AutismKB 2.0

Annotation Detail for ARIH1


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Basic Information Top
Gene Symbol:ARIH1 ( ARI,DKFZp686O13120,FLJ20329,FLJ93118,HARI,HHARI,UBCH7BP )
Gene Full Name: ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)
Band: 15q24.1
Quick LinksEntrez ID:25820; OMIM: 605624; Uniprot ID:ARI1_HUMAN; ENSEMBL ID: ENSG00000166233; HGNC ID: 689
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ARIH1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ARIH1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ARIH1 mRNAaffects expression 17562736
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of ARIH1 mRNA]affects reaction|increases expression 18700144
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ARIH1 mRNAdecreases expression 20018196
19150397
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ARIH1 mRNAincreases expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of ARIH1 mRNAincreases expression 20106945
D010634 Phenobarbital Phenobarbital results in increased expression of ARIH1 mRNAincreases expression 19270015
D012402 Rotenone Rotenone results in decreased expression of ARIH1 mRNAdecreases expression 19013527
D012643 Selenium Selenium results in decreased expression of ARIH1 mRNAdecreases expression 19244175
D002762 Cholecalciferol Cholecalciferol results in increased expression of ARIH1 mRNAincreases expression 16508948
D014810 Vitamin E Vitamin E results in decreased expression of ARIH1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.636195326
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.1617620307
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001327 Autoimmune Diseases Cholecalciferol 5.2016142846
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 10.533786805 15721981 16124888 16227642 16192424 10355542 16050911 15673190 18705752 15700767 16097048 16011737
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 10.5316050911
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.0816705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.0816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.083084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 9.0818788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 9.0817173139 20935162 6705139 20007298 1701930
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.696135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.6920889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.6912371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.434080065
MESH:D002779 Cholestasis Cyclosporine 3.0219486331
MESH:D003092 Colitis Selenium 3.9517936198
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.4918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.4918551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.4321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.4321346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.4319416960 14550746 17562736 11529661 19370779 14725611 19085960 16781746 16109766 10915739 17522070 12540782 15968718 19739265 16081117 12705907 14986274 11287661 10774834 17906064 16393943 12153990 12392966 19420014 16227642 18713872 16177239 19164858 12958197 12594235 16485898 15619225 11834606 11743745 18071297 10663392 11461765 11739529 11421492 19923254 2444490
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 12.4310915739 6884620 2869522 15998439 21278145 15027814 7440962 7179309 16177239 19336974 4309450 11566570 3732212 10092053 19085960 6623471 7120509 3786805 15968718 17522070 16227642 9327722
MESH:D056486 Drug-Induced Liver Injury Selenium 12.4315131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004421 Dystonia Phenobarbital 4.151851702
MESH:C538011 Eales disease Vitamin E 4.929068938
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.283659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.0911558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.9520417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.676401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.437750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.213659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1020426865
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.1861145 15959796 19224547 17595544 12631006 16239168 12795759 16045604
MESH:D005234 Fatty Liver Cyclosporine 8.1819224547
MESH:D005355 Fibrosis Carbon Tetrachloride 9.2618705752
MESH:D005355 Fibrosis Cyclosporine 9.2612168785 12639820
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0516080930
MESH:D006333 Heart Failure Selenium 3.1517162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7619900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 3.6616109766
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7416490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.1914716179
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7316899240
MESH:D006973 Hypertension Cyclosporine 2.1410903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2615338365
MESH:D007251 Influenza, Human Selenium 11.7016624496
MESH:D007251 Influenza, Human Vitamin E 11.7016624496
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Acetaminophen 10.4512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.458314463 10903974 18776723
MESH:D007674 Kidney Diseases Vitamin E 10.4512488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0216518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.0616705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.0616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.0612371664
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.8811903743 16943688 21278145 17157831 16239168 16221502 17334410 17174718 11408273
MESH:D008103 Liver Cirrhosis Phenobarbital 6.8821047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.5615996030 14724832 12741479 18429990 18205269 17640975 15123356 18156304 15362042 18705752 10355542 17900296 12958196 12609069 16192424 12445418 18376398 18481824 12632512 15959796 17721639 18054572 17631135 17944888 18339082 15650968 18187930 15057751 18279442 14512876 12586293 14716496 18251166 16097048 17766677 16011737 18395914 18006644 17714472 17525996 13678700 18420326 18412020 17565644 15818738 12666154 12649538 15925388 12546737 12389079 18472094 15876570 15730626 14716833 18277467 18166357 16136751 16027843 12632514 17976157 12898905 16116963 17708605 14620537 14748882 17698563 17481882 18418968 17761835 18395095 18472332 15370692 17869086 11481614 15338365 18317297 17557913 18263696 17805973 12667390 16638106 15052691 17922224 20821823 18210741 12445421 16248980 15893842 15931870 17823541 15673190 16033810 16015684
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.5616169303
MESH:D008107 Liver Diseases Acetaminophen 6.6712969438 16610002 19014921 11587558 19784758 12587719 19460945 16611625
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.6716246199 17285989 15720792 16964402 15830285
MESH:D008107 Liver Diseases Phenobarbital 6.6719363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.8516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.8516899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.747678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.7419294768
MESH:D008113 Liver Neoplasms Phenobarbital 7.7419812893 8742319 19073162 19482888 21047994 15975961
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.366135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.3612014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.3618308698 6150874 2563599 17172636 1399818
MESH:D008171 Lung Diseases Vitamin E 3.2716863852
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8515318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008654 Mesothelioma Selenium 2.8415107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.6717484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.0018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.0018551238 7678174
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D009410 Nerve Degeneration Rotenone 3.9915790535 18619942 17356569
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.3312819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.3316049721
MESH:D010018 Osteomalacia Phenobarbital 4.5617016548
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5316965848
MESH:D010300 Parkinson Disease Rotenone 3.0216140633 18191903 11445065 19114014 11535288 15451049 16412576 18619942 19232380
MESH:D020734 Parkinsonian Disorders Rotenone 4.2115795934 18197244 15927086 15574749
MESH:D010954 Plasmacytoma Selenium 5.1115087411
MESH:D011230 Precancerous Conditions Cyclosporine 9.3912371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.392563599
MESH:D011471 Prostatic Neoplasms Cholecalciferol 3.6117024972
MESH:D011471 Prostatic Neoplasms Vitamin E 3.6115084515
MESH:D019310 Pseudolymphoma Phenobarbital 4.7112752131
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D012640 Seizures 2,4-dinitrotoluene 10.3618551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.3618551238
MESH:D012640 Seizures Phenobarbital 10.363137016 11442880 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.026407741
MESH:D012871 Skin Diseases Vitamin E 2.4718709164
MESH:D020521 Stroke Vitamin E 3.6316517955
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.161399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.1816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1816049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.6510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.6510091137
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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