AutismKB 2.0

Annotation Detail for GAD2


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Basic Information Top
Gene Symbol:GAD2 ( GAD65,MGC161605,MGC161607 )
Gene Full Name: glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
Band: 10p12.1
Quick LinksEntrez ID:2572; OMIM: 138275; Uniprot ID:DCE2_HUMAN; ENSEMBL ID: ENSG00000136750; HGNC ID: 4093
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
GLUDEG-I-PWYglutamate degradation III (via 4-aminobutyrate)
PWY0-1305glutamate dependent acid resistance
Pathway IDPathway Name
hsa00410beta-Alanine metabolism
hsa00250Alanine, aspartate and glutamate metabolism
hsa00430Taurine and hypotaurine metabolism
hsa01100Metabolic pathways
hsa04940Type I diabetes mellitus
hsa00650Butanoate metabolism
Pathway IDPathway Name
Synaptic Transmission
No data
Pathway IDPathway Name
P04384Gamma-aminobutyric acid synthesis
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1718Anxiety disorder
1789Movement disorder
1821Spinal cord disease
1850Herpes
1856Obesity
1870Drug abuse
1894Abortion
1904Diabetes mellitus
1923Generalized anxiety disorder
2069Schizophrenia
Desease Name
body mass glucose tolerance glycemia obesity, localized
Birth Weight
PSYCH
schizophrenia
METABOLIC
obesity
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D013196 Dihydrotestosterone Dihydrotestosterone results in decreased expression of GAD2 mRNAdecreases expression 14967907
D005680 gamma-Aminobutyric Acid GAD2 protein results in increased chemical synthesis of gamma-Aminobutyric Acidincreases chemical synthesis 9634146
D005680 gamma-Aminobutyric Acid GAD2 protein results in increased chemical synthesis of gamma-Aminobutyric Acidincreases chemical synthesis 15368537
D005680 gamma-Aminobutyric Acid GAD2 protein results in increased chemical synthesis of gamma-Aminobutyric Acidincreases chemical synthesis 12376704
D005680 gamma-Aminobutyric Acid GAD2 protein results in increased chemical synthesis of gamma-Aminobutyric Acidincreases chemical synthesis 12634427
D000625 Aminooxyacetic Acid Aminooxyacetic Acid results in decreased activity of GAD2 proteindecreases activity 12634427
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GAD2 mRNAaffects expression 16483693
C027423 aroclor 1242 [aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of GAD2 proteinaffects cotreatment|decreases expression 17324953
C028617 aroclor 1248 [aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of GAD2 proteinaffects cotreatment|decreases expression 17324953
C026987 aroclor 1260 [aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of GAD2 proteinaffects cotreatment|decreases expression 17324953
D020111 Chlorodiphenyl (54% Chlorine) [aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of GAD2 proteinaffects cotreatment|decreases expression 17324953
D003024 Clozapine Clozapine results in increased expression of GAD2 mRNAincreases expression 17266109
D003024 Clozapine Clozapine results in increased expression of GAD2 mRNAincreases expression 18923069
D003042 Cocaine Cocaine affects the expression of GAD2 proteinaffects expression 15722053
D003975 Diazepam Diazepam results in decreased expression of GAD2 mRNAdecreases expression 15802192
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in decreased expression of GAD2 mRNAdecreases expression 15620428
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of GAD2 mRNAdecreases expression 12807726
D007980 Levodopa Levodopa results in increased expression of GAD2 mRNAincreases expression 15837143
D004958 Estradiol Estradiol results in increased expression of GAD2 mRNAincreases expression 15677881
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of GAD2 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of GAD2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GAD2 mRNAaffects cotreatment|increases expression 17942748
D005033 Ethylmaleimide Ethylmaleimide results in decreased activity of GAD2 proteindecreases activity 15836621
D005473 Fluoxetine Fluoxetine results in increased expression of GAD2 proteinincreases expression 19359144
D006220 Haloperidol Haloperidol results in decreased expression of GAD2 mRNAdecreases expression 18923069
D006220 Haloperidol Haloperidol results in decreased expression of GAD2 proteindecreases expression 19359144
D006220 Haloperidol Haloperidol results in increased expression of GAD2 mRNAincreases expression 18923069
C029424 hydrazine hydrazine results in decreased activity of GAD2 proteindecreases activity 12634427
D006854 Hydrocortisone Hydrocortisone results in increased expression of GAD2 proteinincreases expression 15531528
