Annotation Detail for GABRR2
Basic Information Top
| Gene Symbol: | GABRR2 ( - ) |
|---|---|
| Gene Full Name: | gamma-aminobutyric acid (GABA) receptor, rho 2 |
| Band: | 6q15 |
| Quick Links | Entrez ID:2570; OMIM: 137162; Uniprot ID:GBRR2_HUMAN; ENSEMBL ID: ENSG00000111886; HGNC ID: 4091 |
| Relate to Another Database: | SFARIGene; denovo-db |
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| Pathway ID | Pathway Name |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| No data |
| No data |
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| Desease Name |
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| HEMATOLOGICAL |
| serum creatinine |
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| No data |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D000082 | Acetaminophen | Acetaminophen affects the expression of GABRR2 mRNA | affects expression | 17562736 |
| D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of GABRR2 mRNA | affects expression | 16483693 |
| C002791 | bismuth tripotassium dicitrate | bismuth tripotassium dicitrate results in increased expression of GABRR2 mRNA | increases expression | 15912405 |
| D002251 | Carbon Tetrachloride | Carbon Tetrachloride results in increased expression of GABRR2 mRNA | increases expression | 19784758 |
| C121718 | dicyclanil | dicyclanil results in increased expression of GABRR2 mRNA | increases expression | 15664270 |
| D008743 | Methyl Parathion | Methyl Parathion results in increased expression of GABRR2 mRNA | increases expression | 19784758 |
| D010278 | Parathion | Parathion results in increased expression of GABRR2 mRNA | increases expression | 19784758 |
| C006253 | pirinixic acid | pirinixic acid results in decreased expression of GABRR2 mRNA | decreases expression | 17950772 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000138 | Acidosis | Ammonium Chloride | 3.90 | 18287403 | |
| MESH:D055371 | Acute Lung Injury | pirinixic acid | 3.38 | 18653653 | |
| MESH:D018248 | Adenoma, Liver Cell | dicyclanil | 11.68 | 17162532 | |
| MESH:D018248 | Adenoma, Liver Cell | pirinixic acid | 11.68 | 16434500 | |
| MESH:D000382 | Agricultural Workers' Diseases | Parathion | 5.34 | 17119214 11874814 | |
| MESH:D000799 | Angioedema | Acetaminophen | 4.22 | 10982225 | |
| MESH:D001321 | Autistic Disorder | Acetaminophen | 1.40 | 18445737 | |
| MESH:D001778 | Blood Coagulation Disorders | pirinixic acid | 3.39 | 19483382 | |
| MESH:D001943 | Breast Neoplasms | Parathion | 3.83 | 12762645 | |
| MESH:D002252 | Carbon Tetrachloride Poisoning | Carbon Tetrachloride | 4.08 | 18705752 16124888 15700767 10355542 15673190 16097048 16227642 3786805 15721981 16011737 16050911 16192424 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Acetaminophen | 4.87 | 3084413 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Carbon Tetrachloride | 4.87 | 18788625 | |
| MESH:D006528 | Carcinoma, Hepatocellular | dicyclanil | 4.87 | 17162532 | |
| MESH:D002386 | Cataract | Acetaminophen | 2.71 | 10977129 | |
| MESH:D002779 | Cholestasis | pirinixic acid | 3.00 | 19176532 | |
| MESH:D003876 | Dermatitis, Atopic | pirinixic acid | 2.52 | 18249437 | |
| MESH:D056486 | Drug-Induced Liver Injury | Acetaminophen | 3.94 | 19923254 17906064 2444490 19085960 11421492 15968718 17522070 16177239 12594235 16781746 14550746 16081117 18713872 14986274 19416960 10915739 19420014 12705907 11739529 14725611 15619225 19739265 18071297 11287661 10774834 16109766 19370779 12958197 11743745 11834606 16485898 16227642 12540782 12153990 19164858 11529661 11461765 10663392 16393943 17562736 12392966 | |
