AutismKB 2.0

Annotation Detail for SULT4A1


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Basic Information Top
Gene Symbol:SULT4A1 ( BR-STL-1,BRSTL1,DJ388M5.3,MGC40032,NST,SULTX3,hBR-STL-1 )
Gene Full Name: sulfotransferase family 4A, member 1
Band: 22q13.31
Quick LinksEntrez ID:25830; OMIM: 608359; Uniprot ID:ST4A1_HUMAN; ENSEMBL ID: ENSG00000130540; HGNC ID: 14903
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Biological oxidations
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C028405 2-naphthol SULT4A1 protein results in increased metabolism of 2-naphtholincreases metabolic processing 12039030
C028405 2-naphthol SULT4A1 protein results in increased metabolism of 2-naphtholincreases metabolic processing 12039030
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of SULT4A1 mRNAincreases expression 16788091
C024836 4-nitrophenol SULT4A1 protein results in increased metabolism of 4-nitrophenolincreases metabolic processing 12039030
C024836 4-nitrophenol SULT4A1 protein results in increased metabolism of 4-nitrophenolincreases metabolic processing 12039030
D015081 2-Naphthylamine SULT4A1 protein results in increased metabolism of 2-Naphthylamineincreases metabolic processing 12039030
D015081 2-Naphthylamine SULT4A1 protein results in increased metabolism of 2-Naphthylamineincreases metabolic processing 12039030
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SULT4A1 mRNAaffects cotreatment|decreases expression 18544905
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with kojic acid] results in decreased expression of SULT4A1 mRNAaffects cotreatment|decreases expression 18544905
D004052 Diethylnitrosamine [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of SULT4A1 mRNAaffects cotreatment|decreases expression 18253720
D004970 Estrone SULT4A1 protein results in increased metabolism of Estroneincreases metabolic processing 12039030
D004970 Estrone SULT4A1 protein results in increased metabolism of Estroneincreases metabolic processing 12039030
D011345 Fenofibrate [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of SULT4A1 mRNAaffects cotreatment|decreases expression 18253720
C011890 kojic acid [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SULT4A1 mRNAaffects cotreatment|decreases expression 18544905
C011890 kojic acid [Diethylnitrosamine co-treated with kojic acid] results in decreased expression of SULT4A1 mRNAaffects cotreatment|decreases expression 18544905
D014284 Triiodothyronine SULT4A1 protein results in increased metabolism of Triiodothyronineincreases metabolic processing 12039030
D014284 Triiodothyronine SULT4A1 protein results in increased metabolism of Triiodothyronineincreases metabolic processing 12039030
D013974 Thyroxine SULT4A1 protein results in increased metabolism of Thyroxineincreases metabolic processing 12039030
D013974 Thyroxine SULT4A1 protein results in increased metabolism of Thyroxineincreases metabolic processing 12039030
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma Diethylnitrosamine 2.946695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.1417162532 18056438 19052882 17620307 16434500 19061943
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2117474063
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 1.8620214788 19701751 17162532 19519916 20512989 20084675 16830150 18506893 19822196 19539802 19418558 18393292 18971187 19052882 16698587 19171122 10737359 18210153 16328049 17428255 18665156 19394651 16878318 3084413 11831363 18785209 19208518 16288022 18788625 17761372 20727157 16807293 16779866 20524982 18978308 17138121 21159647 20935162 16540662 17173139 18691550 17978847 16681979 18056438 20514400 16502159 20432363 17055752 18494052 20007298 19335982 19383236 19107877 3581430 16569478 16935385 19919837 10672840 20101231
MESH:D006332 Cardiomegaly Thyroxine 4.1918093424
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.972727394 17174075 21159647 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8419052882
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2220387270
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 2.1019107877
MESH:D050171 Dyslipidemias Fenofibrate 4.5516707586
MESH:D016889 Endometrial Neoplasms Fenofibrate 4.2016569247
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3816302075
MESH:D005234 Fatty Liver Diethylnitrosamine 3.3520387270 21071580
MESH:D007249 Inflammation Diethylnitrosamine 2.4618785209
MESH:D007680 Kidney Neoplasms Estrone 4.9015610895
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9118407596 18522880 19638242 20032147 18665156
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 2.7915474484
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1317034775
MESH:D008113 Liver Neoplasms Diethylnitrosamine 5.1620501860 18644402 19642983 19426721 19996281 20452335 18648771 9163691 19551842 19499222 21167192 19256749 19073162 20137499 19850985 18754104 2862719 12112319 20583210 12771043 20434301 19638242 19833225 19690152 19294768 20492335 19090486 21278145 20101389 20405173 19427195 10737359 15175105 19812893 15885732 2422723 16942905 21047994 19255062 19254457 20118626 18977376 21071580 18978307
MESH:D008113 Liver Neoplasms Fenofibrate 5.1618978307
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.7018253720 2563599 18079962 3124819 18775883 18308698 18544905 17854601 17942915 18282651 16267830 9362446 19009564 18093689 18164116 19539802 19004024 19126423 17174075 16842330 21159647 19519916
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 10.7018775883 18253720
MESH:D008114 Liver Neoplasms, Experimental kojic acid 10.7018544905
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7621163286 20970405 20512841 6695378
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.629029167 3581430
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3820387270
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4716540662
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.702563599
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013959 Thyroid Diseases Thyroxine 5.9019910387
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.117505956
MESH:D001749 Urinary Bladder Neoplasms 2-Naphthylamine 3.7911144890
Pathway ID Pathway Name
REACT:13433 Biological oxidations
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA412
  • No data
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    PA447304estrogen-dependent carcinogenesis
    Releated drug ID Related drug Name
    PA4519933-beta-hydroxy-5-androsten-17-one
    PA133822447catecholamines
    PA449503estradiol
    PA451581tamoxifen
    PA452604xenobiotics
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018