AutismKB 2.0

Annotation Detail for CIZ1


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Basic Information Top
Gene Symbol:CIZ1 ( LSFR1,NP94,ZNF356 )
Gene Full Name: CDKN1A interacting zinc finger protein 1
Band: 9q34.11
Quick LinksEntrez ID:25792; OMIM: 611420; Uniprot ID:CIZ1_HUMAN; ENSEMBL ID: ENSG00000148337; HGNC ID: 16744
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CIZ1 mRNAaffects expression 21346803
D016572 Cyclosporine Cyclosporine results in increased expression of CIZ1 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CIZ1 mRNAincreases expression 17942748
D008727 Methotrexate CIZ1 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D012643 Selenium Selenium results in increased expression of CIZ1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 4.7812039119
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.5517505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8814692618
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8615885639
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.1617286800
MESH:D001943 Breast Neoplasms Methotrexate 3.0716978400
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 1.7816705839
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7612371664
MESH:D002779 Cholestasis Cyclosporine 8.6519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.6517110522 15861022 17333356 16105132 17681005 11677210 16919318
MESH:D003092 Colitis Selenium 4.2617936198
MESH:D019465 Craniofacial Abnormalities Methotrexate 2.669562676 12039119
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.5018551238
MESH:D003550 Cystic Fibrosis Methotrexate 4.5819747007
MESH:D003882 Dermatomyositis Methotrexate 5.5720191521
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 4.2118551238 21346803
MESH:D056486 Drug-Induced Liver Injury Selenium 4.2115131321
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.6312538720
MESH:D005234 Fatty Liver Cyclosporine 8.8419224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.8415345470
MESH:D005355 Fibrosis Cyclosporine 3.6212639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D006086 Graft vs Host Disease Methotrexate 5.6316518429
MESH:D006333 Heart Failure Selenium 3.2717162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D006973 Hypertension Cyclosporine 2.2010903974
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2916569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7117937319
MESH:D007251 Influenza, Human Selenium 4.8116624496
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007674 Kidney Diseases Cyclosporine 2.5218776723 10903974 8314463
MESH:D007676 Kidney Failure, Chronic Selenium 4.2616518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.3016705839
MESH:D007680 Kidney Neoplasms Cyclosporine 8.3012371664
MESH:D007805 Language Development Disorders Methotrexate 5.519562676
MESH:D008103 Liver Cirrhosis Methotrexate 3.8714986274
MESH:D017563 Lung Diseases, Interstitial Methotrexate 5.6318516814
MESH:D008223 Lymphoma Methotrexate 4.1917352296
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9715318939
MESH:D008654 Mesothelioma Selenium 2.9015107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D052016 Mucositis Methotrexate 5.8217488658
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.4018551238
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6118481113 19348381
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.7816049721 12819281
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0911578682
MESH:D010954 Plasmacytoma Selenium 5.5015087411
MESH:D011230 Precancerous Conditions Cyclosporine 3.5512371664
MESH:D011537 Pruritus Ethinyl Estradiol 3.8516919318 15861022
MESH:D011565 Psoriasis Cyclosporine 6.2416882103
MESH:D011565 Psoriasis Methotrexate 6.2417410198
MESH:D051437 Renal Insufficiency Methotrexate 5.2017352296
MESH:D012512 Sarcoma, Ewing's marker/mechanism 17508423
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7618551238
MESH:D013088 Spermatocele Ethinyl Estradiol 4.5516709447
MESH:D013576 Syndactyly Methotrexate 5.479562676
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4815669648
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3916049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.8610091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.7414692618
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9114671159 15869587
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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