AutismKB 2.0

Annotation Detail for C11orf41


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Basic Information Top
Gene Symbol:C11orf41 ( C11orf69,FLJ36988,G2,MGC34830 )
Gene Full Name: chromosome 11 open reading frame 41
Band: 11p13
Quick LinksEntrez ID:25758; OMIM: 612297; Uniprot ID:CK041_HUMAN; ENSEMBL ID: ENSG00000110427; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of C11ORF41 mRNAdecreases expression 20382639
D004317 Doxorubicin C11ORF41 protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D004958 Estradiol Estradiol affects the expression of C11ORF41 mRNAaffects expression 14699072
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Doxorubicin 4.7817418594
MESH:D000230 Adenocarcinoma Estradiol 4.7811473722
MESH:D000419 Albuminuria Doxorubicin 5.1321441931
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.5714601052
MESH:D001932 Brain Neoplasms Doxorubicin 4.2617150277
MESH:D001943 Breast Neoplasms Doxorubicin 2.2318695136 16595493 18382427 17426702 15939500 18234424 15692762 16115903 16264153 16322301 16096432 15668708 16826403 15567936 15994142 11325840 15993339 15634643 15136595 16935488 17369602 17983394 18628466 19526202
MESH:D001943 Breast Neoplasms Estradiol 2.2314630087 17289903 17018787 19861407 17261762 12948864 18497071 16675129
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.2116111702
MESH:D002276 Carcinoid Tumor Doxorubicin 5.6816051944
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 3.2916023760 17876044 16234567 18059187
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.2916924424
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.3316201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.736189445
MESH:D009202 Cardiomyopathies Doxorubicin 3.8015505089 16612575 17924179 16278810 16269455 17329180 17382496 16242529 16109756 16952015 17928571 17007740 17974986 15811867 18627295 17131338 17351982 16364871 16731534 15792986 16651473 16455267 17308081 17519947 15476868
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0617334414 16243910
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.6320889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.6318566989
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1518802399 18259882
MESH:D003928 Diabetic Nephropathies Estradiol 3.8319279558
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 2.5317416283
MESH:D004362 Drug Toxicity Doxorubicin 3.9918602426
MESH:D016889 Endometrial Neoplasms Doxorubicin 8.4417359293
MESH:D016889 Endometrial Neoplasms Estradiol 8.4419148513 11473722 18566989
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 6.0218037988
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1520426865
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 5.3319069698
MESH:D005909 Glioblastoma Doxorubicin 3.6117150277
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.8115692506
MESH:D006331 Heart Diseases Doxorubicin 3.7816495754 18674790 16244372 17888722 18006777 16330681 17875725 12587719 16244371 16879835 16144979 14766674 16707910
MESH:D006333 Heart Failure Doxorubicin 3.5917481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.3815692506
MESH:D006558 Herpes Genitalis Estradiol 5.9015709030
MESH:D006689 Hodgkin Disease Doxorubicin 3.8218501091 15147373 17606976
MESH:D019584 Hot Flashes Estradiol 4.6217088409
MESH:D007333 Insulin Resistance Estradiol 3.2316393666 16627594
MESH:D007674 Kidney Diseases Doxorubicin 6.9616775033 15369732 15699352
MESH:D007674 Kidney Diseases Estradiol 6.9615618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.6416707910
MESH:D007680 Kidney Neoplasms Estradiol 3.3615610895
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 6.0216085563
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.6916439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.6914716833 14659978
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 3.2617085340 16842330
MESH:D008175 Lung Neoplasms Doxorubicin 2.1517418594 6189445
MESH:D008223 Lymphoma Doxorubicin 3.7716098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 4.1817654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 5.2215621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 7.0115458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 7.0116891317 11807958 11408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 5.3519453300
MESH:D008545 Melanoma Doxorubicin 2.3316827129
MESH:D008654 Mesothelioma Doxorubicin 3.2017638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.9815792986
MESH:D052016 Mucositis Doxorubicin 5.5317415656
MESH:D009203 Myocardial Infarction Doxorubicin 3.0919429709 15857846
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.6216810080
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0918259882
MESH:D009389 Neovascularization, Pathologic Estradiol 4.4717289903
MESH:D009401 Nephrosis Doxorubicin 5.4216636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.4215640375 16889571
MESH:D009421 Nervous System Malformations Estradiol 4.2311399458 16427766
MESH:D009447 Neuroblastoma Doxorubicin 3.4515555623
MESH:D012516 Osteosarcoma Doxorubicin 4.4815930896
MESH:D010051 Ovarian Neoplasms Estradiol 2.3219401270
MESH:D003557 Phyllodes Tumor Doxorubicin 6.0217983394
MESH:D010997 Pleural Neoplasms Doxorubicin 6.0217638057
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.3720887781
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.2315749863 15897917 16888761 18437689 16868541 16729912
MESH:D011471 Prostatic Neoplasms Estradiol 3.2316740699
MESH:D051437 Renal Insufficiency Doxorubicin 4.8717922066
MESH:D012509 Sarcoma Doxorubicin 4.4417710206 15625365 16767912 17203757 15675481 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.8314601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.5317846226
MESH:D012878 Skin Neoplasms Doxorubicin 3.1215692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 5.2217203757 15625365 16767912
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.7116010429 17909728
MESH:D013978 Tibial Fractures Estradiol 5.5519048282
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 2.8917653716
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.8717638931 17334414 16364871 17678736
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA142672301
    • No data
    Releated disease ID Related disease Name
    PA447216Schizophrenia
    No data
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    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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