| MESH:D056486 | Drug-Induced Liver Injury | Carbon Tetrachloride | 3.94 | 15968718 3732212 10915739 19336974 16177239 7120509 4309450 15998439 19085960 15027814 17522070 11566570 16227642 7440962 9327722 3786805 21278145 7179309 10092053 6623471 2869522 6884620 | |
| MESH:D056487 | Drug-Induced Liver Injury, Chronic | Acetaminophen | 4.47 | 19426721 | |
| MESH:D004487 | Edema | pirinixic acid | 2.72 | 12083418 | |
| MESH:D005234 | Fatty Liver | Carbon Tetrachloride | 8.49 | 12631006 15959796 19224547 16239168 61145 17595544 12795759 16045604 | |
| MESH:D005234 | Fatty Liver | pirinixic acid | 8.49 | 20131406 19236843 | |
| MESH:D005355 | Fibrosis | Carbon Tetrachloride | 3.76 | 18705752 | |
| MESH:D005756 | Gastritis | Acetaminophen | 4.05 | 16983495 | |
| MESH:D006333 | Heart Failure | pirinixic acid | 2.67 | 20558911 | |
| MESH:D006505 | Hepatitis | Carbon Tetrachloride | 3.88 | 19900420 19110552 | |
| MESH:D006529 | Hepatomegaly | pirinixic acid | 3.30 | 19176532 16221962 19772884 18467677 | |
| MESH:D006930 | Hyperalgesia | Acetaminophen | 2.89 | 16870215 | |
| MESH:D006932 | Hyperbilirubinemia | Carbon Tetrachloride | 4.87 | 16899240 | |
| MESH:D006943 | Hyperglycemia | pirinixic acid | 3.41 | 20558911 | |
| MESH:D006975 | Hypertension, Portal | Carbon Tetrachloride | 4.39 | 15338365 | |
| MESH:D007248 | Infertility, Male | Parathion | 4.64 | 16029889 | |
| MESH:D007333 | Insulin Resistance | pirinixic acid | 2.78 | 16306350 | |
| MESH:D007674 | Kidney Diseases | Acetaminophen | 2.32 | 15629191 12587719 | |
| MESH:D008103 | Liver Cirrhosis | Carbon Tetrachloride | 2.92 | 11903743 16943688 17174718 11408273 21278145 17334410 16221502 17157831 16239168 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Carbon Tetrachloride | 2.38 | 18395095 16136751 17766677 15818738 12609069 17640975 11481614 17805973 15123356 12649538 12741479 12632514 13678700 17525996 18420326 14620537 15650968 12445421 12586293 18418968 18156304 18277467 14724832 18472094 12958196 16248980 16097048 12898905 18429990 17557913 18279442 17481882 15893842 17698563 15057751 16015684 18705752 12667390 15996030 14748882 17944888 15673190 14716833 15730626 16033810 15338365 17900296 14716496 17631135 18054572 16192424 18412020 12632512 17869086 18481824 16638106 18166357 18472332 17721639 12546737 15362042 17708605 18187930 12445418 18205269 18210741 18339082 17922224 16027843 18376398 20821823 15876570 10355542 18395914 18263696 12389079 18317297 18251166 17976157 17823541 15959796 14512876 16116963 17714472 15931870 17761835 17565644 15370692 15052691 12666154 16011737 15925388 18006644 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | pirinixic acid | 2.38 | 15474484 | |
| MESH:D008107 | Liver Diseases | marker/mechanism | 19784758 | ||
| MESH:D008107 | Liver Diseases | Acetaminophen | 4.07 | 11587558 19014921 12587719 19784758 16610002 19460945 16611625 12969438 | |
| MESH:D008107 | Liver Diseases | Carbon Tetrachloride | 4.07 | 16246199 15720792 17285989 15830285 16964402 | |
| MESH:D017093 | Liver Failure | Carbon Tetrachloride | 4.47 | 15123358 | |
| MESH:D017114 | Liver Failure, Acute | Acetaminophen | 10.18 | 16871587 17185352 | |
| MESH:D017114 | Liver Failure, Acute | Carbon Tetrachloride | 10.18 | 16899240 14706259 | |
| MESH:D008113 | Liver Neoplasms | Carbon Tetrachloride | 8.03 | 19294768 | |
| MESH:D008113 | Liver Neoplasms | dicyclanil | 8.03 | 20118626 | |
| MESH:D008113 | Liver Neoplasms | pirinixic acid | 8.03 | 20007298 15890375 16377806 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Carbon Tetrachloride | 2.75 | 15583823 12014681 | |
| MESH:D008546 | Melanoma, Experimental | Acetaminophen | 3.87 | 19513568 | |
| MESH:D009135 | Muscular Diseases | pirinixic acid | 3.81 | 16239165 | |
