Gene Symbol:	GAD1 ( FLJ45882,GAD,SCP )
Gene Full Name:	glutamate decarboxylase 1 (brain, 67kDa)
Band:	2q31.1
Quick Links	Entrez ID:2571; OMIM: 605363; Uniprot ID:DCE1_HUMAN; ENSEMBL ID: ENSG00000128683; HGNC ID: 4092
Relate to Another Database:	SFARIGene; denovo-db

Pathway ID	Pathway Name
GLUDEG-I-PWY	glutamate degradation III (via 4-aminobutyrate)
PWY0-1305	glutamate dependent acid resistance

Pathway ID	Pathway Name
hsa00410	beta-Alanine metabolism
hsa00250	Alanine, aspartate and glutamate metabolism
hsa00430	Taurine and hypotaurine metabolism
hsa01100	Metabolic pathways
hsa04940	Type I diabetes mellitus
hsa00650	Butanoate metabolism

Desease ID	Desease Name
1718	Anxiety disorder
1755	Cleft palate
1789	Movement disorder
1791	Neuropathy
1923	Generalized anxiety disorder
1982	Myopathy
2045	Bipolar disorder
2124	Autistic disorder
2198	Psychotic disorder

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
C012587	3,5,6-trichloro-2-pyridinol	3,5,6-trichloro-2-pyridinol results in decreased activity of GAD1 protein	decreases activity	15541749
C024836	4-nitrophenol	4-nitrophenol results in decreased activity of GAD1 protein	decreases activity	15541749
D000082	Acetaminophen	Acetaminophen affects the expression of GAD1 mRNA	affects expression	17562736
D019342	Acetic Acid	Acetic Acid results in increased expression of GAD1 mRNA	increases expression	17065238
C069206	alpha helical corticotropin-releasing hormone	alpha helical corticotropin-releasing hormone results in increased expression of GAD1 protein	increases expression	15486230
C010845	aluminum chloride	aluminum chloride results in increased activity of GAD1 protein	increases activity	11696403
D005680	gamma-Aminobutyric Acid	GAD1 protein results in increased chemical synthesis of gamma-Aminobutyric Acid	increases chemical synthesis	11875278 9634146
D005680	gamma-Aminobutyric Acid	GAD1 protein results in increased chemical synthesis of gamma-Aminobutyric Acid	increases chemical synthesis	15571623
D005680	gamma-Aminobutyric Acid	GAD1 protein results in increased chemical synthesis of gamma-Aminobutyric Acid	increases chemical synthesis	15368530 12376704
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of GAD1 mRNA	affects expression	16483693
D000661	Amphetamine	Amphetamine results in increased expression of GAD1 mRNA	increases expression	18312583
D000661	Amphetamine	Amphetamine results in increased expression of GAD1 protein	increases expression	14725721
D014150	Antipsychotic Agents	Antipsychotic Agents results in increased expression of GAD1 mRNA	increases expression	18923069
C027423	aroclor 1242	[aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of GAD1 protein	affects cotreatment\|decreases expression	17324953
C028617	aroclor 1248	[aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of GAD1 protein	affects cotreatment\|decreases expression	17324953
C026987	aroclor 1260	[aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of GAD1 protein	affects cotreatment\|decreases expression	17324953
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of GAD1 mRNA	increases expression	20106945
C006780	bisphenol A	bisphenol A results in decreased expression of GAD1 mRNA	decreases expression	18180321
D002087	Butyrates	GAD1 protein results in decreased susceptibility to Butyrates	decreases response to substance	15369822
D020111	Chlorodiphenyl (54% Chlorine)	[aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of GAD1 protein	affects cotreatment\|decreases expression	17324953
D002746	Chlorpromazine	Chlorpromazine results in decreased methylation of GAD1 promoter	decreases methylation	19110320