C049985 K 252 K 252 results in decreased expression of GAD2 mRNAdecreases expression 12859332
C049985 K 252 K 252 results in decreased expression of GAD2 proteindecreases expression 12859332
D015097 3-Mercaptopropionic Acid 3-Mercaptopropionic Acid results in decreased activity of GAD2 proteindecreases activity 4154755
D008694 Methamphetamine Methamphetamine results in increased expression of GAD2 mRNAincreases expression 15601951
C025256 nonylphenol nonylphenol results in decreased expression of GAD2 mRNAdecreases expression 15620428
C076029 olanzapine olanzapine results in decreased expression of GAD2 proteindecreases expression 19359144
D010433 Pentylenetetrazole GAD2 gene mutant form results in increased susceptibility to Pentylenetetrazoleincreases response to substance 8954991
D010622 Phencyclidine Phencyclidine results in increased expression of GAD2 mRNAincreases expression 17266109
D010634 Phenobarbital Phenobarbital results in increased expression of GAD2 mRNAincreases expression 12807726
C033457 phenobarbital quinidine phenobarbital quinidine results in decreased expression of GAD2 mRNAdecreases expression 15802192
D010852 Picrotoxin GAD2 gene mutant form results in increased susceptibility to Picrotoxinincreases response to substance 8954991
D010852 Picrotoxin Picrotoxin results in increased expression of GAD2 mRNAincreases expression 15170462
D010852 Picrotoxin Picrotoxin results in increased expression of GAD2 proteinincreases expression 15382257
D010862 Pilocarpine Pilocarpine affects the expression of GAD2 proteinaffects expression 15857427
D010862 Pilocarpine Pilocarpine results in increased expression of GAD2 proteinincreases expression 15987249
D011732 Pyridoxal Phosphate Pyridoxal Phosphate binds to GAD2 proteinaffects binding 15690345
15686475
15836621
D011732 Pyridoxal Phosphate Pyridoxal Phosphate binds to GAD2 protein modified formaffects binding 15686475
C017947 sodium arsenite sodium arsenite results in decreased expression of GAD2 mRNAdecreases expression 20308225
C017947 sodium arsenite sodium arsenite results in increased expression of GAD2 mRNAincreases expression 20376865
D013629 Tamoxifen Tamoxifen affects the expression of GAD2 mRNAaffects expression 17555576
D043343 Testosterone Propionate Testosterone Propionate results in increased expression of GAD2 mRNAincreases expression 14967907
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GAD2 mRNAaffects cotreatment|increases expression 17942748
D014212 Tretinoin Tretinoin results in increased expression of GAD2 mRNAincreases expression 11841568
D014635 Valproic Acid Valproic Acid results in increased expression of GAD2 proteinincreases expression 15379904
D014635 Valproic Acid Valproic Acid results in decreased expression of GAD2 mRNAdecreases expression 19359144
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.1314745880
MESH:D000014 Abnormalities, Drug-Induced Diethylhexyl Phthalate 17.046734493
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 17.046195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 17.0415322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 17.048875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.5619490988
MESH:D000138 Acidosis Ammonium Chloride 3.1518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5317505938
MESH:D000230 Adenocarcinoma Estradiol 3.8311473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.8314692618
MESH:D000236 Adenoma Diethylnitrosamine 2.6110737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 14.9916434500 19052882 18056438 17620307 17162532 19061943
MESH:D018248 Adenoma, Liver Cell Phenobarbital 14.9917620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 14.9916835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.2815276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.4916712894 17306315
MESH:D000380 Agranulocytosis Clozapine 4.6614617031 12649775 16160616
MESH:D000505 Alopecia Tretinoin 3.2915955085
MESH:D000550 Amblyopia Valproic Acid 4.8217688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6011748828
MESH:D001008 Anxiety Disorders Diazepam 13.3316284244 18313124
MESH:D001008 Anxiety Disorders Fluoxetine 13.3318083778
MESH:D001008 Anxiety Disorders Valproic Acid 13.3317497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.3515885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.3516412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1616292516
MESH:D001249 Asthma Tretinoin 2.2116456186
MESH:D001321 Autistic Disorder Fluoxetine 2.6919232924 18775368
