AutismKB 2.0

Annotation Detail for POU2F3


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Basic Information Top
Gene Symbol:POU2F3 ( Epoc-1,FLJ40063,MGC126698,OCT11,PLA-1,Skn-1a )
Gene Full Name: POU class 2 homeobox 3
Band: 11q23.3
Quick LinksEntrez ID:25833; OMIM: 607394; Uniprot ID:PO2F3_HUMAN; ENSEMBL ID: ENSG00000137709; HGNC ID: 19864
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C021296 2-ethoxyethanol 2-ethoxyethanol results in increased expression of POU2F3 mRNAincreases expression 19643169
D000643 Ammonium Chloride Ammonium Chloride affects the expression of POU2F3 mRNAaffects expression 16483693
C006780 bisphenol A bisphenol A results in increased expression of POU2F3 mRNAincreases expression 17989879
C011890 kojic acid kojic acid results in decreased expression of POU2F3 mRNAdecreases expression 16595896
D008628 Mercury Mercury results in increased expression of POU2F3 mRNAincreases expression 16823088
C005219 methyl cellosolve methyl cellosolve results in increased expression of POU2F3 mRNAincreases expression 19643169
D009151 Mustard Gas Mustard Gas results in decreased expression of POU2F3 mRNAdecreases expression 15674843
D009151 Mustard Gas Mustard Gas results in decreased expression of POU2F3 mRNAdecreases expression 18988085
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 2-ethoxyethanol 10.786499812 7151721 6499823 6499796 6499820
MESH:D000014 Abnormalities, Drug-Induced methyl cellosolve 10.783652986 6499812 6474471
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D000748 Anemia, Macrocytic methyl cellosolve 6.793699323
MESH:D053627 Asthenozoospermia 2-ethoxyethanol 13.966499823 10689203 6499807
MESH:D053627 Asthenozoospermia methyl cellosolve 13.963987992
MESH:D001249 Asthma Mustard Gas 2.7810378619
MESH:D001259 Ataxia 2-ethoxyethanol 5.767151721
MESH:D001284 Atrophy 2-ethoxyethanol 12.536499799 15850284
MESH:D001284 Atrophy methyl cellosolve 12.536705890 3699323 2626667
MESH:D001321 Autistic Disorder Mercury 2.7617497416
MESH:D001327 Autoimmune Diseases Mercury 5.2316634805
MESH:D053713 Azoospermia 2-ethoxyethanol 5.946499807 6492198
MESH:D001724 Birth Weight 2-ethoxyethanol 6.966499823 2884743
MESH:D001768 Blister Mustard Gas 5.5619167455
MESH:D001836 Body Weight Changes 2-ethoxyethanol 6.156499796 7151721
MESH:D001862 Bone Resorption bisphenol A 4.1411985600
MESH:D001943 Breast Neoplasms bisphenol A 2.4417123778
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.5615286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.4217687719 10378619
MESH:D002278 Carcinoma in Situ bisphenol A 5.3817123778
MESH:D002311 Cardiomyopathy, Dilated Mercury 3.5310334427
MESH:D002764 Cholecystitis 2-ethoxyethanol 15.186499794
MESH:D002764 Cholecystitis methyl cellosolve 15.186499794
MESH:D000013 Congenital Abnormalities methyl cellosolve 5.066499821 12530607
MESH:D003643 Death 2-ethoxyethanol 6.416499796
MESH:D017449 Dermatitis, Allergic Contact Mercury 4.1516823706
MESH:D004487 Edema Mustard Gas 3.5911402378 11428631 9260866 11428647
MESH:D020964 Embryo Loss 2-ethoxyethanol 6.966499796
MESH:D004890 Erythema Mustard Gas 5.569357497
MESH:D005313 Fetal Death 2-ethoxyethanol 5.736499823 2884743 7198755 6499820 7151721
MESH:D005317 Fetal Growth Retardation 2-ethoxyethanol 5.746499796
MESH:D005327 Fetal Resorption 2-ethoxyethanol 14.206499820 6499812
MESH:D005327 Fetal Resorption methyl cellosolve 14.206474471 6499812 6499821 3987992
MESH:D020567 Fetal Weight 2-ethoxyethanol 15.187151721 2884743 6499820
MESH:D020567 Fetal Weight methyl cellosolve 15.186474471 6499812 6499821
MESH:D005532 Foot Deformities, Congenital methyl cellosolve 5.813652986
MESH:D006345 Heart Septal Defects, Ventricular methyl cellosolve 6.186499821
MESH:D006402 Hematologic Diseases 2-ethoxyethanol 5.6910514026 20172899
MESH:D006461 Hemolysis 2-ethoxyethanol 13.8719051582 17874071
MESH:D006461 Hemolysis methyl cellosolve 13.8717874071
MESH:D007247 Infertility, Female 2-ethoxyethanol 5.536499823
MESH:D007248 Infertility, Male 2-ethoxyethanol 8.296499823
MESH:D007248 Infertility, Male methyl cellosolve 8.293987992
MESH:D007249 Inflammation Mustard Gas 2.9117524151 9357497 11428631 8975870 11428620 11428647 11402378 16001271 9260866
MESH:D007333 Insulin Resistance bisphenol A 3.4616393666
MESH:D007674 Kidney Diseases Mercury 3.7017934191
MESH:D017880 Limb Deformities, Congenital methyl cellosolve 4.696499821
MESH:D008114 Liver Neoplasms, Experimental kojic acid 3.4918544905
MESH:D008171 Lung Diseases Mustard Gas 3.6218702808 18161513
MESH:D008175 Lung Neoplasms Mustard Gas 2.178781369 3148597
MESH:D008231 Lymphopenia methyl cellosolve 6.183699323
MESH:D009336 Necrosis 2-ethoxyethanol 5.7420172899
MESH:D009421 Nervous System Malformations bisphenol A 4.3016427766 11399458
MESH:D009503 Neutropenia Mustard Gas 4.277688884 16761898
MESH:D009845 Oligospermia 2-ethoxyethanol 12.7320172899
MESH:D009845 Oligospermia methyl cellosolve 12.733987992
MESH:D010049 Ovarian Diseases bisphenol A 5.3811985600
MESH:D011041 Poisoning Mustard Gas 4.1015727166
MESH:D011297 Prenatal Exposure Delayed Effects 2-ethoxyethanol 19.116499817 7198755 2884743
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 19.1110548101
MESH:D011297 Prenatal Exposure Delayed Effects methyl cellosolve 19.116499817 7974496 12530607
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.4920887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.3616740699
MESH:D011537 Pruritus Mustard Gas 4.4918058305
MESH:D011629 Puberty, Precocious bisphenol A 5.1810548101
MESH:D011658 Pulmonary Fibrosis Mustard Gas 3.0117266442 17894541 17620002 10334151 17720292
MESH:D012871 Skin Diseases Mustard Gas 2.7716961503 12880345 15451306
MESH:D013276 Stomach Ulcer 2-ethoxyethanol 4.666499799
MESH:D019966 Substance-Related Disorders bisphenol A 4.3816045194 16684133
MESH:D013733 Testicular Diseases 2-ethoxyethanol 12.426499806 10514026 10048760
MESH:D013733 Testicular Diseases methyl cellosolve 12.426499806
MESH:D014591 Uterine Diseases bisphenol A 5.4514652134
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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