Annotation Detail for SULT4A1


Gene Symbol: | SULT4A1 ( BR-STL-1,BRSTL1,DJ388M5.3,MGC40032,NST,SULTX3,hBR-STL-1 ) |
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Gene Full Name: | sulfotransferase family 4A, member 1 |
Band: | 22q13.31 |
Quick Links | Entrez ID:25830; OMIM: 608359; Uniprot ID:ST4A1_HUMAN; ENSEMBL ID: ENSG00000130540; HGNC ID: 14903 |
Relate to Another Database: | SFARIGene; denovo-db |
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Pathway ID | Pathway Name |
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Biological oxidations |
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Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
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C028405 | 2-naphthol | SULT4A1 protein results in increased metabolism of 2-naphthol | increases metabolic processing | 12039030 |
C028405 | 2-naphthol | SULT4A1 protein results in increased metabolism of 2-naphthol | increases metabolic processing | 12039030 |
C472791 | 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid | 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of SULT4A1 mRNA | increases expression | 16788091 |
C024836 | 4-nitrophenol | SULT4A1 protein results in increased metabolism of 4-nitrophenol | increases metabolic processing | 12039030 |
C024836 | 4-nitrophenol | SULT4A1 protein results in increased metabolism of 4-nitrophenol | increases metabolic processing | 12039030 |
D015081 | 2-Naphthylamine | SULT4A1 protein results in increased metabolism of 2-Naphthylamine | increases metabolic processing | 12039030 |
D015081 | 2-Naphthylamine | SULT4A1 protein results in increased metabolism of 2-Naphthylamine | increases metabolic processing | 12039030 |
D004052 | Diethylnitrosamine | [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SULT4A1 mRNA | affects cotreatment|decreases expression | 18544905 |
D004052 | Diethylnitrosamine | [Diethylnitrosamine co-treated with kojic acid] results in decreased expression of SULT4A1 mRNA | affects cotreatment|decreases expression | 18544905 |
D004052 | Diethylnitrosamine | [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of SULT4A1 mRNA | affects cotreatment|decreases expression | 18253720 |
D004970 | Estrone | SULT4A1 protein results in increased metabolism of Estrone | increases metabolic processing | 12039030 |
D004970 | Estrone | SULT4A1 protein results in increased metabolism of Estrone | increases metabolic processing | 12039030 |
D011345 | Fenofibrate | [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of SULT4A1 mRNA | affects cotreatment|decreases expression | 18253720 |
C011890 | kojic acid | [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SULT4A1 mRNA | affects cotreatment|decreases expression | 18544905 |
C011890 | kojic acid | [Diethylnitrosamine co-treated with kojic acid] results in decreased expression of SULT4A1 mRNA | affects cotreatment|decreases expression | 18544905 |
D014284 | Triiodothyronine | SULT4A1 protein results in increased metabolism of Triiodothyronine | increases metabolic processing | 12039030 |
D014284 | Triiodothyronine | SULT4A1 protein results in increased metabolism of Triiodothyronine | increases metabolic processing | 12039030 |
D013974 | Thyroxine | SULT4A1 protein results in increased metabolism of Thyroxine | increases metabolic processing | 12039030 |
D013974 | Thyroxine | SULT4A1 protein results in increased metabolism of Thyroxine | increases metabolic processing | 12039030 |
Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
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MESH:D000236 | Adenoma | Diethylnitrosamine | 2.94 | 6695378 10737359 | |
MESH:D018248 | Adenoma, Liver Cell | Diethylnitrosamine | 4.14 | 17162532 18056438 19052882 17620307 16434500 19061943 | |
