AutismKB 2.0

Annotation Detail for NGEF


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Basic Information Top
Gene Symbol:NGEF ( ARHGEF27,EPHEXIN )
Gene Full Name: neuronal guanine nucleotide exchange factor
Band: 2q37.1
Quick LinksEntrez ID:25791; OMIM: 605991; Uniprot ID:NGEF_HUMAN; ENSEMBL ID: ENSG00000066248; HGNC ID: 7807
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04360Axon guidance
Pathway IDPathway Name
Signaling by GPCR
Signalling by NGF
Signaling by Rho GTPases
Pathway IDPathway Name
200121EPHA forward signaling
200165Regulation of RAC1 activity
200050Regulation of RhoA activity
200059Regulation of CDC42 activity
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of NGEF mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of NGEF proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NGEF mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of NGEF mRNAdecreases expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of NGEF mRNAdecreases expression 20106945
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of NGEF mRNAdecreases expression 19371625
D004958 Estradiol Estradiol affects the expression of NGEF mRNAaffects expression 15598610
D015025 Zearalenone Zearalenone results in decreased expression of NGEF mRNAdecreases expression 19371625
D005419 Flavonoids Flavonoids results in decreased expression of NGEF mRNAdecreases expression 18035473
D010634 Phenobarbital Phenobarbital results in increased expression of NGEF mRNAincreases expression 19270015
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NGEF mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of NGEF mRNAdecreases expression 18445702
C017947 sodium arsenite sodium arsenite results in increased expression of NGEF mRNAincreases expression 16014739
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.596195326
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3720127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.3711473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.716695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.6417620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.6416434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.8715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.0817306315 16712894
MESH:D000686 Amyloidosis Diethylstilbestrol 4.6115469931
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2619483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9117474063 20146248
MESH:D001943 Breast Neoplasms Diethylstilbestrol 1.9115324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 1.9118497071 12948864 17261762 17289903 17018787 16675129 14630087 19861407
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6216111702
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.613084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 11.6112619106 12907637 21507988
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 11.6115948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.6116924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 11.6117173139 1701930 20935162 6705139 20007298
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 11.6115276417 16507464 17306315
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7020419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.7018572023
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.6112371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.6118566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 11.6119524636 20056578
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.394080065
MESH:D002779 Cholestasis Cyclosporine 8.0319486331
MESH:D002779 Cholestasis pirinixic acid 8.0319176532
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.6812952375 16002989
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003928 Diabetic Nephropathies Estradiol 3.5119279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6111529661 18713872 2444490 11461765 19420014 11834606 12153990 17906064 12594235 16227642 16485898 11743745 12540782 11739529 11421492 12705907 12392966 16781746 15619225 15968718 16393943 14986274 19164858 16177239 17562736 16081117 14550746 10915739 17522070 14725611 10774834 12958197 10663392 18071297 19370779 11287661 19923254 19739265 19416960 16109766 19085960
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004421 Dystonia Phenobarbital 4.121851702
MESH:D004487 Edema pirinixic acid 2.5912083418
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.8516402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 7.7815700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 7.7811473722 18566989 19148513
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.253659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.043922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.646401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.397750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.173659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0316530937
MESH:D005234 Fatty Liver Cyclosporine 7.9319224547
MESH:D005234 Fatty Liver pirinixic acid 7.9319236843 20131406
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7216513791 16534752 16002989 15751030 16611131
MESH:D005355 Fibrosis Cyclosporine 3.2812639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 13.3416452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 13.3416452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7120471113
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006529 Hepatomegaly Phenobarbital 8.9516109766
MESH:D006529 Hepatomegaly pirinixic acid 8.9519176532 16221962 18467677 19772884
MESH:D006558 Herpes Genitalis Estradiol 5.2115709030
MESH:D006689 Hodgkin Disease sodium arsenite 3.2512676792
MESH:D019584 Hot Flashes Estradiol 3.9317088409
