AutismKB 2.0

Annotation Detail for GAK


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Basic Information Top
Gene Symbol:GAK ( FLJ16629,FLJ40395,MGC99654 )
Gene Full Name: cyclin G associated kinase
Band: 4p16.3
Quick LinksEntrez ID:2580; OMIM: 602052; Uniprot ID:GAK_HUMAN; ENSEMBL ID: ENSG00000178950; HGNC ID: 4113
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Membrane Trafficking
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
Parkinson's disease (familial)
NEUROLOGICAL
Desease Name
Parkinson's disease
Parkinson's disease (familial)
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of GAK mRNAdecreases expression 12419474
D000082 Acetaminophen Acetaminophen affects the expression of GAK mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GAK mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of GAK mRNAincreases expression 20458559
D001205 Ascorbic Acid [Tretinoin co-treated with Ascorbic Acid] results in decreased expression of GAK mRNAaffects cotreatment|decreases expression 16443354
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GAK mRNAdecreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of GAK mRNAdecreases expression 12419474
D018038 Sodium Selenite Sodium Selenite results in increased expression of GAK mRNAincreases expression 18175754
D014212 Tretinoin [Tretinoin co-treated with Ascorbic Acid] results in decreased expression of GAK mRNAaffects cotreatment|decreases expression 16443354
D014810 Vitamin E Vitamin E results in decreased expression of GAK mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3211798837 19825857
MESH:D000505 Alopecia Tretinoin 3.7515955085
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.2010965797
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.1816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001471 Barrett Esophagus Tretinoin 4.6016935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.7516206674
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.7516206674 16197459
MESH:D001943 Breast Neoplasms Ascorbic Acid 2.4916443354
MESH:D001943 Breast Neoplasms Tretinoin 2.4916443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8316813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5111589617
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1516050911
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4216168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.683084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.6815073043 16217749 11135700 14691202 15553829
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.681917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1419014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2812490120
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3316096774 16051514
MESH:D002386 Cataract Acetaminophen 7.5410977129
MESH:D002386 Cataract Tretinoin 7.5417460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8420889678
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8316129372
MESH:D002822 Choriocarcinoma Tretinoin 5.4216461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9715894690
MESH:D002972 Cleft Palate Tretinoin 2.739407595
MESH:D003092 Colitis Tretinoin 3.9217035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D003139 Common Cold Ascorbic Acid 5.7417323712
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.9410525206
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.948800419 17551590 9125849 10589399 14991402 9224671 9142499 9211117 9664655 16925845
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.9419769572
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2815213294
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9316285004
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 3.1316506275
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9817522070 12705907 15968718 19164858 11421492 14550746 19420014 10663392 16227642 12594235 16109766 16393943 10915739 19923254 19739265 14725611 18071297 2444490 11461765 16781746 19085960 15619225 12958197 10774834 14986274 12392966 16081117 17562736 16177239 11743745 11287661 11529661 11834606 18713872 17906064 16485898 19416960 12153990 19370779 12540782 11739529
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 3.9815131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:C538011 Eales disease Ascorbic Acid 13.979068938
MESH:C538011 Eales disease Vitamin E 13.979068938
MESH:D004489 Edema, Cardiac Tretinoin 4.7318230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2116569247
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5920426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5912903497
MESH:D005124 Eye Abnormalities Tretinoin 3.709664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 3.4615073043
MESH:D005355 Fibrosis Tretinoin 3.7317994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4616904648
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005909 Glioblastoma Tretinoin 3.1117312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4216084493
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 11.8116080930
MESH:D006330 Heart Defects, Congenital Tretinoin 11.8114991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin E 11.8116080930
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 6.3016490937 16863852
MESH:D006548 Hernia, Diaphragmatic Vitamin E 6.3016490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.2414716179
MESH:D006930 Hyperalgesia Acetaminophen 8.0916870215
MESH:D006930 Hyperalgesia Tretinoin 8.0916870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7816778211
