AutismKB 2.0

Annotation Detail for HECTD1


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Basic Information Top
Gene Symbol:HECTD1 ( FLJ38315,KIAA1131 )
Gene Full Name: HECT domain containing 1
Band: 14q12
Quick LinksEntrez ID:25831; OMIM: NA; Uniprot ID:HECD1_HUMAN; ENSEMBL ID: ENSG00000092148; HGNC ID: 20157
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of HECTD1 mRNAdecreases expression 20406850
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of HECTD1 mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HECTD1 mRNAdecreases expression 19150397
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HECTD1 mRNAaffects cotreatment|increases expression 17942748
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of HECTD1 geneincreases mutagenesis 15755804
C006253 pirinixic acid pirinixic acid results in increased expression of HECTD1 mRNAincreases expression 18301758
D011794 Quercetin Quercetin affects the expression of HECTD1 mRNAaffects expression 18178720
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HECTD1 mRNAaffects cotreatment|increases expression 17942748
C025643 vinclozolin vinclozolin affects the expression of HECTD1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1314514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3220127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3214692618
MESH:D000236 Adenoma Benzo(a)pyrene 7.326695378
MESH:D000236 Adenoma Ethylnitrosourea 7.326695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.8716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.4517084956
MESH:D001008 Anxiety Disorders vinclozolin 3.8019015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001260 Ataxia Telangiectasia Quercetin 5.2615336622
MESH:D001327 Autoimmune Diseases Quercetin 4.6719761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.4619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001927 Brain Diseases Ethylnitrosourea 5.0714991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.4816357521 16436596 18412241 15144691 16651633
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8617474063 20146248
MESH:D001943 Breast Neoplasms Quercetin 1.8618628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8620435547
MESH:D002105 Cadmium Poisoning Quercetin 5.8616962696
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.2316705839
MESH:D006528 Carcinoma, Hepatocellular Quercetin 3.2319519916 12508355
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.2117234771
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D006332 Cardiomegaly Quercetin 7.1519794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.1518670907 16120746 18850075
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 12.116135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 12.1120889678
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 12.1116003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.3017160924
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2517333356 16919318 17110522 16105132 11677210 17681005 15861022
MESH:D002779 Cholestasis pirinixic acid 8.2519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1815668235 8697196 16354765 15340226 12621046
MESH:D003110 Colonic Neoplasms Quercetin 2.4511134977 16640504 19056647 17148506 19440933 17191121 15741050
MESH:D015179 Colorectal Neoplasms Quercetin 2.1918852136 18095365
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.5814966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.2818551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.9019496084
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 3.8721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.3018357618
MESH:D004487 Edema pirinixic acid 7.2312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2218230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4212538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.219294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5020426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5016530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.2415345470
MESH:D005234 Fatty Liver pirinixic acid 8.2420131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Quercetin 9.6419474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.6420067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2216973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6216417039
MESH:D005909 Glioblastoma Ethylnitrosourea 7.9916436596
MESH:D005909 Glioblastoma Quercetin 7.9919804834
MESH:D005910 Glioma Ethylnitrosourea 6.6518412241 16651633 16357521
MESH:D005910 Glioma Quercetin 6.6517643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7710048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly pirinixic acid 9.1416221962 19772884 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.1415340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3615340226 16959395 8697196 16354765 18606429
MESH:D006943 Hyperglycemia pirinixic acid 9.8920558911
MESH:D006943 Hyperglycemia Quercetin 9.8911834736 18262572
MESH:D006973 Hypertension Quercetin 5.4518356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.4518850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.1017937319
MESH:D007248 Infertility, Male vinclozolin 7.1016467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9512200463 12878042
MESH:D007251 Influenza, Human Quercetin 4.8216624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007627 Keloid Quercetin 5.2117086741
MESH:D007674 Kidney Diseases Quercetin 3.2016962696
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.2916705839
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 8.2917379185
MESH:D007938 Leukemia Quercetin 3.2517468513
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0216417039
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5615474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 3.5612741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5612878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.977678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.9721137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 14.9720007298 16377806 15890375
MESH:D008113 Liver Neoplasms Quercetin 14.9718980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.9716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.566135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Quercetin 10.5619519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.5612151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.056695378 18569708 18520028 18816296 17053015 20464547 20135361 20064080 20869020
MESH:D008175 Lung Neoplasms Ethylnitrosourea 5.056695378 16271038 17703301 16019985
MESH:D008175 Lung Neoplasms Quercetin 5.0516280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0519555203 11884234
MESH:D008223 Lymphoma Ethylnitrosourea 4.0815790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.3115375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.6318041768 10767621 10838139
MESH:D008579 Meningioma Ethylnitrosourea 6.3017943659
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 5.9719151258
MESH:D009203 Myocardial Infarction Quercetin 5.9719595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.9716411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 8.9719207477
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.157678174 18551238
MESH:D009369 Neoplasms Benzo(a)pyrene 8.7911141357
MESH:D009369 Neoplasms pirinixic acid 8.7917405874
MESH:D009369 Neoplasms Quercetin 8.7915185748
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.6616707424
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.7017160924 16003739 16651423
MESH:D020078 Neurogenic Inflammation Quercetin 4.5817929310
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.6216049721
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.3017160924
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.4419495926
MESH:D010051 Ovarian Neoplasms Quercetin 2.7819005980
MESH:D010190 Pancreatic Neoplasms Quercetin 2.9116965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011230 Precancerous Conditions Quercetin 4.1619056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.4611118676 11896295 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.4618220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.2218220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2517292933
MESH:D011471 Prostatic Neoplasms Quercetin 3.2514715546 17292933
MESH:D011472 Prostatitis vinclozolin 5.2218629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.6016919318 15861022
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012554 Schistosomiasis japonica Quercetin 5.8616862918
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6718551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7619755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7616192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2616709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.4515790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.7516049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.7517053015
MESH:D001749 Urinary Bladder Neoplasms Quercetin 8.7516720314
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6010091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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