MESH:D001321 Autistic Disorder Haloperidol 2.6918080171 19368416
MESH:D001321 Autistic Disorder olanzapine 2.6918685284 17069543
MESH:D001321 Autistic Disorder Valproic Acid 2.6917507914 18940202 18985861 16609825 18316065 19460635 15238991 17157402 18558336 19232924 20603192 17688650 18177632 18775368 18396377
MESH:D001471 Barrett Esophagus Tretinoin 4.0216935849
MESH:D001714 Bipolar Disorder Valproic Acid 2.8617594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.7312125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 7.7316206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.1415746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.148888407
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1817474063
MESH:D001943 Breast Neoplasms Estradiol 2.1819861407 17018787 17289903 16675129 17261762 18497071 12948864 14630087
MESH:D001943 Breast Neoplasms Tamoxifen 2.1818821012 19084267 18997820 20544844 19244106 16202921 11161223 19189210 18351453 18855134 20065188 19142967 16818667 19189212 19155303 15668708 20135344 19221464 19059307 18629630 19487384 18815881 19410462 17893378 19289846 19011961 21138602 15565566 18425577 20859285 19200415 20005174 17242785 19288272 19115204 16273361 17440819 19103187 17261762 21152245 20390343 18984771 16873071 17049068 19066611
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1820435547
MESH:D001943 Breast Neoplasms Tretinoin 2.1816873071 16166294 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.1816813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0616111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.4816835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1119066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.7416168501
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 10.3718788625 17138121 16878318 17978847 16502159 21159647 19052882 19822196 16328049 20007298 16288022 16779866 20514400 19171122 18506893 19539802 18056438 16698587 17761372 11831363 16569478 20101231 18210153 20084675 16681979 19394651 19383236 19335982 10672840 18978308 19107877 3581430 20727157 19418558 20214788 17428255 19208518 20512989 16935385 18785209 18393292 16807293 18691550 20935162 17055752 18971187 17173139 10737359 20432363 16540662 19701751 16830150 3084413 20524982 19919837 18665156 18494052 19519916 17162532
MESH:D006528 Carcinoma, Hepatocellular Estradiol 10.3716924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 10.3717173139 1701930 20007298 6705139 20935162
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 10.3715276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 10.3716924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 10.371917145
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.2518572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.2516096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.2617572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1418850075 18670907 16120746
MESH:D002375 Catalepsy Haloperidol 4.5015215559 1977408
MESH:D002386 Cataract Tretinoin 2.8517460283
MESH:D002389 Catatonia olanzapine 5.8318071103 16772815
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 9.5817174075 2727394 21159647 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 9.5818566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 9.5819524636 20056578
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.854080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.1816129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5520734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.1919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.1916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.5717110522 17681005 17333356 16919318 15861022 16105132 11677210
MESH:D002822 Choriocarcinoma Tretinoin 4.7416461808
MESH:D002972 Cleft Palate Diazepam 12.723629520
MESH:D002972 Cleft Palate Hydrocortisone 12.7215826874
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 12.7212621046 8697196 16354765 15340226 15668235
MESH:D002972 Cleft Palate Tretinoin 12.729407595
MESH:D019970 Cocaine-Related Disorders Cocaine 5.3119606084
MESH:D003072 Cognition Disorders Clozapine 4.5717123785
MESH:D003092 Colitis Tretinoin 3.3117035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7217141729 14669216
MESH:D019465 Craniofacial Abnormalities Hydrocortisone 5.0317728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.0320055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.039664655 10589399 8800419 17551590 9125849 16925845 9211117 9142499 9224671 14991402
MESH:D019465 Craniofacial Abnormalities Valproic Acid 5.0316575769 17688650 8888407
