AutismKB 2.0

Annotation Detail for ATXN10


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Basic Information Top
Gene Symbol:ATXN10 ( E46L,FLJ37990,HUMEEP,SCA10 )
Gene Full Name: ataxin 10
Band: 22q13.31
Quick LinksEntrez ID:25814; OMIM: 611150; Uniprot ID:ATX10_HUMAN; ENSEMBL ID: ENSG00000130638; HGNC ID: 10549
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Desease IDDesease Name
Nervous system diseases
Neurodegenerative diseases
H00063Spinocerebellar ataxia
No data
No data
No data
Desease Name
Spinocerebellar ataxia-10
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ATXN10 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ATXN10 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ATXN10 mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ATXN10 mRNAaffects cotreatment|increases expression 18164116
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ATXN10 mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ATXN10 mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ATXN10 mRNAaffects cotreatment|affects expression 17602206
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ATXN10 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ATXN10 mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of ATXN10 mRNA]affects reaction|decreases expression 15016801
C056933 fumonisin B1 fumonisin B1 results in increased expression of ATXN10 mRNAincreases expression 16221962
C006253 pirinixic acid pirinixic acid results in increased expression of ATXN10 mRNAincreases expression 18301758
16221962
20059764
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of ATXN10 mRNA]increases expression|increases reaction 20059764
C017947 sodium arsenite sodium arsenite results in decreased expression of ATXN10 mRNAdecreases expression 19072884
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in increased expression of ATXN10 mRNAaffects cotreatment|increases expression 19465110
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ATXN10 mRNAaffects cotreatment|increases expression 17942748
D014501 Uranium Uranium affects the expression of ATXN10 mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of ATXN10 mRNAaffects expression 15672453
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9314514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3814692618
MESH:D000230 Adenocarcinoma Fluorouracil 4.3817638652
MESH:D000236 Adenoma beta-Naphthoflavone 6.9819389873
MESH:D000236 Adenoma Diethylnitrosamine 6.986695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.7816434500 17620307 19061943 17162532 19052882 18056438
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.7816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.7816835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.8015276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.0016712894 17306315
MESH:D000740 Anemia Fluorouracil 8.8516511603 15504547 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.8511748828
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6915885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.9519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.9512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8617474063
MESH:D001943 Breast Neoplasms Fluorouracil 1.8618608205 16595493 16110121 15136595 16557594 19217205 18357371
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8620435547
MESH:D002276 Carcinoid Tumor Fluorouracil 4.7616051944
MESH:D002277 Carcinoma Fluorouracil 8.3317121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.3316835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.9616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.963084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.9611831363 19107877 16779866 19919837 21159647 16502159 19418558 19383236 20512989 18978308 19822196 20101231 3581430 17162532 19394651 16698587 19335982 20214788 18665156 16830150 10737359 20727157 18056438 18494052 20524982 16569478 16681979 16878318 18691550 18788625 20007298 16540662 20432363 16328049 18971187 19208518 19539802 16935385 17978847 20084675 10672840 17138121 19519916 17055752 20935162 19701751 17428255 18210153 18393292 20514400 17761372 16288022 18506893 19171122 3084413 18785209 16807293 19052882 17173139
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 8.9616799960 17971768 18930000 17088986 16332177 17045692
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.9615276417 17306315 16507464
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0418695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.8118986760 17066447 16280240 16757204
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.8118572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3916120746 18850075 18670907
MESH:D002386 Cataract Acetaminophen 2.6110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.436135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.437505956 17174075 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 11.4320056578 19524636
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.4919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.4916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.8816919318 15861022 11677210 17333356 16105132 17110522 17681005
MESH:D002779 Cholestasis pirinixic acid 7.8819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1212621046 8697196 15340226 16354765 15668235
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2417172411 15001691 17018589 18772588 17287894 16510598 16340194 17725105 17016597 17169374
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0018509181 16282729 18383874 16524972 18949393 20501625 16331619 18448328 15289873 18802399 18288408 17695437 17401013 16391804 16303861 17255274 17016601 14970324 17594712 17094418 17454858 15148649
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0918551238
MESH:D007644 Darier Disease Fluorouracil 4.8716733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2617107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.1918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.1914986274 14550746 19739265 12153990 11834606 10663392 19416960 12705907 16227642 11529661 18071297 11287661 11461765 10915739 14725611 17906064 16781746 12540782 17522070 16109766 11421492 10774834 12958197 16485898 15619225 12594235 18713872 19370779 16177239 2444490 12392966 11743745 19085960 19923254 11739529 17562736 15968718 16081117 19420014 19164858 16393943
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.1919107877
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 12.1916221962
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.1920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004487 Edema pirinixic acid 6.7212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.7211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0015322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2512538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.079294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2116302075
