AutismKB 2.0

Annotation Detail for ABTB2


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Basic Information Top
Gene Symbol:ABTB2 ( DKFZp586C1619 )
Gene Full Name: ankyrin repeat and BTB (POZ) domain containing 2
Band: 11p13
Quick LinksEntrez ID:25841; OMIM: NA; Uniprot ID:A8K6S9_HUMAN; ENSEMBL ID: ENSG00000166016; HGNC ID: 23842
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ABTB2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ABTB2 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ABTB2 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ABTB2 mRNAdecreases expression 19150397
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ABTB2 mRNAincreases expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of ABTB2 mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of ABTB2 mRNAincreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of ABTB2 mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ABTB2 mRNA]decreases reaction|increases expression 17942915
C041786 palm oil palm oil results in increased expression of ABTB2 mRNAincreases expression 18042831
D010634 Phenobarbital Phenobarbital results in increased expression of ABTB2 mRNAincreases expression 19270015
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.686195326
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000236 Adenoma Diethylnitrosamine 2.946695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.0816434500 19052882 19061943 17620307 17162532 18056438
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.0817620307
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.1015238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001943 Breast Neoplasms Dietary Fats 2.1620435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1617474063
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9918705752 16124888 16192424 16011737 16050911 15673190 16097048 15721981 10355542 3786805 16227642 15700767
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.1216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.123084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 9.1218788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 9.1216878318 21159647 3084413 19394651 18393292 17173139 18788625 20084675 19919837 19335982 16569478 16779866 19701751 18785209 20514400 17978847 19052882 19519916 19539802 17138121 10672840 17428255 18210153 20935162 18506893 16288022 17055752 19171122 18971187 17761372 10737359 16807293 18056438 19822196 19418558 11831363 19383236 3581430 19107877 20524982 16830150 20512989 18691550 20007298 16502159 17162532 20727157 18978308 20432363 16328049 16540662 16935385 18665156 20214788 16681979 19208518 20101231 18494052 16698587
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 9.126705139 1701930 17173139 20007298 20935162
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.8320889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.8312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.8317174075 21159647 7505956 2727394
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.474080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8419052882
MESH:D002779 Cholestasis Cyclosporine 3.0419486331
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2318551238
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2220387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.3521346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.3510774834 10663392 16177239 11421492 16227642 12705907 16109766 12958197 11834606 10915739 15968718 18071297 12392966 11461765 16081117 17906064 19420014 14725611 14986274 11287661 19085960 17522070 17562736 11529661 19370779 14550746 16485898 19739265 19923254 12540782 2444490 12153990 11739529 19416960 11743745 16781746 19164858 18713872 12594235 16393943 15619225
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.3517522070 10092053 4309450 6884620 7440962 7179309 3732212 19336974 6623471 11566570 3786805 2869522 16177239 21278145 15998439 10915739 15968718 15027814 7120509 19085960 9327722 16227642
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.3519107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D050171 Dyslipidemias Dietary Fats 3.5718367378
MESH:D004421 Dystonia Phenobarbital 4.191851702
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.323659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.143922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.696401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.477750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.263659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3816302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1120426865
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.2612631006 17595544 12795759 15959796 19224547 16239168 61145 16045604
MESH:D005234 Fatty Liver Cyclosporine 20.2619224547
MESH:D005234 Fatty Liver Dietary Fats 20.2618296743 17967931 19551842 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 20.2620387270 21071580
MESH:D005355 Fibrosis Carbon Tetrachloride 16.1018705752
MESH:D005355 Fibrosis Cyclosporine 16.1012168785 12639820
MESH:D005355 Fibrosis Dietary Fats 16.1018296743
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7919110552 19900420
MESH:D006529 Hepatomegaly Phenobarbital 3.7016109766
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7621332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.8021332399
MESH:D006973 Hypertension Cyclosporine 2.1510903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D007249 Inflammation Dietary Fats 5.3820412841
MESH:D007249 Inflammation Diethylnitrosamine 5.3818785209
MESH:D007333 Insulin Resistance Dietary Fats 3.2118457598 11836018
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1015629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.1018776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.7616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.7612371664
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 16.4917334410 17157831 17174718 16239168 11903743 16221502 21278145 11408273 16943688
MESH:D008103 Liver Cirrhosis Dietary Fats 16.4918296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 16.4918665156 18407596 20032147 19638242 18522880
MESH:D008103 Liver Cirrhosis Phenobarbital 16.4921047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7512741479 18705752 18376398 15052691 13678700 17976157 18187930 18006644 17766677 18263696 12586293 16116963 16192424 17481882 17631135 17565644 17525996 14620537 17900296 18472094 15996030 18166357 15123356 12445418 15818738 18481824 10355542 15057751 18156304 15893842 18279442 17944888 15362042 14512876 16097048 18420326 17708605 11481614 18429990 20821823 15876570 15925388 18339082 15370692 12958196 15650968 16027843 16011737 17640975 12649538 17714472 15959796 18205269 17698563 17721639 14716833 12632512 18317297 18418968 17922224 16033810 18395095 18251166 18054572 12445421 12389079 17761835 12609069 12667390 17869086 16638106 16136751 17805973 14724832 15338365 18412020 16015684 18395914 16248980 15931870 18210741 12666154 17823541 18277467 15673190 14748882 15730626 18472332 14716496 12546737 12898905 12632514 17557913
MESH:D008107 Liver Diseases Acetaminophen 9.7112969438 16611625 19460945 11587558 19784758 12587719 19014921 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 9.7116246199 17285989 15720792 16964402 15830285
MESH:D008107 Liver Diseases Diethylnitrosamine 9.7117034775
MESH:D008107 Liver Diseases Phenobarbital 9.7119363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.9516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.9516899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.8119294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.8119426721 19255062 19638242 19294768 19499222 21167192 18754104 19996281 19690152 19850985 21278145 16942905 18644402 20434301 19073162 2862719 20452335 20101389 19256749 20501860 19427195 2422723 12112319 18977376 19833225 20118626 12771043 21071580 21047994 18978307 20492335 20583210 20405173 18648771 19812893 19090486 9163691 19551842 20137499 15175105 10737359 19642983 19254457 15885732
MESH:D008113 Liver Neoplasms Phenobarbital 7.8119073162 8742319 15975961 21047994 19812893 19482888
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.4812014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.4816842330 18164116 9362446 18253720 18282651 3124819 17174075 18093689 17854601 18079962 18308698 17942915 19126423 18544905 19519916 18775883 2563599 19009564 21159647 19539802 19004024 16267830
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.481399818 18308698 2563599 6150874 17172636
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.766695378 20970405 20512841 21163286
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7117484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0918551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.629029167 3581430
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4419348381 18481113
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.6718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.6720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3820387270
MESH:D009765 Obesity Dietary Fats 2.3221332399 17217161 18674790 20132043 19632207 11836018 16723640 18457598 20518802
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5916049721 12819281
MESH:D010018 Osteomalacia Phenobarbital 4.6017016548
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4416540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.4416965848
MESH:D011230 Precancerous Conditions Cyclosporine 16.1812371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 16.182563599
MESH:D011230 Precancerous Conditions Phenobarbital 16.182563599
MESH:D019310 Pseudolymphoma Phenobarbital 4.7612752131
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3018551238
MESH:D012640 Seizures Phenobarbital 6.304039156 3137016 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.066407741
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.627505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.621399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3416049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5510091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D015430 Weight Gain Dietary Fats 3.8916723640
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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