D002746	Chlorpromazine	Valproic Acid promotes the reaction [Chlorpromazine results in decreased methylation of GAD1 promoter]	decreases methylation\|increases reaction	19110320
D003024	Clozapine	Clozapine results in increased expression of GAD1 mRNA	increases expression	17942719
D003024	Clozapine	Clozapine promotes the reaction [MLL1 protein binds to GAD1 promoter]	affects binding\|increases reaction	17942719
D003024	Clozapine	Clozapine results in decreased methylation of GAD1 promoter	decreases methylation	18757738
D003024	Clozapine	Valproic Acid promotes the reaction [Clozapine results in decreased methylation of GAD1 promoter]	decreases methylation\|increases reaction	18757738
D003024	Clozapine	Clozapine results in increased expression of GAD1 mRNA	increases expression	18923069 15061247 12887421
D003975	Diazepam	Diazepam results in decreased expression of GAD1 mRNA	decreases expression	15802192
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of GAD1 mRNA	increases expression	15620428
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in increased expression of GAD1 mRNA	increases expression	17065238
D007980	Levodopa	Levodopa results in increased expression of GAD1 mRNA	increases expression	14622157
D007980	Levodopa	Levodopa results in increased expression of GAD1 mRNA	increases expression	15837143
D018492	Dopamine Antagonists	Dopamine Antagonists results in increased expression of GAD1 mRNA	increases expression	15044549
D004317	Doxorubicin	Doxorubicin results in increased expression of GAD1 mRNA	increases expression	17065238
D004958	Estradiol	Estradiol results in increased expression of GAD1 mRNA	increases expression	15677881
D000431	Ethanol	Ethanol results in increased expression of GAD1 mRNA	increases expression	15729141
D005033	Ethylmaleimide	Ethylmaleimide results in decreased activity of GAD1 protein	decreases activity	15836621
C045989	eticlopride	eticlopride results in increased expression of GAD1 mRNA	increases expression	15044549
D016666	Fluvoxamine	[Haloperidol co-treated with Fluvoxamine] affects the expression of GAD1 protein	affects cotreatment\|affects expression	15967061
D005665	Furosemide	Furosemide results in decreased expression of GAD1 mRNA	decreases expression	14596865
D005947	Glucose	Glucose promotes the reaction [[IPF1 protein binds to GAD1 promoter] which results in increased expression of GAD1 mRNA]	affects binding\|increases expression\|increases reaction	12150938
D005947	Glucose	Glucose results in increased expression of GAD1 mRNA	increases expression	12150938
D006220	Haloperidol	[Haloperidol co-treated with Fluvoxamine] affects the expression of GAD1 protein	affects cotreatment\|affects expression	15967061
D006220	Haloperidol	Haloperidol results in decreased expression of GAD1 mRNA	decreases expression	14519413
D006220	Haloperidol	Haloperidol results in decreased expression of GAD1 protein	decreases expression	19359144
D006220	Haloperidol	Haloperidol results in increased expression of GAD1 mRNA	increases expression	12887421 18923069 15061247
D006854	Hydrocortisone	Hydrocortisone results in increased expression of GAD1 protein	increases expression	15531528
D006861	Hydrogen Peroxide	GAD1 protein results in decreased susceptibility to Hydrogen Peroxide	decreases response to substance	15369822
D016627	Oxidopamine	Oxidopamine results in increased expression of GAD1 mRNA	increases expression	14622157
D016627	Oxidopamine	Oxidopamine results in increased expression of GAD1 mRNA	increases expression	12077209 15610165 15044549
C049985	K 252	K 252 results in decreased expression of GAD1 mRNA	decreases expression	12859332
C049985	K 252	K 252 results in decreased expression of GAD1 protein	decreases expression	12859332
