AutismKB 2.0

Annotation Detail for TTLL1


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Basic Information Top
Gene Symbol:TTLL1 ( C22orf7,HS323M22B )
Gene Full Name: tubulin tyrosine ligase-like family, member 1
Band: 22q13.2
Quick LinksEntrez ID:25809; OMIM: 608955; Uniprot ID:TTLL1_HUMAN; ENSEMBL ID: ENSG00000100271; HGNC ID: 1312
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of TTLL1 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of TTLL1 mRNAdecreases expression 18648102
D004041 Dietary Fats Dietary Fats results in decreased expression of TTLL1 mRNAdecreases expression 18042831
C041786 palm oil palm oil results in decreased expression of TTLL1 mRNAdecreases expression 18042831
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.963712494
MESH:D001161 Arteriosclerosis Dietary Fats 4.4515238619
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.741440618 11289319
MESH:D001943 Breast Neoplasms Dietary Fats 2.2420435547
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.1016705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.103581430 7296757
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.837296757
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.546135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.547505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.4419486331 9022650
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.5818551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.3518759878 12868966 8970840 8156756 11298694 2524372 14531868 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.953621924 2952479
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.1618551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.1611289319 1440618 18648102 6679447 18692083 18289764 8291058 7440962 6482804 16192314 9022650 9328219 9653073
MESH:D050171 Dyslipidemias Dietary Fats 3.7318367378
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.183581430
MESH:D005234 Fatty Liver Dietary Fats 3.6618296743 19551842 19004024 17967931
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.746705139
MESH:D005355 Fibrosis Dietary Fats 4.0818296743
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.507505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.026705139
MESH:D006937 Hypercholesterolemia Dietary Fats 4.0221332399
MESH:D006949 Hyperlipidemias Dietary Fats 4.0821332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.5015034207
MESH:D007249 Inflammation Dietary Fats 2.6020412841
MESH:D007333 Insulin Resistance Dietary Fats 3.3411836018 18457598
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.748074119 9022650
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.5216705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.526582329
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0718296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.429327722 15034207
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.277678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.666135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.663712494 6587162 598648 1399818
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.497678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.593581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.156679447
MESH:D009765 Obesity Dietary Fats 2.3617217161 21332399 16723640 18674790 11836018 19632207 18457598 20518802 20132043
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 10.2316049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 10.236482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.743988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.047296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.196228378
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.673692021
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7918551238
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.197505956 6582329 6587162 3712494 1399818
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.4316049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.438074119
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.9510091137
MESH:D015430 Weight Gain Dietary Fats 4.1116723640
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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