MESH:D001943 | Breast Neoplasms | Diethylnitrosamine | 2.21 | 17474063 | |
MESH:D006528 | Carcinoma, Hepatocellular | Diethylnitrosamine | 1.86 | 20214788 19701751 17162532 19519916 20512989 20084675 16830150 18506893 19822196 19539802 19418558 18393292 18971187 19052882 16698587 19171122 10737359 18210153 16328049 17428255 18665156 19394651 16878318 3084413 11831363 18785209 19208518 16288022 18788625 17761372 20727157 16807293 16779866 20524982 18978308 17138121 21159647 20935162 16540662 17173139 18691550 17978847 16681979 18056438 20514400 16502159 20432363 17055752 18494052 20007298 19335982 19383236 19107877 3581430 16569478 16935385 19919837 10672840 20101231 | |
MESH:D006332 | Cardiomegaly | Thyroxine | 4.19 | 18093424 | |
MESH:D002471 | Cell Transformation, Neoplastic | Diethylnitrosamine | 2.97 | 2727394 17174075 21159647 7505956 | |
MESH:D018281 | Cholangiocarcinoma | Diethylnitrosamine | 3.84 | 19052882 | |
MESH:D003924 | Diabetes Mellitus, Type 2 | Diethylnitrosamine | 2.22 | 20387270 | |
MESH:D056486 | Drug-Induced Liver Injury | Diethylnitrosamine | 2.10 | 19107877 | |
MESH:D050171 | Dyslipidemias | Fenofibrate | 4.55 | 16707586 | |
MESH:D016889 | Endometrial Neoplasms | Fenofibrate | 4.20 | 16569247 | |
MESH:D004931 | Esophageal Achalasia | Diethylnitrosamine | 5.38 | 16302075 | |
MESH:D005234 | Fatty Liver | Diethylnitrosamine | 3.35 | 20387270 21071580 | |
MESH:D007249 | Inflammation | Diethylnitrosamine | 2.46 | 18785209 | |
MESH:D007680 | Kidney Neoplasms | Estrone | 4.90 | 15610895 | |
MESH:D008103 | Liver Cirrhosis | Diethylnitrosamine | 2.91 | 18407596 18522880 19638242 20032147 18665156 | |
MESH:D008106 | Liver Cirrhosis, Experimental | Fenofibrate | 2.79 | 15474484 | |
MESH:D008107 | Liver Diseases | Diethylnitrosamine | 2.13 | 17034775 | |
MESH:D008113 | Liver Neoplasms | Diethylnitrosamine | 5.16 | 20501860 18644402 19642983 19426721 19996281 20452335 18648771 9163691 19551842 19499222 21167192 19256749 19073162 20137499 19850985 18754104 2862719 12112319 20583210 12771043 20434301 19638242 19833225 19690152 19294768 20492335 19090486 21278145 20101389 20405173 19427195 10737359 15175105 19812893 15885732 2422723 16942905 21047994 19255062 19254457 20118626 18977376 21071580 18978307 | |
MESH:D008113 | Liver Neoplasms | Fenofibrate | 5.16 | 18978307 | |
MESH:D008114 | Liver Neoplasms, Experimental | Diethylnitrosamine | 10.70 | 18253720 2563599 18079962 3124819 18775883 18308698 18544905 17854601 17942915 18282651 16267830 9362446 19009564 18093689 18164116 19539802 19004024 19126423 17174075 16842330 21159647 19519916 | |
MESH:D008114 | Liver Neoplasms, Experimental | Fenofibrate | 10.70 | 18775883 18253720 | |
MESH:D008114 | Liver Neoplasms, Experimental | kojic acid | 10.70 | 18544905 | |
MESH:D008175 | Lung Neoplasms | Diethylnitrosamine | 1.76 | 21163286 20970405 20512841 6695378 | |
MESH:D009362 | Neoplasm Metastasis | Diethylnitrosamine | 2.62 | 9029167 3581430 | |
MESH:D019636 | Neurodegenerative Diseases | Diethylnitrosamine | 3.48 | 20387270 | |
MESH:D009461 | Neurologic Manifestations | Diethylnitrosamine | 5.38 | 20387270 | |
MESH:D010190 | Pancreatic Neoplasms | Diethylnitrosamine | 2.47 | 16540662 | |
MESH:D011230 | Precancerous Conditions | Diethylnitrosamine | 3.70 | 2563599 | |
MESH:D013274 | Stomach Neoplasms | Diethylnitrosamine | 1.76 | 18456281 | |
MESH:D013959 | Thyroid Diseases | Thyroxine | 5.90 | 19910387 | |
MESH:D013964 | Thyroid Neoplasms | Diethylnitrosamine | 3.11 | 7505956 | |
MESH:D001749 | Urinary Bladder Neoplasms | 2-Naphthylamine | 3.79 | 11144890 |
Pathway ID | Pathway Name |
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REACT:13433 | Biological oxidations |