AutismKB 2.0

Annotation Detail for NEGR1


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Basic Information Top
Gene Symbol:NEGR1 ( DMML2433,IGLON4,KILON,MGC46680,Ntra )
Gene Full Name: neuronal growth regulator 1
Band: 1p31.1
Quick LinksEntrez ID:257194; OMIM: 613173; Uniprot ID:NEGR1_HUMAN; ENSEMBL ID: ENSG00000172260; HGNC ID: 17302
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04514Cell adhesion molecules (CAMs)
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
HEMATOLOGICAL
hemostatic factors and hematological phenotypes
Body mass index
systemic lupus erythematosus
IMMUNE
weight
METABOLIC
Desease Name
Hemostatic factors and hematological phenotypes
Body mass index
Systemic lupus erythematosus
Weight
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NEGR1 mRNAaffects expression 21346803
D001104 Arbutin Arbutin results in decreased expression of NEGR1 mRNAdecreases expression 17103032
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of NEGR1 mRNAdecreases expression 20713471
D004041 Dietary Fats Dietary Fats results in decreased expression of NEGR1 mRNAdecreases expression 18042831
D004958 Estradiol Estradiol results in decreased expression of NEGR1 mRNAdecreases expression 20068009
D005419 Flavonoids Flavonoids results in decreased expression of NEGR1 mRNAdecreases expression 18035473
C041786 palm oil palm oil results in decreased expression of NEGR1 mRNAdecreases expression 18042831
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of NEGR1 mRNAdecreases expression 19465110
D014303 Trinitrotoluene Trinitrotoluene affects the expression of NEGR1 mRNAaffects expression 21346803
D014635 Valproic Acid Valproic Acid results in increased expression of NEGR1 mRNAincreases expression 19101580
C025643 vinclozolin vinclozolin affects the expression of NEGR1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 15.4814514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 15.487525203
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 15.488875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0719490988
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3920127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.3911473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.736695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000550 Amblyopia Valproic Acid 5.4517688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D001008 Anxiety Disorders Valproic Acid 9.2317497229
MESH:D001008 Anxiety Disorders vinclozolin 9.2319015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001161 Arteriosclerosis Dietary Fats 4.0615238619
MESH:D001321 Autistic Disorder Valproic Acid 1.9918940202 18558336 17688650 15238991 17507914 20603192 17157402 18985861 19460635 18316065 16609825 18177632 18775368 19232924 18396377
MESH:D001714 Bipolar Disorder Valproic Acid 3.1417594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.3115746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.318888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9420146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 1.9420435547
MESH:D001943 Breast Neoplasms Estradiol 1.9417018787 17289903 14630087 12948864 18497071 17261762 16675129 19861407
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6616111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.0216705839
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.0216924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4416120746 18670907 18850075
MESH:D002386 Cataract Trinitrotoluene 3.9514694615 15817613
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.8618566989
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7520734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1515668235 8697196 15340226 16354765 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.6914669216 17141729
MESH:D000013 Congenital Abnormalities Trinitrotoluene 9.6915095906
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5115322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.518888407 17688650 16575769
MESH:D003456 Cryptorchidism vinclozolin 4.5014966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.8218551238
MESH:D003490 Cyanosis Trinitrotoluene 11.8218551238
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5419279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.3321346803 18551238
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.3320420201
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 9.3318551238 21346803
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.331733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5518367378
MESH:D004421 Dystonia Valproic Acid 4.201851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1215322242 18230668 16714409
MESH:D016889 Endometrial Neoplasms Estradiol 3.0711473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.333659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.133922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0020417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.717562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.477750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.263659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Dietary Fats 8.3718296743 19004024 19551842 17967931
MESH:D005234 Fatty Liver Valproic Acid 8.3719224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005315 Fetal Diseases Valproic Acid 5.1016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.298888407 18558336
MESH:D005355 Fibrosis Dietary Fats 9.2218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2220067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5216417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6710048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.3115340226 12621046 16120746
MESH:D006529 Hepatomegaly Trinitrotoluene 9.3115817613
MESH:D006558 Herpes Genitalis Estradiol 5.2515709030
MESH:D019584 Hot Flashes Estradiol 3.9717088409
MESH:D006849 Hydrocephalus Valproic Acid 5.0617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.268697196 18606429 15340226 16354765 16959395
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7321332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.7621332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518850075 18670907
MESH:D007248 Infertility, Male Trinitrotoluene 7.4012150543
MESH:D007248 Infertility, Male vinclozolin 7.4016467254
MESH:D007249 Inflammation Dietary Fats 8.7220412841
MESH:D007249 Inflammation Flavonoids 8.7217296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.7212200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 7.6618457598 11836018
MESH:D007333 Insulin Resistance Estradiol 7.6616627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007674 Kidney Diseases Estradiol 2.6615618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.7616705839
MESH:D007680 Kidney Neoplasms Estradiol 7.7615610895
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1716294345 17596541
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9316417039
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9518296743
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3012878042
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.4921137059 20195826
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.4916984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1912151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4817228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.2220135361 20064080 18520028 20464547 17053015 18816296 6695378 18569708 20869020
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2211884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6411807958 11408345 16891317 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.7019453300
MESH:D008881 Migraine Disorders Valproic Acid 3.2918803445 18765137
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.178888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2317596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3916810080
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.3418551238
MESH:D009336 Necrosis Trinitrotoluene 11.3418551238
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2311141357
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9317289903
MESH:D009421 Nervous System Malformations Estradiol 10.0111399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.0114600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.218888407 16359493
MESH:D009765 Obesity marker/mechanism 19079261
MESH:D009765 Obesity Dietary Fats 2.3121332399 20132043 17217161 11836018 19632207 18674790 18457598 16723640 20518802
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.6612819281 16049721
MESH:D009784 Occupational Diseases Trinitrotoluene 9.6614694615 17852074 12819281
MESH:D010051 Ovarian Neoplasms Estradiol 2.2519401270
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 17.4211896295 11222880 11399792 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 17.4220603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 17.4218220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.1318220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0220887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0717292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.0716740699
MESH:D011472 Prostatitis vinclozolin 5.1318629315
MESH:D019310 Pseudolymphoma Valproic Acid 4.7611422049 12752131
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3219155313
MESH:D012559 Schizophrenia Valproic Acid 2.0819110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 10.4918551238
MESH:D012640 Seizures Trinitrotoluene 10.4918551238
MESH:D012640 Seizures Valproic Acid 10.4911044598 1511512 14763951 15475178 3137016 11738929 16876388 17978042
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.6719755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6716192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8919490988
MESH:D013163 Splenomegaly Trinitrotoluene 5.3815817613
MESH:D013226 Status Epilepticus Valproic Acid 4.7612833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013978 Tibial Fractures Estradiol 4.9019048282
MESH:D014178 Translocation, Genetic Valproic Acid 5.4517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.713119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.1316049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1317053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.828888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5110091137
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D015430 Weight Gain Dietary Fats 3.8616723640
Pathway ID Pathway Name
KEGG:04514 Cell adhesion molecules (CAMs)
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134862452
    • No data
    Releated disease ID Related disease Name
    PA445131Obesity
    PA153906318Autism Spectrum Disorder
    PA444395Hematologic Diseases
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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