AutismKB 2.0

Annotation Detail for ARMC8


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Basic Information Top
Gene Symbol:ARMC8 ( HSPC056,MGC10058,MGC4880 )
Gene Full Name: armadillo repeat containing 8
Band: 3q22.3
Quick LinksEntrez ID:25852; OMIM: NA; Uniprot ID:ARMC8_HUMAN; ENSEMBL ID: ENSG00000114098; HGNC ID: 24999
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ARMC8 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ARMC8 mRNAaffects expression 21346803
C006632 arsenic trioxide arsenic trioxide results in increased expression of ARMC8 mRNAincreases expression 20458559
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ARMC8 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ARMC8 mRNAdecreases expression 19150397
C051890 irinotecan irinotecan analog results in decreased expression of ARMC8 mRNAdecreases expression 18927307
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of ARMC8 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of ARMC8 mRNAincreases expression 19270015
19482888
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ARMC8 mRNAdecreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.446195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.4411752688 14514962 15322242
MESH:D000230 Adenocarcinoma arsenic trioxide 4.5211798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5220464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.786695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.2317620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.2316835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.7816206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.7812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8720146248 17474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8720435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5911589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8416705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.8411135700 16217749 15553829 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.841701930 6705139 17173139 20935162 20007298
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.2519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3512490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4916120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.186135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.1820889678
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.564080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.198697196 15668235 15340226 12621046 16354765
MESH:D003110 Colonic Neoplasms irinotecan 2.6217725105 17287894
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.7220501625
MESH:D015179 Colorectal Neoplasms irinotecan 2.7217159606 15273666 16391804 16303861 18259882 18509181 17454858
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5310525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5320055451 10048152 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.9418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.9418551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3615213294
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.5221346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.5221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004421 Dystonia Phenobarbital 4.261851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2818230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.259294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.413659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.2511558140 3922381
MESH:D004827 Epilepsy Phenobarbital 3.0020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.766401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.363659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.5220426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.5212903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.5216530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver arsenic trioxide 3.5315073043
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2520067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5416904648
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.8220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8210048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Phenobarbital 9.4816109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.4815340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4215340226 16959395 8697196 18606429 16354765
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9612200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.0416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.0416705839
MESH:D007938 Leukemia arsenic trioxide 2.9315070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0412560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.6416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1719850784 20471514 16968895 17050201 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3616330433 17712046 17869043 19642359 19075265 16891316 12679006 9834237 19225113 15213294 15622746 17649720 11161223 12712474 16966277 16823087 15336539 17107899 16112521 11468182 16331271 12018890 15748426 19035177 17217047
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6316882451
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0121047994
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Phenobarbital 2.2219363144
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 15.097678174
MESH:D008113 Liver Neoplasms arsenic trioxide 15.0914682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 15.0921137059 20195826
MESH:D008113 Liver Neoplasms Phenobarbital 15.098742319 19482888 19812893 15975961 19073162 21047994
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 15.0916984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 15.306135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 15.3020377131
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 15.3017172636 1399818 6150874 2563599 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.3012151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5315213294
MESH:D008175 Lung Neoplasms arsenic trioxide 3.4811798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.486695378 18520028 20869020 20464547 18816296 17053015 20064080 18569708 20135361
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4811884234 19555203
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D052016 Mucositis irinotecan 5.3517159606
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2719549372 14977855 11468182 15949261 19417148
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.0518349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2616882451 16105982
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8117484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.5018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.5018551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2416624393
MESH:D009362 Neoplasm Metastasis irinotecan 3.2518259882
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2711141357
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2610525206
MESH:D009447 Neuroblastoma irinotecan 3.598761367
MESH:D017599 Neuroectodermal Tumors irinotecan 5.078761367
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.6616049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.6616049721
MESH:D010018 Osteomalacia Phenobarbital 4.7017016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4719769630 16624393 12452020
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.5415580305
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.5416965848
MESH:D010235 Paraganglioma arsenic trioxide 4.4219927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.842563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311118676 11896295 11399792 11222880
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.1219131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1217292933
MESH:D019310 Pseudolymphoma Phenobarbital 4.8712752131
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2416646077
MESH:D012640 Seizures 2,4-dinitrotoluene 10.7518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.7518551238
MESH:D012640 Seizures Phenobarbital 10.753137016 4039156 11442880 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 5.166407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.8019755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8016192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.5217007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.522093021 20155912
MESH:D013274 Stomach Neoplasms irinotecan 3.5215723263
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.8319014326
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.831399818
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3015213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.5916049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.5916049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.5912845720 20435036 11780464 12973940
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.5917053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.1410091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.1410091137
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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