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006965 Hyperplasia Diethylstilbestrol 4.5712960047 14722030
MESH:D006973 Hypertension Cyclosporine 2.1310903974
MESH:D007021 Hypospadias Diethylstilbestrol 4.7216002989
MESH:D007246 Infertility Diethylstilbestrol 4.4815036965
MESH:D007248 Infertility, Male sodium arsenite 3.0615346721 12646999
MESH:D007249 Inflammation Flavonoids 2.7017296493
MESH:D007333 Insulin Resistance Estradiol 7.4316393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.4316306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Acetaminophen 14.9212587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 14.9218776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 14.9215618244
MESH:D007674 Kidney Diseases sodium arsenite 14.9220008137
MESH:D007680 Kidney Neoplasms Cyclosporine 12.9812371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 12.9816762066 14681315 15003126
MESH:D007680 Kidney Neoplasms Estradiol 12.9815610895
MESH:D007859 Learning Disorders Diethylstilbestrol 4.2017184923
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9521047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3315474484
MESH:D008107 Liver Diseases Acetaminophen 4.0116611625 19784758 11587558 19460945 12587719 19014921 16610002 12969438
MESH:D008107 Liver Diseases Phenobarbital 4.0119363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3416871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 18.5115890375 2125692 9163691 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 18.5121137059 20195826
MESH:D008113 Liver Neoplasms Diethylstilbestrol 18.5115890375 16712894
MESH:D008113 Liver Neoplasms Phenobarbital 18.5119073162 19482888 15975961 19812893 8742319 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 18.5120007298 15890375 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 18.5115276417 16712894
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.248603461
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.242563599 17172636 18308698 1399818 6150874
MESH:D008171 Lung Diseases sodium arsenite 3.2419095001
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.5114755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5118569708 17053015 20464547 18520028 20135361 20064080 6695378 20869020 18816296
MESH:D008175 Lung Neoplasms sodium arsenite 3.5115276417 17306315 19931552 16712894 17077188
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.3015166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.5515700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.6916002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6217203775 11807958 16891317 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.6619453300
MESH:D008545 Melanoma sodium arsenite 2.0416487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.5316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.5316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.6317484760
MESH:D009369 Neoplasms Benzo(a)pyrene 12.2911141357
MESH:D009369 Neoplasms Diethylstilbestrol 12.2915313581
MESH:D009369 Neoplasms pirinixic acid 12.2917405874
MESH:D009369 Neoplasms sodium arsenite 12.2911559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8020056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009421 Nervous System Malformations Diethylstilbestrol 10.2311399458
MESH:D009421 Nervous System Malformations Estradiol 10.2316427766 11399458
MESH:D009436 Neural Tube Defects sodium arsenite 3.2112854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010018 Osteomalacia Phenobarbital 4.5217016548
MESH:D010051 Ovarian Neoplasms Estradiol 4.9419401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.9415276417 17306315
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5316965848
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.3414722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.8115687265 16977796
MESH:D011230 Precancerous Conditions Cyclosporine 9.3012371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.302563599
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 4.2717184923
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0617292933
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.0617136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 2.0616740699
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0616039940
MESH:D019310 Pseudolymphoma Phenobarbital 4.6712752131
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012640 Seizures Phenobarbital 2.7611442880 3137016 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.986407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.8719755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 5.8719524636 18572023
MESH:D013088 Spermatocele Diethylstilbestrol 4.8916002989 16709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8812854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.141399818
MESH:D013978 Tibial Fractures Estradiol 4.8619048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.5917053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 8.5916712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.5911723127 16712894 16452187 17306315
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 9.8916175088
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.8911813266
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.3414652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.1915809267 16690809
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.5716513791 16002989
MESH:D014652 Vascular Diseases sodium arsenite 4.5817056641
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
Pathway ID Pathway Name
KEGG:04360 Axon guidance
REACT:14797 Signaling by GPCR
REACT:11044 Signaling by Rho GTPases
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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