MESH:D007251 Influenza, Human Vitamin E 4.4816624496
MESH:D007333 Insulin Resistance Sodium Selenite 3.3814714311
MESH:D007410 Intestinal Diseases Tretinoin 3.9817994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.0717551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 6.2715629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 6.2712488133
MESH:D007938 Leukemia arsenic trioxide 6.6015070760
MESH:D007938 Leukemia Tretinoin 6.6017143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9717077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 10.0519077051
MESH:D007951 Leukemia, Myeloid Tretinoin 10.0516482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.9716467208 19850784 16968895 20471514 17050201
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.9719850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.9917869043 12712474 15336539 17649720 19075265 16112521 12679006 9834237 12018890 15213294 16966277 16891316 15748426 17712046 19225113 19035177 15622746 11468182 16330433 16823087 16331271 17217047 11161223 19642359 17107899
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.9917506722 16331271 17217047 15748426 12679006 19642359 19029980 16766008 19225113 17712046 16935935 9834237 17301526 16788101 16140955 17649720 16891316 16823087 17368321 17339181 19075265 19035177 17294898 17361223 17107899
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5516882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.439224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.5916248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.5916169303
MESH:D008107 Liver Diseases Acetaminophen 1.6612587719 12969438 16611625 19014921 16610002 19460945 11587558 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 2.4014682389
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.6720377131
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 6.6718544905
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4815213294
MESH:D008171 Lung Diseases Ascorbic Acid 8.1016863852
MESH:D008171 Lung Diseases Vitamin E 8.1016863852
MESH:D008175 Lung Neoplasms arsenic trioxide 3.6911798837 19825857
MESH:D008175 Lung Neoplasms Ascorbic Acid 3.6916401635
MESH:D008175 Lung Neoplasms Vitamin E 3.6911062179
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2414737004
MESH:D008527 Medulloblastoma Tretinoin 2.8417453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008591 Meningomyelocele Tretinoin 4.6416940565
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2211468182 19549372 19417148 15949261 14977855
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.6916882451 16105982
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.6917596541
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1616624393
MESH:D009369 Neoplasms Tretinoin 2.4816594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 3.989125849
MESH:D009436 Neural Tube Defects arsenic trioxide 7.6610525206
MESH:D009436 Neural Tube Defects Tretinoin 7.669142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009765 Obesity Ascorbic Acid 3.1717217161
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.0319769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Tretinoin 5.0316936753
MESH:D010146 Pain Acetaminophen 7.0716870215
MESH:D010146 Pain Tretinoin 7.0716870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.4715580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.4715976015
MESH:D010235 Paraganglioma arsenic trioxide 4.3519927285
MESH:D010300 Parkinson Disease marker/mechanism 20711177
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.7711550810
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.5819131511
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.5818760546
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5815084515
MESH:D011507 Proteinuria Tretinoin 3.7916636307
MESH:D011625 Pterygium Tretinoin 5.0316723453
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 5.6014606601
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.3516849425
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2816283617 16116481
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1616646077
MESH:D012871 Skin Diseases Ascorbic Acid 5.3418709164
MESH:D012871 Skin Diseases Vitamin E 5.3418709164
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 6.048532709
MESH:D012878 Skin Neoplasms Tretinoin 6.0416467112
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4917007042
MESH:D013274 Stomach Neoplasms Tretinoin 2.4917261132
MESH:D013276 Stomach Ulcer Ascorbic Acid 4.0618726076
MESH:D020521 Stroke Ascorbic Acid 9.3516403987 16517955
MESH:D020521 Stroke Vitamin E 9.3516517955
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.6519014326
MESH:D013964 Thyroid Neoplasms Tretinoin 7.6517045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.9516051514
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2015213294
MESH:D014376 Tuberculosis Tretinoin 3.3316040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5320435036 11780464 12973940 12845720
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8416129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.8816752155
MESH:D014820 Vitiligo Tretinoin 4.2516761959
MESH:D009396 Wilms Tumor Tretinoin 4.1216287080
Pathway ID Pathway Name
REACT:11123 Membrane Trafficking
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28528
    • No data
    Releated disease ID Related disease Name
    PA445254Parkinson Disease
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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