AutismKB 2.0

Annotation Detail for MTO1


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Basic Information Top
Gene Symbol:MTO1 ( - )
Gene Full Name: mitochondrial translation optimization 1 homolog (S. cerevisiae)
Band: 6q13
Quick LinksEntrez ID:25821; OMIM: NA; Uniprot ID:MTO1_HUMAN; ENSEMBL ID: ENSG00000135297; HGNC ID: 19261
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MTO1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of MTO1 mRNAaffects expression 17562736
D018038 Sodium Selenite Sodium Selenite results in increased expression of MTO1 mRNAincreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000799 Angioedema Acetaminophen 4.7110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.3918445737
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 2.9716705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.973084413
MESH:D002386 Cataract Acetaminophen 2.8110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 3.066135515
MESH:D019457 Chromosome Breakage Sodium Selenite 5.4115894690
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.6718551238
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.1916285004
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.8221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.8216081117 19416960 11461765 16781746 18071297 14725611 11834606 12392966 16227642 19739265 17906064 12594235 11287661 11743745 14986274 18713872 16177239 12540782 12705907 14550746 19085960 16485898 16109766 10663392 12958197 17562736 10915739 12153990 17522070 2444490 11421492 19164858 15968718 19420014 15619225 19370779 19923254 11739529 11529661 16393943 10774834
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.8215131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.9619426721
MESH:D005756 Gastritis Acetaminophen 4.5416983495
MESH:D006930 Hyperalgesia Acetaminophen 3.0616870215
MESH:D007333 Insulin Resistance Sodium Selenite 3.5414714311
MESH:D007674 Kidney Diseases Acetaminophen 2.4212587719 15629191
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.3616705839
MESH:D008107 Liver Diseases Acetaminophen 1.7119460945 16610002 12969438 12587719 19784758 16611625 19014921 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6817185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.287678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.792876784 2876786 6135515
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.5914737004
MESH:D008546 Melanoma, Experimental Acetaminophen 4.2219513568
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.607678174 18551238
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2618514411
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.8816049721
MESH:D010146 Pain Acetaminophen 2.7716870215
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3318760546
MESH:D012640 Seizures 2,6-dinitrotoluene 2.8218551238
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.4216049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 5.0610091137
MESH:D014581 Urticaria Acetaminophen 3.5010982225
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018