Neoplasms Lindane 5.7916818664 12807735
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.906679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8518514411
MESH:D009765 Obesity Dietary Fats 2.2818457598 17217161 16723640 21332399 19632207 20518802 11836018 18674790 20132043
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.404026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.023988306
MESH:D010024 Osteoporosis Raloxifene 3.3817882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.2117823083 17893378 15579764 15758505
MESH:D010146 Pain Acetaminophen 2.3716870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.477296757
MESH:D010300 Parkinson Disease Dieldrin 3.5216112328 11181820 11445065 17291500 16809432
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.476228378
MESH:D011014 Pneumonia Bleomycin 5.4018024389 17071938 16317386
MESH:D011225 Pre-Eclampsia Zinc 4.1617114810
MESH:D011471 Prostatic Neoplasms Lindane 2.8414688026 12661182
MESH:D011471 Prostatic Neoplasms Raloxifene 2.8416220300 15731164 16536755
MESH:D011471 Prostatic Neoplasms Zinc 2.8416606632 16700911 16517595 12429649
MESH:D011654 Pulmonary Edema Bleomycin 5.3215808516
MESH:D011658 Pulmonary Fibrosis Bleomycin 3.8618008008 17241526 21435439 14609568 15322207 11554783 17434272 12624602 17177178 16115399 18162602 15541506 12574379 16314464
MESH:D011693 Purpura Raloxifene 5.5515770314
MESH:D012021 Reflex, Abnormal Pentobarbital 6.0110930210
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.953692021
MESH:D012162 Retinal Degeneration Zinc 8.9516584753
MESH:D012640 Seizures Endosulfan 14.217539098 10698677
MESH:D012640 Seizures Lindane 14.2112842176 7539098 15475178
MESH:D012640 Seizures Pentobarbital 14.219754883 10087439
MESH:D012640 Seizures Picrotoxin 14.218954991 8635557
MESH:D020521 Stroke Raloxifene 3.8016837676
MESH:D013375 Substance Withdrawal Syndrome Pentobarbital 4.969754883 11529278
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.871399818 6582329 7505956 3712494 6587162
MESH:D013978 Tibial Fractures Raloxifene 5.2119048282
MESH:D014062 Tongue Neoplasms Zinc 4.3816543248
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.178074119
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.1717572228
MESH:D014581 Urticaria Acetaminophen 2.9610982225
MESH:D054556 Venous Thromboembolism Raloxifene 5.2116837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.5516343187
MESH:D015430 Weight Gain Dietary Fats 3.7216723640
MESH:D015431 Weight Loss Bleomycin 5.6312624602
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:13685 Synaptic Transmission
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00186 potentiator Lorazepam Anti-anxiety Agents;Hypnotics and Sedatives;Antiemetics;Anticonvulsants;Benzodiazepines;GABA Modulators
DB00231 potentiator Temazepam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators
DB00349 potentiator Clobazam Anticonvulsants;Benzodiazepines
DB00404 potentiator Alprazolam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators
DB00466 antagonist Picrotoxin Central Nervous System Stimulants;Stimulants;Anti-barbituates;GABA receptor antagonists;Antidotes;Convulsants;GABA Antagonists
DB00475 potentiator Pro Chlorax Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators
DB00546 potentiator Adinazolam Anti-anxiety Agents;Antidepressive Agents
DB00628 potentiator Clorazepate Anti-anxiety Agents;Anticonvulsants;GABA Modulators
DB00683 potentiator Midazolam Anti-anxiety Agents;Hypnotics and Sedatives;Adjuvants, Anesthesia;GABA Modulators;Anesthetics, Intravenous
DB00690 potentiator Flurazepam Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators
DB00801 potentiator Halazepam Anti-anxiety Agents;Muscle Relaxants;Benzodiazepines;Sedative
DB00829 potentiator Diazepam Anti-anxiety Agents;Hypnotics and Sedatives;Antiemetics;Anticonvulsants;Adjuvants, Anesthesia;GABA Modulators;Anesthetics, Intravenous;Muscle Relaxants, Central
DB00842 potentiator Oxazepam Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators
DB00897 potentiator Triazolam Anti-anxiety Agents;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators
DB01068 potentiator Clonazepam Anticonvulsants;Benzodiazepines;GABA Modulators
DB01215 potentiator Estazolam Anti-anxiety Agents;Anticonvulsants;GABA Modulators
DB01558 potentiator Bromazepam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators
DB01559 potentiator Clotiazepam Anti-anxiety Agents;Hypnotics and Sedatives;Anticonvulsants;Benzodiazepines
DB01567 potentiator Fludiazepam Anti-anxiety Agents;Benzodiazepines
DB01588 potentiator Prazepam Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators
DB01589 potentiator Quazepam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators
DB01594 potentiator Cinolazepam Anticonvulsants;Benzodiazepines;Sedatives and Hypnotics
DB01595 potentiator Nitrazepam Anti-anxiety Agents;Hypnotics and Sedatives;Anticonvulsants;GABA Modulators
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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