| MESH:D009203 | Myocardial Infarction | pirinixic acid | 2.22 | 19151258 | |
| MESH:D015428 | Myocardial Reperfusion Injury | pirinixic acid | 3.13 | 16411023 | |
| MESH:D009369 | Neoplasms | pirinixic acid | 2.05 | 17405874 | |
| MESH:D019636 | Neurodegenerative Diseases | Acetaminophen | 3.07 | 18514411 | |
| MESH:D020258 | Neurotoxicity Syndromes | marker/mechanism | 19784758 | ||
| MESH:D020258 | Neurotoxicity Syndromes | Methyl Parathion | 4.99 | 19784758 | |
| MESH:D009765 | Obesity | pirinixic acid | 1.86 | 20558911 | |
| MESH:D010146 | Pain | Acetaminophen | 2.59 | 16870215 | |
| MESH:D011041 | Poisoning | Methyl Parathion | 5.29 | 17603234 | |
| MESH:D015427 | Reperfusion Injury | pirinixic acid | 2.49 | 19058328 | |
| MESH:D012135 | Respiratory Sounds | Parathion | 5.60 | 17119214 11874814 | |
| MESH:D012140 | Respiratory Tract Diseases | Parathion | 5.93 | 17119214 | |
| MESH:D014581 | Urticaria | Acetaminophen | 3.24 | 10982225 |
| Pathway ID | Pathway Name |
|---|---|
| KEGG:04080 | Neuroactive ligand-receptor interaction |
| REACT:13685 | Synaptic Transmission |
| REACT:15518 | Transmembrane transport of small molecules |
Pharmacogenomics Knowledge Base | Drugbank ID | Action | Drug Name | Description |
|---|---|---|---|
| DB00186 | potentiator | Lorazepam | Anti-anxiety Agents;Hypnotics and Sedatives;Antiemetics;Anticonvulsants;Benzodiazepines;GABA Modulators |
| DB00231 | potentiator | Temazepam | Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators |
| DB00349 | potentiator | Clobazam | Anticonvulsants;Benzodiazepines |
| DB00404 | potentiator | Alprazolam | Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators |
| DB00475 | potentiator | Pro Chlorax | Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators |
| DB00546 | potentiator | Adinazolam | Anti-anxiety Agents;Antidepressive Agents |
| DB00628 | potentiator | Clorazepate | Anti-anxiety Agents;Anticonvulsants;GABA Modulators |
| DB00683 | potentiator | Midazolam | Anti-anxiety Agents;Hypnotics and Sedatives;Adjuvants, Anesthesia;GABA Modulators;Anesthetics, Intravenous |
| DB00690 | potentiator | Flurazepam | Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators |
| DB00801 | potentiator | Halazepam | Anti-anxiety Agents;Muscle Relaxants;Benzodiazepines;Sedative |
| DB00829 | potentiator | Diazepam | Anti-anxiety Agents;Hypnotics and Sedatives;Antiemetics;Anticonvulsants;Adjuvants, Anesthesia;GABA Modulators;Anesthetics, Intravenous;Muscle Relaxants, Central |
| DB00842 | potentiator | Oxazepam | Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators |
| DB00897 | potentiator | Triazolam | Anti-anxiety Agents;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators |
| DB01068 | potentiator | Clonazepam | Anticonvulsants;Benzodiazepines;GABA Modulators |
| DB01215 | potentiator | Estazolam | Anti-anxiety Agents;Anticonvulsants;GABA Modulators |
| DB01558 | potentiator | Bromazepam | Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators |
| DB01559 | potentiator | Clotiazepam | Anti-anxiety Agents;Hypnotics and Sedatives;Anticonvulsants;Benzodiazepines |
| DB01567 | potentiator | Fludiazepam | Anti-anxiety Agents;Benzodiazepines |
| DB01588 | potentiator | Prazepam | Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators |
| DB01589 | potentiator | Quazepam | Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators |
| DB01594 | potentiator | Cinolazepam | Anticonvulsants;Benzodiazepines;Sedatives and Hypnotics |
| DB01595 | potentiator | Nitrazepam | Anti-anxiety Agents;Hypnotics and Sedatives;Anticonvulsants;GABA Modulators |
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