MESH:D003643 Death Pentylenetetrazole 6.336431079
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.4720210726
MESH:D003704 Dementia Haloperidol 4.2211575062
MESH:D003711 Demyelinating Diseases Tamoxifen 3.9619031437
MESH:D003866 Depressive Disorder Fluoxetine 4.3115014590
MESH:D003876 Dermatitis, Atopic Diethylhexyl Phthalate 3.8516882537
MESH:D002658 Developmental Disabilities olanzapine 4.4217069543
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 6.5016402076
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.5020387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.5017107852
MESH:D003928 Diabetic Nephropathies Estradiol 7.7119279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 7.7119279558
MESH:D003967 Diarrhea Hydrocortisone 4.347237001
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.1415331141
MESH:D056486 Drug-Induced Liver Injury aroclor 1260 10.626156243
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 10.6217851650
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 10.6219107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 10.6220420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 10.621733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4611462148
MESH:D004409 Dyskinesia, Drug-Induced Levodopa 5.953690436 15893579
MESH:D050171 Dyslipidemias Clozapine 3.8916402076
MESH:D004421 Dystonia Diazepam 15.731851702
MESH:D004421 Dystonia Phenobarbital 15.731851702
MESH:D004421 Dystonia Valproic Acid 15.731851702
MESH:D004487 Edema Fluoxetine 6.0512798668
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.0511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.5615322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.5618230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.6712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 7.6719031437
MESH:D016889 Endometrial Neoplasms Estradiol 10.8618566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 10.8616202921 17893378 19155303 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 10.8616569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.679294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 9.473659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 9.473659116 17275665
MESH:D004828 Epilepsies, Partial Diazepam 14.643922381
MESH:D004828 Epilepsies, Partial Phenobarbital 14.643922381 11558140
MESH:D004828 Epilepsies, Partial Valproic Acid 14.643922381 16628512
MESH:D004827 Epilepsy Diazepam 14.10821787
MESH:D004827 Epilepsy Phenobarbital 14.1020417680
MESH:D004827 Epilepsy Pilocarpine 14.1011162239 19439326 19700373
MESH:D004827 Epilepsy Valproic Acid 14.1020417680 18234410
MESH:D004832 Epilepsy, Absence Diazepam 18.586426943 6401628
MESH:D004832 Epilepsy, Absence Pentylenetetrazole 18.586426943
MESH:D004832 Epilepsy, Absence Phenobarbital 18.586401628
MESH:D004832 Epilepsy, Absence Valproic Acid 18.587562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 9.987750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 9.987750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 9.133659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 9.133659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7016302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.8311564622
MESH:D005124 Eye Abnormalities Tretinoin 7.839664655 16938888
MESH:D005234 Fatty Liver Diethylnitrosamine 15.8020387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.8015345470
MESH:D005234 Fatty Liver Tamoxifen 15.8019224547 14986274
MESH:D005234 Fatty Liver Valproic Acid 15.8014986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.9816709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0611858732
MESH:D005315 Fetal Diseases Valproic Acid 4.4716575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.758888407 18558336
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.1214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.7819069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.3020067830
MESH:D005355 Fibrosis Tretinoin 7.3017994277
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.2716452187
MESH:D005909 Glioblastoma Tretinoin 2.7417312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1810696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.9116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.7416084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.7911294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 5.799664655 14991402
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9711000095
