AutismKB 2.0

Annotation Detail for SERINC5


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Basic Information Top
Gene Symbol:SERINC5 ( C5orf12,TPO1 )
Gene Full Name: serine incorporator 5
Band: 5q14.1
Quick LinksEntrez ID:256987; OMIM: NA; Uniprot ID:SERC5_HUMAN; ENSEMBL ID: ENSG00000164300; HGNC ID: 18825
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SERINC5 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of SERINC5 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SERINC5 mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SERINC5 mRNAaffects expression 17484886
D004041 Dietary Fats Dietary Fats results in increased expression of SERINC5 mRNAincreases expression 18042831
D005419 Flavonoids Flavonoids results in increased expression of SERINC5 mRNAincreases expression 18035473
C041786 palm oil palm oil results in increased expression of SERINC5 mRNAincreases expression 18042831
D010634 Phenobarbital Phenobarbital results in increased expression of SERINC5 mRNAincreases expression 19270015
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.786195326
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.3117620307
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.1915238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Dietary Fats 2.2620435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0815673190 16011737 16192424 18705752 15721981 16124888 16227642 16097048 15700767 3786805 16050911 10355542
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.823084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.8218788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.826705139 17173139 20935162 20007298 1701930
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.936135515
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.564080065
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3218551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.5418551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5419923254 12153990 12392966 16781746 11739529 10915739 17522070 11287661 2444490 18713872 12958197 16109766 16393943 14725611 15619225 19739265 17562736 19085960 11421492 15968718 19370779 11461765 16485898 19416960 12594235 16177239 19164858 12705907 14550746 18071297 10663392 17906064 14986274 11743745 11834606 10774834 12540782 19420014 11529661 16227642 16081117
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.5419085960 6884620 15968718 10915739 2869522 7179309 9327722 7120509 15998439 3732212 6623471 10092053 7440962 15027814 11566570 21278145 16227642 3786805 4309450 19336974 17522070 16177239
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D050171 Dyslipidemias Dietary Fats 3.6218367378
MESH:D004421 Dystonia Phenobarbital 4.261851702
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.413659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.2511558140 3922381
MESH:D004827 Epilepsy Phenobarbital 3.0020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.766401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.363659116
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.6712795759 15959796 16239168 12631006 16045604 61145 19224547 17595544
MESH:D005234 Fatty Liver Dietary Fats 8.6719004024 17967931 18296743 19551842
MESH:D005355 Fibrosis Carbon Tetrachloride 9.8518705752
MESH:D005355 Fibrosis Dietary Fats 9.8518296743
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8819110552 19900420
MESH:D006529 Hepatomegaly Phenobarbital 3.7916109766
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8321332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.8721332399
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D007249 Inflammation Dietary Fats 5.5820412841
MESH:D007249 Inflammation Flavonoids 5.5817296493
MESH:D007333 Insulin Resistance Dietary Fats 3.2511836018 18457598
MESH:D007674 Kidney Diseases Acetaminophen 2.3212587719 15629191
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.1816705839
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 11.7316239168 11408273 17174718 17334410 16943688 21278145 17157831 16221502 11903743
MESH:D008103 Liver Cirrhosis Dietary Fats 11.7318296743
MESH:D008103 Liver Cirrhosis Phenobarbital 11.7321047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7518187930 12445418 15876570 16015684 17766677 12666154 15123356 17823541 14724832 14512876 17525996 15370692 18279442 15052691 17805973 18395914 16192424 18277467 16027843 17557913 12741479 15959796 15730626 14716496 10355542 14620537 17631135 16116963 12632514 16097048 18205269 15925388 12445421 18472332 17708605 17900296 18166357 17869086 15996030 17944888 12667390 18006644 18429990 12389079 18156304 15057751 12586293 15931870 20821823 15818738 18339082 16033810 15362042 17761835 18418968 18395095 17640975 18054572 15673190 14716833 17721639 17698563 12958196 18420326 15893842 17976157 13678700 12609069 18481824 17565644 11481614 17714472 12632512 12546737 15338365 18251166 18210741 12898905 16248980 18376398 15650968 12649538 17922224 18317297 18263696 16136751 16011737 14748882 17481882 18412020 16638106 18705752 18472094
MESH:D008107 Liver Diseases Acetaminophen 6.7911587558 16611625 16610002 12969438 19784758 19460945 19014921 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.7915830285 17285989 16964402 16246199 15720792
MESH:D008107 Liver Diseases Phenobarbital 6.7919363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.1816871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.1816899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.927678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.9219294768
MESH:D008113 Liver Neoplasms Phenobarbital 7.9219073162 19812893 15975961 21047994 8742319 19482888
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.692876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.6915583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.696150874 17172636 18308698 1399818 2563599
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8117484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.207678174 18551238
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009765 Obesity Dietary Fats 2.3318457598 21332399 18674790 11836018 17217161 20132043 16723640 19632207 20518802
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.6616049721
MESH:D010018 Osteomalacia Phenobarbital 4.7017016548
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5616965848
MESH:D011230 Precancerous Conditions Phenobarbital 3.842563599
MESH:D019310 Pseudolymphoma Phenobarbital 4.8712752131
MESH:D012640 Seizures 2,6-dinitrotoluene 6.4518551238
MESH:D012640 Seizures Phenobarbital 6.4511442880 16876388 4039156 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 5.166407741
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.231399818
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3716049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6610091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D015430 Weight Gain Dietary Fats 3.9516723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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