D015097	3-Mercaptopropionic Acid	3-Mercaptopropionic Acid results in decreased activity of GAD1 protein	decreases activity	4154755
D008715	Methionine	Methionine results in decreased expression of GAD1 mRNA	decreases expression	15671176
D008727	Methotrexate	GAD1 protein affects the susceptibility to Methotrexate	affects response to substance	16217747
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GAD1 mRNA	increases expression	15363887
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GAD1 protein	increases expression	15882945
D009020	Morphine	Morphine results in increased expression of GAD1 mRNA	increases expression	18312583 15673448
D009151	Mustard Gas	Mustard Gas results in increased expression of GAD1 mRNA	increases expression	15674844
D009538	Nicotine	Nicotine results in increased expression of GAD1 mRNA	increases expression	18312583
C025256	nonylphenol	nonylphenol results in increased expression of GAD1 mRNA	increases expression	15620428
C076029	olanzapine	olanzapine results in decreased expression of GAD1 mRNA	decreases expression	14519413
C076029	olanzapine	olanzapine results in decreased expression of GAD1 protein	decreases expression	19359144
D010269	Paraquat	Paraquat results in decreased expression of GAD1 mRNA	decreases expression	17493592
C033457	phenobarbital quinidine	phenobarbital quinidine results in decreased expression of GAD1 mRNA	decreases expression	15802192
D010852	Picrotoxin	Picrotoxin results in increased expression of GAD1 mRNA	increases expression	15170462
D011732	Pyridoxal Phosphate	Pyridoxal Phosphate binds to GAD1 protein modified form	affects binding	15686475
D020849	Raloxifene	[Raloxifene co-treated with ESR2 protein] results in increased expression of GAD1 mRNA	affects cotreatment\|increases expression	19059307
C017947	sodium arsenite	sodium arsenite results in increased expression of GAD1 mRNA	increases expression	20376865
D013469	Sulpiride	Sulpiride results in decreased methylation of GAD1 promoter	decreases methylation	18757738
D013469	Sulpiride	Valproic Acid promotes the reaction [Sulpiride results in decreased methylation of GAD1 promoter]	decreases methylation\|increases reaction	18757738
D013629	Tamoxifen	[Tamoxifen co-treated with ESR2 protein] results in increased expression of GAD1 mRNA	affects cotreatment\|increases expression	19059307
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of GAD1 mRNA	increases expression	16714409
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of GAD1 mRNA	increases expression	20106945
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of GAD1 mRNA	decreases expression	12060831
D015647	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of GAD1 mRNA	increases expression	14622157
D014212	Tretinoin	Tretinoin results in increased expression of GAD1 mRNA	increases expression	11841568
D014212	Tretinoin	Tretinoin results in increased expression of GAD1 protein alternative form	increases expression	11841568
D014635	Valproic Acid	Valproic Acid promotes the reaction [Chlorpromazine results in decreased methylation of GAD1 promoter]	decreases methylation\|increases reaction	19110320
D014635	Valproic Acid	Valproic Acid promotes the reaction [Clozapine results in decreased methylation of GAD1 promoter]	decreases methylation\|increases reaction	18757738
D014635	Valproic Acid	Valproic Acid promotes the reaction [Sulpiride results in decreased methylation of GAD1 promoter]	decreases methylation\|increases reaction	18757738
D014635	Valproic Acid	Valproic Acid results in increased expression of GAD1 mRNA	increases expression	15737665
D014635	Valproic Acid	Valproic Acid results in increased expression of GAD1 protein	increases expression	15379904