MESH:D006529 Hepatomegaly Phenobarbital 7.1316109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.1316120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.6215709030
MESH:D006689 Hodgkin Disease sodium arsenite 2.8212676792
MESH:D019584 Hot Flashes Estradiol 9.1617088409
MESH:D019584 Hot Flashes Fluoxetine 9.1614716179
MESH:D006849 Hydrocephalus Valproic Acid 4.4617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6315340226 16959395 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Tretinoin 2.9016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.1716778211
MESH:D020138 Hyperhomocysteinemia Levodopa 5.3616275827 16787708
MESH:D006948 Hyperkinesis Clozapine 10.4716046005
MESH:D006948 Hyperkinesis Methamphetamine 10.4717658665
MESH:D006963 Hyperphagia olanzapine 5.8217933447
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.7518850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4116945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.7317937319
MESH:D007248 Infertility, Male sodium arsenite 5.7315346721 12646999
MESH:D007249 Inflammation Diethylnitrosamine 10.1918785209
MESH:D007249 Inflammation Fluoxetine 10.1912798668
MESH:D007249 Inflammation Tamoxifen 10.1919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.1912200463 12878042
MESH:D007333 Insulin Resistance Estradiol 2.7016393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 3.3717994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.7216580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.7215992940 17551590
MESH:D007674 Kidney Diseases Estradiol 5.3115618244
MESH:D007674 Kidney Diseases sodium arsenite 5.3120008137
MESH:D007680 Kidney Neoplasms Estradiol 6.3015610895
MESH:D007680 Kidney Neoplasms Tamoxifen 6.3018625569
MESH:D007938 Leukemia Tretinoin 2.5617143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.3416482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.6019850784 16294345 17596541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.6016294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.8817301526 9834237 17217047 19035177 19225113 16823087 12679006 17339181 17649720 17294898 16140955 19075265 15748426 16788101 16935935 17361223 17368321 17107899 17506722 16891316 16766008 19642359 16331271 17712046 19029980
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.029224671
MESH:D008064 Lipidoses Clozapine 11.6917567588
MESH:D008064 Lipidoses Fluoxetine 11.6915342952 17567588
MESH:D008064 Lipidoses Tamoxifen 11.6917567588 15342952
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 5.8718665156 18407596 20032147 19638242 18522880
MESH:D008103 Liver Cirrhosis Phenobarbital 5.8721047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.4614716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.4618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.4612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.4618397230 16248980
MESH:D008107 Liver Diseases Diethylnitrosamine 3.7117034775
MESH:D008107 Liver Diseases Phenobarbital 3.7119363144
MESH:D008113 Liver Neoplasms Diethylhexyl Phthalate 15.8011940454
MESH:D008113 Liver Neoplasms Diethylnitrosamine 15.8019426721 19551842 18644402 10737359 18648771 20492335 20118626 21071580 12771043 2862719 15175105 19642983 19294768 20501860 19812893 21167192 21278145 9163691 15885732 21047994 20101389 2422723 18978307 19090486 18977376 19850985 18754104 19256749 20137499 20434301 20452335 19996281 19638242 19255062 19254457 20583210 19499222 20405173 19073162 16942905 12112319 19427195 19690152 19833225
MESH:D008113 Liver Neoplasms Phenobarbital 15.8019482888 21047994 15975961 19073162 8742319 19812893
MESH:D008113 Liver Neoplasms sodium arsenite 15.8015276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 15.8016684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 15.8016984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 8.3118093689 18544905 19126423 16267830 18308698 18079962 17854601 19539802 16842330 19004024 17942915 19009564 9362446 18775883 17174075 3124819 2563599 21159647 19519916 18282651 18253720 18164116
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 8.316150874 1399818 2563599 17172636 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.3112151625
MESH:D008133 Long QT Syndrome olanzapine 4.4220210726
MESH:D008171 Lung Diseases sodium arsenite 2.9019095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.8517228818
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.3720970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms sodium arsenite 4.3717306315 19931552 16712894 17077188 15276417