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.4616481741 15173087 16337965 17638652 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver Diethylnitrosamine 13.3720387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.3715345470
MESH:D005234 Fatty Liver pirinixic acid 13.3720131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0220067830
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.7616452187
MESH:D005910 Glioma Fluorouracil 2.8916145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4215102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3610048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5720558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly fumonisin B1 14.9316221962
MESH:D006529 Hepatomegaly pirinixic acid 14.9316221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.9315340226 16120746 12621046
MESH:D006689 Hodgkin Disease sodium arsenite 3.2012676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1418606429 16959395 15340226 8697196 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.7416870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9218850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.7617937319
MESH:D007248 Infertility, Male sodium arsenite 6.7612646999 15346721
MESH:D007249 Inflammation Diethylnitrosamine 4.9818785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.9812200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.6616306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007674 Kidney Diseases Acetaminophen 6.0615629191 12587719
MESH:D007674 Kidney Diseases sodium arsenite 6.0620008137
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.6316705839
MESH:D007680 Kidney Neoplasms Fluorouracil 7.6316985049
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8518522880 18665156 18407596 20032147 19638242
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1515474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1512878042
MESH:D008107 Liver Diseases Acetaminophen 3.9511587558 16611625 12587719 16610002 19784758 12969438 19460945 19014921
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9517034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2917185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 26.377678174
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 26.3721295105 19389873
MESH:D008113 Liver Neoplasms Clofibric Acid 26.3717602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 26.3715885732 18644402 20101389 19426721 21167192 9163691 19996281 20492335 18648771 12771043 20583210 19690152 19294768 10737359 18977376 20405173 19255062 19833225 19254457 18754104 15175105 19812893 19427195 19499222 21071580 19256749 19073162 21047994 2422723 20452335 19642983 21278145 20118626 20137499 18978307 19638242 19551842 12112319 20434301 20501860 19850985 2862719 16942905 19090486
MESH:D008113 Liver Neoplasms Fluorouracil 26.3715113037 16603448 17045692 18383874
MESH:D008113 Liver Neoplasms pirinixic acid 26.3720007298 15890375 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 26.3715276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 26.3716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.416135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 14.4118164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.4116267830 18079962 21159647 18775883 18282651 17942915 16842330 18093689 19539802 19009564 18308698 18544905 18164116 3124819 18253720 2563599 17174075 9362446 17854601 19126423 19004024 19519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.4112151625
MESH:D008171 Lung Diseases sodium arsenite 3.2119095001
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.9020512841 20970405 21163286 6695378
MESH:D008175 Lung Neoplasms Fluorouracil 4.9015246190
MESH:D008175 Lung Neoplasms sodium arsenite 4.9015276417 17077188 17306315 19931552 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9019555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.8715086387
MESH:D008545 Melanoma sodium arsenite 2.0419082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D009062 Mouth Neoplasms Fluorouracil 3.6716757204 18986760
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9916411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.9418551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.599029167 3581430
MESH:D009369 Neoplasms Fluorouracil 8.4116928823 18600527 18239605
MESH:D009369 Neoplasms pirinixic acid 8.4117405874
MESH:D009369 Neoplasms sodium arsenite 8.4111559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.7420056578
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2814600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.1812854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.3318514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.3320387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2120387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4716436463
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.4816049721
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4515276417 17306315
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.3816540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.3819003803 16929163 15113037 16500647
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.602563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711222880 11896295 11399792 11118676
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3418626508 19082440
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.3416039940
MESH:D011537 Pruritus Ethinyl Estradiol 3.3916919318 15861022
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0618286688 16160472 15538739 18722050
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5718551238
MESH:D012878 Skin Neoplasms sodium arsenite 5.6718572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0416709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8412854658
MESH:D020754 Spinocerebellar Ataxias marker/mechanism
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.5018456281
MESH:D013274 Stomach Neoplasms Fluorouracil 2.5018567086 19084572 17498489 17172411 19015929 17522103 18396642 16424979 16951190 15786421
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.027505956
MESH:D014062 Tongue Neoplasms Fluorouracil 4.0416280240
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1616049721
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.1611723127 17306315 16712894 16452187
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4010091137
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.6616803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.6611813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3614692618
MESH:D014652 Vascular Diseases sodium arsenite 4.5117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5914671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34959
    • No data
    Releated disease ID Related disease Name
    PA447066Spinocerebellar Ataxias
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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