Pathway ID	Pathway Name
KEGG:00250	Alanine, aspartate and glutamate metabolism
KEGG:00410	beta-Alanine metabolism
KEGG:00650	Butanoate metabolism
KEGG:01100	Metabolic pathways
REACT:13685	Synaptic Transmission
KEGG:00430	Taurine and hypotaurine metabolism
KEGG:04940	Type I diabetes mellitus

Drugbank ID	Action	Drug Name	Description
DB00114	-	Pyridoxal Phosphate	Dietary supplement;Micronutrient;Vitamin B Complex
DB00142	-	L-Glutamic Acid	Dietary supplement;Micronutrient;Non-Essential Amino Acids

Desease Name
neuroticism
CHEMDEPENDENCY
alcohol consumption
PSYCH
cleft lip with cleft palate
cleft lip without cleft palate
anxiety disorder
depressive disorder, major
schizophrenia
DEVELOPMENTAL

Disease ID	Disease Name	Inference Chemical Name	Inference Score	Publication
MESH:D000008	Abdominal Neoplasms	Tamoxifen	3.93	14745880
MESH:D000014	Abnormalities, Drug-Induced	Ethanol	15.50	18926900 17676605
MESH:D000014	Abnormalities, Drug-Induced	Methotrexate	15.50	12039119
MESH:D000014	Abnormalities, Drug-Induced	Tetrachlorodibenzodioxin	15.50	14514962 15322242 11752688
MESH:D000014	Abnormalities, Drug-Induced	Valproic Acid	15.50	8875741
MESH:D000015	Abnormalities, Multiple	Valproic Acid	3.39	19490988
MESH:D000138	Acidosis	Ammonium Chloride	8.48	18287403
MESH:D000138	Acidosis	Ethanol	8.48	11192467
MESH:D000230	Adenocarcinoma	Benzo(a)pyrene	5.96	20127859 20464547
MESH:D000230	Adenocarcinoma	Doxorubicin	5.96	17418594
MESH:D000230	Adenocarcinoma	Estradiol	5.96	11473722
MESH:D000236	Adenoma	Benzo(a)pyrene	2.28	6695378
MESH:D018248	Adenoma, Liver Cell	Tetrachlorodibenzodioxin	2.78	16835633
MESH:D000310	Adrenal Gland Neoplasms	sodium arsenite	4.09	15276417
MESH:D018246	Adrenocortical Adenoma	sodium arsenite	4.29	16712894 17306315
MESH:D000380	Agranulocytosis	Clozapine	4.47	14617031 12649775 16160616
MESH:D000382	Agricultural Workers' Diseases	Paraquat	3.18	11874814
MESH:D000419	Albuminuria	Doxorubicin	9.56	21441931
MESH:D000419	Albuminuria	Raloxifene	9.56	17308373 17451421
MESH:D020268	Alcohol-Induced Disorders, Nervous System	Ethanol	4.71	15451039 15451040
MESH:D000505	Alopecia	Tretinoin	3.13	15955085
MESH:D000544	Alzheimer Disease	Nicotine	4.10	16627626
MESH:D000544	Alzheimer Disease	Raloxifene	4.10	15800139
MESH:D000550	Amblyopia	Valproic Acid	4.62	17688650
MESH:D019969	Amphetamine-Related Disorders	Amphetamine	5.45	16916582 16459022 15010207 18475255
MESH:D000740	Anemia	Tetrachlorodibenzodioxin	2.43	11748828
MESH:D000799	Angioedema	Acetaminophen	3.23	10982225
MESH:D000853	Anophthalmos	Ethanol	4.23	15513904
MESH:D000855	Anorexia	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	9.13	12183048
MESH:D000855	Anorexia	Amphetamine	9.13	12183048 12005258 16101753 16084549
MESH:D001008	Anxiety Disorders	Diazepam	12.27	16284244 18313124
MESH:D001008	Anxiety Disorders	Ethanol	12.27	11141031
MESH:D001008	Anxiety Disorders	Valproic Acid	12.27	17497229
MESH:D017544	Aortic Aneurysm, Abdominal	Benzo(a)pyrene	3.49	19183758
MESH:D001169	Arthritis, Experimental	Tretinoin	2.69	16412693
MESH:D001172	Arthritis, Rheumatoid	Methotrexate	4.25	17286800
MESH:D001172	Arthritis, Rheumatoid	Tretinoin	4.25	16292516
MESH:D001249	Asthma	Mustard Gas	4.23	10378619
MESH:D001249	Asthma	Tretinoin	4.23	16456186
MESH:D001289	Attention Deficit Disorder with Hyperactivity	Oxidopamine	4.23	14699433

AutismKB 2.0

Annotation Detail for GAD1

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics