AutismKB 2.0

Annotation Detail for ABHD14A


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Basic Information Top
Gene Symbol:ABHD14A ( DKFZp564O243,DORZ1,FLJ60317,FLJ60467 )
Gene Full Name: abhydrolase domain containing 14A
Band: 3p21.2
Quick LinksEntrez ID:25864; OMIM: NA; Uniprot ID:ABHEA_HUMAN; ENSEMBL ID: ENSG00000114786; HGNC ID: 24538
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of ABHD14A mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of ABHD14A mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ABHD14A mRNAincreases expression 20382639
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of ABHD14A mRNAdecreases expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of ABHD14A mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of ABHD14A mRNAdecreases expression 17557909
C006253 pirinixic acid pirinixic acid results in increased expression of ABHD14A mRNAincreases expression 18301758
D014810 Vitamin E Vitamin E results in decreased expression of ABHD14A mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.883712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.401440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 10.9815673190 18705752 16227642 16097048 15700767 16011737 16192424 16050911 15721981 10355542 16124888 3786805
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 10.9816050911
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.693581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.693084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.6918788625
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.777296757
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 12.087505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 12.0820889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 12.0812371664
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 20.709022650 19486331
MESH:D002779 Cholestasis Cyclosporine 20.7019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 20.7017333356 17110522 16919318 11677210 17681005 15861022 16105132
MESH:D002779 Cholestasis pirinixic acid 20.7019176532
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1011906362 8156756 12868966 11298694 14531868 18759878 2524372 8970840
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.753621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.5418289764 7440962 18692083 16192314 6482804 9328219 8291058 1440618 18648102 6679447 11289319 9653073 9022650
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5416177239 16109766 15968718 16081117 18071297 19164858 19085960 19923254 17906064 11834606 19739265 16393943 11743745 16485898 18713872 17562736 10915739 16227642 16781746 17522070 11461765 12594235 11739529 12958197 12705907 2444490 19416960 14986274 14725611 19370779 11287661 11421492 12153990 12540782 19420014 14550746 10774834 10663392 12392966 15619225 11529661
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.5421278145 15998439 2869522 3786805 10915739 15027814 6884620 7120509 7179309 6623471 17522070 10092053 19085960 3732212 19336974 7440962 9327722 16177239 4309450 16227642 11566570 15968718
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:C538011 Eales disease Vitamin E 5.089068938
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4712538720
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.563581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5620426865
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.8519224547 16239168 61145 12631006 17595544 15959796 16045604 12795759
MESH:D005234 Fatty Liver Cyclosporine 20.8519224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.8515345470
MESH:D005234 Fatty Liver pirinixic acid 20.8519236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D005355 Fibrosis Carbon Tetrachloride 9.7118705752
MESH:D005355 Fibrosis Cyclosporine 9.7112168785 12639820
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.307505956
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1016080930
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 10.186705139
MESH:D006505 Hepatitis Carbon Tetrachloride 10.1819900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 3.3016221962 19176532 19772884 18467677
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7716490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.3514716179
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2515034207
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007251 Influenza, Human Vitamin E 4.5916624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.408074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Acetaminophen 10.7515629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 10.7510903974 8314463 18776723
MESH:D007674 Kidney Diseases Vitamin E 10.7512488133
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.956582329
MESH:D007680 Kidney Neoplasms Cyclosporine 7.9512371664
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9221278145 11903743 17334410 16943688 11408273 16221502 17174718 17157831 16239168
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.6018156304 15959796 17805973 18395095 17525996 17976157 17631135 18277467 12958196 18481824 15673190 17944888 18205269 15052691 15338365 18420326 18395914 18705752 15650968 12666154 18210741 18263696 15876570 18472332 15996030 14716496 16192424 16116963 18429990 18317297 12898905 12609069 17721639 15057751 18412020 14716833 18187930 17900296 12667390 17823541 12586293 16011737 14724832 16033810 15123356 18166357 11481614 16097048 15730626 17565644 18339082 14748882 16027843 12445418 12445421 17714472 17766677 18376398 18279442 15931870 12546737 18251166 15362042 16015684 12632512 18472094 12741479 18006644 16248980 18054572 20821823 14620537 18418968 15925388 13678700 17698563 10355542 16136751 15893842 12389079 17557913 14512876 12632514 15370692 17640975 17922224 17761835 15818738 16638106 17869086 17708605 17481882 12649538
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.6015474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.6016169303
MESH:D008107 Liver Diseases Acetaminophen 4.0716610002 16611625 19784758 12969438 11587558 12587719 19460945 19014921
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0715720792 15830285 16964402 17285989 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.1816871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.1816899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.6919294768
MESH:D008113 Liver Neoplasms pirinixic acid 4.6915890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.381399818 3712494 6587162 598648
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.3815583823 12014681
MESH:D008171 Lung Diseases Vitamin E 3.3316863852
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.553581430
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.066679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.654026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2615084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.6516919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
MESH:D012871 Skin Diseases Vitamin E 2.4918709164
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D020521 Stroke Vitamin E 3.7116517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.066582329 1399818 3712494 7505956 6587162
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.358074119
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7815869587 14671159
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
Pathway ID Pathway Name
KEGG:00330 Arginine and proline metabolism
KEGG:01100 Metabolic pathways
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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