AutismKB 2.0

Annotation Detail for SHPRH


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Basic Information Top
Gene Symbol:SHPRH ( FLJ27258,FLJ37625,FLJ45012,FLJ90837,KIAA2023,MGC134886,bA545I5.2 )
Gene Full Name: SNF2 histone linker PHD RING helicase
Band: 6q24.3
Quick LinksEntrez ID:257218; OMIM: 608048; Uniprot ID:SHPRH_HUMAN; ENSEMBL ID: ENSG00000146414; HGNC ID: 19336
Relate to Another Database: SFARIGene; denovo-db
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Chemical ID Chemical Name Interaction Interaction Action Publication
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SHPRH mRNAdecreases expression 19150397
C006253 pirinixic acid pirinixic acid results in decreased expression of SHPRH mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased expression of SHPRH mRNAincreases expression 18301758
C017947 sodium arsenite sodium arsenite results in decreased expression of SHPRH mRNAdecreases expression 16014739
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SHPRH mRNAdecreases expression 20106945
17101203
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SHPRH mRNAincreases expression 19465110
C025643 vinclozolin vinclozolin results in decreased expression of SHPRH mRNAdecreases expression 18042343
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3815322242 14514962 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.7716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.7716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.3115276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.5116712894 17306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2911748828
MESH:D001008 Anxiety Disorders vinclozolin 3.9319015723
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 10.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9715746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0916835633
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 2.0017306315 15276417 16507464
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4618572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5416120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.5220889678
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.5219524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4916835633
MESH:D002779 Cholestasis pirinixic acid 3.0819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2216354765 15340226 8697196 12621046 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2720055451 10048152 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.7814966744
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7317107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0211462148
MESH:D004487 Edema pirinixic acid 7.7912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.7911000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.5118230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.379294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1420426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2711564622
MESH:D005234 Fatty Liver pirinixic acid 3.1419236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.9411858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.4320067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.4716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.9116417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.2216452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.2110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4910048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7111000095
MESH:D006529 Hepatomegaly pirinixic acid 9.9219772884 16221962 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.9215340226 16120746 12621046
MESH:D006689 Hodgkin Disease sodium arsenite 3.4712676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.668697196 16354765 15340226 18606429 16959395
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0118850075 18670907
MESH:D007248 Infertility, Male sodium arsenite 7.6012646999 15346721
MESH:D007248 Infertility, Male vinclozolin 7.6016467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0112200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7116580747
MESH:D007674 Kidney Diseases sodium arsenite 2.9820008137
MESH:D007984 Leydig Cell Tumor vinclozolin 5.2716417039
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.2215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2212878042
MESH:D008113 Liver Neoplasms pirinixic acid 8.0116377806 15890375 20007298
MESH:D008113 Liver Neoplasms sodium arsenite 8.0116712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 8.0116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3112151625
MESH:D008171 Lung Diseases sodium arsenite 3.4019095001
MESH:D008175 Lung Neoplasms sodium arsenite 2.3815276417 16712894 19931552 17306315 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3819555203 11884234
MESH:D008545 Melanoma sodium arsenite 2.0716487513 19082730
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009369 Neoplasms pirinixic acid 5.4517405874
MESH:D009369 Neoplasms sodium arsenite 5.4511559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.1520056578
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.6514600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.3612854658
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5215276417 17306315
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.8612520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 11.3511399792 11118676 11222880 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 11.3518042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.4718220299
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2416039940
MESH:D011472 Prostatitis vinclozolin 5.4718629315
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2818990726
MESH:D012878 Skin Neoplasms sodium arsenite 6.0718572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0716192470
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0712854658
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.5112697716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.6217306315 16452187 16712894 11723127
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.1111813266
MESH:D014652 Vascular Diseases sodium arsenite 4.9617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.2112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.8615886252
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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