MESH:D008175 Lung Neoplasms Tamoxifen 4.3718625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.3711884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.3619428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.1011408345 17203775 16891317 11807958
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.1014580682 19196723 11731420 19196722 16827153
MESH:D020149 Manganese Poisoning Estradiol 11.2719453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.2719453300
MESH:D008527 Medulloblastoma Tretinoin 2.6217453147
MESH:D008545 Melanoma sodium arsenite 4.6119082730 16487513
MESH:D008545 Melanoma Tamoxifen 4.6112393984 19393235
MESH:D008545 Melanoma Tretinoin 4.6116752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.7815990972
MESH:D008591 Meningomyelocele Tretinoin 4.0316940565
MESH:D001523 Mental Disorders Clozapine 15.5116856516
MESH:D001523 Mental Disorders Fluoxetine 15.5116856516
MESH:D001523 Mental Disorders Haloperidol 15.5116856516
MESH:D001523 Mental Disorders olanzapine 15.5116856516
MESH:D008659 Metabolic Diseases olanzapine 5.0319142110
MESH:D024821 Metabolic Syndrome X Clozapine 4.0819142101
MESH:D008881 Migraine Disorders Valproic Acid 2.9018765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.668888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.6017596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 6.6017596541
MESH:D009203 Myocardial Infarction Cocaine 3.8118072171
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 2.9716810080
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.0717484760
MESH:D009207 Myoclonus Fluoxetine 5.478041377
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.159029167 3581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.1519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3719410462
MESH:D009369 Neoplasms sodium arsenite 4.4211559025
MESH:D009369 Neoplasms Tretinoin 4.4216946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.2720056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.5919189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3317289903
MESH:D009421 Nervous System Malformations Estradiol 20.3416427766 11399458
MESH:D009421 Nervous System Malformations Pilocarpine 20.3415987249
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 20.3414600291
MESH:D009421 Nervous System Malformations Tretinoin 20.349125849
MESH:D009436 Neural Tube Defects sodium arsenite 10.6012854658
MESH:D009436 Neural Tube Defects Tretinoin 10.609142499
MESH:D009436 Neural Tube Defects Valproic Acid 10.6016359493 8888407
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.0120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7020387270
MESH:D009765 Obesity Clozapine 5.0218515891 19142110
MESH:D009765 Obesity olanzapine 5.0218515891
MESH:D009771 Obsessive-Compulsive Disorder Fluoxetine 5.0820418887
MESH:D010018 Osteomalacia Phenobarbital 3.9617016548
MESH:D010051 Ovarian Neoplasms Estradiol 7.0419401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.0417306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 7.0416936753
MESH:D010146 Pain Fluoxetine 6.2312798668
MESH:D010146 Pain Tretinoin 6.2316870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 7.6816540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 7.6816965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 7.6815976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3111578682
MESH:D010300 Parkinson Disease Levodopa 4.4118328768 11432539 20334432 7566641 19594199
MESH:D020734 Parkinsonian Disorders Levodopa 5.3111246459 8817341 18722529
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8312520081
MESH:D020774 Pick Disease of the Brain Fluoxetine 5.608041377
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1718163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 7.962563599
MESH:D011230 Precancerous Conditions Phenobarbital 7.962563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.1111118676 11896295 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 8.1120603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5220887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.6916740699
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.6916039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.6915067354
MESH:D011507 Proteinuria Tretinoin 3.2316636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.9115861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 10.8112752131
MESH:D019310 Pseudolymphoma Valproic Acid 10.8112752131 11422049
MESH:D011595 Psychomotor Agitation Haloperidol 10.4911575062
MESH:D011595 Psychomotor Agitation olanzapine 10.4918685284
MESH:D011618 Psychotic Disorders Clozapine 13.1315331141
MESH:D011618 Psychotic Disorders Cocaine 13.1316134406
MESH:D011618 Psychotic Disorders Haloperidol 13.1311575062
MESH:D011625 Pterygium Tretinoin 4.3816723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4518990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 9.6216283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 9.6219155313
MESH:D012559 Schizophrenia marker/mechanism 18923069
MESH:D012559 Schizophrenia Clozapine 7.3919369910 20107430 20521320 20521326 16141801 17726453 20580759 20452607 20168265 18855531 11151749 11763009 17667964 17123785 18806925
MESH:D012559 Schizophrenia Haloperidol 7.391830565 19369910 20107430 18513383
MESH:D012559 Schizophrenia olanzapine 7.3917726453 20521326 20107430
MESH:D012559 Schizophrenia Valproic Acid 7.3915737665 19110320
MESH:C537537 Segawa syndrome, autosomal recessive Levodopa 6.288817341
MESH:D012640 Seizures marker/mechanism 8954991
MESH:D012640 Seizures Aminooxyacetic Acid 28.291511512
MESH:D012640 Seizures Cocaine 28.2910454489
MESH:D012640 Seizures Diazepam 28.299754883 15946322 10087439
MESH:D012640 Seizures Pentylenetetrazole 28.293037702 8954991 18657176 15475178 19660546 16054440 18164287 3352866 2616065 6431079
MESH:D012640 Seizures Phenobarbital 28.293137016 4039156 11442880 16876388
MESH:D012640 Seizures Picrotoxin 28.298635557 8954991
MESH:D012640 Seizures Pilocarpine 28.2919660546 7750514
MESH:D012640 Seizures Valproic Acid 28.293137016 11738929 1511512 17978042 11044598 15475178 14763951 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.416407741
MESH:D020230 Serotonin Syndrome Fluoxetine 5.488704074
MESH:D012878 Skin Neoplasms sodium arsenite 8.2518572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.2516192470
MESH:D012878 Skin Neoplasms Tretinoin 8.2516467112
MESH:D013088 Spermatocele Ethinyl Estradiol 10.1816709447
MESH:D013088 Spermatocele Tamoxifen 10.1816709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.6319457130
MESH:D016135 Spinal Dysraphism sodium arsenite 8.5112854658
MESH:D016135 Spinal Dysraphism Valproic Acid 8.5119490988
MESH:D013226 Status Epilepticus Pilocarpine 11.4619430551 19951488 19055492 15987249 19570321 11259499 15857427
MESH:D013226 Status Epilepticus Valproic Acid 11.4612833885
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3118456281
MESH:D013274 Stomach Neoplasms Tretinoin 2.3117261132
MESH:D013375 Substance Withdrawal Syndrome Diazepam 5.099754883
MESH:D017180 Tachycardia, Ventricular Haloperidol 9.6720210726
MESH:D017180 Tachycardia, Ventricular olanzapine 9.6720210726
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4912697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.197505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 10.191399818
MESH:D013964 Thyroid Neoplasms Tretinoin 10.1916026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.2719048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.4416051514
MESH:D014178 Translocation, Genetic Valproic Acid 4.8217262798
MESH:D014202 Tremor Pilocarpine 5.3917594079
MESH:D014376 Tuberculosis Tretinoin 2.9716040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.113119515
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 4.5511723127 16712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 4.5517572228 16712894 8653321
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.248888407
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.2411813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.2416129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9214692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.2016752155
MESH:D014652 Vascular Diseases sodium arsenite 4.0217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1814671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.6716761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8315886252
MESH:D015430 Weight Gain Clozapine 9.2116141801 17502770 16402076 20107430 20564506 20521320
MESH:D015430 Weight Gain olanzapine 9.2120107430 17933447 19434072
MESH:D015431 Weight Loss Clozapine 4.6717933447
MESH:D009396 Wilms Tumor Tretinoin 3.6316287080
Pathway ID Pathway Name
KEGG:00250 Alanine, aspartate and glutamate metabolism
KEGG:00410 beta-Alanine metabolism
KEGG:00650 Butanoate metabolism
KEGG:01100 Metabolic pathways
REACT:13685 Synaptic Transmission
KEGG:00430 Taurine and hypotaurine metabolism
KEGG:04940 Type I diabetes mellitus
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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